Masatsugu Moriyama

Summary

Affiliation: Oita University
Country: Japan

Publications

  1. pmc MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2
    Mitsuhiro Matsuo
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita, Japan
    Mol Cancer 12:15. 2013
  2. pmc Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma
    Keiko Matsuura
    Department of Molecular Pathology, Oita University, Oita, Japan
    BMC Cancer 11:523. 2011
  3. pmc Evaluation of the anti-East Asian CagA-specific antibody for CagA phenotyping
    Lam Tung Nguyen
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Yufu City, Oita, Japan
    Clin Vaccine Immunol 16:1687-92. 2009
  4. doi request reprint Genotyping of the cagA gene of Helicobacter pylori on immunohistochemistry with East Asian CagA-specific antibody
    Ryoko Kanada
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita, Japan
    Pathol Int 58:218-25. 2008
  5. pmc Genomic profiling of submucosal-invasive gastric cancer by array-based comparative genomic hybridization
    Akiko Kuroda
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita, Japan
    PLoS ONE 6:e22313. 2011
  6. doi request reprint Evaluation of rapid urine test for the detection of Helicobacter pylori infection in the Vietnamese population
    Lam Tung Nguyen
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Yufu City, Oita 879 5593, Japan
    Dig Dis Sci 55:89-93. 2010
  7. doi request reprint A novel diagnostic monoclonal antibody specific for Helicobacter pylori CagA of East Asian type
    Aiko Yasuda
    Institute of Scientific Research, Faculty of Medicine, Oita University, Oita, Japan
    APMIS 117:893-9. 2009
  8. doi request reprint Enhanced phosphorylation of the epidermal growth factor receptor at the site of tyrosine 992 in esophageal carcinomas
    Michiyo Miyawaki
    Department of Surgery II, Oita University Faculty of Medicine, Oita, Japan
    APMIS 116:1097-106. 2008
  9. doi request reprint Overexpression of miR-210, a downstream target of HIF1α, causes centrosome amplification in renal carcinoma cells
    Chisato Nakada
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita 879 5593, Japan
    J Pathol 224:280-8. 2011
  10. doi request reprint Genomic profiling of gastric carcinoma in situ and adenomas by array-based comparative genomic hybridization
    Masahiro Uchida
    Department of Molecular Pathology, Oita University, Oita, Japan
    J Pathol 221:96-105. 2010

Collaborators

Detail Information

Publications30

  1. pmc MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2
    Mitsuhiro Matsuo
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita, Japan
    Mol Cancer 12:15. 2013
    ..For this purpose, we verified the downregulation of miR-29c in gastric carcinoma tissues, and assessed the biological effect of miR-29c on gastric carcinoma cells...
  2. pmc Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma
    Keiko Matsuura
    Department of Molecular Pathology, Oita University, Oita, Japan
    BMC Cancer 11:523. 2011
    ..Therefore, we investigated the SAV1 function on cell proliferation and apoptosis in vitro. Furthermore, we attempted to clarify the downstream signaling which is regulated by SAV1...
  3. pmc Evaluation of the anti-East Asian CagA-specific antibody for CagA phenotyping
    Lam Tung Nguyen
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Yufu City, Oita, Japan
    Clin Vaccine Immunol 16:1687-92. 2009
    ..7%, 97.9%, and 97.1%, respectively. Moreover, anti-EAS Ab was not cross-reactive with noninfected gastric mucosa. In conclusion, immunohistochemistry with anti-EAS Ab appears to be a good method for determination of CagA phenotype...
  4. doi request reprint Genotyping of the cagA gene of Helicobacter pylori on immunohistochemistry with East Asian CagA-specific antibody
    Ryoko Kanada
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita, Japan
    Pathol Int 58:218-25. 2008
    ..2%) and specific (specificity 72.7%), suggesting that immunohistochemical diagnosis of the cagA genotype is useful for diagnosis of the cagA genotype...
  5. pmc Genomic profiling of submucosal-invasive gastric cancer by array-based comparative genomic hybridization
    Akiko Kuroda
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita, Japan
    PLoS ONE 6:e22313. 2011
    ....
  6. doi request reprint Evaluation of rapid urine test for the detection of Helicobacter pylori infection in the Vietnamese population
    Lam Tung Nguyen
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Yufu City, Oita 879 5593, Japan
    Dig Dis Sci 55:89-93. 2010
    ..This study attempted to assess the value of the RAPIRUN test for the diagnosis of Helicobacter pylori infection in the Vietnamese population...
  7. doi request reprint A novel diagnostic monoclonal antibody specific for Helicobacter pylori CagA of East Asian type
    Aiko Yasuda
    Institute of Scientific Research, Faculty of Medicine, Oita University, Oita, Japan
    APMIS 117:893-9. 2009
    ..We also analyzed the localization of the CagA protein in H. pylori-infected gastric mucosa with fluorescence immunohistochemistry, and found that CagA protein expression was up-regulated by adhesion to epithelial cells...
  8. doi request reprint Enhanced phosphorylation of the epidermal growth factor receptor at the site of tyrosine 992 in esophageal carcinomas
    Michiyo Miyawaki
    Department of Surgery II, Oita University Faculty of Medicine, Oita, Japan
    APMIS 116:1097-106. 2008
    ..The present findings suggest that phosphorylation of EGFR( Tyr992) may play some specific functional role in esophageal carcinomas besides promotion of cell proliferation...
  9. doi request reprint Overexpression of miR-210, a downstream target of HIF1α, causes centrosome amplification in renal carcinoma cells
    Chisato Nakada
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita 879 5593, Japan
    J Pathol 224:280-8. 2011
    ..On the basis of these results, we propose that miR-210 up-regulation due to HIF1α accumulation may induce aneuploidy via E2F3 down-regulation at least in part, and may play a role in tumourigenesis and/or progression of CCC...
  10. doi request reprint Genomic profiling of gastric carcinoma in situ and adenomas by array-based comparative genomic hybridization
    Masahiro Uchida
    Department of Molecular Pathology, Oita University, Oita, Japan
    J Pathol 221:96-105. 2010
    ..Since HGA is believed to have a higher risk of progression to invasive carcinoma than LGA, these data suggest that 8q gain is important for the malignant transformation of gastric adenoma...
  11. pmc Analysis of virulence factors of Helicobacter pylori isolated from a Vietnamese population
    Tomohisa Uchida
    Department of Molecular Pathology, Oita University Faculty of Medicine, Yufu, Japan
    BMC Microbiol 9:175. 2009
    ..The aim of this study was to investigate several genetic factors regarded as virulence or molecular epidemiologic markers in H. pylori isolates from Vietnamese subjects...
  12. doi request reprint Genomic profiling of renal cell carcinoma in patients with end-stage renal disease
    Toru Inoue
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita, Japan
    Cancer Sci 103:569-76. 2012
    ....
  13. doi request reprint Helicobacter pylori virulence and the diversity of gastric cancer in Asia
    Lam Tung Nguyen
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita 879 5593, Japan
    J Med Microbiol 57:1445-53. 2008
    ..The possible link between the geographical distribution of cagPAI and cagA variations and gastric cancer diversity in Asia is also discussed...
  14. doi request reprint Impact of Helicobacter pylori CagA diversity on gastric mucosal damage: an immunohistochemical study of East-Asian-type CagA
    Takashi Abe
    Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan
    J Gastroenterol Hepatol 26:688-93. 2011
    ..In this study, the correlations between Helicobacter pylori CagA protein diversity and gastric mucosal condition was investigated using immunohistochemical staining with α-EAS Ab in Japan...
  15. doi request reprint MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta
    Yoshiyuki Tsukamoto
    Department of Molecular Pathology, Faculty of Medicine and Institute of Scientific Research, Oita University, Oita, Japan
    Cancer Res 70:2339-49. 2010
    ..Taken together, we propose that miR-375 is a candidate tumor suppressor miRNA in gastric carcinoma...
  16. doi request reprint Analysis of p53 mutations and the expression of p53 and p21WAF1/CIP1 protein in 15 cases of sebaceous carcinoma of the eyelid
    Kunihiro Kiyosaki
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita, Japan
    Invest Ophthalmol Vis Sci 51:7-11. 2010
    ....
  17. ncbi request reprint Arpp/Ankrd2, a member of the muscle ankyrin repeat proteins (MARPs), translocates from the I-band to the nucleus after muscle injury
    Yoshiyuki Tsukamoto
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Yufu City, Oita, 879 5593, Japan
    Histochem Cell Biol 129:55-64. 2008
    ..Based on these findings, we suggest that Arpp/Ankrd2 may translocate from the I-band to the nucleus in response to muscle damage and may participate in the regulation of gene expression...
  18. doi request reprint Aberrant DNA methylation status of endometriosis: epigenetics as the pathogenesis, biomarker and therapeutic target
    Kaei Nasu
    Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan
    J Obstet Gynaecol Res 37:683-95. 2011
    ..We also discuss the recent information on the diagnostic and therapeutic implications of epigenetic alterations occurring in endometriosis...
  19. doi request reprint Extrahepatic bile duct cancer: invasion of the posterior hepatic plexuses--evaluation using multidetector CT
    Yasunari Yamada
    Departments of Radiology, Oita University Faculty of Medicine, Oita, Japan
    Radiology 263:419-28. 2012
    ..To assess the utility of axial and coronal reformatted multidetector computed tomographic (CT) images in the evaluation of the invasion of posterior hepatic plexuses by extrahepatic bile duct cancer...
  20. doi request reprint Induction of GNE in myofibers after muscle injury
    Kenichiro Nakamura
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Yufu City, Japan
    Pathobiology 77:191-9. 2010
    ..The aim of the present study was to clarify the expression of uridine diphospho-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) protein and mRNA in damaged or regenerating myofibers...
  21. pmc Helicobacter pylori infection and gastroduodenal diseases in Vietnam: a cross-sectional, hospital-based study
    Tung L Nguyen
    Department of Molecular Pathology, Oita University, Yufu City, Japan
    BMC Gastroenterol 10:114. 2010
    ..The virulence of Vietnamese H. pylori has also not been investigated in detail...
  22. doi request reprint Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells
    Haili Li
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita, Japan
    Cancer Lett 297:198-206. 2010
    ..We found a strong anticancer activity of TPL and identified some potential target genes of this drug, raising hopes that TPL may become a useful therapy for endometrial and ovarian cancers...
  23. ncbi request reprint Immunohistochemical diagnosis of the cagA-gene genotype of Helicobacter pylori with anti-East Asian CagA-specific antibody
    Tomohisa Uchida
    Department of Molecular Pathology, Oita University, Yufu City, Oita 879 5593, Japan
    Cancer Sci 98:521-8. 2007
    ....
  24. ncbi request reprint Upregulated expression of cardiac ankyrin-repeated protein in renal podocytes is associated with proteinuria severity in lupus nephritis
    Keiko Matsuura
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Hasama machi, Yufu, Oita 879 5593, Japan
    Hum Pathol 38:410-9. 2007
    ..Therefore, we propose that examination of CARP expression is useful for precise differential diagnosis of membranous glomerulonephritis and membranous lupus nephritis...
  25. ncbi request reprint Extracellular signal-regulated protein kinase is activated in cervical intraepithelial neoplasms but inactivated in invasive cervical carcinoma
    Keiko Matsuura
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Yufu, Oita, Japan
    Pathol Int 56:368-74. 2006
    ..These findings suggest that the phosphorylation status of ERK differs between CIN and invasive carcinomas, and that downregulation of the ERK signaling pathway may contribute to transformation of CIN to invasive cervical carcinomas...
  26. doi request reprint Visinin-like protein-1 overexpression is an indicator of lymph node metastasis and poor prognosis in colorectal cancer patients
    Tomonori Akagi
    Department of Surgery I, Oita University Faculty of Medicine, Hasama machi, Oita, Japan
    Int J Cancer 131:1307-17. 2012
    ..045). This study is the first to demonstrate a prognostic role for VSNL-1 at the mRNA level, suggesting the possible usefulness of VSNL-1 as a predictor of lymph node metastasis and poor prognosis in CRC...
  27. doi request reprint The α-lipoic acid derivative sodium zinc dihydrolipoylhistidinate reduces chemotherapy-induced alopecia in a rat model: a pilot study
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama machi, Yufu, Oita, 879 5593, Japan
    Surg Today 41:693-7. 2011
    ..In the present study, we evaluated the effects of sodium zinc dihydrolipoylhistidinate (DHLHZn), a new derivative of the multifunctional antioxidant α-lipoic acid, to treat chemotherapy-induced alopecia...
  28. doi request reprint Phosphorylation status of epidermal growth factor receptor is closely associated with responsiveness to gefitinib in pulmonary adenocarcinoma
    Naoki Hijiya
    Department of Molecular Pathology, Oita University Faculty of Medicine, Oita 879 5593, Japan
    Hum Pathol 39:316-23. 2008
    ..0011). These findings suggest that immunohistochemical evaluation with anti-pEGFR-tyr992 antibody is useful for prediction of responsiveness to gefitinib...
  29. doi request reprint Invasive carcinomas originating from intraductal papillary mucinous neoplasms of the pancreas: conspicuity and primary sites of the solid masses on triple-phase dynamic CT imaging
    Yasunari Yamada
    Department of Diagnostic and Interventional Radiology, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    Abdom Imaging 35:181-8. 2010
    ..To assess the conspicuity of invasive carcinomas (solid masses) originating from pancreatic intraductal papillary mucinous neoplasms (invasive IPMNs) and the primary sites of the solid masses on thin-slice dynamic CT...
  30. ncbi request reprint A case of right isomerism showing long survival without surgery
    Keiko Matsuura
    Department of Molecular Pathology, Faculty of Medicine, Oita University, Yufu City, Oita, Japan
    South Med J 100:218-21. 2007
    ..The presence of pulmonary outflow obstruction that is reported to confer a better prognosis might also have contributed to his longevity...