Makoto Kodama

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. ncbi request reprint Early and long-term mortality of the clinical subtypes of myocarditis
    M Kodama
    Division of Cardiology, Niigata Graduate School of Medicine and Dental Science, Japan
    Jpn Circ J 65:961-4. 2001
  2. ncbi request reprint Ventricular fibrillation in two cases with dilated cardiomyopathy and mechanical alternans
    Makoto Kodama
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Pacing Clin Electrophysiol 28:1347-9. 2005
  3. ncbi request reprint Linkage between mechanical and electrical alternans in patients with chronic heart failure
    Makoto Kodama
    Division of Cardiology, Department of Cardiovascular and Vital Control, Niigata Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Cardiovasc Electrophysiol 15:295-9. 2004
  4. ncbi request reprint [Effects of humoral factors on left ventricular remodeling under chronic heart failure]
    Makoto Kodama
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Japan
    Nihon Yakurigaku Zasshi 123:63-70. 2004
  5. ncbi request reprint Comparative effects of perindopril with enalapril in rats with dilated cardiomyopathy
    Kenichi Watanabe
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    J Cardiovasc Pharmacol 42:S105-9. 2003
  6. doi request reprint Olmesartan attenuates the development of heart failure after experimental autoimmune myocarditis in rats through the modulation of ANG 1-7 mas receptor
    Vijayakumar Sukumaran
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Mol Cell Endocrinol 351:208-19. 2012
  7. doi request reprint Telmisartan, an angiotensin-II receptor blocker ameliorates cardiac remodeling in rats with dilated cardiomyopathy
    Vijayakumar Sukumaran
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Hypertens Res 33:695-702. 2010
  8. doi request reprint Long-term carperitide treatment attenuates left ventricular remodeling in rats with heart failure after autoimmune myocarditis
    Komei Tanaka
    Division of Cardiology, Niigata University School of Medical and Dental Sciences, Niigata, Japan
    J Cardiovasc Pharmacol 54:232-9. 2009
  9. ncbi request reprint Comparative effects of pranidipine with amlodipine in rats with heart failure
    Punniyakoti T Veeraveedu
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Pharmacology 77:1-10. 2006
  10. pmc Cardioprotective effects of telmisartan against heart failure in rats induced by experimental autoimmune myocarditis through the modulation of angiotensin-converting enzyme-2/angiotensin 1-7/mas receptor axis
    Vijayakumar Sukumaran
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Int J Biol Sci 7:1077-92. 2011

Collaborators

Detail Information

Publications106 found, 100 shown here

  1. ncbi request reprint Early and long-term mortality of the clinical subtypes of myocarditis
    M Kodama
    Division of Cardiology, Niigata Graduate School of Medicine and Dental Science, Japan
    Jpn Circ J 65:961-4. 2001
    ..Thus, the early mortality of patients with myocarditis was very high regardless of the subtype, but if patients can survive the active phase, they have a favorable prognosis except with the chronic latent form...
  2. ncbi request reprint Ventricular fibrillation in two cases with dilated cardiomyopathy and mechanical alternans
    Makoto Kodama
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Pacing Clin Electrophysiol 28:1347-9. 2005
    ..They suddenly died due to ventricular fibrillation before the induction of beta-blocker therapy. Patients with mechanical alternans should be treated under intense monitoring until the induction of beta-blocker therapy...
  3. ncbi request reprint Linkage between mechanical and electrical alternans in patients with chronic heart failure
    Makoto Kodama
    Division of Cardiology, Department of Cardiovascular and Vital Control, Niigata Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Cardiovasc Electrophysiol 15:295-9. 2004
    ..Visible T wave alternans occasionally is a precursor of ventricular fibrillation. We investigated the occurrence of both cardiac alternans in 94 patients with chronic heart failure...
  4. ncbi request reprint [Effects of humoral factors on left ventricular remodeling under chronic heart failure]
    Makoto Kodama
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Japan
    Nihon Yakurigaku Zasshi 123:63-70. 2004
    ..AII receptor blockers were less effective than ACEI. In order to prevent ventricular remodeling in chronic heart failure, wide and complete blocking of neuro-humoral factors is important...
  5. ncbi request reprint Comparative effects of perindopril with enalapril in rats with dilated cardiomyopathy
    Kenichi Watanabe
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    J Cardiovasc Pharmacol 42:S105-9. 2003
    ....
  6. doi request reprint Olmesartan attenuates the development of heart failure after experimental autoimmune myocarditis in rats through the modulation of ANG 1-7 mas receptor
    Vijayakumar Sukumaran
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Mol Cell Endocrinol 351:208-19. 2012
    ....
  7. doi request reprint Telmisartan, an angiotensin-II receptor blocker ameliorates cardiac remodeling in rats with dilated cardiomyopathy
    Vijayakumar Sukumaran
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Hypertens Res 33:695-702. 2010
    ..Our results indicate that telmisartan treatment significantly improved LV function and ameliorated the progression of cardiac remodeling in rats with CHF after EAM...
  8. doi request reprint Long-term carperitide treatment attenuates left ventricular remodeling in rats with heart failure after autoimmune myocarditis
    Komei Tanaka
    Division of Cardiology, Niigata University School of Medical and Dental Sciences, Niigata, Japan
    J Cardiovasc Pharmacol 54:232-9. 2009
    ..The effects of carperitide treatment are associated with increased neovascularization among the residual myocytes and an increase of VASP activation...
  9. ncbi request reprint Comparative effects of pranidipine with amlodipine in rats with heart failure
    Punniyakoti T Veeraveedu
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Pharmacology 77:1-10. 2006
    ....
  10. pmc Cardioprotective effects of telmisartan against heart failure in rats induced by experimental autoimmune myocarditis through the modulation of angiotensin-converting enzyme-2/angiotensin 1-7/mas receptor axis
    Vijayakumar Sukumaran
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Int J Biol Sci 7:1077-92. 2011
    ....
  11. ncbi request reprint Effects of angiotensin-II receptor blocker candesartan cilexetil in rats with dilated cardiomyopathy
    Ken Shirai
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Mol Cell Biochem 269:137-42. 2005
    ..These results suggest that candesartan cilexetil can improve the function of inefficient heart...
  12. pmc Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy
    Somasundaram Arumugam
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    J Cell Mol Med 16:2176-85. 2012
    ..Our results suggest that edaravone ameliorated the progression of DCM by modulating oxidative and ER stress-mediated myocardial apoptosis and fibrosis...
  13. doi request reprint Quercetin offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via endothelin-1/MAPK signalling
    Somasundaram Arumugam
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Free Radic Res 46:154-63. 2012
    ..Collectively, the present study provides data to support the role of quercetin in protecting the hearts of the rats with post myocarditis DCM...
  14. ncbi request reprint Glycogen synthase kinase 3beta together with 14-3-3 protein regulates diabetic cardiomyopathy: effect of losartan and tempol
    Narasimman Gurusamy
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, 5 13 2 Kamishinei cho, Niigata City, Japan
    FEBS Lett 580:1932-40. 2006
    ..Our results suggest that GSK3beta together with 14-3-3 protein plays essential roles in the signaling of diabetic cardiomyopathy, and treatment with either losartan or tempol prevents these changes...
  15. ncbi request reprint Comparative effects of quinapril with enalapril in rats with heart failure
    Kenichi Watanabe
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Pharmacology 71:157-61. 2004
    ..These results suggest that quinapril may confer greater protection than enalapril against injury from the renin-angiotensin system in heart failure...
  16. ncbi request reprint Effect of hydrodynamics-based gene delivery of plasmid DNA encoding interleukin-1 receptor antagonist-Ig for treatment of rat autoimmune myocarditis: possible mechanism for lymphocytes and noncardiac cells
    Hui Liu
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Japan
    Circulation 111:1593-600. 2005
    ..The purpose of this study was to evaluate the effect and possible mechanism of hydrodynamics-based delivery of the IL-1 receptor antagonist (IL-1RA)-immunoglobulin (Ig) gene for treatment of rat experimental autoimmune myocarditis (EAM)...
  17. doi request reprint Olmesartan medoxomil treatment potently improves cardiac myosin-induced dilated cardiomyopathy via the modulation of ACE-2 and ANG 1-7 mas receptor
    Vijayakumar Sukumaran
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Free Radic Res 46:850-60. 2012
    ..Our present study might serve as a new therapeutic target of DCM in cardiovascular diseases and cardiac myosin-induced DCM via the modulation of ACE-2/ANG 1-7 mas receptor axis in rats with DCM after myosin-immunisation...
  18. ncbi request reprint Torasemide, a long-acting loop diuretic, reduces the progression of myocarditis to dilated cardiomyopathy
    Punniyakoti T Veeraveedu
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Eur J Pharmacol 581:121-31. 2008
    ....
  19. ncbi request reprint Alteration of IL-17 related protein expressions in experimental autoimmune myocarditis and inhibition of IL-17 by IL-10-Ig fusion gene transfer
    He Chang
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Circ J 72:813-9. 2008
    ..Experimental autoimmune myocarditis (EAM) is a T cell-mediated autoimmune disease; however, the pathogenic role of IL-17 in the development of rat EAM remains largely unknown...
  20. doi request reprint Comparative effects of olmesartan and azelnidipine on atrial structural remodeling in spontaneously hypertensive rats
    Kazuki Okamura
    Division of Cardiology, Niigata University Graduate School of Medicine and Dental Sciences, Niigata, Japan
    Pharmacology 83:360-6. 2009
    ..These results suggest that the ARB was more effective than the CCB in ameliorating atrial structural remodeling due to the suppression of oxidative stress...
  21. doi request reprint 14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy
    Rajarajan A Thandavarayan
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265 1 Higashijima, Niigata City, Japan
    Biochem Pharmacol 75:1797-806. 2008
    ....
  22. ncbi request reprint Chymase inhibition reduces the progression to heart failure after autoimmune myocarditis in rats
    Suresh S Palaniyandi
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, 956 8603, Japan
    Exp Biol Med (Maywood) 232:1213-21. 2007
    ..Inhibition of chymase reduces the pathogenesis of postmyocarditis dilated cardiomyopathy and progression to heart failure by preventing the pathological remodeling and residual inflammation in rats...
  23. doi request reprint Effects of V2-receptor antagonist tolvaptan and the loop diuretic furosemide in rats with heart failure
    Punniyakoti T Veeraveedu
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265 1 Higashijima Akiha ku, Niigata City, Niigata 956 8603, Japan
    Biochem Pharmacol 75:1322-30. 2008
    ..Our results suggest that, tolvaptan have a potential medical benefit for the treatment of edematous conditions in CHF by removing excess water from the body without activating the RAAS or causing serum electrolyte imbalances...
  24. ncbi request reprint Characterization of outpatients with isolated diastolic dysfunction and evaluation of the burden in a Japanese community: Sado Heart Failure Study
    Yuji Okura
    Division of Cardiology, First Department of Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi, Niigata, Japan
    Circ J 71:1013-21. 2007
    ..However, very little information is available about such patients in the Japanese community...
  25. ncbi request reprint Comparative analysis of systolic and isolated diastolic dysfunction: Sado heart failure study
    Mahmoud M Ramadan
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Int Heart J 49:459-69. 2008
    ..769-4.808]) was independently associated with SD. In conclusion, some factors/comorbidities were more likely to associate with IDD (female gender, stroke, and malignancy) or SD (previous MI) when IDD and SD were compared with each other...
  26. doi request reprint Force-frequency relationship as a predictor of long-term prognosis in patients with heart diseases
    Komei Tanaka
    Division of Cardiology, Department of Cardiovascular and Vital Control, Niigata University Graduate School of Medical and Dental Sciences, 1 754 Asahimachi dori, Chuo Ku, Niigata, 951 8510, Japan
    Heart Vessels 26:153-9. 2011
    ..992, P = 0.061) tended to be independent predictors for cardiovascular death. Analysis of FFR, especially FG, seems to be useful to evaluate the nature of the failing myocardium and the prognosis of patients with heart diseases...
  27. ncbi request reprint Effects of imidapril and TA-606 on rat dilated cardiomyopathy after myocarditis
    Takeshi Kashimura
    Division of Cardiology, Niigata Graduate School of Medical and Dental Sciences, 1 754 Asahimachi, Niigata City 951 8510, Japan
    Jpn Heart J 44:735-44. 2003
    ..The hemodynamic effects of ARB and combination therapy of both drugs at low doses were not significant...
  28. doi request reprint Attenuation of CHOP-mediated myocardial apoptosis in pressure-overloaded dominant negative p38α mitogen-activated protein kinase mice
    Flori R Sari
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Higashijima, Niigata City, Japan
    Cell Physiol Biochem 27:487-96. 2011
    ..p38 mitogen-activated protein kinase (MAPK) plays an important role in mediating apoptotic processes, however, the roles of this kinase in activating ERS-initiated apoptosis in pressure-overloaded hearts are largely unknown...
  29. doi request reprint Telmisartan ameliorates experimental autoimmune myocarditis associated with inhibition of inflammation and oxidative stress
    Vijayakumar Sukumaran
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Eur J Pharmacol 652:126-35. 2011
    ....
  30. doi request reprint Role of mineralocorticoid receptor on atrial structural remodeling and inducibility of atrial fibrillation in hypertensive rats
    Shinpei Kimura
    Division of Cardiology, Niigata University School of Medical and Dental Sciences, Niigata City, Niigata, Japan
    Hypertens Res 34:584-91. 2011
    ..Thus, MR has important roles in atrial structural remodeling and AF inducibility in Dahl rats. The effects of MR are associated, at least in part, with activation of Rac1-oxidative stress/inflammatory axis...
  31. ncbi request reprint Lipocalin-2/neutrophil gelatinase-B associated lipocalin is strongly induced in hearts of rats with autoimmune myocarditis and in human myocarditis
    Limin Ding
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Japan
    Circ J 74:523-30. 2010
    ..Because Lcn2/NGAL is thought to be induced by interleukin-1, it might be strongly induced in the presence of myocarditis...
  32. ncbi request reprint Hydrodynamic-based delivery of an interleukin-22-Ig fusion gene ameliorates experimental autoimmune myocarditis in rats
    He Chang
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Immunol 177:3635-43. 2006
    ....
  33. ncbi request reprint Expression of immunological molecules by cardiomyocytes and inflammatory and interstitial cells in rat autoimmune myocarditis
    Tsuyoshi Yoshida
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Science, Japan
    Cardiovasc Res 68:278-88. 2005
    ....
  34. doi request reprint Beneficial effects of angiotensin II receptor blocker, olmesartan, in limiting the cardiotoxic effect of daunorubicin in rats
    Wawaimuli Arozal
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Free Radic Res 44:1369-77. 2010
    ..In conclusion, the result demonstrated that Ang II and oxidative stress play a key role in anthracycline-induced cardiotoxicity and that treatment with ARB will be beneficial against DNR-induced cardiotoxicity...
  35. doi request reprint Sulfated polysaccharide fucoidan ameliorates experimental autoimmune myocarditis in rats
    Komei Tanaka
    Division of Cardiology, Department of Cardiovascular and Vital Control, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Cardiovasc Pharmacol Ther 16:79-86. 2011
    ..Fucoidan, a nonselective selectin blocker, attenuates the progression of EAM. This observation may be explained, at least in part, by blocking the extravasation of inflammatory cells into the myocardium...
  36. doi request reprint Expression of the peptide hormone hepcidin increases in cardiomyocytes under myocarditis and myocardial infarction
    Manabu Isoda
    Department of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Nutr Biochem 21:749-56. 2010
    ..0032+/-0.0017, P=.0045). Hepcidin is strongly induced in cardiomyocytes under myocarditis and MI, conditions in which inflammatory cytokine levels increase and may play an important role in iron homeostasis and free radical generation...
  37. ncbi request reprint Quinapril inhibits progression of heart failure and fibrosis in rats with dilated cardiomyopathy after myocarditis
    Wen Juan
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Mol Cell Biochem 251:77-82. 2003
    ..Furthermore, myocardial fibrosis was regressed and myocardial structure returned to nearly normal in animals treated with quinapril...
  38. ncbi request reprint Prevention of experimental autoimmune myocarditis by hydrodynamics-based naked plasmid DNA encoding CTLA4-Ig gene delivery
    Satoru Abe
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Science, Osaka, Japan
    J Card Fail 11:557-64. 2005
    ..Soluble CTLA4 improves some autoimmune diseases by blocking costimulatory signals on T cell. We investigated the effect of hydrodynamics-based naked plasmid DNA encoding CTLA4-immunoglobulin (Ig) gene delivery...
  39. ncbi request reprint Swimming stress in DN 14-3-3 mice triggers maladaptive cardiac remodeling: role of p38 MAPK
    Ken ichi Watanabe
    Dept of Clinical Pharmacology, Niigata Univ of Pharmacy and Applied Life Sciences, Higashijima, Niigata City, Japan
    Am J Physiol Heart Circ Physiol 292:H1269-77. 2007
    ..These results indicate for the first time that 14-3-3 protein along with p38 MAPK plays a crucial role in left ventricular remodeling associated with swimming stress...
  40. doi request reprint Comparison of patients with pulmonary arterial hypertension with versus without right-sided mechanical alternans
    Masahiro Ito
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Am J Cardiol 109:428-31. 2012
    ..The existence of alternans is associated with the severity of PAH and right ventricular dysfunction and implies a poor prognosis in the short term...
  41. doi request reprint Telmisartan acts through the modulation of ACE-2/ANG 1-7/mas receptor in rats with dilated cardiomyopathy induced by experimental autoimmune myocarditis
    Vijayakumar Sukumaran
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Life Sci 90:289-300. 2012
    ..We investigated the cardioprotective effects of telmisartan in rats with dilated cardiomyopathy [DCM] after experimental autoimmune myocarditis [EAM]...
  42. ncbi request reprint Effects of angiotensin receptor blocker on oxidative stress and cardio-renal function in streptozotocin-induced diabetic rats
    Wawaimuli Arozal
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Biol Pharm Bull 32:1411-6. 2009
    ..These results provided evidence that oxidative stress plays a major role in diabetic rats induced by STZ, and treatment with the ARB might be beneficial for preventing the development and progression of diabetic disease...
  43. ncbi request reprint The effect of hydrodynamics-based delivery of an IL-13-Ig fusion gene for experimental autoimmune myocarditis in rats and its possible mechanism
    Raafat Elnaggar
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Eur J Immunol 35:1995-2005. 2005
    ..We conclude that IL-13-Ig ameliorates EAM and suppose that its effectiveness may be due to the influence on these immunologic molecules in CD11b(+) and NCNI cells...
  44. doi request reprint Telmisartan attenuates oxidative stress and renal fibrosis in streptozotocin induced diabetic mice with the alteration of angiotensin-(1-7) mas receptor expression associated with its PPAR-γ agonist action
    Arun Prasath Lakshmanan
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Free Radic Res 45:575-84. 2011
    ..These findings suggest that Ang-II plays a significant role in DN and telmisartan would be beneficial in reducing oxidative stress and fibrosis in STZ-induced DN...
  45. doi request reprint Inducibility of atrial fibrillation depends not on inflammation but on atrial structural remodeling in rat experimental autoimmune myocarditis
    Makoto Hoyano
    Division of Cardiology, Niigata University School of Medical and Dental Sciences, 1 757 Asahimachi, Niigata City, Niigata 951 8510, Japan
    Cardiovasc Pathol 19:e149-57. 2010
    ..There is increasing evidence to support a link between inflammation and atrial fibrillation (AF). However, the role of inflammation on new-onset AF is still to be elucidated...
  46. doi request reprint Effect of telmisartan in limiting the cardiotoxic effect of daunorubicin in rats
    Wawaimuli Arozal
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    J Pharm Pharmacol 62:1776-83. 2010
    ..We therefore investigated whether the co-treatment of telmisartan, an angiotensin (Ang II) type-1 receptor blocker, might offer protection against daunorubicin cardiotoxic properties in rats...
  47. ncbi request reprint Cardioprotective effects of recombinant human erythropoietin in rats with experimental autoimmune myocarditis
    Wataru Mitsuma
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Japan
    Biochem Biophys Res Commun 344:987-94. 2006
    ..The EPO receptor (EPO-R) was upregulated in the myocardium of EAM compared with that of healthy rats. These results may suggest that EPO ameliorated the progression of EAM by modulating myocardial inflammation and apoptosis...
  48. ncbi request reprint [Prognostic factors for critical limb ischemia after autologous bone marrow implantation]
    Masato Oda
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata
    J Cardiol 50:235-42. 2007
    ..The outcome of BMI treatment for ischemic legs was investigated related to the clinical background of the patient, and short-term effects of BMI. The end event was defined as unexpected lower limb amputation...
  49. doi request reprint IL-1 receptor accessory protein-Ig/IL-1 receptor type II-Ig heterodimer inhibits IL-1 response more strongly than other IL-1 blocking biopharmaceutical agents
    Haruo Hanawa
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, 951 8120, Japan
    J Clin Immunol 31:455-64. 2011
    ..IL-1 is bound to the complex of two receptor components with much higher affinity than with either receptor component alone...
  50. doi request reprint Mechanical alternans in human idiopathic dilated cardiomyopathy is caused with impaired force-frequency relationship and enhanced poststimulation potentiation
    Takeshi Kashimura
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi, Niigata, 951 8510, Japan
    Heart Vessels 28:336-44. 2013
    ..In conclusion, MA is caused with an impaired force-frequency relationship despite significant poststimulation potentiation, suggesting that MA reflects ineffective utilization of the potentiated intrinsic force during tachycardia...
  51. ncbi request reprint Angiopoietin-1, angiopoietin-2 and tie-2 in the coronary circulation of patients with and without coronary collateral vessels
    Wataru Mitsuma
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Circ J 71:343-7. 2007
    ....
  52. ncbi request reprint [Effects of various diuretics on cardiac function in rats with heart failure]
    Hiroko Tanaka
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Yakugaku Zasshi 129:871-9. 2009
    ..Our results indicate that torasemide and spironolactone treatment significantly improved cardiac function and LV remodeling compared with furosemide treatment...
  53. doi request reprint Gene expression profiles of cardiomyocytes in rat autoimmune myocarditis by DNA microarray and increase of regenerating gene family
    Ritsuo Watanabe
    Division of Cardiology, Department of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Transl Res 152:119-27. 2008
    ..The Reg/PAP family, which was found to show dramatically increasing gene expressions by DNA microarray analysis, was suspected to play an important role in myocarditis...
  54. doi request reprint Inhibition of cardiac oxidative and endoplasmic reticulum stress-mediated apoptosis by curcumin treatment contributes to protection against acute myocarditis
    Sayaka Mito
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Free Radic Res 45:1223-31. 2011
    ..In summary, our results indicate that curcumin has the potential to protect EAM by modulating cardiac oxidative and ER stress-mediated apoptosis, and provides a novel therapeutic strategy for autoimmune myocarditis...
  55. ncbi request reprint Effects of angiotensin II receptor blocker (candesartan) in daunorubicin-induced cardiomyopathic rats
    Mayako Soga
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Int J Cardiol 110:378-85. 2006
    ..The purpose of this study was to investigate the effects of angiotensin II type-1 receptor antagonist (candesartan) in a rat model of daunorubicin-induced cardiomyopathy...
  56. ncbi request reprint Analysis of postextrasystolic relaxation response in the human heart
    Kiminori Kato
    First Department of Internal Medicine, Niigata University School of Medicine, Niigata, Japan
    Mol Cell Biochem 251:43-6. 2003
    ..PRR: R = -0.520, p < 0.001. Thus, normal or non-failing human hearts showed a decline of -dP/dt in postextrasystole compared with the basal beats, but failing hearts had potentiated relaxation following an extrasystole...
  57. ncbi request reprint Plasma concentrations of cytokines and neurohumoral factors in a case of fulminant myocarditis successfully treated with intravenous immunoglobulin and percutaneous cardiopulmonary support
    Satoru Abe
    Division of Cardiology, Hematology and Endocrinology Metabolism, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi, Niigata, Japan
    Circ J 68:1223-6. 2004
    ..Immunological parameters in those who have been treated with IVIG and PCPS and survived without complications are of great value for evaluation of the therapy. Further analysis with more cases in a multicenter study is necessary...
  58. doi request reprint A novel phenylpyridazinone, T-3999, reduces the progression of autoimmune myocarditis to dilated cardiomyopathy
    Fadia Ali Kamal
    Department of Cellular Physiology, Institute of Nephrology, Niigata University School of Medical and Dental Sciences, Niigata, Japan
    Heart Vessels 26:81-90. 2011
    ..The reduction of the remodeling process and improvement in myocardial function suggest an effect of T-3999 in attenuating ventricular remodeling in post-myocarditis DCM...
  59. ncbi request reprint Relationship between insulin-like growth factor-I and brain natriuretic peptide in patients with acromegaly after surgery
    Masahiro Ito
    Division of Cardiology, Department of Neurosurgery, Brain Institute, Niigata University School of Medicine, Japan
    Circ J 71:1955-7. 2007
    ..On the other hand, acromegaly which is characterized by an excess of IGF-I has been linked to impaired cardiac function...
  60. ncbi request reprint Impending epidemic: future projection of heart failure in Japan to the year 2055
    Yuji Okura
    Division of Cardiology, First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Circ J 72:489-91. 2008
    ..The future burden of heart failure in Japan was projected to 2055 in order to prospectively estimate of the number of these patients...
  61. doi request reprint Curcumin attenuates hyperglycaemia-mediated AMPK activation and oxidative stress in cerebrum of streptozotocin-induced diabetic rat
    Arun Prasath Lakshmanan
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Free Radic Res 45:788-95. 2011
    ..These results provide a new insight into the beneficial effects of curcumin on hyperglycaemia-mediated DE, which are produced through the down-regulation of AMPK-mediated gluconeogenesis associated with its anti-oxidant property...
  62. ncbi request reprint Health-related quality of life of outpatients with systolic and isolated diastolic dysfunction: Sado Heart Failure Study
    Yukiko Ohno
    Division of Cardiology, First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Circ J 72:1436-42. 2008
    ..The impact of isolated diastolic dysfunction (IDD) and systolic dysfunction (SD) on health-related quality of life (HRQOL) is unknown...
  63. ncbi request reprint Comparative effects of torasemide and furosemide in rats with heart failure
    Punniyakoti T Veeraveedu
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265 1 Higashijima Akiha ku, Niigata City, Niigata, Japan
    Biochem Pharmacol 75:649-59. 2008
    ..Our results demonstrate that compared with furosemide, torasemide treatment significantly improved survival rate, LV function and ameliorated the progression of cardiac remodeling in rats with CHF after EAM...
  64. ncbi request reprint Longitudinal change in renal function in patients with idiopathic dilated cardiomyopathy without renal insufficiency at initial diagnosis
    Komei Tanaka
    Division of Cardiology, Department of Clinical Nephroscience, Niigata University Graduate School of Medical and Dental Sciences, Japan
    Circ J 71:1927-31. 2007
    ..Impaired renal function is associated with poor outcomes among patients with chronic heart failure (CHF). However, the long-term changes in renal function in CHF patients without renal insufficiency at initial diagnosis remain unclear...
  65. ncbi request reprint Serial electrocardiographic findings in women with Takotsubo cardiomyopathy
    Wataru Mitsuma
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Am J Cardiol 100:106-9. 2007
    ..05). In conclusion, 4 electrocardiographic phases in patients with Takotsubo cardiomyopathy were shown. This observation may be helpful to understand the pathophysiologic process of Takotsubo cardiomyopathy...
  66. ncbi request reprint Characterization of outpatients with systolic dysfunction in a Japanese community by total enumeration
    Yuji Okura
    Division of Cardiology, First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi, Niigata, Japan
    Circ J 71:1004-12. 2007
    ..Management of patients with systolic dysfunction (SD) is important for prevention of CHF, but there is little information regarding the burden of SD on Japanese communities...
  67. doi request reprint The antioxidant edaravone attenuates ER-stress-mediated cardiac apoptosis and dysfunction in rats with autoimmune myocarditis
    Hiroko Shimazaki
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Free Radic Res 44:1082-90. 2010
    ..These findings suggest that edaravone ameliorated the progression of EAM by inhibiting oxidative and ER stress and, subsequently, cardiac apoptosis...
  68. doi request reprint Partial inactivation of cardiac 14-3-3 protein in vivo elicits endoplasmic reticulum stress (ERS) and activates ERS-initiated apoptosis in ERS-induced mice
    Flori R Sari
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, 265 1 Higashijima, Niigata City, Japan
    Cell Physiol Biochem 26:167-78. 2010
    ..The primary function of 14-3-3 protein is to inhibit apoptosis, but the roles of this protein in protecting against cardiac ERS and apoptosis are largely unknown...
  69. ncbi request reprint Betaxolol improves the survival rate and changes natriuretic peptide expression in rats with heart failure
    Kenichi Watanabe
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    J Cardiovasc Pharmacol 41:S99-103. 2003
    ..These observations suggest that betaxolol may improve the survival rate by reducing sudden death and changing the atrial natriuretic peptide and brain natriuretic peptide mRNA expression in patients with heart failure...
  70. doi request reprint Free heme is a danger signal inducing expression of proinflammatory proteins in cultured cells derived from normal rat hearts
    Kazuhisa Hao
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8120, Japan
    Mol Immunol 48:1191-202. 2011
    ....
  71. ncbi request reprint Systolic dysfunction in urban Japan
    Mahmoud M Ramadan
    Division of Cardiology, First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Circ J 72:349-57. 2008
    ....
  72. ncbi request reprint Evaluation of coronary calcium score by multidetector computed tomography in relation to endothelial function and inflammatory markers in asymptomatic individuals
    Mahmoud M Ramadan
    Division of Cardiology, First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Circ J 72:778-85. 2008
    ....
  73. ncbi request reprint Spatiotemporal changes of coxsackievirus and adenovirus receptor in rat hearts during postnatal development and in cultured cardiomyocytes of neonatal rat
    Takeshi Kashimura
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, 1 754 Asahimachi, 951 8510, Niigata, Japan
    Virchows Arch 444:283-92. 2004
    ..Both the expression level and the localization of CAR are possible determinants of the susceptibility to viral myocarditis of neonates and children...
  74. ncbi request reprint Esophageal varices without portosystemic venous pressure gradient in a patient with post-pericardiotomy constrictive pericarditis: a case report
    Kazuyuki Ozaki
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi dori 1 757, Niigata, Niigata 951 8510
    J Cardiol 45:161-4. 2005
    ..She died at age 53 years. Autopsy showed severe congestive liver but not liver cirrhosis. Esophageal varices may progress in spite of the absence of porto-systemic pressure gradient in patients with severely high venous pressure...
  75. ncbi request reprint High-output heart failure caused by arteriovenous fistula long after nephrectomy
    Kazuyuki Ozaki
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi, Niigata 951 8510, Japan
    Heart Vessels 20:236-8. 2005
    ..Surgical closure of the fistula promptly decreased her cardiac output and improved the heart failure. This is a rare case of an arteriovenous fistula developing long after nephrectomy and causing high-output heart failure...
  76. ncbi request reprint A novel method to assay proteins in blood plasma after intravenous injection of plasmid DNA
    Haruo Hanawa
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Science, Niigata 951 8510, Japan
    Tohoku J Exp Med 202:155-61. 2004
    ..These results demonstrate a useful and convenient method to assay gene therapy products circulating in blood using a glucagon 19-29 tagging vector...
  77. ncbi request reprint Marked decrease of plasma VEGF after implantation of autologous bone marrow mononuclear cells in a patient with critical limb ischemia--a case report
    Takuya Ozawa
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Angiology 57:235-9. 2006
    ..BMI resulted in lower levels of VEGF and bFGF, and this fall is the hallmark of the effectiveness of BMI in the treatment of peripheral artery disease...
  78. ncbi request reprint Contribution of sympathetic nervous system activity during administration of carvedilol in rats with dilated cardiomyopathy
    Kenichi Watanabe
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    J Cardiovasc Pharmacol 42:S93-7. 2003
    ..Therefore, high-dose carvedilol treatment should be used with caution to avoid worsening heart failure...
  79. ncbi request reprint Impact of percutaneous coronary intervention on the levels of interleukin-6 and C-reactive protein in the coronary circulation of subjects with coronary artery disease
    Mahmoud M Ramadan
    Division of Cardiology, First Department of Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Am J Cardiol 98:915-7. 2006
    ....
  80. ncbi request reprint Images in cardiovascular medicine. Intramyocardial hemorrhage caused by myocardial contusion
    Yukio Hosaka
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 754, Niigata, 951 8510 Japan
    Circulation 109:277. 2004
  81. ncbi request reprint FR167653 suppresses the progression of experimental autoimmune myocarditis
    Seitaro Maruyama
    First Department of Internal Medicine, Institute of Nephrology, Niigata University School of Medicine, Niigata, Japan
    Mol Cell Biochem 246:39-44. 2003
    ..However, mRNA of TNF-alpha was not detected in any groups. Our results suggest that FR167653 suppresses the development of myocarditis by suppression of IL-1beta...
  82. ncbi request reprint Serum endostatin in the coronary circulation of patients with coronary heart disease and its relation to coronary collateral formation
    Wataru Mitsuma
    Division of Cardiology, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Am J Cardiol 99:494-8. 2007
    ..In conclusion, endostatin is suggested to be produced from the coronary circulation in patients with CHD and may play an important role in the regulation of the growth of coronary collateral vessels...
  83. ncbi request reprint Comparative effects of angiotensin II receptor blockade (candesartan) with angiotensin-converting enzyme inhibitor (quinapril) in rats with dilated cardiomyopathy
    Kenichi Watanabe
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    J Cardiovasc Pharmacol 41:S93-7. 2003
    ....
  84. ncbi request reprint Angiotensin II type 1 receptor blocker, valsartan, prevented cardiac fibrosis in rat cardiomyopathy after autoimmune myocarditis
    Hitoshi Tachikawa
    First Department of Internal Medicine, Niigata University Graduate School of Medicine, Niigata, Japan
    J Cardiovasc Pharmacol 41:S105-10. 2003
    ..In conclusion,valsartan suppressed myocardial hypertrophy and fibrosis, and it improved the hemodynamics and cardiac function in an animal model of post-myocarditis dilated cardiomyopathy...
  85. ncbi request reprint Time course of gene expression in rat experimental autoimmune myocarditis
    Haruo Hanawa
    First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi 1 754, Niigata, 951 8510, Japan
    Clin Sci (Lond) 103:623-32. 2002
    ..RAA system and ET expressions are changed differently during the EAM time course. Cytokine, chemokine and extracellular matrix greatly increase and, in particular, large numbers of osteopontin mRNA are expressed in early EAM...
  86. ncbi request reprint Plasma brain natriuretic peptide during myeloablative stem cell transplantation
    Masayoshi Masuko
    Division of Hematology and Cardiology, Graduate School of Medical and Dental Science, Niigata University, Niigata, Japan
    Intern Med 46:551-5. 2007
    ..We measured plasma brain natriuretic peptide (BNP) concentrations in patients who received SCT to evaluate possible cardiac toxicity of the regimens employed in SCT...
  87. ncbi request reprint Fenofibrate, a peroxisome proliferator-activated receptor alpha activator, suppresses experimental autoimmune myocarditis by stimulating the interleukin-10 pathway in rats
    Seitaro Maruyama
    First Department of Internal Medicine, Niigata University School of Medicine, Japan
    J Atheroscler Thromb 9:87-92. 2002
    ..620). We suggest that PPARalpha activators may prevent the progression of myocarditis through increased expression of the gene encoding the anti-inflammatory cytokine IL-10, although the mechanisms involved remain to be determined...
  88. ncbi request reprint Life-threatening serotonin syndrome in a patient with chronic heart failure and CYP2D6*1/*5
    Akinori Sato
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Mayo Clin Proc 79:1444-8. 2004
    ..Genetic screening for CYP2D6 in patients with these conditions may prevent life-threatening drug intoxication...
  89. ncbi request reprint Inhibition of mast cells by interleukin-10 gene transfer contributes to protection against acute myocarditis in rats
    Suresh S Palaniyandi
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Eur J Immunol 34:3508-15. 2004
    ..These findings suggest that IL-10 gene transfer by electroporation protected against myocarditis via mast cell inhibition...
  90. ncbi request reprint Potential candidates for cardiac resynchronization therapy in Japanese patients with idiopathic dilated cardiomyopathy--a Niigata multicenter study of DCM--
    Satoru Komura
    First Department of Internal Medicine, Division of Cardiology, Niigata University School of Medicine, Asahimachi, Niigata, Japan
    Circ J 68:1104-9. 2004
    ..The purpose of this study was to assess the candidates suitable for cardiac resynchronization therapy (CRT) and to examine the significance of the QRS duration in Japanese patients with idiopathic dilated cardiomyopathy (DCM)...
  91. ncbi request reprint Short-term prognostic value of initial serum levels of interleukin-10 in patients with acute myocarditis
    Koichi Fuse
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, 1 754 Asahimachi dori, Niigata City 951 8510, Japan
    Eur J Heart Fail 7:109-12. 2005
    ..0 pg/ml) (P=0.0239) strongly predicted high mortality. In conclusion, the elevation in serum IL-10 levels at the initial phase appeared to predict poor short-term prognosis in patients with acute myocarditis...
  92. ncbi request reprint Clinical characteristics, treatment, and outcome of tachycardia induced cardiomyopathy
    Hiroshi Watanabe
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan
    Int Heart J 49:39-47. 2008
    ..A substrate for heart failure and/or life-threatening arrhythmia might persist, and careful, long-term follow-up seems required...
  93. ncbi request reprint Suppression of myocardial inflammation using suramin, a growth factor blocker
    Takaaki Shiono
    First Department of Internal Medicine, Institute of Nephrology, Niigata University School of Medicine, Japan
    Circ J 66:385-9. 2002
    ..Suramin suppressed myocardial inflammation in EAM and was associated with modulation of the Th1/Th2 cytokine milieu and reduced TGF-beta1 expression in the heart...
  94. ncbi request reprint Myocardial sympathetic denervation, fatty acid metabolism, and left ventricular wall motion in vasospastic angina
    Kenichi Watanabe
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Japan
    J Nucl Med 43:1476-81. 2002
    ....
  95. ncbi request reprint A pilot-controlled study of myeloperoxidase-specific anti-neutrophil cytoplasmic autoantibody (MPO-ANCA) in the coronary circulation
    Mahmoud M Ramadan
    Int J Cardiol 128:114-6. 2008
    ....
  96. ncbi request reprint Infusion of adrenomedullin improves acute myocarditis via attenuation of myocardial inflammation and edema
    Bobby Yanagawa
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka, Japan
    Cardiovasc Res 76:110-8. 2007
    ..Our aim was to assess whether adrenomedullin (AM), a potent vasodilator peptide with a variety of cardioprotective effects, has a therapeutic potential for the treatment of acute myocarditis in a rat model...
  97. ncbi request reprint CNP infusion attenuates cardiac dysfunction and inflammation in myocarditis
    Hiroaki Obata
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Biochem Biophys Res Commun 356:60-6. 2007
    ..In conclusion, CNP infusion attenuated cardiac function in acute myocarditis through anti-inflammatory and angiogenic effects...
  98. ncbi request reprint Transplantation of mesenchymal stem cells attenuates myocardial injury and dysfunction in a rat model of acute myocarditis
    Shunsuke Ohnishi
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Fujishirodai 5 7 1, Osaka 565 8565, Japan
    J Mol Cell Cardiol 42:88-97. 2007
    ..MSC transplantation attenuated myocardial injury and dysfunction in a rat model of acute myocarditis, at least in part through paracrine effects of MSC...
  99. ncbi request reprint Transient left ventricular apical ballooning developing after the Central Niigata Prefecture Earthquake: two case reports
    Minoru Tagawa
    Department of Cardiology, Nagaoka Chuo General Hospital, Niigata
    J Cardiol 48:153-8. 2006
    ..Due to strong emotional stress, earthquakes may induce transient left ventricular apical ballooning (takotsubo cardiomyopathy)...
  100. ncbi request reprint Increased incidence of transient left ventricular apical ballooning (so-called 'Takotsubo' cardiomyopathy) after the mid-Niigata Prefecture earthquake
    Masahito Sato
    Cardiovascular Center, Tachikawa General Hospital, and Niigata University Graduate School of Medical and Dental Science, Japan
    Circ J 70:947-53. 2006
    ....
  101. ncbi request reprint Involvement of mast cells in the development of fibrosis in rats with postmyocarditis dilated cardiomyopathy
    Suresh Palaniyandi Selvaraj
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Japan
    Biol Pharm Bull 28:2128-32. 2005
    ..DSCG reduced myocardial fibrosis besides preventing infiltration and degranulation of mast cells. Our findings confirm the active participation of mast cells in the progression of myocardial fibrosis in rats with postmyocarditis DCM...