Tetsuji Shinohara

Summary

Affiliation: Oita University
Country: Japan

Publications

  1. ncbi request reprint Effects of insulin resistance on geranylgeranylacetone-induced expression of heat shock protein 72 and cardioprotection in high-fat diet rats
    Tatsuhiko Ooie
    Department of Laboratory Medicine, Faculty of Medicine, Oita University, 1 1, Hasama, Oita, 879 5593, Japan
    Life Sci 77:869-81. 2005
  2. ncbi request reprint Pilsicainide-induced ventricular tachycardia originating from right ventricular outflow tract
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita, Japan
    J Cardiovasc Electrophysiol 18:552. 2007
  3. ncbi request reprint Mitochondria are targets for geranylgeranylacetone-induced cardioprotection against ischemia-reperfusion in the rat heart
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    Am J Physiol Heart Circ Physiol 293:H1892-9. 2007
  4. doi request reprint Role of interleukin-6 levels in cardiovascular autonomic dysfunction in type 2 diabetic patients
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama machi, Yuhu, Oita, Japan
    Eur J Nucl Med Mol Imaging 35:1616-23. 2008
  5. ncbi request reprint Brugada syndrome with complete right bundle branch block disclosed by a febrile illness
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita
    Intern Med 47:843-6. 2008
  6. ncbi request reprint Pioglitazone but not glibenclamide improves cardiac expression of heat shock protein 72 and tolerance against ischemia/reperfusion injury in the heredity insulin-resistant rat
    Yayoi Taniguchi
    Department of Internal Cardiovascular Science, Facutly of Medicine, Oita University, Oita, Japan
    Diabetes 55:2371-8. 2006
  7. doi request reprint Hyperthermia-induced cardioprotection is potentiated by ischemic postconditioning in rats
    Yukichi Murozono
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Yufu, Oita 879 5593, Japan
    Exp Biol Med (Maywood) 234:573-81. 2009
  8. ncbi request reprint Receptor-mediated suppression of cardiac heat-shock protein 72 expression by testosterone in male rat heart
    Hiroaki Kohno
    Department of Internal Medicine, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    Endocrinology 148:3148-55. 2007
  9. doi request reprint Candesartan restored cardiac Hsp72 expression and tolerance against reperfusion injury in hereditary insulin-resistant rats
    Yayoi Taniguchi
    Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Yufu, Oita 879 5593, Japan
    Cardiovasc Res 92:439-48. 2011
  10. ncbi request reprint Phosphatidylinositol 3-kinase-dependent activation of akt, an essential signal for hyperthermia-induced heat-shock protein 72, is attenuated in streptozotocin-induced diabetic heart
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    Diabetes 55:1307-15. 2006

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Effects of insulin resistance on geranylgeranylacetone-induced expression of heat shock protein 72 and cardioprotection in high-fat diet rats
    Tatsuhiko Ooie
    Department of Laboratory Medicine, Faculty of Medicine, Oita University, 1 1, Hasama, Oita, 879 5593, Japan
    Life Sci 77:869-81. 2005
    ..This is the first demonstration that expression of HSP72 was depressed in the heart and that reduced HSP72 was related with less cardioprotection against ischemic insult in high-fat diet-induced insulin resistance rats...
  2. ncbi request reprint Pilsicainide-induced ventricular tachycardia originating from right ventricular outflow tract
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita, Japan
    J Cardiovasc Electrophysiol 18:552. 2007
  3. ncbi request reprint Mitochondria are targets for geranylgeranylacetone-induced cardioprotection against ischemia-reperfusion in the rat heart
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    Am J Physiol Heart Circ Physiol 293:H1892-9. 2007
    ..These processes may involve opening of the mitoK(ATP) channel...
  4. doi request reprint Role of interleukin-6 levels in cardiovascular autonomic dysfunction in type 2 diabetic patients
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama machi, Yuhu, Oita, Japan
    Eur J Nucl Med Mol Imaging 35:1616-23. 2008
    ..The aim of this study was to determine whether serum IL-6 levels are associated with cardiovascular autonomic dysfunction in type 2 diabetic patients...
  5. ncbi request reprint Brugada syndrome with complete right bundle branch block disclosed by a febrile illness
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita
    Intern Med 47:843-6. 2008
    ..Our observations suggest that physicians should be careful to evaluate ECG change in response to a febrile state, even if the ECG shows a typical CRBBB pattern with deep and wide S waves in the left leads...
  6. ncbi request reprint Pioglitazone but not glibenclamide improves cardiac expression of heat shock protein 72 and tolerance against ischemia/reperfusion injury in the heredity insulin-resistant rat
    Yayoi Taniguchi
    Department of Internal Cardiovascular Science, Facutly of Medicine, Oita University, Oita, Japan
    Diabetes 55:2371-8. 2006
    ....
  7. doi request reprint Hyperthermia-induced cardioprotection is potentiated by ischemic postconditioning in rats
    Yukichi Murozono
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Yufu, Oita 879 5593, Japan
    Exp Biol Med (Maywood) 234:573-81. 2009
    ..Although the opening of the mitoKATP channel is predominantly involved as an effecter in HT-induced protection, potentiated protection by ischemic PostC may involve mechanisms other than the mitoKATP channel...
  8. ncbi request reprint Receptor-mediated suppression of cardiac heat-shock protein 72 expression by testosterone in male rat heart
    Hiroaki Kohno
    Department of Internal Medicine, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    Endocrinology 148:3148-55. 2007
    ..Our results indicate that testosterone potentially has inhibitory effects on cardiac HSP72 expression by modulating transcription, through testosterone receptor-mediated genomic mechanisms...
  9. doi request reprint Candesartan restored cardiac Hsp72 expression and tolerance against reperfusion injury in hereditary insulin-resistant rats
    Yayoi Taniguchi
    Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Yufu, Oita 879 5593, Japan
    Cardiovasc Res 92:439-48. 2011
    ....
  10. ncbi request reprint Phosphatidylinositol 3-kinase-dependent activation of akt, an essential signal for hyperthermia-induced heat-shock protein 72, is attenuated in streptozotocin-induced diabetic heart
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    Diabetes 55:1307-15. 2006
    ....
  11. doi request reprint Role of leptin signaling in the pathogenesis of angiotensin II-mediated atrial fibrosis and fibrillation
    Akira Fukui
    Department of Laboratory Examination and Diagnostics, Department of Internal Medicine 1, and Department of Molecular Pathology, Oita University Faculty of Medicine, Yufu, Japan
    Circ Arrhythm Electrophysiol 6:402-9. 2013
    ..We examined the hypothesis that leptin signaling contributes to the atrial fibrosis and atrial fibrillation (AF) evoked by angiotensin II (AngII)...
  12. ncbi request reprint Hyperthermia treatment prevents angiotensin II-mediated atrial fibrosis and fibrillation via induction of heat-shock protein 72
    Osamu Wakisaka
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    J Mol Cell Cardiol 43:616-26. 2007
    ..Our results suggest that HT treatment is effective in suppressing AII-mediated atrial fibrosis and AF via induction of HSP72 at least in parts, and is thus expected to be a novel strategy for prevention of AF...
  13. ncbi request reprint Baroreflex sensitivity predicts cardiovascular events in patients with type 2 diabetes mellitus without structural heart disease
    Norihiro Okada
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita, Japan
    Circ J 74:1379-83. 2010
    ..The present study aimed to assess the long-term cardiovascular predictive value of baroreflex sensitivity (BRS) in Japanese patients with type 2 DM without structural heart disease...
  14. ncbi request reprint Diazoxide-induced cardioprotection via DeltaPsim loss depending on timing of application
    Hidetoshi Yonemochi
    Department of Cardiovascular Science, Division of Laboratory Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama, Oita, 879 5593, Japan
    Life Sci 79:1906-12. 2006
    ..Our results suggest that mitoKATP channels act as a trigger and mediator of cardioprotection through a transient or persistent DeltaPsim loss depending on phenotypic consequence in response to oxidants...
  15. ncbi request reprint Gender difference in baroreflex sensitivity to predict cardiac and cerebrovascular events in type 2 diabetic patients
    Kunio Yufu
    Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, Yufu, Japan
    Circ J 75:1418-23. 2011
    ..The hypothesis that cardiovascular events are associated with gender differences in BRS was tested in the present study...
  16. ncbi request reprint Combined assessment of baroreflex sensitivity with iodine 123 metaiodobenzylguanidine scintigraphic findings strengthens the power of predictive value for cerebral and cardiovascular events in type 2 diabetic patients
    Yukichi Murozono
    Cardiovascular Science, Faculty of Medicine, Oita University, Oita University, Yufu, Japan
    Circ J 77:130-6. 2013
    ..We therefore tested the hypothesis that the combination of BRS and (123)I-MIBG scintigraphic findings could strengthen the predictive power for major adverse cerebral and cardiovascular events (MACCE)...
  17. ncbi request reprint Cardiac iodine-123 metaiodobenzylguanidine (123I-MIBG) scintigraphy parameter predicts cardiac and cerebrovascular events in type 2 diabetic patients without structural heart disease
    Kunio Yufu
    Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, Japan
    Circ J 76:399-404. 2012
    ..The aim of the present study was to investigate the long-term cardiovascular predictive value of cardiac (123)I-MIBG scintigraphy parameters in Japanese type 2 diabetic patients without structural heart disease...
  18. doi request reprint Effect of cardiac resynchronization therapy on cardiac sympathetic nervous dysfunction and serum C-reactive protein level
    Tetsuji Shinohara
    Department of Internal Medicine 1 Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, Oita, Japan
    Pacing Clin Electrophysiol 34:1225-30. 2011
    ..To test our hypothesis, we evaluated cardiac sympathetic activity and serum levels of high sensitive C-reactive protein (hs-CRP) before and after CRT...
  19. ncbi request reprint Hypoadiponectinemia in type 2 diabetes mellitus in men is associated with sympathetic overactivity as evaluated by cardiac 123I-metaiodobenzylguanidine scintigraphy
    Naohiko Takahashi
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita 879 5593, Japan
    Metabolism 56:919-24. 2007
    ..985). Our results suggest that in middle-aged men with type 2 diabetes mellitus, hypoadiponectinemia is associated with cardiac sympathetic overactivity as determined by (123)I-MIBG scintigraphy...
  20. doi request reprint Telmisartan effectively improves insulin sensitivity in hypertensive patients with insulin resistance
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama machi, Yufu, Oita 879 5593, Japan Electronic
    Obes Res Clin Pract 5:e267-360. 2011
    ..We tested the hypothesis that telmisartan can increase the serum level of adiponectin and improve insulin resistance...
  21. doi request reprint Electrocardiographic characteristics of patients with false tendon: possible association of false tendon with J waves
    Mikiko Nakagawa
    Department of Clinical Examination and Diagnosis, Oita University School of Medicine, Yufu City, Oita, Japan
    Heart Rhythm 9:782-8. 2012
    ..The presence of J waves is associated with vulnerability to ventricular arrhythmias; however, the mechanisms underlying the manifestation of J waves remain to be elucidated...
  22. doi request reprint Endothelial Function Predicts New Hospitalization due to Heart Failure Following Cardiac Resynchronization Therapy
    Kunio Yufu
    From the Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu, Oita, Japan
    Pacing Clin Electrophysiol 38:1260-6. 2015
    ..We tested the hypothesis that assessment of peripheral endothelial function is associated with the long-term outcome of CRT and its linkage to coronary flow reserve (CFR) was also investigated...
  23. doi request reprint Cardiac autonomic dysfunction in patients with head-up tilt test-induced vasovagal syncope
    Tetsuji Shinohara
    Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Oita, Japan
    Pacing Clin Electrophysiol 37:1694-701. 2014
    ..However, whether syncopal symptoms are associated with pathological cardiac autonomic modulation is not fully known. We tested the hypothesis that cardiac autonomic function is impaired in patients with VVS...
  24. doi request reprint False tendons may be associated with the genesis of J-waves: prospective study in young healthy male
    Mikiko Nakagawa
    Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Yufu City, Oita 879 5593, Japan Electronic address
    Int J Cardiol 172:428-33. 2014
    ..Recent studies showed that J-waves are associated with vulnerability to ventricular fibrillation. Recently we reported the association between false tendons (FTs) and J-waves in a retrospective study...
  25. doi request reprint Establishment of a model of atrial fibrillation associated with chronic kidney disease in rats and the role of oxidative stress
    Naoya Fukunaga
    Department of Internal Medicine 1, Oita University Faculty of Medicine, Oita, Japan
    Heart Rhythm 9:2023-31. 2012
    ..An animal model of atrial fibrillation (AF) associated with chronic kidney disease (CKD) has not been available...
  26. ncbi request reprint Estrogen inhibits hyperthermia-induced expression of heat-shock protein 72 and cardioprotection against ischemia/reperfusion injury in female rat heart
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    J Mol Cell Cardiol 37:1053-61. 2004
    ..This observation may be due to the inhibitory effects of estrogen on HSP72 expression at a transcriptional level...
  27. ncbi request reprint Oral administration of geranylgeranylacetone blunts the endothelial dysfunction induced by ischemia and reperfusion in the rat heart
    Zhen Zhu
    Department of Laboratory Medicine, Faculty of Medicine, Oita University, Oita, Japan
    J Cardiovasc Pharmacol 45:555-62. 2005
    ..The PI3 kinase and/or Rho kinase pathways appear to be involved in this process, whereas adrenomedullin and endothelin-1 are not necessary for the GGA-induced cardioprotection...
  28. doi request reprint Plasma norepinephrine is an independent predictor of adverse cerebral and cardiovascular events in type 2 diabetic patients without structural heart disease
    Kunio Yufu
    Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu, Oita, Japan Electronic address
    J Cardiol 64:225-30. 2014
    ..The current study investigated whether resting NE could predict long-term major adverse cerebral and cardiovascular events (MACCEs) in Japanese type 2 diabetic patients without heart disease...
  29. doi request reprint Combination therapy of cilostazol and bepridil suppresses recurrent ventricular fibrillation related to J-wave syndromes
    Tetsuji Shinohara
    Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Oita, Japan Electronic address
    Heart Rhythm 11:1441-5. 2014
    ..In such patients, an implantable cardioverter-defibrillator (ICD) is first-line therapy for prevention of sudden cardiac death. However, frequent ICD shocks due to recurrent VF remain serious problems...
  30. ncbi request reprint Characterization of J wave in a patient with idiopathic ventricular fibrillation
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita, Japan
    Heart Rhythm 3:1082-4. 2006
  31. ncbi request reprint Influence of systolic blood pressure and cigarette smoking on endothelial function in young healthy people
    Kunio Yufu
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Hasama, Yufu, Japan
    Circ J 73:174-8. 2009
    ....
  32. ncbi request reprint [Atrial standstill]
    Naohiko Takahashi
    Department of Cardiovascular Science, Faculty of Medicine, Oita University
    Nippon Rinsho . 2007
  33. doi request reprint Exaggerated Reactivity of Parasympathetic Nerves is Involved in Ventricular Fibrillation in J-Wave Syndrome
    Tetsuji Shinohara
    Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Oita, Japan
    J Cardiovasc Electrophysiol . 2016
    ..In most cases of J-wave syndrome, ventricular fibrillation (VF) often occurs around midnight or in the early morning when parasympathetic tone is augmented...
  34. doi request reprint Splenectomy exacerbates atrial inflammatory fibrosis and vulnerability to atrial fibrillation induced by pressure overload in rats: Possible role of spleen-derived interleukin-10
    Hidekazu Kondo
    Department of Cardiology and Clinical Examination, Oita University Faculty of Medicine, Oita, Japan
    Heart Rhythm 13:241-50. 2016
    ..The spleen is important for cardiac remodeling induced by myocardial infarction. However, the role of the spleen in inflammatory atrial fibrosis induced by pressure overload is unknown...
  35. ncbi request reprint Wolff-Parkinson-White syndrome concomitant with idiopathic ventricular fibrillation associated with inferior early repolarization
    Naohiko Takahashi
    Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, Japan
    Intern Med 51:1861-4. 2012
    ....
  36. doi request reprint The characteristics of an abnormal electrogram on the atrialized right ventricle in a patient with Ebstein's anomaly
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita, Japan
    Pacing Clin Electrophysiol 32:269-72. 2009
    ..We suggest that the abnormal electrogram might represent delayed local ventricular activation, and that the potential conduction might be impaired in the ARV...
  37. doi request reprint Mast Cells Play an Important Role in the Pathogenesis of Hyperglycemia-Induced Atrial Fibrillation
    Kenshi Uemura
    Department of Cardiology and Clinical Examination, Oita University Faculty of Medicine, Oita, Japan
    J Cardiovasc Electrophysiol 27:981-9. 2016
    ..However, the role of MCs in diabetes-induced atrial fibrillation (AF) has not been notably investigated. We tested the hypothesis that MC deficiency attenuates hyperglycemia-induced AF in mice...
  38. doi request reprint Outcome of Patients with Cardiac Sarcoidosis Who Received Cardiac Resynchronization Therapy: Comparison with Dilated Cardiomyopathy Patients
    Kunio Yufu
    Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu City, Oita, Japan
    J Cardiovasc Electrophysiol . 2016
    ..Cardiac resynchronization therapy (CRT) has been shown to be effective for patients with chronic heart failure; however, the efficacy of CRT in patients with cardiac sarcoidosis (CS) has not been established...
  39. ncbi request reprint Ischemia-induced translocation of protein kinase C-epsilon mediates cardioprotection in the streptozotocin-induced diabetic rat
    Tatsuhiko Ooie
    Department of Laboratory Medicine, Oita Medical University, Hasama, Japan
    Circ J 67:955-61. 2003
    ..These results suggest that persistent translocation of PKC-epsilon during ischemia plays a major role in cardioprotection against ischemia/reperfusion injury in STZ-induced diabetic rats...
  40. doi request reprint White matter lesions are associated with the results of 123I-metaiodobenzylguanidine myocardial scintigraphy in type 2 diabetes mellitus patients
    Futoshi Anan
    Department of Cardiology, Oita Red Cross Hospital, Oita 870 0033, Japan
    Metabolism 58:696-703. 2009
    ....
  41. doi request reprint Interventricular septal mass in a patient with cardiac sarcoidosis
    Mio Uchida
    Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, Oita, Japan
    J Cardiovasc Electrophysiol 23:433-5. 2012
    ..We describe a case of cardiac sarcoidosis resulting in a myocardial mass in the basal portion of the interventricular septum that was sensitive to corticosteroid treatment...
  42. doi request reprint Rescue of mutant alpha-galactosidase A in the endoplasmic reticulum by 1-deoxygalactonojirimycin leads to trafficking to lysosomes
    Ryoji Hamanaka
    Department of Anatomy, Biology and Medicine, Faculty of Medicine, Oita University, Oita, Japan
    Biochim Biophys Acta 1782:408-13. 2008
    ..These data suggest that the rescue of R301Q from ERAD is a key step for normalization of intracellular trafficking of R301Q...
  43. ncbi request reprint [Evaluation of autonomic function using posture change]
    Mikiko Nakagawa
    Department of Cardiovascular Science, Division of Laboratory Medicine, Oita University School of Medicine, Yufu
    Rinsho Byori 54:838-43. 2006
    ..DT-BRS and the squatting test may provide promising information for the assessment of reflex vagal activity in diabetes...