Keiji Iwatsuki

Summary

Affiliation: Okayama University
Country: Japan

Publications

  1. ncbi request reprint Staphylococcal cutaneous infections: invasion, evasion and aggression
    Keiji Iwatsuki
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Dermatol Sci 42:203-14. 2006
  2. doi request reprint Karyotypic analysis of bone marrow cells in pyodermic lesions associated with myelodysplastic syndrome
    Toshihisa Hamada
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Arch Dermatol 144:643-8. 2008
  3. ncbi request reprint A spectrum of clinical manifestations caused by host immune responses against Epstein-Barr virus infections
    Keiji Iwatsuki
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Acta Med Okayama 58:169-80. 2004
  4. ncbi request reprint Pathogenic link between hydroa vacciniforme and Epstein-Barr virus-associated hematologic disorders
    Keiji Iwatsuki
    Departments of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Arch Dermatol 142:587-95. 2006
  5. doi request reprint Induction of immune response against NY-ESO-1 by CHP-NY-ESO-1 vaccination and immune regulation in a melanoma patient
    Kazuhide Tsuji
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Cancer Immunol Immunother 57:1429-37. 2008
  6. doi request reprint Production of proinflammatory cytokines without invocation of cytotoxic effects by an Epstein-Barr virus-infected natural killer cell line established from a patient with hypersensitivity to mosquito bites
    Daisuke Suzuki
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Exp Hematol 38:933-44. 2010
  7. ncbi request reprint Effect of formaldehyde gas exposure in a murine allergic contact hypersensitivity model
    Kazuyasu Fujii
    Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Immunopharmacol Immunotoxicol 27:163-75. 2005
  8. ncbi request reprint Assessment of cadexomer iodine against Staphylococcus aureus biofilm in vivo and in vitro using confocal laser scanning microscopy
    Hisanori Akiyama
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Dermatol 31:529-34. 2004
  9. ncbi request reprint A novel fusion gene of collagen type I alpha 1 (exon 31) and platelet-derived growth factor B-chain (exon 2) in dermatofibrosarcoma protuberans
    Gen Nakanishi
    Department of Dermatology, Okayama University Medical School, Okayama, Japan
    Eur J Dermatol 17:217-9. 2007
  10. doi request reprint A higher correlation of the antibody activities against the calcium-dependent epitopes of desmoglein 3 quantified by ethylenediaminetetraacetic acid-treated enzyme-linked immunosorbent assay with clinical disease activities of pemphigus vulgaris
    Koji Kamiya
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Dermatol Sci 70:190-5. 2013

Detail Information

Publications94

  1. ncbi request reprint Staphylococcal cutaneous infections: invasion, evasion and aggression
    Keiji Iwatsuki
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Dermatol Sci 42:203-14. 2006
    ..There is no doubt that targeting the quorum-sensing signaling pathway or anti-toxin therapy is a promising therapeutic approach supportive of primary antibiotic therapy...
  2. doi request reprint Karyotypic analysis of bone marrow cells in pyodermic lesions associated with myelodysplastic syndrome
    Toshihisa Hamada
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Arch Dermatol 144:643-8. 2008
    ..Karyotypic analysis was performed in bone marrow cells and peripheral blood lymphocytes obtained. Serum levels of granulocyte colony-stimulating factor were measured...
  3. ncbi request reprint A spectrum of clinical manifestations caused by host immune responses against Epstein-Barr virus infections
    Keiji Iwatsuki
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Acta Med Okayama 58:169-80. 2004
    ..EBV-associated NK/T cell lymphoproliferative disorders are prevalent in Asia, but quite rare in Western countries. The genetic immunological background, therefore, is closely linked to the development of EBV-associated neoplasms...
  4. ncbi request reprint Pathogenic link between hydroa vacciniforme and Epstein-Barr virus-associated hematologic disorders
    Keiji Iwatsuki
    Departments of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Arch Dermatol 142:587-95. 2006
    ..To determine the pathogenic association of latent Epstein-Barr virus (EBV) infections with both typical hydroa vacciniforme (HV) and severe HV-like eruptions, and to survey the complications and outcomes of patients...
  5. doi request reprint Induction of immune response against NY-ESO-1 by CHP-NY-ESO-1 vaccination and immune regulation in a melanoma patient
    Kazuhide Tsuji
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Cancer Immunol Immunother 57:1429-37. 2008
    ..Cholesterol-bearing hydrophobized pullulan (CHP) is a nanoparticle-forming antigen-delivery vehicle and CHP complexed with NY-ESO-1 protein (CHP-NY-ESO-1) efficiently activates CD4 and CD8 T cells in vitro...
  6. doi request reprint Production of proinflammatory cytokines without invocation of cytotoxic effects by an Epstein-Barr virus-infected natural killer cell line established from a patient with hypersensitivity to mosquito bites
    Daisuke Suzuki
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Exp Hematol 38:933-44. 2010
    ..In order to understand the pathogenesis of HMB, we established an EBV-infected cell line and characterized the cytological profiles...
  7. ncbi request reprint Effect of formaldehyde gas exposure in a murine allergic contact hypersensitivity model
    Kazuyasu Fujii
    Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Immunopharmacol Immunotoxicol 27:163-75. 2005
    ....
  8. ncbi request reprint Assessment of cadexomer iodine against Staphylococcus aureus biofilm in vivo and in vitro using confocal laser scanning microscopy
    Hisanori Akiyama
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Dermatol 31:529-34. 2004
    ..aureus cells within biofilm. Cadexomer iodine is a promising treatment to clear S. aureus cells within biofilm from skin lesions of exudative or infectious wounds and to prevent wound exacerbation...
  9. ncbi request reprint A novel fusion gene of collagen type I alpha 1 (exon 31) and platelet-derived growth factor B-chain (exon 2) in dermatofibrosarcoma protuberans
    Gen Nakanishi
    Department of Dermatology, Okayama University Medical School, Okayama, Japan
    Eur J Dermatol 17:217-9. 2007
    ..The exon 2 of the PDGFB gene fused with exon 31 of the COL1A1 gene was a novel fusion gene...
  10. doi request reprint A higher correlation of the antibody activities against the calcium-dependent epitopes of desmoglein 3 quantified by ethylenediaminetetraacetic acid-treated enzyme-linked immunosorbent assay with clinical disease activities of pemphigus vulgaris
    Koji Kamiya
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Dermatol Sci 70:190-5. 2013
    ..Previously, ethylenediaminetetraacetic acid (EDTA)-treated enzyme-linked immunosorbent assay (ELISA) was found to detect only nonpathogenic anti-Dsg3 antibodies against the non-calcium (Ca(2+))-dependent epitopes...
  11. doi request reprint Hydroa vacciniforme is associated with increased numbers of Epstein-Barr virus-infected γδT cells
    Yoji Hirai
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kawasaki Medical School, Okayama, Japan
    J Invest Dermatol 132:1401-8. 2012
    ..Our observations indicate that HV is associated with increased numbers of EBV(+) γδT cells, whereas HMB is associated with EBV(+) NK cells...
  12. ncbi request reprint [Hypersensitivity to mosquito bites and hydroa vacciniforme]
    Keiji Iwatsuki
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    Nihon Rinsho 64:657-61. 2006
  13. doi request reprint Comparative study on driver mutations in primary and metastatic melanomas at a single Japanese institute: A clue for intra- and inter-tumor heterogeneity
    Tatsuya Kaji
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8558, Japan Melanoma Center, Okayama University Hospital, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8558, Japan
    J Dermatol Sci . 2016
    ..Searching for driver mutations in melanoma is critical to understanding melanoma genesis, progression and response to therapy...
  14. doi request reprint Clues to diagnosis for unusual mucosal pemphigus demonstrating undetectable anti-desmoglein 3 serum antibodies by routine tests
    Koji Kamiya
    Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Dermatol 42:572-9. 2015
    ..In conclusion, the detection of morphological changes in Dsg3 distribution and highly sensitive ELISA method could be useful for the early diagnosis of PV recurrence. ..
  15. pmc Cathelicidin antimicrobial peptide LL-37 in psoriasis enables keratinocyte reactivity against TLR9 ligands
    Shin Morizane
    Division of Dermatology, Department of Medicine, University of California, San Diego and VA San Diego Healthcare System, San Diego, California, USA
    J Invest Dermatol 132:135-43. 2012
    ..These findings suggest that keratinocytes recognize and respond to DNA and can actively participate in contributing to the immunological environment that characterizes psoriasis...
  16. doi request reprint Human leukocyte antigen genotypes and antibody profiles associated with familial pemphigus in Japanese
    Tetsuya Yamamoto
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Dermatol 38:711-6. 2011
    ..These results indicate that an HLA-DRB1*1405 (DQB1*0503) haplotype may confer susceptibility to both PV and PF, and that genetic susceptibility alone is not always responsible for the clinical phenotype and autoantibody profile...
  17. doi request reprint Dendritic cell subsets and immunological milieu in inflammatory human papilloma virus-related skin lesions
    Yumi Nakayama
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    J Dermatol Sci 63:173-83. 2011
    ..Human papilloma virus (HPV)-related warts persist, evading host immune surveillance, but sometimes disappear with inflammation...
  18. ncbi request reprint The association between Staphylococcus aureus strains carrying panton-valentine leukocidin genes and the development of deep-seated follicular infection
    Osamu Yamasaki
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, 700 8558, Japan
    Clin Infect Dis 40:381-5. 2005
    ..However, the clinical manifestations of furuncles caused by PVL-producing Staphylococcus aureus and the role of patients' background are not fully understood...
  19. ncbi request reprint A novel, noninvasive diagnostic probe for hydroa vacciniforme and related disorders: detection of latency-associated Epstein-Barr virus transcripts in the crusts
    Takenobu Yamamoto
    Department of Dermatology, Okayama University School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Microbiol Methods 68:403-7. 2007
    ..To establish a new diagnostic method for Epstein-Barr virus (EBV)-associated cutaneous disorders...
  20. ncbi request reprint Assessment of Streptococcus pyogenes microcolony formation in infected skin by confocal laser scanning microscopy
    Hisanori Akiyama
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Shikata cho 2 5 1, 700 8558, Okayama, Japan
    J Dermatol Sci 32:193-9. 2003
    ..Streptococcus pyogenes and Staphylococcus aureus are often simultaneously detected from many cases of non-bullous impetigo with atopic dermatitis...
  21. doi request reprint Epstein-Barr virus reactivation is induced, but abortive, in cutaneous lesions of systemic hydroa vacciniforme and hypersensitivity to mosquito bites
    Takenobu Yamamoto
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan Department of Dermatology, Kawasaki Medical School, 577 Matsushima, Kurashiki 701 0192, Japan
    J Dermatol Sci 82:153-9. 2016
    ..Epstein-Barr virus (EBV)-associated T/natural killer (NK)-lymphoproliferative disorders (LPDs) include hydroa vacciniforme (HV) and hypersensitivity to mosquito bites (HMB). The pathomechanisms of these diseases are still unclear...
  22. doi request reprint Immune escape phenomenon in molluscum contagiosum and the induction of apoptosis
    Akiko Yamauchi-Yamada
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Dermatol 41:1058-64. 2014
    ....
  23. ncbi request reprint Dynamic alteration of human beta-defensin 2 localization from cytoplasm to intercellular space in psoriatic skin
    Wook Kang Huh
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Mol Med (Berl) 80:678-84. 2002
    ..This dynamic change in hBD-2 distribution in epidermis is certainly relevant to function as an innate host defense mechanism against invading micro-organisms...
  24. doi request reprint Eccrine poromatosis associated with polychemotherapy
    Kazuyasu Fujii
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Acta Derm Venereol 92:687-90. 2012
    ..In addition to radiation therapy, intensive chemotherapy may play a role in the pathogenesis of multiple eccrine poromas even many years after treatment...
  25. doi request reprint Proteomic study identified HSP 70 kDa protein 1A as a possible therapeutic target, in combination with histone deacetylase inhibitors, for lymphoid neoplasms
    Kazuyasu Fujii
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry Pharmaceutical Sciences, Okayama 700 0815, Japan
    J Proteomics 75:1401-10. 2012
    ..Treatment with KNK-437 facilitated the apoptotic effects of VPA. In conclusion, we identified HSPA1A as a possible therapeutic target, in combination with HDACi, for lymphoid neoplasms...
  26. ncbi request reprint Mosquito salivary gland extracts induce EBV-infected NK cell oncogenesis via CD4 T cells in patients with hypersensitivity to mosquito bites
    Hideo Asada
    Department of Dermatology, Nara Medical University School of Medicine, Karshihara, Japan
    J Invest Dermatol 125:956-61. 2005
    ..These results suggest that mosquito bites can induce expression of the viral oncogene LMP1 in NK cells via mosquito antigen-specific CD4+ T cells, which is involved in the oncogenesis of NK cells in vivo...
  27. ncbi request reprint Leukocyte common antigen-negative, aggressive cutaneous anaplastic large cell lymphoma with prominent pseudocarcinomatous hyperplasia
    Hiroko Sugiyama
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Eur J Dermatol 18:74-7. 2008
    ..The diagnosis of ALCL was delayed in our case because of the prominent PCH, the lack of LCA, and the unusually rapid progression of the tumor...
  28. ncbi request reprint CpG immunostimulatory sequences enhance contact hypersensitivity responses in mice
    Hitoshi Akiba
    Department of Dermatology, Fukushima Medical University School of Medicine, Hikarigaoka 1, Fukushima 960 1295, Japan
    J Invest Dermatol 123:488-93. 2004
    ..Taken together, the results show that CpG ODN may be responsible for immune side-effects such as worsening of T cell-mediated skin diseases...
  29. ncbi request reprint Actions of gluco-oligosaccharide against Staphylococcus aureus
    Hisanori Akiyama
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Japan
    J Dermatol 29:580-6. 2002
    ..Further, 5% C-OS can inhibit glycocalyx production by S. aureus cells and consequently have some suppressive effect on the colonization of S. aureus on the horny cells of AD lesions...
  30. doi request reprint Usefulness of serum 5-S-cysteinyl-dopa as a biomarker for predicting prognosis and detecting relapse in patients with advanced stage malignant melanoma
    Hiroshi Umemura
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Dermatol . 2016
    ..These results indicate the usefulness of measuring serum 5-S-cysteinyl-dopa levels at initial hospital visit and during follow up for early and effective therapeutic interventions using newly developed molecular targeted drugs...
  31. doi request reprint Phase I/II study of the oral retinoid X receptor agonist bexarotene in Japanese patients with cutaneous T-cell lymphomas
    Toshihisa Hamada
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Dermatol . 2016
    ..No patients discontinued bexarotene due to the AE during the study, but dose reduction or suspension was required. Bexarotene was shown to be well tolerated at 300 mg/m2 once daily and effective in Japanese patients with CTCL...
  32. doi request reprint Valproic acid inhibits proliferation of EB virus-infected natural killer cells
    Kazuyasu Fujii
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    Hematology 17:163-9. 2012
    ..Finally, sub-G1 accumulation was increased after 72 hours following stimulation. These findings indicate that VPA might be a therapeutic option for EBV-associated NK-cell LPDs...
  33. doi request reprint Oculomucosal and gastrointestinal involvement in Epstein-Barr virus-associated hydroa vacciniforme
    Takenobu Yamamoto
    Department of Dermatology, Okayama Graduate School of Medicine, Okayama, Japan
    Eur J Dermatol 22:380-3. 2012
    ..2%) presented with severe HV complicated gastrointestinal involvement. Oculomucosal lesions are sometimes complicated in patients with EBV-related HV and HMB, and gastrointestinal involvement may occur in the severe form...
  34. doi request reprint A prospective analysis of anti-desmoglein antibody profiles in patients with rheumatoid arthritis treated with thiol compounds
    Tetsuya Yamamoto
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry Pharmaceutical Sciences, Kita ku, Okayama 700 8558, Japan
    J Dermatol Sci 59:170-5. 2010
    ..Drug-induced pemphigus is mainly caused by drugs containing sulfhydryl (thiol) groups in their molecules...
  35. ncbi request reprint A case of intravascular large B-cell lymphoma with multiple organ involvement
    Hirokatsu Yanagihori
    Department of Dermatology, Fukushima Medical University School of Medicine, Fukushima 960 1295, Japan
    J Dermatol 30:910-4. 2003
    ..Despite various clinical presentations, no neurological abnormality was observed until the patient died 12 months after the initial combination chemotherapy...
  36. ncbi request reprint Bullous Systemic Lupus Erythematosus as an Initial Manifestation of SLE
    Wataru Fujimoto
    Department of Dermatology, Kawasaki Medical School, Matsushima 577, Kurashiki shi, Okayama 701 0192, Japan
    J Dermatol 32:1021-7. 2005
    ..Our case illustrates that a generalized vesiculobullous eruption can be the sole presenting manifestation of SLE. It also emphasizes the close temporal relationship between BSLE and lupus nephritis...
  37. ncbi request reprint Assessment of melanoma-initiating cell markers and conventional parameters in sentinel lymph nodes of malignant melanoma
    Norihiro Suzuki
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 69:17-27. 2015
    ..To make a definite diagnosis of metastasis, we still need a combination of immunohistochemical and molecular probes. ABCB5 might be a suitable molecular marker for the detection of melanoma-initiating cells in SLNs. ..
  38. doi request reprint Increase of DC-LAMP+ mature dendritic cell subsets in dermatopathic lymphadenitis of mycosis fungoides
    Kotaro Tada
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan, Department of Dermatology, Kurashiki Daiichi Hospital, Kurashiki 710 0826, Japan
    Eur J Dermatol 24:670-5. 2014
    ..Little is known about the immunological milieu of the skin-draining lymph nodes (LNs) in mycosis fungoides (MF)...
  39. ncbi request reprint Expression of double-stranded RNA-activated protein kinase in keratinocytes and keratinocytic neoplasia
    Michiyo Kuyama
    Department of Dermatology, Konkô Hospital, Okayama 719 0104, Japan
    J Dermatol 30:579-89. 2003
    ....
  40. doi request reprint Novel and recurrent PORCN gene mutations in almost unilateral and typical focal dermal hypoplasia patients
    Gen Nakanishi
    Department of Dermatology, Shiga University of Medical Science, Seta tsukinowa cho, Otsu City, Shiga, 520 2192, Japan
    Eur J Dermatol 23:64-7. 2013
    ..We report a typical FDH patient with a recurrent PORCN mutation, which was previously identified in a male Japanese FDH patient, and a second female, an almost unilateral FDH patient with a postzygotic PORCN mutation...
  41. ncbi request reprint Actions of farnesol and xylitol against Staphylococcus aureus
    Hisanori Akiyama
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Chemotherapy 48:122-8. 2002
    ..aureus is high in strains from AD in Japan. Our objective in the present study was to investigate the actions of farnesol and xylitol against S. aureus for the control of AD skin lesion-colonizing S. aureus...
  42. pmc T cell immunomonitoring and tumor responses in patients immunized with a complex of cholesterol-bearing hydrophobized pullulan (CHP) and NY-ESO-1 protein
    Akiko Uenaka
    Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata cho, Okayama, Japan
    Cancer Immun 7:9. 2007
    ..The use of whole protein, containing multiple CD4 and CD8 epitopes, may be beneficial for cancer vaccines to prevent tumors from evading the immune response...
  43. ncbi request reprint Prospective study of clinical symptoms and skin test reactions in medical students exposed to formaldehyde gas
    Sachiko Takahashi
    Department of Dermatology, Okayama Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Dermatol 34:283-9. 2007
    ..Students with an episode of atopic dermatitis and allergic rhinitis were susceptible to formaldehyde exposure, and developed mucocutaneous symptoms, probably due to the impaired barrier function and remodeling of the skin and mucosa...
  44. ncbi request reprint A case of infectious eccrine hidradenitis
    Takashi Oono
    Department of Dermatology, Okayama Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan
    J Dermatol 33:142-5. 2006
    ..Gram-positive cocci were present in the lesional eccrine duct indicating an infective origin of the disease. Human beta defensin-2, one of epithelial antimicrobial peptides, was present in the lesional epidermis and eccrine duct...
  45. ncbi request reprint Interferon-gamma-induced 15-lipoxygenase-2 expression in normal human epidermal keratinocytes and a pathogenic link to psoriasis vulgaris
    Namiko Setsu
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata cho 2 5 1, Okayama 700 8558, Japan
    Eur J Dermatol 16:141-5. 2006
    ..These results indicate that 15-lipoxygenase-2 is implicated in interferon-gamma-induced inflammatory processes in normal human epidermal keratinocytes and psoriatic skin...
  46. doi request reprint Atypical pemphigus with immunoglobulin G autoantibodies against desmoglein 3 and desmocollin 3
    Koji Kamiya
    Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Dermatol 43:429-31. 2016
    ..Our case suggests that anti-Dsc3 antibodies may be pathogenic in cases positive for the dual cadherin autoantibodies. ..
  47. doi request reprint Vaccination with NY-ESO-1 overlapping peptides mixed with Picibanil OK-432 and montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen
    Hisashi Wada
    Department of Gastroenterological Surgery, Graduate School of Medicine Experimental Immunology, Immunology Frontier Research Center, Osaka University, Suita, Osaka Department of Respiratory Medicine, Kawasaki Medical School Faculty of Health and Welfare, Kawasaki University of Medical Welfare, Kurashiki Departments of Medicine Dermatology Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama Departments of Immunotherapeutics Gastrointestinal Surgery, University of Tokyo Hospital, Bunkyo ku Department of Pathology, Tokyo Medical University, Shinjuku ku Department of Gastroenterological Surgery, The Cancer Institute Hospital, Koto ku, Tokyo, Japan Ludwig Institute for Cancer Research, New York, NY
    J Immunother 37:84-92. 2014
    ..In conclusion, our study indicated that the NY-ESO-1 OLP vaccine mixed with Picibanil OK-432 and Montanide ISA-51 was well tolerated and elicited NY-ESO-1-specific humoral and CD4 and CD8 T-cell responses in immunized patients. ..
  48. doi request reprint Guidelines for the management of cutaneous lymphomas (2011): a consensus statement by the Japanese Skin Cancer Society - Lymphoma Study Group
    Makoto Sugaya
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Dermatol 40:2-14. 2013
    ..These guidelines, together with the degrees of recommendation, have been made in the context of limited medical treatment resources, and standard medical practice within the framework of the Japanese National Health Insurance system...
  49. ncbi request reprint Introduction of an N-terminal peptide of S100C/A11 into human cells induces apoptotic cell death
    Eiichi Makino
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikatachou, 700 8558, Okayama, Japan
    J Mol Med (Berl) 82:612-20. 2004
    ..These results indicate that MAK19 induces apoptosis in human cell lines and may therefore lead to the establishment of a new molecular target for the treatment of human cancer...
  50. doi request reprint Phase I and pharmacokinetic study of the oral histone deacetylase inhibitor vorinostat in Japanese patients with relapsed or refractory cutaneous T-cell lymphoma
    Hidefumi Wada
    Department of Dermatology, Yokohama City University School of Medicine, Yokohama, Japan
    J Dermatol 39:823-8. 2012
    ..One of the three evaluable patients experienced pruritus relief. Vorinostat was well tolerated at a dose of 400 mg p.o. once daily and showed potential efficacy in Japanese patients with CTCL, warranting further investigation...
  51. doi request reprint Epidermolysis bullosa nevus arising in a patient with Dowling-Meara type epidermolysis bullosa simplex with a novel K5 mutation
    Hiroko Sugiyama-Fukamatsu
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Phartmaceutical Sciences, Okayama, Japan
    J Dermatol 36:447-52. 2009
    ..Gene analysis revealed an E478K (Glu to Lys) mutation in exon 5 of the keratin 5 (K5) gene. These findings, together with clinical features, were consistent with those of Dowling-Meara type EB associated with so-called EB nevus...
  52. doi request reprint Catabolism of pemphigus foliaceus autoantibodies by high-dose IVIg therapy
    Yumi Aoyama
    Department of Dermatology, Okayama University Graduate School of Medicine, Okayama, 700 8558, Japan
    Eur J Dermatol 21:58-61. 2011
    ..IVIg itself appears to accelerate IgG degradation rather than suppress IgG production. Sufficient suppression of antibody production is critical for successful treatment with IVIg...
  53. ncbi request reprint A case of SAPHO syndrome with pyoderma gangrenosum and inflammatory bowel disease masquerading as Behçet's disease
    Osamu Yamasaki
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Adv Exp Med Biol 528:339-41. 2003
  54. ncbi request reprint Multicentric Castleman's disease associated with inherited epidermolysis bullosa
    Yoshio Kawakami
    Department of Dermatology, Fukushima Medical University School of Medicine, Fukushima, Japan
    J Dermatol 30:689-93. 2003
    ..In addition, his serum interleukin-6, which is thought to be responsible for the clinical symptoms in MCD, was elevated...
  55. ncbi request reprint Fatal natural killer cell lymphoma arising in a patient with a crop of Epstein-Barr virus-associated disorders
    Yukiko Nitta
    Department of Dermatology, National Hospital Organization Nagoya Medical Center, Nagoya 460 0001, Japan
    Eur J Dermatol 15:503-6. 2005
    ..Our observations confirm the spectrum of EBV-associated cutaneous disorders and indicate the importance of long-term follow-up...
  56. ncbi request reprint Different properties of three isoforms (alpha, beta, and gamma) of transcription factor AP-2 in the expression of human keratinocyte genes
    Noritaka Oyama
    Department of Dermatology, Fukushima Medical University School of Medicine, Japan
    Arch Dermatol Res 294:273-80. 2002
    ..Disruption of the epidermal AP-2 balance may contribute to hyperproliferative conditions, such as psoriasis and SCC...
  57. doi request reprint Tracing of the molecular remnants of herpes virus infections in necrotic skin tissue
    Takenobu Yamamoto
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Eur J Dermatol 18:499-503. 2008
    ..Herpes virus- and host-derived transcripts contained in crusts can be detected by RT-PCR amplification. Crusts or dry epidermal necrosis with inflammatory cells may provide beneficial diagnostic information...
  58. ncbi request reprint Bilateral conjunctival lesions in blastic plasmacytoid dendritic cell neoplasm
    Toshihiko Matsuo
    Department of Ophthalmology, Okayama University Medical School and Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
    J Clin Exp Hematop 51:49-55. 2011
    ..In conclusion, the conjunctiva could be involved with BPDCN and pathological differential diagnosis by biopsy is mandatory to establish the correct diagnosis...
  59. ncbi request reprint Confocal laser microscopic observation of glycocalyx production by Staphylococcus aureus in vitro
    Hisanori Akiyama
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Dermatol Sci 29:54-61. 2002
    ..We consider that this simple method is very useful for the detection of S. aureus glycocalyx on dermatology field...
  60. ncbi request reprint Generalized morphea-like lesions arising in mechanically-compressed areas by underclothes
    Mutsuko Ehara
    Department of Dermatology, Okayama University School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
    Eur J Dermatol 16:307-9. 2006
    ..We believe that the Koebner phenomenon, resulting from local compression by underclothes, might be responsible for the development of morphea-like lesions in patients with subclinical systemic sclerosis...
  61. doi request reprint Markedly elevated serum levels of calcium-binding S100A8/A9 proteins in psoriatic arthritis are due to activated monocytes/macrophages
    Seiko Aochi
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    J Am Acad Dermatol 64:879-87. 2011
    ..Serum levels of S100A8/A9 may correlate with disease activity in psoriasis...
  62. ncbi request reprint Paraneoplastic pemphigus associated with Castleman's disease and asymptomatic bronchiolitis obliterans
    Wataru Fujimoto
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Eur J Dermatol 12:355-9. 2002
    ..The expiratory images of high resolution computed tomography showed air trapping, indicating the presence of asymptomatic but gradually progressive bronchiolitis obliterans...
  63. doi request reprint The involvement of serum amyloid A in psoriatic inflammation
    Shin Morizane
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan Electronic address
    J Invest Dermatol . 2016
    ..Here we report that psoriatic inflammation increases serum amyloid A (SAA) expression in epidermal keratinocytes, and that SAA also induces cytokines, chemokines, and AMPs in the cells...
  64. doi request reprint Hypocomplementemic urticarial vasculitis arising in a patient with immunoglobulin G4-related disease
    Mariko Takao
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Int J Dermatol 55:430-3. 2016
    ..Various cutaneous lesions may occur in IgG4-related disease...
  65. doi request reprint Sentinel lymph node biopsy for 102 patients with primary cutaneous melanoma at a single Japanese institute
    Masaki Otsuka
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Dermatol 42:954-61. 2015
    ..Features of ALM may be different between Asians and Caucasians...
  66. doi request reprint Grading criteria for disease severity by pemphigus disease area index
    Tomoko Shimizu
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Dermatol 41:969-73. 2014
    ..The PDAI is not only a useful tool to measure the extent of cutaneous lesions, but also an excellent scoring system for evaluating pemphigus disease severity. ..
  67. doi request reprint Phase II study of i.v. interferon-gamma in Japanese patients with mycosis fungoides
    Makoto Sugaya
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Dermatol 41:50-6. 2014
    ..Another patient was withdrawn from the study due to drug-related cough, which disappeared after discontinuation of the drug. Overall, interferon-γ was effective and well-tolerated in Japanese patients with MF. ..
  68. doi request reprint Diversity of Epstein-Barr virus BamHI-A rightward transcripts and their expression patterns in lytic and latent infections
    Takenobu Yamamoto
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    J Med Microbiol 61:1445-53. 2012
    ..These data indicate that at least six splicing forms can be expressed by EBV-infected cells or tissues, although the expression patterns or levels differ for different infection states such as lytic and latent infections...
  69. ncbi request reprint Primary cutaneous marginal zone B-cell lymphoma
    Kazuhide Tsuji
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata cho 2 5 1, Okayama 700 8558, Japan
    Eur J Dermatol 15:480-3. 2005
    ..1;q32) were not reported in any of the Japanese cases. Although two patients developed metastasis on the skin after radiation therapy, none died of lymphoma...
  70. ncbi request reprint Hydroa vacciniforme-like eruptions in a patient with chronic active EB virus infection
    Yoshiyuki Katagiri
    Department of Dermatology, Yamagata University School of Medicine, Japan
    J Dermatol 30:400-4. 2003
    ..A real time PCR method showed 171,741 copies/ micro g DNA in CD 16 positive cells. Although latent EBV infection-associated eruptions have been documented, detailed skin manifestations in CAEBV are less well known...
  71. ncbi request reprint Effects of human neutrophil peptide-1 on the expression of interstitial collagenase and type I collagen in human dermal fibroblasts
    Takashi Oono
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Shikata cho, 2 5 1, Okayama 700 8558, Japan
    Arch Dermatol Res 294:185-9. 2002
    ..In contrast, the expression of MMP-1 was decreased at both the mRNA and protein levels. Our observations suggest that HNP-1 may promote wound repair by enhancing extracellular matrix deposition and by controlling its degradation...
  72. ncbi request reprint A mutilating arthropathy, "rhupus hands" associated with multiple synovial cysts in a patient with systemic lupus erythematosus
    Katsuhiro Hitomi
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Dermatol 33:415-8. 2006
    ..Herein, we report a case of rhupus hands with multiple synovial cysts arising in a 60-year-old woman with SLE...
  73. ncbi request reprint Cutaneous angiolipoleiomyoma
    Eiichi Makino
    Department of Dermatology, Okayama University, Graduate School of Medicine and Dentistry, Okayama Shi, Japan
    J Am Acad Dermatol 54:167-71. 2006
    ....
  74. doi request reprint Surgical management of axillary necrotizing fasciitis: a case report
    Osamu Yamasaki
    Department of Dermatology, Okayama Red Cross Hospital, Okayama, Japan
    J Dermatol 39:309-11. 2012
    ..We performed reconstruction with a pedicled latissimus dorsi flap on day 78. This case highlights some of the important surgical considerations in the management of axillary NF...
  75. ncbi request reprint Initial recruitment of interferon-gamma-producing CD8+ effector cells, followed by infiltration of CD4+ cells in 2,4,6-trinitro-1-chlorobenzene (TNCB)-induced murine contact hypersensitivity reactions
    Fusako Okazaki
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Dermatol 29:699-708. 2002
    ....
  76. ncbi request reprint Hypersensitivity to mosquito bites with natural-killer cell lymphocytosis: the possible implication of Epstein-Barr virus reactivation
    Masataka Satoh
    Department of Dermatology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Eur J Dermatol 12:381-4. 2002
    ..Based on this evidence, he was diagnosed as being in a smoldering stage of HMB, in which EBV-associated NK cell lymphoproliferation might participate in its pathogenesis...
  77. doi request reprint Retrospective analysis of 133 patients with cutaneous lymphomas from a single Japanese medical center between 1995 and 2008
    Atsushi Fujita
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Shikata cho, Okayama, Japan
    J Dermatol 38:524-30. 2011
    ..6%), but that of the patients with primary cutaneous anaplastic large cell lymphoma (C-ALCL) was extremely less favorable than previously reported (5-year survival rate of 47.4%)...
  78. ncbi request reprint Over-expression of the testis-specific gene TSGA10 in cancers and its immunogenicity
    Ryo Tanaka
    Departments of Immunology, Okayama University Graduate School of Medicine and Dentistry, Japan
    Microbiol Immunol 48:339-45. 2004
    ..Serological analysis revealed that 3 out of 346 patients with various types of cancer possessed antibody against recombinant TSGA10 protein. They included 2 patients with hepatocellular carcinoma and a patient with malignant melanoma...
  79. doi request reprint A randomized double-blind trial of intravenous immunoglobulin for pemphigus
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Am Acad Dermatol 60:595-603. 2009
    ..It has been difficult to conduct a double-blind clinical study for pemphigus partly because, in a placebo group, appropriate treatment often must be provided when the disease flares...
  80. ncbi request reprint Neutrophilic eccrine hidradenitis in actinic reticuloid syndrome
    Michiko Tojo
    Department of Dermatology, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima 960 1295, Japan
    Eur J Dermatol 12:198-200. 2002
    ..We report the first case of NEH arising in a patient with actinic reticuloid syndrome who had been treated with methotrexate...
  81. ncbi request reprint Recombinant human intelectin binds bovine lactoferrin and its peptides
    Kouichirou Shin
    Food Science and Technology Institute, Morinaga Milk Industry Co, Ltd, Kanagawa, Japan
    Biol Pharm Bull 31:1605-8. 2008
    ..A very low binding of rhIntL was observed for bovine serum albumin or transferrin. These findings suggest that hIntL acts as a receptor for bLF and its digested fragments...
  82. ncbi request reprint Antibody response against NY-ESO-1 in CHP-NY-ESO-1 vaccinated patients
    Ryohei Kawabata
    Department of Surgery, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Int J Cancer 120:2178-84. 2007
    ..The antigenic epitopes recognized by antibodies in the vaccinated patients were similar to those recognized in cancer patients with spontaneous humoral immunity against NY-ESO-1...
  83. ncbi request reprint In vitro Th1 cytokine-independent Th2 suppressive effects of bifidobacteria
    Noriyuki Iwabuchi
    Food Science and Technology Institute, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa, Japan
    Microbiol Immunol 51:649-60. 2007
    ..These results suggested that BB536 suppressed Th2 immune responses, partially independent of Th1-inducing cytokines and independent of regulatory cytokines, mediated by antigen-presenting cells such as dendritic cells...
  84. ncbi request reprint Influence of Bifidobacterium longum BB536 intake on faecal microbiota in individuals with Japanese cedar pollinosis during the pollen season
    Toshitaka Odamaki
    Food Research and Development Laboratory Morinaga Milk Industry Co Ltd, Zama, Kanagawa 228 8583, Japan
    J Med Microbiol 56:1301-8. 2007
    ..05). These results suggest that faecal microbiota in JCPsis subjects, but not healthy subjects, fluctuate at the end of the pollen season and that BB536 intake plays a role in maintaining normal microbiota...
  85. ncbi request reprint Clinical efficacy of probiotic Bifidobacterium longum for the treatment of symptoms of Japanese cedar pollen allergy in subjects evaluated in an environmental exposure unit
    Jin Zhong Xiao
    Food Research and Development Laboratory, Morinaga Milk Industry Co, Ltd, Kanagawa, Japan
    Allergol Int 56:67-75. 2007
    ..Japanese cedar pollinosis (JCPsis) affects nearly one in six Japanese. Oral administration of Bifidobacterium longum BB536 has been shown to be effective in relieving JCPsis symptoms during the pollen season...
  86. ncbi request reprint An immunostimulatory DNA sequence from a probiotic strain of Bifidobacterium longum inhibits IgE production in vitro
    Noritoshi Takahashi
    Food Research and Development Laboratory, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa, Japan
    FEMS Immunol Med Microbiol 46:461-9. 2006
    ..The results suggest the potential of ODNs BL07 and BL07S in preventing IgE-related immune responses and the possible involvement of ODN BL07 in the antiallergic efficacy of B. longum BB536...
  87. ncbi request reprint Changes in plasma TARC levels during Japanese cedar pollen season and relationships with symptom development
    Jin Zhong Xiao
    Food Research and Development Laboratory, Morinaga Milk Industry, Zama, Japan
    Int Arch Allergy Immunol 144:123-7. 2007
    ..The present study aims to evaluate the relationship between TARC levels and disease symptoms during the pollen season...
  88. ncbi request reprint Database of two-dimensional polyacrylamide gel electrophoresis of proteins labeled with CyDye DIGE Fluor saturation dye
    Kazuyasu Fujii
    Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Proteomics 6:1640-53. 2006
    ....
  89. ncbi request reprint Oral administration of an immunostimulatory DNA sequence from Bifidobacterium longum improves Th1/Th2 balance in a murine model
    Noritoshi Takahashi
    Food Research and Development Laboratory, Morinaga Milk Industry Co, Ltd, Zama, Japan
    Biosci Biotechnol Biochem 70:2013-7. 2006
    ..ODN BL07S increased Th1 cytokine and decreased Th2 cytokine production in splenocytes. These results suggest that immunostimulatory ODNs are potentially associated with the antiallergic effects of probiotics...
  90. ncbi request reprint Defining early mycosis fungoides
    Nicola Pimpinelli
    Department of Dermatological Sciences, University of Florence, Florence, Italy
    J Am Acad Dermatol 53:1053-63. 2005
    ....
  91. ncbi request reprint Characterization of Epstein-Barr virus-infected natural killer lymphocytes in a patient with hypersensitivity to mosquito bites
    Takenobu Yamamoto
    J Am Acad Dermatol 53:912-4. 2005
  92. ncbi request reprint NK-cell neoplasms in Japan
    Kazuo Oshimi
    Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
    Hematology 10:237-45. 2005
    ..In nasal NK-cell lymphoma, Epstein-Barr virus in tumor cells was detected in all patients tested, suggesting its causative role...
  93. ncbi request reprint Eradication of Epstein-Barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNA1
    Md Nasimuzzaman
    Department of Molecular Microbiology and Infections, Kochi Medical School, Kohasu, Oko cho, Nankoku, Kochi 783 8505, Japan
    Mol Ther 11:578-90. 2005
    ..The mutant will afford an additional therapeutic strategy specifically targeting EBV-associated malignancies...
  94. ncbi request reprint Protein expression pattern distinguishes different lymphoid neoplasms
    Kazuyasu Fujii
    Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Proteomics 5:4274-86. 2005
    ..These proteins may have potential as differential diagnostic markers for lymphoid neoplasms...