Xin Zhang

Summary

Affiliation: Nippon Shinyaku Co
Country: Japan

Publications

  1. pmc Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats
    Xin Zhang
    Department of Pharmacology, Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, Kyoto 601 8550, Japan
    World J Gastroenterol 14:4784-90. 2008
  2. ncbi request reprint Phosphodiesterase type IV inhibitors prevent ischemia-reperfusion-induced gastric injury in rats
    Takashi Kyoi
    Research Laboratories, Nippon Shinyaku Co, Ltd, Kisshoin, Minami, Kyoto 601 8550, Japan
    J Pharmacol Sci 95:321-8. 2004
  3. doi request reprint Synthesis and biological evaluation of novel phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors
    Kohei Kagayama
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, 14 Nishinosho Monguchi cho, Kisshoin, Minami Ku, Kyoto 601 8550, Japan
    Bioorg Med Chem 17:6959-70. 2009
  4. ncbi request reprint Pharmacological profile of the novel anti-inflammatory corticosteroid NS-126, a therapeutic agent for allergic rhinitis
    Naoki Inoue
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, Japan
    J Pharmacol Sci 112:73-82. 2010
  5. doi request reprint Mast cells can mediate vascular permeability through regulation of the PI3K-HIF-1alpha-VEGF axis
    Kyung Sun Lee
    Department of Internal Medicine, Chonbuk National University Medical School, San 2 20, Geumam dong, Deokjin gu, Jeonju, 561 180, South Korea
    Am J Respir Crit Care Med 178:787-97. 2008
  6. ncbi request reprint Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes
    Xin Zhang
    Department of Neurology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 180:6988-96. 2008
  7. ncbi request reprint Mast cells play a key role in the development of late airway hyperresponsiveness through TNF-alpha in a murine model of asthma
    Young Suk Kim
    Department of Immunology, Chonbuk National University Medical School, Chonju, Republic of Korea
    Eur J Immunol 37:1107-15. 2007
  8. ncbi request reprint Understanding metastatic SCCHN cells from unique genotypes to phenotypes with the aid of an animal model and DNA microarray analysis
    Xin Zhang
    Department of Hematology and Oncology, Winship Cancer Institute of Emory University, 1365 Clifton Rd, NE, Building C, Atlanta, GA 30322, USA
    Clin Exp Metastasis 23:209-22. 2006
  9. ncbi request reprint Inhibition of anaphylaxis-like reaction and mast cell activation by water extract from the fruiting body of Phellinus linteus
    Yun Ho Choi
    Department of Anatomy, Chonbuk National University Medical School, Jeonbuk, Republic of Korea
    Biol Pharm Bull 29:1360-5. 2006
  10. ncbi request reprint The nonspecific anti-inflammatory therapy with methotrexate for patients with chronic heart failure
    Kaizheng Gong
    Department of Cardiology, The First People s Hospital of Yangzhou, Yangzhou, China
    Am Heart J 151:62-8. 2006

Collaborators

  • Takashi Kyoi
  • Naoki Inoue
  • Yosuke Takahashi
  • Chang Ho Song
  • Kohei Kagayama
  • Kyung Sun Lee
  • Young Suk Kim
  • Ok Hee Chai
  • Yun Ho Choi
  • Kaizheng Gong
  • Yong Lin
  • Ying Wang
  • Ze Guang Han
  • Hua Sheng Xiao
  • Tatsuya Morimoto
  • Tomoko Niwa
  • Kiyoto Kageyama
  • Jiro Shikaura
  • Seigo Nagata
  • Asami Hashino
  • Fumitaka Katoh
  • Ka Young Lee
  • Seung Yong Park
  • Yong Chul Lee
  • Yeong Hun Choe
  • Kyung Hoon Min
  • Seoung Ju Park
  • So Ri Kim
  • Jae Hong Kim
  • Hern Ku Lee
  • Gi Young Kim
  • Hyun Mi Ko
  • Young Min Park
  • Shun Young Im
  • Nam In Kang
  • Woo Chan Chung
  • In Hak Choi
  • Eui Hyeog Han
  • So Young Sung
  • Yiliang Feng
  • Ji Hyun Kim
  • Su Hwan Choi
  • Qiuping Luo
  • Jung Min Lim
  • Aihua Li
  • Yang Gao
  • Zhengang Zhang
  • Moo Sam Lee
  • Hyoung Tae Kim
  • Xiaonin Sun
  • Guang Hai Yan
  • Junfeng Yan
  • Hui Qiang
  • Xin Zeng
  • Wei fen Xie
  • Zhong Bing Zhang
  • Wei zhong Chen
  • Yue Xiang Chen
  • Xiu Jiang Yang
  • Ling Dong Kong
  • Christopher Hon Ki Cheng
  • Ji Xiao Zhu
  • Cheng Yang
  • Wein Jing Huang
  • Fang Xiong Zhang
  • Chao Guo
  • Qing Yan
  • Gang Fu
  • Liang Yang
  • Xi Ping Cheng
  • Zhi dong Zhu
  • Zhu Chen
  • Ying Jin Lu
  • Lan Bao
  • Qiu Hua Huang
  • Shu Hua Xu

Detail Information

Publications15

  1. pmc Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats
    Xin Zhang
    Department of Pharmacology, Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, Kyoto 601 8550, Japan
    World J Gastroenterol 14:4784-90. 2008
    ..To investigate the mucosal protective effect and the mechanisms of action of the anti-ulcer drug irsogladine maleate in gastric injury induced by indomethacin in rats...
  2. ncbi request reprint Phosphodiesterase type IV inhibitors prevent ischemia-reperfusion-induced gastric injury in rats
    Takashi Kyoi
    Research Laboratories, Nippon Shinyaku Co, Ltd, Kisshoin, Minami, Kyoto 601 8550, Japan
    J Pharmacol Sci 95:321-8. 2004
    ..Our experiments suggest that drugs that inhibit PDE4 isoenzyme, such as the anti-ulcer drug irsogladine, may be a useful adjunct therapy for the treatment of the gastric damage that follows ischemia-reperfusion...
  3. doi request reprint Synthesis and biological evaluation of novel phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors
    Kohei Kagayama
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, 14 Nishinosho Monguchi cho, Kisshoin, Minami Ku, Kyoto 601 8550, Japan
    Bioorg Med Chem 17:6959-70. 2009
    ..The most potent of these, when topically administered, were effective in a mouse model of dermatitis...
  4. ncbi request reprint Pharmacological profile of the novel anti-inflammatory corticosteroid NS-126, a therapeutic agent for allergic rhinitis
    Naoki Inoue
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, Japan
    J Pharmacol Sci 112:73-82. 2010
    ..NS-126 is a long-acting intranasal corticosteroid and a promising therapeutic agent for allergic rhinitis...
  5. doi request reprint Mast cells can mediate vascular permeability through regulation of the PI3K-HIF-1alpha-VEGF axis
    Kyung Sun Lee
    Department of Internal Medicine, Chonbuk National University Medical School, San 2 20, Geumam dong, Deokjin gu, Jeonju, 561 180, South Korea
    Am J Respir Crit Care Med 178:787-97. 2008
    ..However, the effects of mast cells on VEGF-mediated signaling in allergic airway disease are not clearly understood...
  6. ncbi request reprint Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes
    Xin Zhang
    Department of Neurology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 180:6988-96. 2008
    ..Based on the described immunomodulatory mechanisms, good safety profile and oral bioavailability, statins represent a promising therapeutic approach for multiple sclerosis and other chronic inflammatory diseases...
  7. ncbi request reprint Mast cells play a key role in the development of late airway hyperresponsiveness through TNF-alpha in a murine model of asthma
    Young Suk Kim
    Department of Immunology, Chonbuk National University Medical School, Chonju, Republic of Korea
    Eur J Immunol 37:1107-15. 2007
    ..These data indicate that mast cells play a key role in the development of late AHR through liberation of TNF-alpha...
  8. ncbi request reprint Understanding metastatic SCCHN cells from unique genotypes to phenotypes with the aid of an animal model and DNA microarray analysis
    Xin Zhang
    Department of Hematology and Oncology, Winship Cancer Institute of Emory University, 1365 Clifton Rd, NE, Building C, Atlanta, GA 30322, USA
    Clin Exp Metastasis 23:209-22. 2006
    ....
  9. ncbi request reprint Inhibition of anaphylaxis-like reaction and mast cell activation by water extract from the fruiting body of Phellinus linteus
    Yun Ho Choi
    Department of Anatomy, Chonbuk National University Medical School, Jeonbuk, Republic of Korea
    Biol Pharm Bull 29:1360-5. 2006
    ..Furthermore, WEPL increased the level of intracellular cAMP and significantly inhibited the compound 48/80-induced cAMP reduction in RPMC. These results suggest that WEPL may serve as an effective therapeutic agent for allergic diseases...
  10. ncbi request reprint The nonspecific anti-inflammatory therapy with methotrexate for patients with chronic heart failure
    Kaizheng Gong
    Department of Cardiology, The First People s Hospital of Yangzhou, Yangzhou, China
    Am Heart J 151:62-8. 2006
    ..However, no studies have assessed the effects of MTX on plasma levels of inflammatory mediators in patients with CHF...
  11. ncbi request reprint Treatment of experimental hepatic fibrosis by combinational delivery of urokinase-type plasminogen activator and hepatocyte growth factor genes
    Yong Lin
    Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China
    Liver Int 25:796-807. 2005
    ..To investigate the effect of combinational delivery of urokinase-type plasminogen activator (uPA) and hepatocyte growth factor (HGF) genes on hepatic fibrosis...
  12. ncbi request reprint BAFF supports human B cell differentiation in the lymphoid follicles through distinct receptors
    Xin Zhang
    Department of Cellular Immunology, Ochsner Clinic Foundation, 1516 Jefferson Highway, New Orleans, LA, USA
    Int Immunol 17:779-88. 2005
    ..In conclusion, BAFF in the GC plays an important role through more than one receptor, and the three known receptors are differentially modulated as GC-B cells differentiate to PCs...
  13. ncbi request reprint Administration of procyanidins from grape seeds reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate-treated mice
    Ying Wang
    Institute of Functional Biomolecule, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
    Basic Clin Pharmacol Toxicol 94:232-7. 2004
    ..These results demonstrated for the first time that the procyanidins from grape seeds possess in vivo urate-lowering activities. The potential application of these natural compounds in the treatment of hyperuricaemia is discussed...
  14. ncbi request reprint A lymph node metastatic mouse model reveals alterations of metastasis-related gene expression in metastatic human oral carcinoma sublines selected from a poorly metastatic parental cell line
    Xin Zhang
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 95:1663-72. 2002
    ..Changes in gene expression that regulate metastasis of SCC to lymph nodes have not been identified...
  15. pmc Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain
    Hua Sheng Xiao
    Laboratory of Sensory System, Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Proc Natl Acad Sci U S A 99:8360-5. 2002
    ..Our findings therefore reveal dynamic and complex changes in molecular diversity among DRG neurons after axotomy. Sequences reported in this paper have been deposited in the GenBank database (accession numbers BG 662484-BG 673712)..