E Gohda

Summary

Affiliation: Okayama University
Country: Japan

Publications

  1. ncbi request reprint Induction of hepatocyte growth factor/scatter factor by interferon-gamma in human leukemia cells
    E Gohda
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Japan
    J Cell Physiol 174:107-14. 1998
  2. ncbi request reprint Induction of apoptosis by hepatocyte growth factor/scatter factor and its augmentation by phorbol esters in Meth A cells
    E Gohda
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Naka, Okayama, 700 8530, Japan
    Biochem Biophys Res Commun 245:278-83. 1998
  3. ncbi request reprint [Function and regulation of production of hepatocyte growth factor (HGF)]
    Eiichi Gohda
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Naka, Okayama 700 8530, Japan
    Nihon Yakurigaku Zasshi 119:287-94, 309. 2002
  4. ncbi request reprint Synergism between interferon-gamma and cAMP in induction of hepatocyte growth factor in human skin fibroblasts
    E Gohda
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Naka, Okayama, 700 8530, Japan
    Cytokine 12:780-5. 2000
  5. ncbi request reprint Stimulation of hepatocyte growth factor production in human fibroblasts by the protein phosphatase inhibitor okadaic acid
    E Gohda
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Naka, 700 8530, Okayama, Japan
    Biochem Pharmacol 60:1531-7. 2000
  6. ncbi request reprint Increased hepatocyte growth factor production by aging human fibroblasts mainly due to autocrine stimulation by interleukin-1
    M Miyazaki
    Department of Cell Biology, Okayama University Medical School, Japan
    Biochem Biophys Res Commun 246:255-60. 1998
  7. ncbi request reprint Transforming growth factor-beta 1 stimulates or inhibits cell growth via down- or up-regulation of p21/Waf1
    M Miyazaki
    Department of Cell Biology, Okayama University Medical School, Japan
    Biochem Biophys Res Commun 246:873-80. 1998
  8. ncbi request reprint An isocratic HPLC method for the simultaneous determination of novel stable lipophilic ascorbic acid derivatives and their metabolites
    Akihiro Tai
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700 8530, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 840:38-43. 2006
  9. ncbi request reprint Determination of ascorbic acid and its related compounds in foods and beverages by hydrophilic interaction liquid chromatography
    Akihiro Tai
    Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8530, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 853:214-20. 2007
  10. ncbi request reprint Promotion of antigen-specific antibody production in murine B cells by a moderate increase in histone acetylation
    T Kohge
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Japan
    Biochem Pharmacol 56:1359-64. 1998

Collaborators

  • Itaru Yamamoto
  • Akihiro Tai
  • Masaharu Takigawa
  • T Matsunaga
  • S Nakamura
  • T Tsuji
  • R Ohashi
  • M Yanagida
  • Tomomi Goto
  • Morio Saito
  • Ming Zhong
  • T Nagao
  • Yoichiro Takami
  • Jun Takebayashi
  • Takahiro Motoki
  • Hirohito Tsubouchi
  • Yohsuke Matsumoto
  • Kaori Hiramatsu
  • Yasuyuki Yagi
  • Takehiro Ono
  • Yoshihiro Sugiura
  • Satoshi Kubota
  • Ritsuko Yoshihara
  • M Miyazaki
  • Masayoshi Iwasaki
  • Miho Sakai
  • Hirofumi Uto
  • Chizuko Yukizaki
  • Isao Akagi
  • Hisatoshi Ino
  • Ryuji Asano
  • Saeko Kawai
  • Kenji Ichiyama
  • Eriko Aoyama
  • Kazutaka Makino
  • Hiroaki Kaji
  • Yoshinori Nakae
  • Yusuke Kadota
  • T Kohge
  • M Namba
  • Yasushi Koike
  • Masahiro Miyazaki
  • Fumio Yuasa
  • Yuming Zhang
  • Jianfeng Wang
  • Yasushi Adachi
  • Susumu Ikehara
  • Toshiji Iwasaka
  • Keizo Minamino
  • Keiji Nakano
  • Yasuhiro Suzuki
  • Takashi Nishiue
  • Shigeru Taketani
  • Hiromi Mukaide
  • Takehisa Ishii
  • Kayoko Kanasaki
  • Tomoyo Horio
  • Tomohiro Sotani
  • T Okamura
  • K Mihara
  • K Kaji
  • T Kubin
  • Y Hayashi
  • S Mori

Detail Information

Publications27

  1. ncbi request reprint Induction of hepatocyte growth factor/scatter factor by interferon-gamma in human leukemia cells
    E Gohda
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Japan
    J Cell Physiol 174:107-14. 1998
    ....
  2. ncbi request reprint Induction of apoptosis by hepatocyte growth factor/scatter factor and its augmentation by phorbol esters in Meth A cells
    E Gohda
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Naka, Okayama, 700 8530, Japan
    Biochem Biophys Res Commun 245:278-83. 1998
    ..These results indicate that HGF/SF induced the apoptotic cell death of the Meth A sarcoma cell line and that protein kinase C activation augmented the growth factor-induced apoptosis...
  3. ncbi request reprint [Function and regulation of production of hepatocyte growth factor (HGF)]
    Eiichi Gohda
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Naka, Okayama 700 8530, Japan
    Nihon Yakurigaku Zasshi 119:287-94, 309. 2002
    ..ELISA kits for assays of serum and plasma HGF levels are clinically used to prognosticate the development of fulminant hepatic failure...
  4. ncbi request reprint Synergism between interferon-gamma and cAMP in induction of hepatocyte growth factor in human skin fibroblasts
    E Gohda
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Naka, Okayama, 700 8530, Japan
    Cytokine 12:780-5. 2000
    ..These results indicate that IFN-gamma synergistically stimulates cAMP-induced HGF production and inhibits HGF production induced by growth factors and protein kinase C activators in human skin fibroblasts...
  5. ncbi request reprint Stimulation of hepatocyte growth factor production in human fibroblasts by the protein phosphatase inhibitor okadaic acid
    E Gohda
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Naka, 700 8530, Okayama, Japan
    Biochem Pharmacol 60:1531-7. 2000
    ....
  6. ncbi request reprint Increased hepatocyte growth factor production by aging human fibroblasts mainly due to autocrine stimulation by interleukin-1
    M Miyazaki
    Department of Cell Biology, Okayama University Medical School, Japan
    Biochem Biophys Res Commun 246:255-60. 1998
    ..The increased production of HGF by aging fibroblasts from human embryonic lung tissue is mainly due to autocrine stimulation by interleukin-1...
  7. ncbi request reprint Transforming growth factor-beta 1 stimulates or inhibits cell growth via down- or up-regulation of p21/Waf1
    M Miyazaki
    Department of Cell Biology, Okayama University Medical School, Japan
    Biochem Biophys Res Commun 246:873-80. 1998
    ..Thus the cell growth stimulation or inhibition by TGF-beta 1 are mediated by the down- or up-regulation of p21/ Waf1, respectively...
  8. ncbi request reprint An isocratic HPLC method for the simultaneous determination of novel stable lipophilic ascorbic acid derivatives and their metabolites
    Akihiro Tai
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700 8530, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 840:38-43. 2006
    ..The results show that the procedure is rapid and simple and that it can be employed for in vitro metabolic analysis of various AA derivatives...
  9. ncbi request reprint Determination of ascorbic acid and its related compounds in foods and beverages by hydrophilic interaction liquid chromatography
    Akihiro Tai
    Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8530, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 853:214-20. 2007
    ..The results show that the procedure is simple and sensitive and that it can be employed for the simultaneous determination of AA and its related compounds in foods and beverages...
  10. ncbi request reprint Promotion of antigen-specific antibody production in murine B cells by a moderate increase in histone acetylation
    T Kohge
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Japan
    Biochem Pharmacol 56:1359-64. 1998
    ..These results suggest that a moderate increase in histone acetylation may play a significant role in promoting antigen-specific antibody production in B cells...
  11. ncbi request reprint Inhibition of DNA synthesis of adult rat hepatocytes in primary culture by dibutyrylcytidine 3', 5'-cyclic monophosphate
    T Kubin
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Japan
    Cell Biol Int Rep 13:907-17. 1989
    ..When added at the onset of DNA synthesis, Bt2cAMP was much less effective, but Bt2cCMP was still effective. Thus Bt2cCMP is able to inhibit growth factor-stimulated hepatocyte proliferation...
  12. ncbi request reprint Vitamin C activity in guinea pigs of 6-O-acyl-2-O-alpha-D-glucopyranosyl-L- ascorbic acids with a branched-acyl chain
    Akihiro Tai
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700 8530, Japan
    Biosci Biotechnol Biochem 67:1675-82. 2003
    ..These results indicate that 6-bAcyl-AA-2G is a readily available source of AA in vivo, and may be a promising antioxidant for skin care and treatment of diseases associated with oxidative stress...
  13. ncbi request reprint Modulation of hepatocyte growth factor induction in human skin fibroblasts by retinoic acid
    Yoichiro Takami
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Naka, Okayama 700 8530, Japan
    Biochim Biophys Acta 1743:49-56. 2005
    ..These results suggest that ATRA augments the induction of HGF production caused by increased intracellular cAMP...
  14. ncbi request reprint 2-O-alpha-D-glucopyranosyl-L-ascorbic acid scavenges 1,1-diphenyl-2-picrylhydrazyl radicals via a covalent adduct formation
    Jun Takebayashi
    Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Biosci Biotechnol Biochem 71:754-60. 2007
    ..The radical-scavenging mechanism of AA-2G elucidated in this study should be useful in understanding the biological roles of AA-2G per se in the food and cosmetic fields...
  15. ncbi request reprint Differentiation of murine B cells induced by chondroitin sulfate B
    Ritsuko Yoshihara
    Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    Cell Immunol 250:14-23. 2007
    ..These results demonstrated that CSB promoted differentiation of B cells in the presence of IL-4 and IL-5 and suggested that PKC but not PI3K is crucial for CSB-induced IgM production...
  16. ncbi request reprint Inhibition of tumor-stromal interaction through HGF/Met signaling by valproic acid
    Yohsuke Matsumoto
    Department of Immunochemistry, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1 1 1, Tsushima Naka, Okayama 700 8530, Japan
    Biochem Biophys Res Commun 366:110-6. 2008
    ....
  17. ncbi request reprint Inhibition of free radical-induced erythrocyte hemolysis by 2-O-substituted ascorbic acid derivatives
    Jun Takebayashi
    Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8530, Japan
    Free Radic Biol Med 43:1156-64. 2007
    ....
  18. doi request reprint Induction of hepatocyte growth factor expression by maleic acid in human fibroblasts through MAPK activation
    Takahiro Motoki
    Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima Naka, Okayama 700 8530, Japan
    J Cell Biochem 104:1465-76. 2008
    ..These results suggest that maleic acid indirectly induced HGF expression from human dermal fibroblasts through activation of ERK and JNK and that de novo protein synthesis is required for maleic acid-induced upregulation of HGF mRNA...
  19. ncbi request reprint Characterization of the radical-scavenging reaction of 2-O-substituted ascorbic acid derivatives, AA-2G, AA-2P, and AA-2S: a kinetic and stoichiometric study
    Jun Takebayashi
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Japan
    Biol Pharm Bull 29:766-71. 2006
    ..These data suggest the potential usage of AA derivatives as radical scavengers...
  20. ncbi request reprint Inhibition of hepatocyte growth factor production in human fibroblasts by ursodeoxycholic acid
    Kaori Hiramatsu
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Japan
    Biol Pharm Bull 28:619-24. 2005
    ..These results indicate that non-cytotoxic doses of UDCA inhibited constitutive and induced HGF production and suggest that UDCA supplemented with HGF or HGF inducers could have a more potential therapeutic effect...
  21. ncbi request reprint Inhibition of hepatocyte growth factor induction in human dermal fibroblasts by tryptanthrin
    Takahiro Motoki
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Naka, Okayama 700 8530, Japan
    Biol Pharm Bull 28:260-6. 2005
    ..These results indicate that tryptanthrin potently inhibited induction of HGF production probably through events downstream of MAPK activation...
  22. ncbi request reprint Synergistic induction of hepatocyte growth factor in human skin fibroblasts by the inflammatory cytokines interleukin-1 and interferon-gamma
    Yoichiro Takami
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Naka, Okayama 700 8530, Japan
    Biochem Biophys Res Commun 327:212-7. 2005
    ....
  23. ncbi request reprint Inhibition of hepatocyte growth factor induction in human dermal fibroblasts by interleukin-1 and its prevention by interferon-gamma
    Yoichiro Takami
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Naka, Okayama 700 8530, Japan
    Biochem Biophys Res Commun 325:676-82. 2004
    ..Taken together, our results indicate that IL-1 inhibited HGF production stimulated by various inducers, including protein kinase A-activating agents, and that IFN-gamma overcame this inhibition of induction of HGF production...
  24. ncbi request reprint Induction by staurosporine of hepatocyte growth factor production in human skin fibroblasts independent of protein kinase inhibition
    Yasuyuki Yagi
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Naka, Okayama 700 8530, Japan
    Biochem Pharmacol 66:1797-808. 2003
    ..These results indicate that staurosporine induced HGF in different cell types via a signaling pathway similar to the cAMP-mediated pathway without increasing cAMP levels...
  25. ncbi request reprint Synthesis and characterization of 6-O-acyl-2-O-alpha-D-glucopyranosyl-L-ascorbic acids with a branched-acyl chain
    Akihiro Tai
    Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Japan
    Chem Pharm Bull (Tokyo) 51:175-80. 2003
    ..These characteristics of 6-bAcyl-AA-2G may be available for skin care application as an effective antioxidant...
  26. doi request reprint Induction of hepatocyte growth factor production in human dermal fibroblasts and their proliferation by the extract of bitter melon pulp
    Takehiro Ono
    Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima Naka, Okayama 700 8530, Japan
    Cytokine 46:119-26. 2009
    ..Our findings suggest potential usefulness of the extract for tissue regeneration and provide an insight into the molecular mechanism underlying the wound-healing property of bitter melon...
  27. ncbi request reprint Hepatocyte growth factor delivered by ultrasound-mediated destruction of microbubbles induces proliferation of cardiomyocytes and amelioration of left ventricular contractile function in Doxorubicin-induced cardiomyopathy
    Masayoshi Iwasaki
    First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka 570 8506, Japan
    Stem Cells 23:1589-97. 2005
    ..These results suggest that (IV-rhHGF + UMDM) treatment could morphologically and functionally improve the heart in the case of doxorubicin-induced cardiomyopathy through the proliferation of the myocardial progenitor cells...