Satoshi Hagiwara

Summary

Affiliation: Oita University
Country: Japan

Publications

  1. doi request reprint Continuous hemodiafiltration therapy ameliorates LPS-induced systemic inflammation in a rat model
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 171:791-6. 2011
  2. doi request reprint Filtration leukocytapheresis therapy ameliorates lipopolysaccharide-induced systemic inflammation in a rat model
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 171:777-82. 2011
  3. doi request reprint Danaparoid sodium attenuates the effects of heat stress
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 171:762-8. 2011
  4. doi request reprint ETS-GS, a new anti-oxidative drug, protects against lipopolysaccharide-induced acute lung and liver injury
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 171:734-41. 2011
  5. doi request reprint Infusion of a glucose solution reduces autophagy in the liver after LPS-induced systemic inflammation
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi, Yufu City, Oita, 879 5593, Japan
    Inflammation 35:249-58. 2012
  6. doi request reprint Heat shock protein 47 (HSP47) antisense oligonucleotides reduce cardiac remodeling and improve cardiac function in a rat model of myocardial infarction
    S Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Japan
    Thorac Cardiovasc Surg 59:386-92. 2011
  7. doi request reprint The effect of experimental diabetes on high mobility group box 1 protein expression in endotoxin-induced acute lung injury
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 168:111-8. 2011
  8. doi request reprint Antithrombin III prevents cerulein-induced acute pancreatitis in rats
    Satoshi Hagiwara
    Departments of Anesthesiology and Intensive Care Medicine, Oita University, Yufu City, Japan
    Pancreas 38:746-51. 2009
  9. doi request reprint In vivo and in vitro effects of the anticoagulant, thrombomodulin, on the inflammatory response in rodent models
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Oita University, 1 1 Idaigaoka Hasamamachi Yufu, Oita City, 879 5593, Japan
    Shock 33:282-8. 2010
  10. doi request reprint Antagonist of the type-1 ANG II receptor prevents against LPS-induced septic shock in rats
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi, Yufu, Oita 879 5593, Japan
    Intensive Care Med 35:1471-8. 2009

Collaborators

Detail Information

Publications75

  1. doi request reprint Continuous hemodiafiltration therapy ameliorates LPS-induced systemic inflammation in a rat model
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 171:791-6. 2011
    ..In the present study, we investigated whether continuous hemodiafiltration therapy could prevent LPS-induced systemic inflammation and improve survival in a rat model...
  2. doi request reprint Filtration leukocytapheresis therapy ameliorates lipopolysaccharide-induced systemic inflammation in a rat model
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 171:777-82. 2011
    ..The purpose of this study was to determine whether leukocytapheresis therapy can prevent lipopolysaccharide (LPS)-induced systemic inflammation in a rat model...
  3. doi request reprint Danaparoid sodium attenuates the effects of heat stress
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 171:762-8. 2011
    ..Given that heat stroke is a severe inflammatory response disease, we hypothesized that DA could inhibit inflammation from heat stress and prevent acute heat stroke...
  4. doi request reprint ETS-GS, a new anti-oxidative drug, protects against lipopolysaccharide-induced acute lung and liver injury
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 171:734-41. 2011
    ..We investigated whether the new anti-oxidative drug, ETS-GS, could inhibit secretion of cytokines and mono-nitrogen oxides, thus reducing organ damage in a rat model of lipopolysaccharide-induced sepsis...
  5. doi request reprint Infusion of a glucose solution reduces autophagy in the liver after LPS-induced systemic inflammation
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi, Yufu City, Oita, 879 5593, Japan
    Inflammation 35:249-58. 2012
    ..We also show that a 5% glucose infusion reduces autophagy. We propose that maintaining serum glucose levels with an adequate glucose dose improves systemic inflammation by reducing autophagy...
  6. doi request reprint Heat shock protein 47 (HSP47) antisense oligonucleotides reduce cardiac remodeling and improve cardiac function in a rat model of myocardial infarction
    S Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Japan
    Thorac Cardiovasc Surg 59:386-92. 2011
    ..The 47 kD heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that plays a major role during procollagen processing and/or secretion...
  7. doi request reprint The effect of experimental diabetes on high mobility group box 1 protein expression in endotoxin-induced acute lung injury
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 168:111-8. 2011
    ..Diabetes may exacerbate systemic inflammation as evidenced by higher serum HMGB1 and cytokine levels and enhanced lung damage in the rat systemic inflammation model...
  8. doi request reprint Antithrombin III prevents cerulein-induced acute pancreatitis in rats
    Satoshi Hagiwara
    Departments of Anesthesiology and Intensive Care Medicine, Oita University, Yufu City, Japan
    Pancreas 38:746-51. 2009
    ..Because acute pancreatitis is a severe inflammatory disease, we hypothesized that AT III would inhibit inflammation and prevent cerulein-induced acute pancreatitis...
  9. doi request reprint In vivo and in vitro effects of the anticoagulant, thrombomodulin, on the inflammatory response in rodent models
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Oita University, 1 1 Idaigaoka Hasamamachi Yufu, Oita City, 879 5593, Japan
    Shock 33:282-8. 2010
    ..Given these results, rTM is a strong candidate as a therapeutic agent for various systemic inflammatory diseases...
  10. doi request reprint Antagonist of the type-1 ANG II receptor prevents against LPS-induced septic shock in rats
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi, Yufu, Oita 879 5593, Japan
    Intensive Care Med 35:1471-8. 2009
    ....
  11. doi request reprint Hyperglycemia contributes to cardiac dysfunction in a lipopolysaccharide-induced systemic inflammation model
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi, Yufu City, Oita, Japan
    Crit Care Med 37:2223-7. 2009
    ..The purpose of this study was to determine whether cardiac function is affected by hyperglycemia and its treatment with insulin...
  12. doi request reprint Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-kB
    S Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi, Yufu City, Oita, 879 5593, Japan
    Inflamm Res 58:198-203. 2009
    ..Various studies suggest that sivelestat treatment reduces inflammation. In this study, we tested the hypothesis that sivelestat acts as an inhibitor of inflammatory mediators and prevents nuclear factor-kB (NF-kB) activation...
  13. doi request reprint Heat shock protein 72 protects insulin-secreting beta cells from lipopolysaccharide-induced endoplasmic reticulum stress
    Satoshi Hagiwara
    Department of Anaesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Oita, Japan
    Int J Hyperthermia 25:626-33. 2009
    ..Given that systemic-inflammation induces ER stress, we further examined whether hyperthermia can attenuate the extent of LPS-induced ER stress...
  14. doi request reprint High-dose antithrombin III prevents heat stroke by attenuating systemic inflammation in rats
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University, Yufu City, Japan
    Inflamm Res 59:511-8. 2010
    ..Nevertheless, as heat stroke is a severe inflammatory response disease, we hypothesized that AT III would inhibit inflammation and prevent heat stress-induced acute heat stroke...
  15. doi request reprint Insulin treatment of diabetic rats reduces cardiac function in a lipopolysaccharide-induced systemic inflammation model
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 171:251-8. 2011
    ..The purpose of this study was to examine how strict glucose control affects systemic inflammation in diabetic patients...
  16. doi request reprint Recombinant thrombomodulin prevents heatstroke by inhibition of high-mobility group box 1 protein in sera of rats
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    Shock 34:402-6. 2010
    ..As TM exhibited a strong anti-inflammatory effect in a rat model of acute inflammation induced by heat stress, TM represents a potential therapeutic for heatstroke prevention or management in patients...
  17. doi request reprint ETS-GS, a new antioxidant, ameliorates renal ischemia-reperfusion injury in a rodent model
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Oita, Japan
    J Surg Res 171:226-33. 2011
    ..The current study examined whether a new antioxidant, ETS-GS, inhibits reactive oxygen species (ROS) generation and thereby prevents renal I/R injury in rodent models...
  18. doi request reprint Adenosine diphosphate receptor antagonist clopidogrel sulfate attenuates LPS-induced systemic inflammation in a rat model
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    Shock 35:289-92. 2011
    ..Clopidogrel sulfate pretreatment also reduced LPS-induced HMGB1 expression in lung and liver tissues. Collectively, our findings demonstrate that CS pretreatment may have value as a new therapeutic tool against systemic inflammation...
  19. doi request reprint Total parenteral-nutrition-mediated dendritic-cell activation and infiltration into the small intestine in a rat model
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi, Yufu, Oita 879 5593, Japan
    J Anesth 25:57-64. 2011
    ..However, effects of TPN on the immune system, including dendritic cells (DC), are not well understood. The purpose of this study was to determine whether TPN affects DC activation and infiltration into the intestinal barrier...
  20. ncbi request reprint Stimulation of autophagy in the liver by lipopolysaccharide-induced systemic inflammation in a rat model of diabetes mellitus
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Oita University, Yufu, Oita, Japan
    Biomed Res 31:263-71. 2010
    ..Thus, autophagy might be related to progression to organ injury in patients with DM, and inflammation in these patients might be associated with over-induction of autophagy and increased HMGB1 expression...
  21. doi request reprint Danaparoid sodium prevents cerulein-induced acute pancreatitis in rats
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    Shock 32:94-9. 2009
    ..This study demonstrates that DA treatment prevents cerulein-induced acute pancreatitis in a rat model. This effect may be mediated through inhibition of cytokines, NO, and HMGB1...
  22. doi request reprint Landiolol, an ultrashort-acting beta1-adrenoceptor antagonist, has protective effects in an LPS-induced systemic inflammation model
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    Shock 31:515-20. 2009
    ..Treatment was associated with a significant reduction in serum levels of the inflammation mediator HMGB-1 and histological lung damage...
  23. ncbi request reprint GaAlAs (830 nm) low-level laser enhances peripheral endogenous opioid analgesia in rats
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi Yufu City Oita 879 5593, Japan
    Lasers Surg Med 39:797-802. 2007
    ..The present study investigates whether LLLT may enhance peripheral endogenous opioid analgesia...
  24. doi request reprint Effect of enteral versus parenteral nutrition on inflammation and cardiac function in a rat model of endotoxin-induced sepsis
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    Shock 30:280-4. 2008
    ..The maintenance of higher ghrelin levels in TEN-C rats was associated with inhibiting various inflammatory mediators and maintaining cardiac function during LPS-induced septic shock...
  25. ncbi request reprint Nafamostat mesilate inhibits high-mobility group box 1 by lipopolysaccharide stimulation in murine macrophage RAW 264.7
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    Shock 27:429-35. 2007
    ..Our findings thus suggest that the administration of NM may therefore potentially improve the condition of patients who have septic shock...
  26. ncbi request reprint Coexpression of HSP47 gene and type I and type III collagen genes in LPS-induced pulmonary fibrosis in rats
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi, Yufu City, Oita, 879 5593, Japan
    Lung 185:31-7. 2007
    ..These results suggest that the upregulation of HSP47 and collagen may play an important role in the fibrotic process of LPS-induced ARDS lung...
  27. ncbi request reprint High dose antithrombin III inhibits HMGB1 and improves endotoxin-induced acute lung injury in rats
    Satoshi Hagiwara
    Oita University Faculty of Medicine, Department of Brain and Nerve Science, Anesthesiology, 1 1 Idaigaoka, Hasamamachi, Yufu City, Oita 879 5593, Japan
    Intensive Care Med 34:361-7. 2008
    ..High mobility group box 1 (HMGB1) is an important factor in the development of sepsis. Previous work suggests that antithrombin III (ATIII) inhibits inflammation, but the mechanism of action is still poorly understood...
  28. doi request reprint Comparison of effects of total enteral versus total parenteral nutrition on ischemia/reperfusion-induced heart injury in rats
    S Hagiwara
    Anesthesiology, Department of Brain and Nerve Science, Oita University Faculty of Medicine, Oita, Japan
    Eur Surg Res 40:361-7. 2008
    ..The long-term effect of nutrition on cardiac function remains to be elucidated. One possible link is the newly discovered gastric hormone ghrelin, which has been reported to be cardioprotective...
  29. doi request reprint High-dose intravenous immunoglobulin G improves systemic inflammation in a rat model of CLP-induced sepsis
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama machi, Yufu, Oita 879 5593, Japan
    Intensive Care Med 34:1812-9. 2008
    ..One key mediator in the development of sepsis is high mobility group box 1 (HMGB1). Therefore, we examined the serum and lung tissue levels of HMGB1 in a rat model of sepsis...
  30. ncbi request reprint Introduction of antisense oligonucleotides to heat shock protein 47 prevents pulmonary fibrosis in lipopolysaccharide-induced pneumopathy of the rat
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi, Yufu City, Oita 879 5593, Japan
    Eur J Pharmacol 564:174-80. 2007
    ..These findings suggest that HSP 47 antisense oligonucleotides improve lung fibrosis among rats with LPS-induced pneumopathy...
  31. ncbi request reprint Effect of enteral versus parenteral nutrition on LPS-induced sepsis in a rat model
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, Oita, Japan
    J Surg Res 145:251-6. 2008
    ..The purpose of the present study was to determine whether total enteral nutrition (TEN) or total parenteral nutrition (TPN) differ in their modulation of ghrelin production and cardiac dysfunction induced by lipopolysaccharide (LPS)...
  32. ncbi request reprint Association between heat stress protein 70 induction and decreased pulmonary fibrosis in an animal model of acute lung injury
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasamamachi, Yufu City, Oita, 879 5593, Japan
    Lung 185:287-93. 2007
    ..These data indicate that thermal pretreatment is associated with the induction of HSP70 protein synthesis, which subsequently attenuates tissue damage in experimental lung fibrosis...
  33. doi request reprint Pre-Irradiation of blood by gallium aluminum arsenide (830 nm) low-level laser enhances peripheral endogenous opioid analgesia in rats
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi Yufu City Oita 879 5593, Japan
    Anesth Analg 107:1058-63. 2008
    ..We investigated whether pre-irradiation of blood by LLLT enhances peripheral endogenous opioid analgesia...
  34. ncbi request reprint An antisense oligonucleotide to HSP47 inhibits paraquat-induced pulmonary fibrosis in rats
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama machi, Yufu City, Oita 879 5593, Japan
    Toxicology 236:199-207. 2007
    ..An immunoblot analysis confirmed that the HSP47-antisense oligonucleotide inhibited HSP47 production. These findings indicate that the HSP47-antisense oligonucleotide inhibited paraquat-induced pulmonary fibrosis and pneumopathy in rats...
  35. ncbi request reprint Changes in cell culture temperature alter release of inflammatory mediators in murine macrophagic RAW264.7 cells
    S Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, Oita Prefecture, 1 1 Idaigaoka Hasamamachi Yufu City, Oita 879 5593, Japan
    Inflamm Res 56:297-303. 2007
    ..To examine whether moderate changes in cell culture temperature influence the production of various cytokines and associated mediators of inflammation...
  36. doi request reprint Mechanisms of analgesic action of pulsed radiofrequency on adjuvant-induced pain in the rat: roles of descending adrenergic and serotonergic systems
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    Eur J Pain 13:249-52. 2009
    ..All three drugs were found to significantly inhibit the analgesic effect of PRF. The results suggest that the analgesic action of PRF involves the enhancement of noradrenergic and serotonergic descending pain inhibitory pathways...
  37. doi request reprint A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi Yufu, City Oita 879 5593, Japan
    Inflammation 31:227-34. 2008
    ..Furthermore, inhibition of NF-kappaB activity was observed with the administration of sivelestat. These results suggest that sivelestat reduces LPS-induced lung injury at least partially by inhibiting inflammation and NF-kappaB activity...
  38. ncbi request reprint High mobility group box 1 induces a negative inotropic effect on the left ventricle in an isolated rat heart model of septic shock: a pilot study
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama machi, Yufu 879 5593, Japan
    Circ J 72:1012-7. 2008
    ..High mobility group box 1 (HMGB1) protein is an important mediator in the pathogenesis of sepsis and its role in cardiovascular system dysfunction was investigated in an lipopolysaccharide (LPS)-induced rat model of sepsis...
  39. pmc Antisense oligonucleotide inhibition of heat shock protein (HSP) 47 improves bleomycin-induced pulmonary fibrosis in rats
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, Idaigaoka Hasamamachi Yufu City Oita, Japan
    Respir Res 8:37. 2007
    ..The 47 kDa heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that has been shown to play a major role during the processing and/or secretion of procollagen...
  40. pmc Danaparoid sodium inhibits systemic inflammation and prevents endotoxin-induced acute lung injury in rats
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, Oita, Japan
    Crit Care 12:R43. 2008
    ..We hypothesised that DA would act as an inhibitor of systemic inflammation and prevent endotoxin-induced acute lung injury in a rat model...
  41. doi request reprint EPCK1, a vitamin C and E analogue, reduces endotoxin-induced systemic inflammation in mice
    Chihiro Shingu
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 171:719-25. 2011
    ..In the current study, we tested whether EPCK1 inhibits oxidative stress and prevents systemic inflammation...
  42. doi request reprint Dihydrolipoyl histidinate zinc complex, a new antioxidant, attenuates hepatic ischemia-reperfusion injury in rats
    Takashi Masuda
    Department of Surgery I, Oita University Faculty of Medicine, Oita, Japan
    J Gastroenterol Hepatol 26:1652-8. 2011
    ..The aim of this study was to evaluate the protective effect of dihydrolipoyl histidinate zinc complex (DHLHZn) on oxidative damage after severe hepatic I/R injury...
  43. doi request reprint Human atrial natriuretic peptide attenuates renal ischemia-reperfusion injury
    Hironori Koga
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 173:348-53. 2012
    ..Human atrial natriuretic peptide (hANP) exerts various pharmacologic effects, including renal protection. In the present study, we evaluated the renal protective effect of hANP in a rat model of renal I/R...
  44. doi request reprint Dendritic cell activation in response to ischemia-reperfusion injury of the small intestine
    Satoshi Hagiwara
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi, Yufu, Oita, Japan
    Surg Today 40:137-45. 2010
    ..The aim of this study was to determine whether I/R injury affects DC infiltration into the intestinal barrier...
  45. doi request reprint The antioxidant EPC-K1 attenuates renal ischemia-reperfusion injury in a rat model
    Shunsuke Yamamoto
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Japan
    Am J Nephrol 33:485-90. 2011
    ..ROS subsequently damage renal cells, leading to the development of AKI. Here, we investigated whether renal I/R injury could be attenuated by the antioxidant EPC-K1...
  46. doi request reprint The new vitamin E derivative, ETS-GS, protects against cecal ligation and puncture-induced systemic inflammation in rats
    Hironori Koga
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi, Yufu City, Oita 879 5593, Japan
    Inflammation 35:545-53. 2012
    ..This mechanism appeared to be mediated by the induction of PI3K-Akt and the inhibition of IκBα and MAPK phosphorylation. Given these results, ETS-GS shows promise as a potential therapeutic agent for sepsis...
  47. doi request reprint Vitamin E derivative ETS-GS reduces liver ischemia-reperfusion injury in rats
    Hironori Koga
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Oita, Japan
    J Surg Res 175:118-22. 2012
    ..Recent studies have reported that vitamin E and glutathione can ameliorate ischemia-reperfusion (I/R) injury. In the present study, we evaluated the ability of a new vitamin E derivative, ETS-GS, to improve liver I/R injury...
  48. doi request reprint New α-lipoic acid derivative, DHL-HisZn, ameliorates renal ischemia-reperfusion injury in rats
    Hironori Koga
    Department of Anesthesiology and Intensive Care Medicine, Oita University, Faculty of Medicine, Oita, Japan
    J Surg Res 174:352-8. 2012
    ..The present study evaluated the ability of DHL-HisZn, a new α-lipoic acid derivative, to inhibit ROS generation and prevent renal I/R injury in rats...
  49. ncbi request reprint Effect of hemopurification rate on doripenem pharmacokinetics in critically ill patients receiving high-flow continuous hemodiafiltration
    Yoshifumi Ohchi
    Department of Anesthesiology and Intensive Care, Faculty of Medicine, Oita University, Oita, Japan
    Yakugaku Zasshi 131:1395-9. 2011
    ..These results suggest that clearance via hemodiafiltration increases proportionally to the hemopurification rate. Thus, it is reasonable to conclude that DRPM dose must be increased to 1.0-1.5 g/day when performing high-flow CHDF...
  50. doi request reprint Cepharanthine improves renal ischemia-reperfusion injury in rats
    Junya Kusaka
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 171:212-7. 2011
    ..In this study, we examined whether cepharanthine provides a renal-protective effect in a renal ischemia-reperfusion model...
  51. doi request reprint Effects of hyperglycemia and insulin therapy on high mobility group box 1 in endotoxin-induced acute lung injury in a rat model
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, Oita, Japan
    Crit Care Med 36:2407-13. 2008
    ....
  52. doi request reprint Anti-inflammatory effects of perioperative intensive insulin therapy during cardiac surgery with cardiopulmonary bypass
    Akira Hasegawa
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi, Yufu, Oita, 879 5593, Japan
    Surg Today 41:1385-90. 2011
    ..In the present study, we evaluated how perioperative intensive insulin therapy (IIT) influences the inflammatory response in an artificial pancreas during cardiac surgery with cardiopulmonary bypass...
  53. doi request reprint Remifentanil and glucose suppress inflammation in a rat model of surgical stress
    Akira Hasegawa
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi, Yufu, Oita, 879 5593, Japan
    Surg Today 41:1617-21. 2011
    ..We therefore examined whether remifentanil or glucose administration could ameliorate postsurgical inflammatory responses using a rat model of surgical stress...
  54. doi request reprint The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury: an electron spin resonance study
    Shigekiyo Matsumoto
    Department of Anaesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Oita, Japan
    J Trauma 68:796-801. 2010
    ..Variable baseline levels of oxidative stress in patients with ALI have been proposed as one explanation for inconsistent results...
  55. doi request reprint Age-dependent responses to renal ischemia-reperfusion injury
    Junya Kusaka
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 172:153-8. 2012
    ..In the present study, we assessed kidney morphology, function, and oxidative stress in young and aged rats after renal ischemia and reperfusion...
  56. doi request reprint Cepharanthine exerts anti-inflammatory effects via NF-κB inhibition in a LPS-induced rat model of systemic inflammation
    Kyosuke Kudo
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 171:199-204. 2011
    ..In the present study, we investigated protective effects of CE in a lipopolysaccharide (LPS)-induced systemic inflammatory response model and examined underlying mechanisms...
  57. doi request reprint The vitamin E derivative, EPC-K1, suppresses inflammation during hepatic ischemia-reperfusion injury and exerts hepatoprotective effects in rats
    Kazushige Oishi
    Beppu Medical Center, Beppu City, Oita, Japan
    J Surg Res 176:164-70. 2012
    ..EPC-K1 is a hydroxyl radical scavenger reported to have mitigating effects on I/R injury in many organs. This study evaluates the effects of EPC-K1 on hepatic I/R injury...
  58. doi request reprint Alternate day calorie restriction improves systemic inflammation in a mouse model of sepsis induced by cecal ligation and puncture
    Akira Hasegawa
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 174:136-41. 2012
    ..However, it is unclear whether CR affects sepsis-related inflammation. The purpose of this study was to determine whether CR affects sepsis-induced inflammation in a cecal ligation and puncture (CLP)-induced mouse model of sepsis...
  59. doi request reprint The antinociceptive effects of estradiol on adjuvant-induced hyperalgesia in rats involve activation of adrenergic and serotonergic systems
    Kentaro Okuda
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi, Yufu, Oita, 879 5593, Japan
    J Anesth 25:392-7. 2011
    ..Estradiol has been shown to perform a variety of physiological activities, including pain reduction. In this study, we tested the hypothesis that estradiol exerts antinociceptive effects in a rat model of inflammatory hyperalgesia...
  60. doi request reprint The effect of landiolol on cerebral blood flow in patients undergoing off-pump coronary artery bypass surgery
    Koji Goto
    Department of Anesthesiology and Intensive Care, Faculty of Medicine, Oita University, Idaigaoka 1 1, Hasama, Yufu, Oita, 879 5593, Japan
    J Anesth 24:11-6. 2010
    ..To examine the effect of landiolol on cerebral blood flow in patients with normal or deteriorated cardiac function...
  61. doi request reprint The vitamin E derivative, ESeroS-GS, attenuates renal ischemia-reperfusion injury in rats
    Hironori Koga
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 176:220-5. 2012
    ..In this study, we hypothesized that ESeroS-GS, a vitamin E derivative, inhibits cytokine production and prevents renal ischemia-reperfusion (I/R) injury in rats...
  62. doi request reprint Antiproliferative effects of a new α-lipoic acid derivative, DHL-HisZnNa, in HT29 human colon cancer cells in vitro
    Yohei Kono
    Oita University Faculty of Medicine, Department of Gastroenterological Surgery, 1 1 Idaigaoka, Yufu, Oita 879 5593, Japan
    Expert Opin Ther Targets 16:S103-9. 2012
    ..The antiproliferative effects of DHL-HisZnNa, on human colon cancer cell HT29 in vitro, were evaluated...
  63. doi request reprint Human atrial natriuretic peptide ameliorates LPS-induced acute lung injury in rats
    Hironori Koga
    Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Oita University, 1 1 Idaigaoka Hasamamachi, Yufu City, Oita, 879 5593, Japan
    Lung 188:241-6. 2010
    ..Taken together, these data demonstrate that hANP exerts an anti-inflammatory effect and may have potential as a therapeutic agent to treat systemic inflammatory diseases...
  64. doi request reprint Effects of an angiotensin-converting enzyme inhibitor on the inflammatory response in in vivo and in vitro models
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, Oita, Japan
    Crit Care Med 37:626-33. 2009
    ....
  65. doi request reprint Sivelestat treatment for acute respiratory distress syndrome in an infant
    Shigekiyo Matsumoto
    Department of Brain and Nerve Science and Department of Anesthesiology, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama machi, Yufu, Oita, 879 5593, Japan
    J Anesth 23:288-91. 2009
    ..Our experience suggests that intravenous sivelestat offers a new therapeutic strategy for infantile ARDS/ALI, but further investigation of the indication, administration period, and dosage is required...
  66. ncbi request reprint Nafamostat mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama machi, Yufu, Oita 879 5593, Japan
    J Anesth 21:164-70. 2007
    ..Nafamostat mesilate (NM) is a broad-range synthetic protease inhibitor with some anti-inflammatory action. The purpose of this study was to evaluate the effect of NM on HMGB1 in lipopolysaccharide (LPS)-induced lung injury in rats...
  67. doi request reprint New anthranilic acid derivative, EAntS-GS, attenuates Freund's complete adjuvant-induced acute pain in rats
    Kentaro Okuda
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan
    J Surg Res 175:265-70. 2012
    ..Recent studies have found that antioxidative drugs can have analgesic effects. The present study tested the hypothesis that a new anthranilic acid derivative, EAntS-GS, exerts antinociceptive effects on inflammatory pain in a rat model...
  68. doi request reprint Relationship between HMGB1 and tissue protective effects of HSP72 in a LPS-induced systemic inflammation model
    Akira Hasegawa
    Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Oita University, Yufu City, Oita, Japan
    J Surg Res 169:85-91. 2011
    ..We examined associations between HMGB1 expression and protective effects observed when whole-body hyperthermia (WH) induces HSP72 in a lipopolysaccharide (LPS(b))-induced inflammation model...
  69. doi request reprint Hydrogen-rich saline solution attenuates renal ischemia-reperfusion injury
    Chihiro Shingu
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasamamachi, Yufu, Oita, 879 5593, Japan
    J Anesth 24:569-74. 2010
    ..A recent study has shown that hydrogen has antioxidant properties. In this study, we tested the hypothesis that a hydrogen-rich saline solution (HRSS) attenuates renal I/R injury in a rodent model...
  70. doi request reprint Gabexate mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury
    Seigo Hidaka
    Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Oita University, Yufu City, Oita, Japan
    J Surg Res 165:142-50. 2011
    ..This indicates that GM can inhibit lung injury induced by LPS in rats. GM is a candidate for use in novel strategies to prevent or minimize lung injury in sepsis...
  71. doi request reprint Catecholamine-resistant shock and hypoglycemic coma after cardiotomy in a patient with unexpected isolated ACTH deficiency
    Shigekiyo Matsumoto
    Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi, Yufu, Oita, 879 5593, Japan
    J Anesth 25:431-4. 2011
    ..Therefore, cortisol must be supplemented without delay when acute adrenal insufficiency is suspected during the perioperative period...
  72. doi request reprint An electron spin resonance study for real-time detection of ascorbyl free radicals after addition of dimethyl sulfoxide in murine hippocampus or plasma during kainic acid-induced seizures
    Shigekiyo Matsumoto
    Department of Anaesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, 1 1 Idaigaoka Hasamamachi Yufu, City Oita, 879 5593, Japan
    Neurochem Res 35:1010-6. 2010
    ..Due to the simplicity, good performance, low cost and real-time monitoring of ascorbate, this method may be applied to clinical research and treatment in the future...
  73. doi request reprint Anesthetic management of a patient with hyperthyroidism due to hydatidiform mole
    Shigekiyo Matsumoto
    Department of Anesthesiology and Intensive Care Medicine, Yufu, Oita, Japan
    J Anesth 23:594-6. 2009
    ..The patient became euthyroid within a few days after mole evacuation and did not require an antiarrhythmic agent after her return to the inpatient ward...
  74. doi request reprint Effective control of paroxysmal tachycardia with landiolol hydrochloride during cesarean section in a patient with hypertrophic obstructive cardiomyopathy
    Takakuni Abe
    Department of Anesthesiology and Intensive Care, Faculty of Medicine, Oita University, 1 1 Hasama machi, Yufu, Oita 879 5593, Japan
    J Anesth 24:765-7. 2010
    ..Her circulatory dynamics remained stable after discontinuation of landiolol, and she was moved to a general ward on the following day. She was discharged on postoperative day 14, with her child...
  75. doi request reprint New lipoic acid derivative drug sodium zinc dihydrolipoylhistidinate prevents cardiac dysfunction in an isolated perfused rat heart model
    Satoshi Hagiwara
    Department of Anesthesiology, Oita University Faculty of Medicine, Oita, Japan
    Crit Care Med 39:506-11. 2011
    ..The purpose of the present study was to determine the cardioprotective effects of the new lipoic acid-derivative drug sodium zinc dihydrolipoylhistidinate in a global ischemia isolated perfused rat heart model...