Tetsunori Saikawa

Summary

Affiliation: Oita University
Country: Japan

Publications

  1. doi request reprint Is the reno-protective effect of valsartan dose dependent? A comparative study of 80 and 160 mg day(-1)
    Tetsunori Saikawa
    Department of Clinical Examination and Diagnostics, Oita University, Oita, Japan
    Hypertens Res 33:886-91. 2010
  2. doi request reprint Candesartan restored cardiac Hsp72 expression and tolerance against reperfusion injury in hereditary insulin-resistant rats
    Yayoi Taniguchi
    Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Yufu, Oita 879 5593, Japan
    Cardiovasc Res 92:439-48. 2011
  3. doi request reprint Postchallenge plasma glucose and glycemic spikes are associated with pulse pressure in patients with impaired glucose tolerance and essential hypertension
    Futoshi Anan
    First Department of Internal Medicine, Faculty of Medicine, Oita University, and Department of Cardiology, Oita Red Cross Hospital, Oita, Japan
    Hypertens Res 31:1565-71. 2008
  4. ncbi request reprint Correlations of high-sensitivity C-reactive protein and atherosclerosis in Japanese type 2 diabetic patients
    Futoshi Anan
    Department of Cardiology, Oita Red Cross Hospital, Oita, Japan
    Eur J Endocrinol 157:311-7. 2007
  5. ncbi request reprint Mitochondria are targets for geranylgeranylacetone-induced cardioprotection against ischemia-reperfusion in the rat heart
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    Am J Physiol Heart Circ Physiol 293:H1892-9. 2007
  6. doi request reprint Diabetic retinopathy is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients
    Futoshi Anan
    Department of Cardiology, Oita Red Cross Hospital, Oita, Japan
    Hypertens Res 32:299-305. 2009
  7. doi request reprint Hyperthermia-induced cardioprotection is potentiated by ischemic postconditioning in rats
    Yukichi Murozono
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Yufu, Oita 879 5593, Japan
    Exp Biol Med (Maywood) 234:573-81. 2009
  8. ncbi request reprint Smoking is associated with urinary albumin excretion: an evaluation of premenopausal patients with type 2 diabetes mellitus
    Futoshi Anan
    Department of Cardiovascular Science, Oita University, Oita, Japan
    Metabolism 56:179-84. 2007
  9. ncbi request reprint Pioglitazone but not glibenclamide improves cardiac expression of heat shock protein 72 and tolerance against ischemia/reperfusion injury in the heredity insulin-resistant rat
    Yayoi Taniguchi
    Department of Internal Cardiovascular Science, Facutly of Medicine, Oita University, Oita, Japan
    Diabetes 55:2371-8. 2006
  10. doi request reprint Predictors for prehypertension in patients with impaired glucose tolerance
    Futoshi Anan
    Department of Cardiology, Oita Red Cross Hospital, Oita, Japan
    Hypertens Res 31:1913-20. 2008

Collaborators

Detail Information

Publications72

  1. doi request reprint Is the reno-protective effect of valsartan dose dependent? A comparative study of 80 and 160 mg day(-1)
    Tetsunori Saikawa
    Department of Clinical Examination and Diagnostics, Oita University, Oita, Japan
    Hypertens Res 33:886-91. 2010
    ..The high dose of valsartan resulted in a slightly greater decrease in urinary beta2MG, but it was inconclusive whether the high dose was more reno-protective as compared with the low dose...
  2. doi request reprint Candesartan restored cardiac Hsp72 expression and tolerance against reperfusion injury in hereditary insulin-resistant rats
    Yayoi Taniguchi
    Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Yufu, Oita 879 5593, Japan
    Cardiovasc Res 92:439-48. 2011
    ....
  3. doi request reprint Postchallenge plasma glucose and glycemic spikes are associated with pulse pressure in patients with impaired glucose tolerance and essential hypertension
    Futoshi Anan
    First Department of Internal Medicine, Faculty of Medicine, Oita University, and Department of Cardiology, Oita Red Cross Hospital, Oita, Japan
    Hypertens Res 31:1565-71. 2008
    ..Our results show that age, LVMI, and PGS120 are significantly associated with high PP in Japanese patients with IGT and essential hypertension...
  4. ncbi request reprint Correlations of high-sensitivity C-reactive protein and atherosclerosis in Japanese type 2 diabetic patients
    Futoshi Anan
    Department of Cardiology, Oita Red Cross Hospital, Oita, Japan
    Eur J Endocrinol 157:311-7. 2007
    ..We tested the hypothesis that the HSCRP correlates with aortic stiffness and insulin resistance in type 2 diabetic patients...
  5. ncbi request reprint Mitochondria are targets for geranylgeranylacetone-induced cardioprotection against ischemia-reperfusion in the rat heart
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    Am J Physiol Heart Circ Physiol 293:H1892-9. 2007
    ..These processes may involve opening of the mitoK(ATP) channel...
  6. doi request reprint Diabetic retinopathy is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients
    Futoshi Anan
    Department of Cardiology, Oita Red Cross Hospital, Oita, Japan
    Hypertens Res 32:299-305. 2009
    ....
  7. doi request reprint Hyperthermia-induced cardioprotection is potentiated by ischemic postconditioning in rats
    Yukichi Murozono
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Yufu, Oita 879 5593, Japan
    Exp Biol Med (Maywood) 234:573-81. 2009
    ..Although the opening of the mitoKATP channel is predominantly involved as an effecter in HT-induced protection, potentiated protection by ischemic PostC may involve mechanisms other than the mitoKATP channel...
  8. ncbi request reprint Smoking is associated with urinary albumin excretion: an evaluation of premenopausal patients with type 2 diabetes mellitus
    Futoshi Anan
    Department of Cardiovascular Science, Oita University, Oita, Japan
    Metabolism 56:179-84. 2007
    ....
  9. ncbi request reprint Pioglitazone but not glibenclamide improves cardiac expression of heat shock protein 72 and tolerance against ischemia/reperfusion injury in the heredity insulin-resistant rat
    Yayoi Taniguchi
    Department of Internal Cardiovascular Science, Facutly of Medicine, Oita University, Oita, Japan
    Diabetes 55:2371-8. 2006
    ....
  10. doi request reprint Predictors for prehypertension in patients with impaired glucose tolerance
    Futoshi Anan
    Department of Cardiology, Oita Red Cross Hospital, Oita, Japan
    Hypertens Res 31:1913-20. 2008
    ..Our findings indicate that the presence of PHT was associated with hyperinsulinemia and that the F-IRI was an independent predictor of PHT in these Japanese patients with IGT...
  11. ncbi request reprint Effects of valsartan and perindopril combination therapy on left ventricular hypertrophy and aortic arterial stiffness in patients with essential hypertension
    Futoshi Anan
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita, 879 5593, Japan
    Eur J Clin Pharmacol 61:353-9. 2005
    ....
  12. ncbi request reprint Brain natriuretic peptide and cardiac autonomic function in type 2 diabetic patients
    Kunio Yufu
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    Diabetes Res Clin Pract 72:12-9. 2006
    ..The plasma level of BNP negatively correlated with BRS (r=0.35, p=0.049). These findings suggest that increased plasma BNP levels were related to cardiac reflex parasympathetic dysfunction in our Japanese type 2 diabetic patients...
  13. ncbi request reprint High-sensitivity C-reactive protein is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients
    Futoshi Anan
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Japan
    Metabolism 54:552-8. 2005
    ....
  14. pmc Inhibition of Na⁺-H⁺ exchange as a mechanism of rapid cardioprotection by resveratrol
    Luong Cong Thuc
    Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, Yufu City, Oita, Japan
    Br J Pharmacol 166:1745-55. 2012
    ..The PKC-α-dependent inhibition of NHE and subsequent attenuation of [Ca(2+)](i) overload may be a cardioprotective mechanism...
  15. ncbi request reprint Predictors for silent cerebral infarction in patients with chronic renal failure undergoing hemodialysis
    Futoshi Anan
    Department of Cardiology, Oita Red Cross Hospital, Oita, Japan
    Metabolism 56:593-8. 2007
    ..89; 95% confidence interval, 1.57-3.38; P < .005). Our findings indicate that HGF may be a novel useful predictor of SCI in patients with chronic renal failure undergoing HD...
  16. ncbi request reprint High-density lipoprotein cholesterol and insulin resistance are independent and additive markers of left ventricular hypertrophy in essential hypertension
    Futoshi Anan
    Department of Cardiovascular Science, Faculty of Medicine, Oita University, Japan
    Hypertens Res 30:125-31. 2007
    ..13, p<0.05) as independent significant risk factors for LVH. Our findings suggest that HDL-C, HOMA-index and nighttime systolic ABP are independent predictors for the presence of LVH in Japanese patients with essential hypertension...
  17. ncbi request reprint Microalbuminuria, cardiovascular autonomic dysfunction, and insulin resistance in patients with type 2 diabetes mellitus
    Naohiko Takahashi
    Department of Internal Medicine I, Oita University, Idaigaoka, Hasama, Japan
    Metabolism 53:1359-64. 2004
    ....
  18. doi request reprint Adrenomedullin improves cardiac expression of heat-shock protein 72 and tolerance against ischemia/reperfusion injury in insulin-resistant rats
    Yasuko Torigoe
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Yufu, Oita, Japan
    Endocrinology 150:1450-5. 2009
    ..This intervention was effective even in insulin-resistant hearts...
  19. doi request reprint Role of interleukin-6 levels in cardiovascular autonomic dysfunction in type 2 diabetic patients
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama machi, Yuhu, Oita, Japan
    Eur J Nucl Med Mol Imaging 35:1616-23. 2008
    ..The aim of this study was to determine whether serum IL-6 levels are associated with cardiovascular autonomic dysfunction in type 2 diabetic patients...
  20. doi request reprint Activation of CaMKII as a key regulator of reactive oxygen species production in diabetic rat heart
    Satoru Nishio
    Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Yufu City, Oita 879 5593, Japan
    J Mol Cell Cardiol 52:1103-11. 2012
    ..Consistently, expression of phosphorylated CaMKII was increased in the diabetic heart. Activation of CaMKII by impaired [Ca(2+)](i) metabolism may be a mechanism of ROS increase in the heart with diabetes mellitus...
  21. ncbi request reprint Hyperthermia treatment prevents angiotensin II-mediated atrial fibrosis and fibrillation via induction of heat-shock protein 72
    Osamu Wakisaka
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    J Mol Cell Cardiol 43:616-26. 2007
    ..Our results suggest that HT treatment is effective in suppressing AII-mediated atrial fibrosis and AF via induction of HSP72 at least in parts, and is thus expected to be a novel strategy for prevention of AF...
  22. ncbi request reprint Phosphatidylinositol 3-kinase-dependent activation of akt, an essential signal for hyperthermia-induced heat-shock protein 72, is attenuated in streptozotocin-induced diabetic heart
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    Diabetes 55:1307-15. 2006
    ....
  23. ncbi request reprint Cardioprotective effects of pravastatin against lethal ventricular arrhythmias induced by reperfusion in the rat heart
    Luong Cong Thuc
    Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, Yufu, Japan
    Circ J 75:1601-8. 2011
    ..Statins are reported to reduce mortality in patients with coronary artery disease and that mortality benefit might be related to the drugs' antiarrhythmic properties...
  24. doi request reprint Early atorvastatin therapy improves cardiac function in patients with acute myocardial infarction
    Yasushi Teshima
    Department of Cardiovascular Science, Faculty of Medicine, Oita University, Yufu City, Oita, Japan
    J Cardiol 53:58-64. 2009
    ..A number of experimental and clinical studies have demonstrated a cardioprotective effect of statins; however, the effect of atorvastatin on cardiac function in patients with an acute myocardial infarction (AMI) has not been established...
  25. ncbi request reprint Baroreflex sensitivity predicts cardiovascular events in patients with type 2 diabetes mellitus without structural heart disease
    Norihiro Okada
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita, Japan
    Circ J 74:1379-83. 2010
    ..The present study aimed to assess the long-term cardiovascular predictive value of baroreflex sensitivity (BRS) in Japanese patients with type 2 DM without structural heart disease...
  26. ncbi request reprint Receptor-mediated suppression of cardiac heat-shock protein 72 expression by testosterone in male rat heart
    Hiroaki Kohno
    Department of Internal Medicine, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    Endocrinology 148:3148-55. 2007
    ..Our results indicate that testosterone potentially has inhibitory effects on cardiac HSP72 expression by modulating transcription, through testosterone receptor-mediated genomic mechanisms...
  27. ncbi request reprint Gender difference in baroreflex sensitivity to predict cardiac and cerebrovascular events in type 2 diabetic patients
    Kunio Yufu
    Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, Yufu, Japan
    Circ J 75:1418-23. 2011
    ..The hypothesis that cardiovascular events are associated with gender differences in BRS was tested in the present study...
  28. doi request reprint Pioglitazone attenuates inflammatory atrial fibrosis and vulnerability to atrial fibrillation induced by pressure overload in rats
    Osamu Kume
    Department of Internal Medicine 1, Oita University, Oita, Japan
    Heart Rhythm 8:278-85. 2011
    ..Inflammatory processes are involved in the pathogenesis of atrial fibrillation (AF)...
  29. doi request reprint Establishment of a model of atrial fibrillation associated with chronic kidney disease in rats and the role of oxidative stress
    Naoya Fukunaga
    Department of Internal Medicine 1, Oita University Faculty of Medicine, Oita, Japan
    Heart Rhythm 9:2023-31. 2012
    ..An animal model of atrial fibrillation (AF) associated with chronic kidney disease (CKD) has not been available...
  30. ncbi request reprint Hypoadiponectinemia in type 2 diabetes mellitus in men is associated with sympathetic overactivity as evaluated by cardiac 123I-metaiodobenzylguanidine scintigraphy
    Naohiko Takahashi
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita 879 5593, Japan
    Metabolism 56:919-24. 2007
    ..985). Our results suggest that in middle-aged men with type 2 diabetes mellitus, hypoadiponectinemia is associated with cardiac sympathetic overactivity as determined by (123)I-MIBG scintigraphy...
  31. doi request reprint High-glucose condition reduces cardioprotective effects of insulin against mechanical stress-induced cell injury
    Yasushi Teshima
    Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, Yufu City, Oita, Japan
    Life Sci 87:154-61. 2010
    ..In this study, we investigated whether insulin exerts cardioprotective effects against mechanical stretching-induced cell injury, and whether the protective effect is influenced by high-glucose condition...
  32. doi request reprint The role of microalbuminuria and insulin resistance as significant risk factors for white matter lesions in Japanese type 2 diabetic patients
    Futoshi Anan
    Department of Cardiology, Oita Red Cross Hospital, Oita, Japan
    Curr Med Res Opin 24:1561-7. 2008
    ..This preliminary study was therefore designed to test the hypothesis that the presence of WML correlates with microalbuminuria and insulin resistance in patients with type 2 diabetic mellitus (DM) not receiving insulin treatment...
  33. ncbi request reprint Novel strategy to prevent atrial fibrosis and fibrillation
    Naohiko Takahashi
    Department of Laboratory Examination and Diagnostics, Oita University Faculty of Medicine, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    Circ J 76:2318-26. 2012
    ..Pioglitazone, induction of HSPs and antioxidant agent could be novel therapeutic approaches to preventing atrial fibrosis and AF. ..
  34. doi request reprint Electrocardiographic characteristics of patients with false tendon: possible association of false tendon with J waves
    Mikiko Nakagawa
    Department of Clinical Examination and Diagnosis, Oita University School of Medicine, Yufu City, Oita, Japan
    Heart Rhythm 9:782-8. 2012
    ..The presence of J waves is associated with vulnerability to ventricular arrhythmias; however, the mechanisms underlying the manifestation of J waves remain to be elucidated...
  35. ncbi request reprint Cardiac iodine-123 metaiodobenzylguanidine (123I-MIBG) scintigraphy parameter predicts cardiac and cerebrovascular events in type 2 diabetic patients without structural heart disease
    Kunio Yufu
    Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, Japan
    Circ J 76:399-404. 2012
    ..The aim of the present study was to investigate the long-term cardiovascular predictive value of cardiac (123)I-MIBG scintigraphy parameters in Japanese type 2 diabetic patients without structural heart disease...
  36. doi request reprint Effect of cardiac resynchronization therapy on cardiac sympathetic nervous dysfunction and serum C-reactive protein level
    Tetsuji Shinohara
    Department of Internal Medicine 1 Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, Oita, Japan
    Pacing Clin Electrophysiol 34:1225-30. 2011
    ..To test our hypothesis, we evaluated cardiac sympathetic activity and serum levels of high sensitive C-reactive protein (hs-CRP) before and after CRT...
  37. ncbi request reprint Candesartan, an angiotensin II receptor blocker, improves left ventricular hypertrophy and insulin resistance
    Futoshi Anan
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita, Japan
    Metabolism 53:777-81. 2004
    ..Our findings suggest that pharmacological blockade of angiotensin II receptors by candesartan could improve LVH in never-treated EH patients, which may relate to the improvement of insulin resistance...
  38. ncbi request reprint Measurement of the brachial-ankle pulse wave velocity and flow-mediated dilatation in young, healthy smokers
    Kunio Yufu
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Japan
    Hypertens Res 30:607-12. 2007
    ..381). Our results suggest that a reduction in FMD is closely associated with the early stages of endothelial dysfunction caused by cigarette smoking in young, healthy subjects, which is at least partly reflected by the PWV value...
  39. doi request reprint Homocysteine levels are associated with hippocampus volume in type 2 diabetic patients
    Tsuyoshi Shimomura
    Department of Neurosurgery, Faculty of Medicine, Oita University, Oita, Japan
    Eur J Clin Invest 41:751-8. 2011
    ..We tested the hypothesis that elevated tHcy levels are correlated with hippocampus volume and insulin resistance in nondementia patients with type 2 diabetes...
  40. ncbi request reprint Combined assessment of baroreflex sensitivity with iodine 123 metaiodobenzylguanidine scintigraphic findings strengthens the power of predictive value for cerebral and cardiovascular events in type 2 diabetic patients
    Yukichi Murozono
    Cardiovascular Science, Faculty of Medicine, Oita University, Oita University, Yufu, Japan
    Circ J 77:130-6. 2013
    ..We therefore tested the hypothesis that the combination of BRS and (123)I-MIBG scintigraphic findings could strengthen the predictive power for major adverse cerebral and cardiovascular events (MACCE)...
  41. ncbi request reprint Correlations of urinary albumin excretion and atherosclerosis in Japanese type 2 diabetic patients
    Futoshi Anan
    Department of Cardiology, Oita Red Cross Hospital, Oita, Japan
    Diabetes Res Clin Pract 77:414-9. 2007
    ....
  42. ncbi request reprint Effects of insulin resistance on geranylgeranylacetone-induced expression of heat shock protein 72 and cardioprotection in high-fat diet rats
    Tatsuhiko Ooie
    Department of Laboratory Medicine, Faculty of Medicine, Oita University, 1 1, Hasama, Oita, 879 5593, Japan
    Life Sci 77:869-81. 2005
    ..This is the first demonstration that expression of HSP72 was depressed in the heart and that reduced HSP72 was related with less cardioprotection against ischemic insult in high-fat diet-induced insulin resistance rats...
  43. ncbi request reprint Influence of systolic blood pressure and cigarette smoking on endothelial function in young healthy people
    Kunio Yufu
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Hasama, Yufu, Japan
    Circ J 73:174-8. 2009
    ....
  44. doi request reprint Abdominal visceral fat accumulation is associated with hippocampus volume in non-dementia patients with type 2 diabetes mellitus
    Futoshi Anan
    Department of Cardiology, Oita Red Cross Hospital, 3 2 37 Chiyomachi, Oita, Japan
    Neuroimage 49:57-62. 2010
    ....
  45. doi request reprint New lipoic acid derivative drug sodium zinc dihydrolipoylhistidinate prevents cardiac dysfunction in an isolated perfused rat heart model
    Satoshi Hagiwara
    Department of Anesthesiology, Oita University Faculty of Medicine, Oita, Japan
    Crit Care Med 39:506-11. 2011
    ..The purpose of the present study was to determine the cardioprotective effects of the new lipoic acid-derivative drug sodium zinc dihydrolipoylhistidinate in a global ischemia isolated perfused rat heart model...
  46. ncbi request reprint Gender differences in autonomic modulation of ventricular repolarization in humans
    Mikiko Nakagawa
    Department of Cardiovascular Science, Division of Laboratory Medicine, Oita University, School of Medicine, Oita, Japan
    J Cardiovasc Electrophysiol 16:278-84. 2005
    ..Therefore, we investigated whether there is a gender difference in humans with respect to the dynamic response of ventricular repolarization to beta-adrenergic stimulation and to autonomic blockade...
  47. ncbi request reprint Homocysteine levels are associated with the results of 123I-metaiodobenzylguanidine myocardial scintigraphy in type 2 diabetic patients
    Futoshi Anan
    Department of Cardiovascular Science, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita, 879 5593, Japan
    Eur J Nucl Med Mol Imaging 34:28-35. 2007
    ..We tested the hypothesis that hyperhomocysteinemia is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients not receiving insulin treatment...
  48. doi request reprint Mitochondrial K(ATP) channels-derived reactive oxygen species activate pro-survival pathway in pravastatin-induced cardioprotection
    Luong Cong Thuc
    Department of Laboratory Examination and Diagnostics, Oita University, Yufu City, Japan
    Apoptosis 15:669-78. 2010
    ..Moderately up-regulated ROS production by mitoK(ATP) channels opening is involved in the pro-survival signaling cascade activated by pravastatin...
  49. doi request reprint Gender differences in the effect of auditory stimuli on ventricular repolarization in healthy subjects
    Mikiko Nakagawa
    Division of Laboratory Medicine, Department of Cardiovascular Science, Oita University School of Medicine, 1 1 Idaigaoka, Hasama, Yufu City, Oita, Japan
    J Cardiovasc Electrophysiol 20:653-7. 2009
    ....
  50. ncbi request reprint Diazoxide-induced cardioprotection via DeltaPsim loss depending on timing of application
    Hidetoshi Yonemochi
    Department of Cardiovascular Science, Division of Laboratory Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama, Oita, 879 5593, Japan
    Life Sci 79:1906-12. 2006
    ..Our results suggest that mitoKATP channels act as a trigger and mediator of cardioprotection through a transient or persistent DeltaPsim loss depending on phenotypic consequence in response to oxidants...
  51. ncbi request reprint Hyperhomocysteinemia is a significant risk factor for silent cerebral infarction in patients with chronic renal failure undergoing hemodialysis
    Futoshi Anan
    Department of Cardiology, Oita Red Cross Hospital, and Department of Cardiovascular Science, School of Medicine, Oita University, Oita 879 5593, Japan
    Metabolism 55:656-61. 2006
    ..22; 95% CI, 1.10-1.36; P<.01). Our findings indicate that plasma tHcy may be a novel useful predictor for SCI in patients with chronic renal failure undergoing HD...
  52. doi request reprint Hepatocyte growth factor is a significant risk factor for white matter lesions in Japanese type 2 diabetic patients
    Futoshi Anan
    Department of Cardiology, Oita Red Cross Hospital, Oita, Japan
    Eur J Clin Invest 40:585-90. 2010
    ..The preliminary study was therefore designed to test the hypothesis that the presence of WML correlates with HGF and insulin resistance in type 2 diabetic patients not receiving insulin treatment...
  53. doi request reprint Danaparoid sodium attenuates the effects of heat stress
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 171:762-8. 2011
    ..Given that heat stroke is a severe inflammatory response disease, we hypothesized that DA could inhibit inflammation from heat stress and prevent acute heat stroke...
  54. doi request reprint Splenectomy exacerbates atrial inflammatory fibrosis and vulnerability to atrial fibrillation induced by pressure overload in rats: Possible role of spleen-derived interleukin-10
    Hidekazu Kondo
    Department of Cardiology and Clinical Examination, Oita University Faculty of Medicine, Oita, Japan
    Heart Rhythm 13:241-50. 2016
    ..The spleen is important for cardiac remodeling induced by myocardial infarction. However, the role of the spleen in inflammatory atrial fibrosis induced by pressure overload is unknown...
  55. ncbi request reprint Influence of menstrual cycle on QT interval dynamics
    Mikiko Nakagawa
    Department of Cardiovascular Science, Division of Laboratory Medicine, Oita University School of Medicine, Yufu City, Oita, Japan
    Pacing Clin Electrophysiol 29:607-13. 2006
    ..The aim of this study was to investigate the effects of the menstrual cycle on QT interval dynamics and the autonomic tone in healthy women...
  56. ncbi request reprint Gender differences in the dynamics of terminal T wave intervals
    Mikiko Nakagawa
    Department of Cardiovascular Science, Division of Laboratory Medicine, Oita University School of Medicine, Oita, Japan
    Pacing Clin Electrophysiol 27:769-74. 2004
    ..The observed gender difference in the measurement and dynamics of the Ta-e interval may help to understand the mechanisms underlying the gender difference in the incidence of ventricular arrhythmias...
  57. ncbi request reprint Brugada syndrome with complete right bundle branch block disclosed by a febrile illness
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita
    Intern Med 47:843-6. 2008
    ..Our observations suggest that physicians should be careful to evaluate ECG change in response to a febrile state, even if the ECG shows a typical CRBBB pattern with deep and wide S waves in the left leads...
  58. doi request reprint Glucose fluctuations increase the incidence of atrial fibrillation in diabetic rats
    Shotaro Saito
    Department of Cardiology and Clinical Examination, Oita University, Faculty of Medicine, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    Cardiovasc Res 104:5-14. 2014
    ..We investigated whether glucose fluctuations aggravate cardiac fibrosis and increase the occurrence of atrial fibrillation (AF) in rats with diabetes mellitus (DM)...
  59. ncbi request reprint Wolff-Parkinson-White syndrome concomitant with idiopathic ventricular fibrillation associated with inferior early repolarization
    Naohiko Takahashi
    Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, Japan
    Intern Med 51:1861-4. 2012
    ....
  60. doi request reprint The characteristics of an abnormal electrogram on the atrialized right ventricle in a patient with Ebstein's anomaly
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita, Japan
    Pacing Clin Electrophysiol 32:269-72. 2009
    ..We suggest that the abnormal electrogram might represent delayed local ventricular activation, and that the potential conduction might be impaired in the ARV...
  61. ncbi request reprint Pilsicainide-induced ventricular tachycardia originating from right ventricular outflow tract
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita, Japan
    J Cardiovasc Electrophysiol 18:552. 2007
  62. ncbi request reprint Estrogen inhibits hyperthermia-induced expression of heat-shock protein 72 and cardioprotection against ischemia/reperfusion injury in female rat heart
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    J Mol Cell Cardiol 37:1053-61. 2004
    ..This observation may be due to the inhibitory effects of estrogen on HSP72 expression at a transcriptional level...
  63. ncbi request reprint Progressive facilitation of antegrade conduction via an accessory pathway in a patient with Wolff-Parkinson-White syndrome and permanent atrial fibrillation
    Naohiko Takahashi
    Department of Internal Medicine 1, Oita University, Japan
    Intern Med 44:1264-8. 2005
    ..Radiofrequency catheter ablation using a transseptal approach was performed during AF, resulting in complete elimination of the antegrade accessory pathway conduction...
  64. ncbi request reprint Brachial arterial stiffness predicts coronary atherosclerosis in patients at risk for cardiovascular diseases
    Kunio Yufu
    Department of Internal Medicine I, School of Medicine, Oita Medical University, Oita, Japan
    Jpn Heart J 45:231-42. 2004
    ..62, P = 0.0001 and P = 0.33, P = 0.030, respectively). Our observations suggest that brachial %MPA provides predictive values for coronary atherosclerosis in subjects at risk for cardiovascular disease...
  65. ncbi request reprint Characterization of J wave in a patient with idiopathic ventricular fibrillation
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita, Japan
    Heart Rhythm 3:1082-4. 2006
  66. ncbi request reprint Oral administration of geranylgeranylacetone blunts the endothelial dysfunction induced by ischemia and reperfusion in the rat heart
    Zhen Zhu
    Department of Laboratory Medicine, Faculty of Medicine, Oita University, Oita, Japan
    J Cardiovasc Pharmacol 45:555-62. 2005
    ..The PI3 kinase and/or Rho kinase pathways appear to be involved in this process, whereas adrenomedullin and endothelin-1 are not necessary for the GGA-induced cardioprotection...
  67. ncbi request reprint Predicting no-reflow based on angiographic features of lesions in patients with acute myocardial infarction
    Masahide Hara
    Internal Medicine 1, School of Medicine, Oita University, Oita, Japan
    J Atheroscler Thromb 12:315-21. 2005
    ..We tried to elucidate angiographical predictors of no-reflow and to determine a preferable recanalization therapy based on the morphology of lesions...
  68. ncbi request reprint Leg fat percentage correlates negatively with coronary atherosclerosis
    Masahide Hara
    Internal Medicine I, School of Medicine, Oita University, Oita Gun, Oita, Japan
    Circ J 68:1173-8. 2004
    ..Visceral fat is related to coronary atherosclerosis, but little is known about the relation between coronary atherosclerosis and percent body fat accumulated in different parts of the body...
  69. ncbi request reprint Morphological varieties of the Purkinje fiber network in mammalian hearts, as revealed by light and electron microscopy
    Noriaki Ono
    Department of Cardiovascular Science, Faculty of Medicine, Oita University, Hasama machi, Yufu, Oita ken, Japan
    Arch Histol Cytol 72:139-49. 2009
    ..These findings indicate that the structural variety of the Purkinje fiber network may reflect the conducting function and be related to the phylogeny of the mammalian species...
  70. ncbi request reprint AT1 receptor blockade prevents microvascular dysfunction induced by ischemia/reperfusion injury
    Kumiko Akiyoshi
    Department of Internal Medicine I, School of Medicine, Oita University, 1 1 idaiga oka, Hasama, Yufu City, Oita 879 5593, Japan
    J Atheroscler Thromb 13:231-9. 2006
    ..The effects of LO were lost in the presence of AT2 receptor blocker PD 123319 (PD). In conclusion, LO suppressed and protected against I/R injuries. The possible interaction between AT1 and AT2 receptors was also suggested...
  71. ncbi request reprint Attenuated inhibition of L-type calcium currents by troglitazone in fructose-fed rat cardiac ventricular myocytes
    Masaya Arikawa
    Department of Internal Medicine 1, Oita University, Oita, Japan
    J Cardiovasc Pharmacol 44:109-16. 2004
    ..Contrary to the STZ-induced diabetic rat, the suppressive effect of troglitazone on cardiac ventricular ICa,L was attenuated in fructose-fed rats. Persistent elevation of plasma insulin concentration may play a role in these processes...
  72. doi request reprint Recombinant thrombomodulin prevents heatstroke by inhibition of high-mobility group box 1 protein in sera of rats
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    Shock 34:402-6. 2010
    ..As TM exhibited a strong anti-inflammatory effect in a rat model of acute inflammation induced by heat stress, TM represents a potential therapeutic for heatstroke prevention or management in patients...