Koji Abe

Summary

Affiliation: Okayama University
Country: Japan

Publications

  1. ncbi request reprint Increased autophagy in transgenic mice with a G93A mutant SOD1 gene
    Nobutoshi Morimoto
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 1167:112-7. 2007
  2. doi request reprint Sendai virus-mediated gene transfer of GDNF reduces AIF translocation and ameliorates ischemic cerebral injury
    Guang Jin
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    Neurol Res 30:731-9. 2008
  3. ncbi request reprint Free radical scavenger edaravone administration protects against tissue plasminogen activator induced oxidative stress and blood brain barrier damage
    Violeta Lukic-Panin
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Curr Neurovasc Res 7:319-29. 2010
  4. ncbi request reprint Clinical Features of CADASIL
    Koji Abe
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Ann N Y Acad Sci 977:266-72. 2002
  5. ncbi request reprint Early decrease of mitochondrial DNA repair enzymes in spinal motor neurons of presymptomatic transgenic mice carrying a mutant SOD1 gene
    Tetsuro Murakami
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 1150:182-9. 2007
  6. ncbi request reprint Intrathecal injection of epidermal growth factor and fibroblast growth factor 2 promotes proliferation of neural precursor cells in the spinal cords of mice with mutant human SOD1 gene
    Yasuyuki Ohta
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmacy, Okayama University, Okayama, Japan
    J Neurosci Res 84:980-92. 2006
  7. doi request reprint Progressive decrease in the level of YAPdeltaCs, prosurvival isoforms of YAP, in the spinal cord of transgenic mouse carrying a mutant SOD1 gene
    Nobutoshi Morimoto
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, 2 5 1 Shikata cho, Okayama, Japan
    J Neurosci Res 87:928-36. 2009
  8. ncbi request reprint Potentiation of neurogenesis and angiogenesis by G-CSF after focal cerebral ischemia in rats
    Yoshihide Sehara
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Brain Res 1151:142-9. 2007
  9. ncbi request reprint Increased ER stress during motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis
    Tetsuya Nagata
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Japan
    Neurol Res 29:767-71. 2007
  10. ncbi request reprint Temporal profile of neural stem cell proliferation in the subventricular zone after ischemia/hypoxia in the neonatal rat brain
    Masanori Iwai
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, 700 8558, Japan
    Neurol Res 28:461-8. 2006

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint Increased autophagy in transgenic mice with a G93A mutant SOD1 gene
    Nobutoshi Morimoto
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 1167:112-7. 2007
    ..The present data show the possibility of increased autophagy in an animal model for ALS. And autophagy may be partially regulated by an mTOR signaling pathway in these animals...
  2. doi request reprint Sendai virus-mediated gene transfer of GDNF reduces AIF translocation and ameliorates ischemic cerebral injury
    Guang Jin
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    Neurol Res 30:731-9. 2008
    ....
  3. ncbi request reprint Free radical scavenger edaravone administration protects against tissue plasminogen activator induced oxidative stress and blood brain barrier damage
    Violeta Lukic-Panin
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Curr Neurovasc Res 7:319-29. 2010
    ..Additive edaravone ameliorated such an oxidative damage by t-PA with protecting outer layers of blood-brain barrier (in vivo) and tight junctions (in vitro)...
  4. ncbi request reprint Clinical Features of CADASIL
    Koji Abe
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Ann N Y Acad Sci 977:266-72. 2002
    ..In the present study, we describe the clinical features of CADASIL, hoping to help reveal the mechanism of chronic ischemic brain diseases, including leukoaraiosis or Binswanger's disease...
  5. ncbi request reprint Early decrease of mitochondrial DNA repair enzymes in spinal motor neurons of presymptomatic transgenic mice carrying a mutant SOD1 gene
    Tetsuro Murakami
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 1150:182-9. 2007
    ..The expressions of these enzymes are predominant in spinal motor neurons, suggesting a mechanism of selective motor neuron death in this animal model of ALS...
  6. ncbi request reprint Intrathecal injection of epidermal growth factor and fibroblast growth factor 2 promotes proliferation of neural precursor cells in the spinal cords of mice with mutant human SOD1 gene
    Yasuyuki Ohta
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmacy, Okayama University, Okayama, Japan
    J Neurosci Res 84:980-92. 2006
    ....
  7. doi request reprint Progressive decrease in the level of YAPdeltaCs, prosurvival isoforms of YAP, in the spinal cord of transgenic mouse carrying a mutant SOD1 gene
    Nobutoshi Morimoto
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, 2 5 1 Shikata cho, Okayama, Japan
    J Neurosci Res 87:928-36. 2009
    ..These results suggest that the progressive decrease in the levels of YAPdeltaCs and the relative increase in phosphorylation of p73 over the time course are correlated with disease progression in ALS model animals...
  8. ncbi request reprint Potentiation of neurogenesis and angiogenesis by G-CSF after focal cerebral ischemia in rats
    Yoshihide Sehara
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Brain Res 1151:142-9. 2007
    ..01), in the periischemic area. Our results indicate that G-CSF caused potentiation of neuroprotection and neurogenesis and is expected to have practical therapeutic potential in treating individuals after ischemic brain injury...
  9. ncbi request reprint Increased ER stress during motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis
    Tetsuya Nagata
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Japan
    Neurol Res 29:767-71. 2007
    ....
  10. ncbi request reprint Temporal profile of neural stem cell proliferation in the subventricular zone after ischemia/hypoxia in the neonatal rat brain
    Masanori Iwai
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, 700 8558, Japan
    Neurol Res 28:461-8. 2006
    ..In order to elucidate the dynamic changes in neural stem cells in the neonatal brain after I/H, we investigated the proliferation of new cells in the subventricular zone (SVZ)...
  11. ncbi request reprint Gelatin-siloxane hybrid scaffolds with vascular endothelial growth factor induces brain tissue regeneration
    Hanzhe Zhang
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Curr Neurovasc Res 5:112-7. 2008
    ..Addition of VEGF promoted numbers of these cells. Thus, combination of gelatin-GPTMS scaffolds and VEGF is preferable for brain regeneration...
  12. ncbi request reprint Vascular endothelial growth factor promotes brain tissue regeneration with a novel biomaterial polydimethylsiloxane-tetraethoxysilane
    Hanzhe Zhang
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmacy, Okayama University, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Brain Res 1132:29-35. 2007
    ..These findings show that implantation of PDMS-TEOS scaffold with VEGF might be effective for treating old brain infarction or trauma...
  13. doi request reprint Statins have therapeutic potential for the treatment of Alzheimer's disease, likely via protection of the neurovascular unit in the AD brain
    Tomoko Kurata
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikatacho, Kitaku, Okayama 700 8558, Japan
    J Neurol Sci 322:59-63. 2012
    ..Double immunofluorescent analysis showed that astrocytic endfeet had detached from the capillary endothelium in the APP/Ve group. Overall, these data suggest that statins may have therapeutic potential for AD by protecting NVU...
  14. doi request reprint Atorvastatin and pitavastatin improve cognitive function and reduce senile plaque and phosphorylated tau in aged APP mice
    Tomoko Kurata
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikatacho, Kitaku, Okayama 700 8558, Japan
    Brain Res 1371:161-70. 2011
    ....
  15. ncbi request reprint G-CSF enhances stem cell proliferation in rat hippocampus after transient middle cerebral artery occlusion
    Yoshihide Sehara
    Department of Neurology, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurosci Lett 418:248-52. 2007
    ..01) and in the ipsilateral GCL (14.2+/-2.8/mm(2) in the vehicle-treated group versus 21.0+/-3.8/mm(2) in the G-CSF-treated group, *p<0.05). This result showed the possibility of a neurogenerative role of G-CSF after tMCAO in rats...
  16. ncbi request reprint The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers
    Feng Li
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 1048:59-68. 2005
    ..The present results suggest that dantrolene significantly decreased infarct volume and provided neuroprotective effect on rats after transient MCAO by reducing ER stress-mediated apoptotic signal pathway activation in the ischemic area...
  17. doi request reprint Antiapoptotic and antiautophagic effects of glial cell line-derived neurotrophic factor and hepatocyte growth factor after transient middle cerebral artery occlusion in rats
    Jingwei Shang
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Neurosci Res 88:2197-206. 2010
    ....
  18. ncbi request reprint Reduction of cerebral infarction in rats by biliverdin associated with amelioration of oxidative stress
    Kentaro Deguchi
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmacy, Okayama University, Okayama, Japan
    Brain Res 1188:1-8. 2008
    ..The present study demonstrated that treatment with BV ameliorated the oxidative injuries on neurons and decreased brain infarct size in rat tMCAO model...
  19. doi request reprint Induction of parkinsonism-related proteins in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene
    Nobutoshi Morimoto
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, Okayama, Japan
    J Neurosci Res 88:1804-11. 2010
    ..These results provide further evidence of the profound correlations between spinal motor neurons of amyotrophic lateral sclerosis and parkinsonism-related proteins...
  20. doi request reprint Changes of Nogo-A and receptor NgR in the lumbar spinal cord of ALS model mice
    Kazunori Miyazaki
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurol Res 31:316-21. 2009
    ....
  21. ncbi request reprint Different expression of low density lipoprotein receptor and ApoE between young adult and old rat brains after ischemia
    Takeshi Hayashi
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Neurol Res 28:822-5. 2006
    ..Reduction of brain plasticity underlies the poor outcome of aged stroke patients. The molecular mechanism of plasticity reduction by aging is uncertain, but disturbed lipid metabolism may be implicated...
  22. ncbi request reprint Prevention of neuronal damage by calcium channel blockers with antioxidative effects after transient focal ischemia in rats
    Violeta Lukic Panin
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Brain Res 1176:143-50. 2007
    ..In the present study, we investigated antioxidative and neuroprotective properties of two CCBs, azelnidipine and amlodipine...
  23. doi request reprint Motor impairment and aberrant production of neurochemicals in human alpha-synuclein A30P+A53T transgenic mice with alpha-synuclein pathology
    Masaki Ikeda
    Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Japan
    Brain Res 1250:232-41. 2009
    ..Motor impairment was revealed in a rotarod test. Thus, TgalphaSYN is a useful model for analyzing the pathological cascade from aggregated alphaSYN to motor disturbance, and may be useful for drug trials...
  24. ncbi request reprint Prevention of spinal motor neuron death by insulin-like growth factor-1 associating with the signal transduction systems in SODG93A transgenic mice
    Hisashi Narai
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Japan
    J Neurosci Res 82:452-7. 2005
    ..These results suggest that IGF-1 treatment prevents motor neuron loss by affecting the signal transduction system through IGF-1R and the main downstream signal, IRS-1...
  25. doi request reprint Spinal anterior horn has the capacity to self-regenerate in amyotrophic lateral sclerosis model mice
    Kazunori Miyazaki
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan
    J Neurosci Res 87:3639-48. 2009
    ....
  26. pmc Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice
    Masaki Ikeda
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Am J Pathol 166:521-31. 2005
    ..These findings suggested that TgTauR406W mice would be a useful model in the study of frontotemporal dementia and other tauopathies such as Alzheimer's disease (AD)...
  27. doi request reprint Therapeutic benefits of intrathecal protein therapy in a mouse model of amyotrophic lateral sclerosis
    Yasuyuki Ohta
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Shikata cho, Okayama, Japan
    J Neurosci Res 86:3028-37. 2008
    ..Our results indicate that intrathecal protein therapy using a TAT-fused protein is an effective clinical tool for the treatment of ALS...
  28. ncbi request reprint Expression of netrin-1 and its receptors DCC and neogenin in rat brain after ischemia
    Atsushi Tsuchiya
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmacy, Okayama University, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Brain Res 1159:1-7. 2007
    ..The location of neogenin positive cells differed from that of netrin-1 positive cells, thus its angiogenic activity may not have relevance with netrin-1...
  29. ncbi request reprint Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of Amyotrophic Lateral Sclerosis
    Isao Nagano
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Neurol Sci 235:61-8. 2005
    ..Taken together, the results suggest that direct administration of IGF-1 into the intrathecal space may have a therapeutic benefit for ALS...
  30. ncbi request reprint HMG CoA reductase inhibitors reduce ischemic brain injury of Wistar rats through decreasing oxidative stress on neurons
    Takeshi Hayashi
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 1037:52-8. 2005
    ..Reduction of oxidative stress by statins may be one main reason in ameliorating ischemic brain damage in rats...
  31. doi request reprint Tissue plasminogen activator thrombolytic therapy for acute ischemic stroke in 4 hospital groups in Japan
    Syoichiro Kono
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    J Stroke Cerebrovasc Dis 22:190-6. 2013
    ..7...
  32. doi request reprint Effect of mitochondrial transcription factor a overexpression on motor neurons in amyotrophic lateral sclerosis model mice
    Nobutoshi Morimoto
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, Okayama, Japan
    J Neurosci Res 90:1200-8. 2012
    ..The present study suggests that overexpression of TFAM has a potential to reduce oxidative stress in MN and delay onset of the disease in ALS model mice. © 2012 Wiley Priodicals, Inc...
  33. ncbi request reprint PSP as distinguished from CBD, MSA-P and PD by clinical and imaging differences at an early stage
    Tomoko Kurata
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, Japan
    Intern Med 50:2775-81. 2011
    ....
  34. ncbi request reprint Macrophage infiltration, lectin-like oxidized-LDL receptor-1, and monocyte chemoattractant protein-1 are reduced by chronic HMG-CoA reductase inhibition
    Atsushi Tsuchiya
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmacy, Okayama University, Japan
    Curr Neurovasc Res 4:268-73. 2007
    ..Macrophage infiltration was also decreased. Reduction of cerebrovascular events by statins may be brought by the direct inhibition of atherosclerotic change...
  35. doi request reprint Plasma antibodies to Abeta40 and Abeta42 in patients with Alzheimer's disease and normal controls
    Wuhua Xu
    Department of Neurology, Neuroscience, Biophysiological Science, Okayama University Graduate School of Medicine, Dentistry and Pharmacy, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Brain Res 1219:169-79. 2008
    ..Clarification of the mechanism of the immune response to Abeta42 is necessary for realization of an immunotherapy for AD...
  36. ncbi request reprint Parvalbumin and calbindin D-28k immunoreactivity in transgenic mice with a G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Brain Res 1083:196-203. 2006
    ....
  37. ncbi request reprint Enhanced accumulation of phosphorylated alpha-synuclein in double transgenic mice expressing mutant beta-amyloid precursor protein and presenilin-1
    Tomoko Kurata
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Neurosci Res 85:2246-52. 2007
    ..Additional overexpression of mutant PS-1 accelerated Abeta-induced alpha-synucleinopathy and further facilitated the phosphorylation of alpha-syn, suggesting a direct association between mutant PS-1 and phosphorylation of alpha-syn...
  38. ncbi request reprint Temporal profile of stem cell division, migration, and differentiation from subventricular zone to olfactory bulb after transient forebrain ischemia in gerbils
    Masanori Iwai
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    J Cereb Blood Flow Metab 23:331-41. 2003
    ....
  39. doi request reprint Protection against ischemic stroke damage by synergistic treatment with amlodipine plus atorvastatin in Zucker metabolic rat
    Hiromi Kawai
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Brain Res 1382:308-14. 2011
    ..Thus, the combination therapy with AM plus AT extended the neuroprotectives effect of single treatment with AM or AT on a part of neurovascular unit and a hypertension-related receptor...
  40. pmc Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation
    Tetsuro Murakami
    Department of Neurology, Neuroscience, Biophysiological Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama, 700 8558 Japan
    Am J Pathol 169:1365-75. 2006
    ..These transgenic mice may aid therapeutic development for FTDP-17 and other diseases featuring accumulations of four-repeat tau, such as Alzheimer's disease, corticobasal degeneration, and progressive supranuclear palsy...
  41. doi request reprint Impaired hypoxic sensor Siah-1, PHD3, and FIH system in spinal motor neurons of an amyotrophic lateral sclerosis mouse model
    Kota Sato
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Neurosci Res 91:285-91. 2013
    ..This response could be an important mechanism of neurodegeneration in ALS...
  42. doi request reprint Impaired antioxydative Keap1/Nrf2 system and the downstream stress protein responses in the motor neuron of ALS model mice
    Takafumi Mimoto
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Brain Res 1446:109-18. 2012
    ....
  43. doi request reprint Modifying neurorepair and neuroregenerative factors with tPA and edaravone after transient middle cerebral artery occlusion in rat brain
    Kentaro Deguchi
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Brain Res 1436:168-77. 2012
    ..The present study demonstrates for the first time that exogenous tPA reduced protein factors involved in inhibiting and promoting axonal growth, but that edaravone ameliorated such damage in brain repair after acute ischemia...
  44. doi request reprint Comparisons of acoustic function in SCA31 and other forms of ataxias
    Yoshio Ikeda
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan
    Neurol Res 33:427-32. 2011
    ..To investigate whether acoustic impairment can be one of the characteristic extracerebellar symptoms in sporadic and hereditary ataxias including spinocerebellar ataxia type 31 (SCA31)...
  45. ncbi request reprint Decreased focal inflammatory response by G-CSF may improve stroke outcome after transient middle cerebral artery occlusion in rats
    Yoshihide Sehara
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Neurosci Res 85:2167-74. 2007
    ..05 each). Our data suggest that the suppression of inflammatory cytokines and iNOS expression may be one mechanism of neuroprotection by G-CSF...
  46. ncbi request reprint Enhanced accumulation of tau in doubly transgenic mice expressing mutant betaAPP and presenilin-1
    Eriko Samura
    Department of Neurology, Division of Neuroscience, Biophysical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Brain Res 1094:192-9. 2006
    ..These findings suggest that mutant presenilin-1 accelerated Abeta-induced tauopathy and further promoted fibril formation of tau...
  47. ncbi request reprint Cooperative expression of survival p-ERK and p-Akt signals in rat brain neurons after transient MCAO
    Feng Li
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Brain Res 962:21-6. 2003
    ....
  48. doi request reprint Temporal and spatial differences of multiple protein expression in the ischemic penumbra after transient MCAO in rats
    Xuemei Zhang
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Brain Res 1343:143-52. 2010
    ..Thus, there is a window for rescue of ischemic neural cells from 12 to 48 h after injury...
  49. doi request reprint Combination benefit of amlodipine plus atorvastatin treatment on carotid atherosclerosis in Zucker metabolic rats
    Hiromi Kawai
    Depatment of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Neurol Res 35:181-6. 2013
    ..Obesity is the major risk factor for metabolic syndrome and atherosclerotic cardiocerebrovascular diseases...
  50. doi request reprint Atorvastatin and pitavastatin reduce oxidative stress and improve IR/LDL-R signals in Alzheimer's disease
    Tomoko Kurata
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700 8558, Japan
    Neurol Res 35:193-205. 2013
    ..To examine and compare the pleiotropic effects on oxidative stress and metabolic signaling pathways of atorvastatin and pitavastatin in mouse model of Alzheimer's disease (AD)...
  51. doi request reprint Impaired response of hypoxic sensor protein HIF-1α and its downstream proteins in the spinal motor neurons of ALS model mice
    Kota Sato
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho Okayama 700 8558, Japan
    Brain Res 1473:55-62. 2012
    ....
  52. doi request reprint Disruption of neurovascular unit prior to motor neuron degeneration in amyotrophic lateral sclerosis
    Kazunori Miyazaki
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan
    J Neurosci Res 89:718-28. 2011
    ....
  53. ncbi request reprint Coordinate expression of survival p-ERK and proapoptotic cytochrome c signals in rat brain neurons after transient MCAO
    Feng Li
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, 700 8558 Okayama, Japan
    Brain Res 958:83-8. 2002
    ....
  54. ncbi request reprint In vivo optical imaging of motor neuron autophagy in a mouse model of amyotrophic lateral sclerosis
    FengFeng Tian
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Autophagy 7:985-92. 2011
    ..This method could also be applied as a unique tool for clarifying the role of autophagy, and to monitor the pathologic processes involving autophagy not only in ALS, but also other neurological diseases...
  55. ncbi request reprint Ultrastructural study of aggregates in the spinal cord of transgenic mice with a G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, 162 8666, Tokyo, Japan
    Acta Neuropathol 109:247-55. 2005
    ....
  56. pmc Tridermal tumorigenesis of induced pluripotent stem cells transplanted in ischemic brain
    Hiromi Kawai
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Cereb Blood Flow Metab 30:1487-93. 2010
    ..iPS cells have a promising potential to provide neural cells after ischemic brain injury, if tumorigenesis is properly controlled...
  57. ncbi request reprint Elevation of MCP-1 and MCP-1/VEGF ratio in cerebrospinal fluid of amyotrophic lateral sclerosis patients
    Tetsuya Nagata
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    Neurol Res 29:772-6. 2007
    ..Our data suggested that both MCP-1 levels and MCP-1/VEGF ratio in CSF may be useful markers for the clinical diagnosis of ALS...
  58. doi request reprint Amlodipine and atorvastatin exert protective and additive effects via antiapoptotic and antiautophagic mechanisms after transient middle cerebral artery occlusion in Zucker metabolic syndrome rats
    Xuemei Zhang
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Neurosci Res 89:1228-34. 2011
    ..Further studies are now needed to expand these preliminary results to understand fully the mechanisms involved in the protective effects of amlodipine and atorvastatin against ischemic stroke...
  59. ncbi request reprint Reduction of cerebral infarction in stroke-prone spontaneously hypertensive rats by statins associated with amelioration of oxidative stress
    Shoko Nagotani
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    Stroke 36:670-2. 2005
    ..This study aimed to clarify the effect of statins on spontaneous stroke and to examine the antioxidative effect in artificial transient middle cerebral artery occlusion (tMCAO)...
  60. ncbi request reprint Expression of neurocan after transient middle cerebral artery occlusion in adult rat brain
    Kentaro Deguchi
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 1037:194-9. 2005
    ..These results indicate that accumulation of the full-length neurocan produced by reactive astrocytes may be one of the processes for tissue repair and reconstruction of neural networks after focal brain ischemia as well...
  61. ncbi request reprint Sustained induction of survival p-AKT and p-ERK signals after transient hypoxia in mice spinal cord with G93A mutant human SOD1 protein
    Hristelina Ilieva
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, 700 8558 Okayama, Japan
    J Neurol Sci 215:57-62. 2003
    ..The current results suggest that the presence of mutant SOD1 alters survival p-AKT and p-ERK signals, possibly to compensate for the acquired gain-of-function of the mutant protein...
  62. ncbi request reprint Mitochondrial fusion and fission proteins expression dynamically change in a murine model of amyotrophic lateral sclerosis
    Wentao Liu
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Curr Neurovasc Res 10:222-30. 2013
    ..These data suggest that abnormal changes in mitochondrial morphology began before the onset of ALS and that the balanced mitochondrial morphology becomes altered by fissions in motor neurons (MNs) in this ALS model. ..
  63. doi request reprint Correlation of cerebral spinal fluid pH and HCO3- with disease progression in ALS
    Nobutoshi Morimoto
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, Okayama, Japan
    J Neurol Sci 307:74-8. 2011
    ..These results suggested that cerebral spinal fluid pH provides a biomarker for ALS and could reflect mechanisms of disease progression in ALS patients...
  64. doi request reprint Differentiation of PA from early PSP with different patterns of symptoms and CBF reduction
    Tomoko Kurata
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurol Res 30:860-7. 2008
    ..To clarify the features of pure akinesia (PA) and progressive supranuclear palsy (PSP) in the early stage of disease...
  65. doi request reprint Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brain
    Toru Yamashita
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Cereb Blood Flow Metab 29:715-25. 2009
    ....
  66. ncbi request reprint Spatiotemporal changes of apolipoprotein E immunoreactivity and apolipoprotein E mRNA expression after transient middle cerebral artery occlusion in rat brain
    Hiroshi Kamada
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    J Neurosci Res 73:545-56. 2003
    ....
  67. doi request reprint Gene and stem cell therapy in ischemic stroke
    Toru Yamashita
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Cell Transplant 18:999-1002. 2009
    ..In the future, we will combine these strategies to develop more effective therapies for treatment of strokes...
  68. ncbi request reprint Impairment of axonal transport in the axon hillock and the initial segment of anterior horn neurons in transgenic mice with a G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, Shinjuku ku, Japan
    Acta Neuropathol 110:48-56. 2005
    ..These findings suggest that both the slow axonal transport of neurofilaments and the fast axonal transport of mitochondria are impaired in AH and IS before the onset of disease in this animal model...
  69. doi request reprint Synergistic benefit of combined amlodipine plus atorvastatin on neuronal damage after stroke in Zucker metabolic rat
    Hiromi Kawai
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Brain Res 1368:317-23. 2011
    ....
  70. ncbi request reprint Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease
    Takeshi Kawarabayashi
    Department of Neurology, Okayama University Graduate School of Medicine, Okayama, 700 8558, Japan
    J Neurosci 24:3801-9. 2004
    ..A similar increase in ApoE and a large increase in phosphorylated tau was observed in lipid rafts from AD brain. These findings suggest that lipid rafts may be an important site for interaction between dimeric Abeta, ApoE, and tau...
  71. ncbi request reprint Neural precursor cells division and migration in neonatal rat brain after ischemic/hypoxic injury
    Takeshi Hayashi
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 1038:41-9. 2005
    ..Progenitor cells may have potential for treating perinatal brain disorders...
  72. ncbi request reprint Protection against ischemic brain damage in rats by immunophilin ligand GPI-1046
    Feng Li
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    J Neurosci Res 76:383-9. 2004
    ....
  73. ncbi request reprint Deficiency of PAR-2 gene increases acute focal ischemic brain injury
    Guang Jin
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    J Cereb Blood Flow Metab 25:302-13. 2005
    ..These results show that the deficiency of PAR-2 gene increases the acute ischemic cerebral injury associating with suppression of neuronal ERK activation and reactive astroglial activation...
  74. doi request reprint Therapeutic strategy for ischemic stroke
    Toru Yamashita
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, 700 8558, Japan
    Neurochem Res 34:707-10. 2009
    ..In the future, we will combine these strategies to develop more effective therapies for treatment of strokes...
  75. ncbi request reprint Up-regulation of low-density lipoprotein receptor expression in the ischemic core and the peri-ischemic area after transient MCA occlusion in rats
    Hiroshi Kamada
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res Mol Brain Res 134:181-8. 2005
    ..These results suggest that LDL receptor, interacting with ApoE, is profoundly involved in lipid transport of CNS for tissue repair in the peri-ischemic area after brain ischemia...
  76. ncbi request reprint Unique cerebellar-cerebral form of autosomal recessive ataxia
    Etsuro Matsubara
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    Tohoku J Exp Med 207:81-5. 2005
    ..The mode of inheritance appears to be autosomal recessive. We think that the affected siblings may have a new type of autosomal recessive cerebellar ataxia...
  77. ncbi request reprint Three steps of neural stem cells development in gerbil dentate gyrus after transient ischemia
    Masanori Iwai
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    J Cereb Blood Flow Metab 22:411-9. 2002
    ..The majority of these three steps finished in 2 months after transient global ischemia...
  78. ncbi request reprint Extension of ischemic therapeutic time window by a free radical scavenger, Edaravone, reperfused with tPA in rat brain
    Wenri Zhang
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikatacho, Okayama, Japan
    Neurol Res 26:342-8. 2004
    ..Therefore, Edaravone combination is expected to extend the therapeutic time window of tPA in the clinical situation...
  79. ncbi request reprint Age-related changes in peroxisomal membrane protein 70 and superoxide dismutase 1 in transgenic G93A mice
    Hristelina S Ilieva
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurol Res 25:423-6. 2003
    ..It is conceivable that reduction of PMP70 might underlie decrease in peroxisomal functions and increase in oxidative stress that is well documented in this animal model...
  80. ncbi request reprint Potentiation of Akt and suppression of caspase-9 activations by electroacupuncture after transient middle cerebral artery occlusion in rats
    Shao Jun Wang
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Neurosci Lett 331:115-8. 2002
    ..These results suggest that EA potentiated the Akt and suppressed the caspase-9 activations, and may have a potential to reduce the number of neuronal cells undergoing apoptotic cell death...
  81. ncbi request reprint Neuronal nitric oxide synthase (nNOS) immunoreactivity in the spinal cord of transgenic mice with G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical College, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Acta Neuropathol 103:421-7. 2002
    ....
  82. ncbi request reprint Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia
    Kentaro Ohta
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurosci Lett 335:159-62. 2003
    ..These results suggest that the young brain showed a higher potential of proliferation and process branching of OPCs than the aged brains...
  83. ncbi request reprint Hypoxic induction of vascular endothelial growth factor is selectively impaired in mice carrying the mutant SOD1 gene
    Tetsuro Murakami
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 989:231-7. 2003
    ....
  84. ncbi request reprint Efficacy of the free radical scavenger, edaravone, for motor palsy of acute lacunar infarction
    Yasuyuki Ohta
    Ota Memorial Hospital, Fukuyama, Japan
    Intern Med 48:593-6. 2009
    ..This study investigated the effect of edaravone on the outcome of patients with acute lacunar infarction...
  85. ncbi request reprint Cerebrospinal fluid tau in dementia disorders: a large scale multicenter study by a Japanese study group
    Mikio Shoji
    Department of Neurology, Division of Neuroscience Biophysical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Neurobiol Aging 23:363-70. 2002
    ..Measurement of CSF tau was useful as a biomarker for early and differential diagnosis of AD...
  86. ncbi request reprint Spatiotemporal changes of free cholesterol and neutral lipids after transient middle cerebral artery occlusion in rats
    Hiroshi Kamada
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 500 8558, Japan
    Ann N Y Acad Sci 977:115-22. 2002
  87. ncbi request reprint Modification of a fiber protein in an adenovirus vector improves in vitro gene transfer efficiency to the mouse microglial cell line
    Nobuhiko Omori
    Department of Molecular Cell Physiology, The Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    Neurosci Lett 324:145-8. 2002
    ..These results suggest that Ad-RGD may be a potent tool for the delivery of genes to microglia activated by optimum stimulation, and thus analyzing the function of microglia with utilization of MG5 and PCMG cells...
  88. ncbi request reprint Selective colocalization of transglutaminase-like activity in ubiquitinated intranuclear inclusions of hereditary dentatorubral-pallidoluysian atrophy
    Keiko Sato
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 952:327-30. 2002
    ..The selective and good colocalization of Ub-NII and TG in the cerebellar granule cells may reveal a role of TG in the neurodegenerative process in DRPLA...
  89. ncbi request reprint Benign adult familial myoclonic epilepsy (BAFME) with night blindness
    Yasuhiro Manabe
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Seizure 11:266-8. 2002
    ..3-q24.1, the causative gene has yet to be identified. The present familial case suggests that BAFME may also be a disease of the calcium channel that is present in the retina and the central nervous system (CNS)...
  90. ncbi request reprint Changes of localization of highly polysialylated neural cell adhesion molecule (PSA-NCAM) in rat hippocampus with exposure to repeated kindled seizures
    Keiko Sato
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Japan
    Brain Res 946:323-7. 2002
    ....
  91. ncbi request reprint Early decrease of survival factors and DNA repair enzyme in spinal motor neurons of presymptomatic transgenic mice that express a mutant SOD1 gene
    Isao Nagano
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, 700 8558, Okayama, Japan
    Life Sci 72:541-8. 2002
    ..These results suggest that an early decrease of survival signal proteins and a DNA repair enzyme in the spinal motor neurons may account for the mutant SOD1-mediated motor neuron death in this animal model of ALS...
  92. ncbi request reprint Single-nucleotide polymorphisms in uncoding regions of ALS2 gene of Japanese patients with autosomal-recessive amyotrophic lateral sclerosis
    Isao Nagano
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    Neurol Res 25:505-9. 2003
    ..These results suggest that deletion mutations in ALS2 gene detected in ALS2 patients seem to be uncommon in Japanese AR-ALS, and that SNPs in uncoding regions might possibly be relevant to predisposition to ALS...
  93. ncbi request reprint Cerebral ischemia and angiogenesis
    Takeshi Hayashi
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, Japan
    Curr Neurovasc Res 3:119-29. 2006
    ..In the future however, there is a need to consider angiogenesis in relation with regenerative medicine, as angiogenic factors sometimes possess neuron producing property...
  94. ncbi request reprint Soluble Abeta homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteins
    Etsuro Matsubara
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Schikata cho, Okayama, Okayama 700 8558, Japan
    Neurobiol Aging 25:833-41. 2004
    ....
  95. ncbi request reprint Survival and death-promoting events after transient spinal cord ischemia in rabbits: induction of Akt and caspase3 in motor neurons
    Masahiro Sakurai
    Department of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Thorac Cardiovasc Surg 125:370-7. 2003
    ....
  96. ncbi request reprint Neuroprotective effects of activated protein C through induction of insulin-like growth factor-1 (IGF-1), IGF-1 receptor, and its downstream signal phosphorylated serine-threonine kinase after spinal cord ischemia in rabbits
    Takashi Yamauchi
    Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    Stroke 37:1081-6. 2006
    ..However, the possible mechanism of such beneficial effects is not fully understood. The aim of this study was to investigate the effects and possible mechanisms of APC on ischemic spinal cord damage...
  97. ncbi request reprint Impact of the endoplasmic reticulum stress response in spinal cord after transient ischemia
    Takashi Yamauchi
    Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Brain Res 1169:24-33. 2007
    ..In the present study, we investigate the expression of ER stress-related molecules and discuss the relationship between neuronal vulnerability and ER stress after transient ischemia in the spinal cord...
  98. ncbi request reprint Limited differentiation to neurons and astroglia from neural stem cells in the cortex and striatum after ischemia/hypoxia in the neonatal rat brain
    Tomoaki Ikeda
    Department of Obstetrics and Gynecology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    Am J Obstet Gynecol 193:849-56. 2005
    ..We examined whether progenitor neural stem cells can differentiate successfully into mature neurons and astrocytes in a rat model of neonatal hypoxic-ischemic encephalopathy...
  99. doi request reprint Ubiquitin-mediated stress response in the spinal cord after transient ischemia
    Takashi Yamauchi
    Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Stroke 39:1883-9. 2008
    ..In the present study, we investigated the expression of ubiquitin system molecules and discussed the relationship between the vulnerability and the ubiquitin system after transient ischemia in the spinal cord...
  100. ncbi request reprint Blockade of interleukin-6 signaling aggravates ischemic cerebral damage in mice: possible involvement of Stat3 activation in the protection of neurons
    Toru Yamashita
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    J Neurochem 94:459-68. 2005
    ..These results suggest that endogenous IL-6 plays a critical role in preventing damaged neurons from undergoing apoptosis in the acute phase of cerebral ischemia and that its role may be mediated by Stat3 activation...
  101. ncbi request reprint Endoplasmic reticulum stress induced in motor neurons by transient spinal cord ischemia in rabbits
    Masahiro Sakurai
    Department of Cardiovascular Surgery, National Hospital Organization Sendai Medical Center, Sendai, Japan
    J Thorac Cardiovasc Surg 130:640-5. 2005
    ..Because we previously reported that spinal motor neurons were probably lost as the result of programmed cell death, we investigated a possible mechanism of neuronal death by immunohistochemical analysis for Grp78 and caspase12...