Takahiro Ueno

Summary

Affiliation: Nihon University
Country: Japan

Publications

  1. ncbi Postprandial plasma lipid levels are influenced by the interaction of functional polymorphisms in the microsome triglyceride transfer protein and beta3 adrenergic receptor genes
    Takahiro Ueno
    Department of Medicine, Division of Nephrology and Endocrinology, Nihon University School of Medicine, Tokyo, Japan
    Med Sci Monit 13:BR112-8. 2007
  2. ncbi A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function
    Takahiro Ueno
    Department of Medicine, Division of Nephrology, Hypertension and Endocrinology, Itabashi, Nihon University School of Medicine, Itabashi, Tokyo, Japan
    J Hypertens 27:508-16. 2009
  3. ncbi Association of SLC6A9 gene variants with human essential hypertension
    Takahiro Ueno
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Itabashi 173 8610, Tokyo, Japan
    J Atheroscler Thromb 16:201-6. 2009
  4. doi Association between fatty acid binding protein 3 gene variants and essential hypertension in humans
    Takahiro Ueno
    Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Am J Hypertens 21:691-5. 2008
  5. ncbi Influence of genetic polymorphisms in oxidative stress related genes and smoking on plasma MDA-LDL, soluble CD40 ligand, E-selectin and soluble ICAM1 levels in patients with coronary artery disease
    Takahiro Ueno
    Department of Medicine, Division of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, Tokyo, Japan
    Med Sci Monit 15:CR341-8. 2009
  6. ncbi Paraoxonase1 polymorphism Leu-Met55 is associated with cerebral infarction in Japanese population
    Takahiro Ueno
    2nd Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Med Sci Monit 9:CR208-12. 2003
  7. ncbi Atherogenic dyslipidemia and altered hepatic gene expression in SHRSP.Z-Leprfa/IzmDmcr rats
    Takahiro Ueno
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Itabashi ku, Tokyo 173 8610, Japan
    Int J Mol Med 23:313-20. 2009
  8. ncbi Development of a novel gene silencer pyrrole-imidazole polyamide targeting human connective tissue growth factor
    Jian Xin Wan
    Division of Nephrology Hypertension and Endocrinology, Department of Medicine, School of Medicine, Nihon University, Tokyo, Japan
    Biol Pharm Bull 34:1572-7. 2011
  9. doi Losartan improves the impaired function of endothelial progenitor cells in hypertension via an antioxidant effect
    En Hui Yao
    Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Hypertens Res 30:1119-28. 2007
  10. doi A pyrrole-imidazole polyamide targeting transforming growth factor-beta1 inhibits restenosis and preserves endothelialization in the injured artery
    En Hui Yao
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Cardiovasc Res 81:797-804. 2009

Detail Information

Publications47

  1. ncbi Postprandial plasma lipid levels are influenced by the interaction of functional polymorphisms in the microsome triglyceride transfer protein and beta3 adrenergic receptor genes
    Takahiro Ueno
    Department of Medicine, Division of Nephrology and Endocrinology, Nihon University School of Medicine, Tokyo, Japan
    Med Sci Monit 13:BR112-8. 2007
    ..The effects of polymorphisms in the genes encoding microsome triglycerides transfer protein (MTP) and beta3-adrenergic receptor (beta3-AR) on lipid and glucose metabolism were investigated...
  2. ncbi A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function
    Takahiro Ueno
    Department of Medicine, Division of Nephrology, Hypertension and Endocrinology, Itabashi, Nihon University School of Medicine, Itabashi, Tokyo, Japan
    J Hypertens 27:508-16. 2009
    ..Molecular recognition of DNA by small molecules could provide insight into the development of new human medicines...
  3. ncbi Association of SLC6A9 gene variants with human essential hypertension
    Takahiro Ueno
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Itabashi 173 8610, Tokyo, Japan
    J Atheroscler Thromb 16:201-6. 2009
    ..In the present study, we therefore explored the role of SLC6A9 genetic variations in human essential hypertension (EH)...
  4. doi Association between fatty acid binding protein 3 gene variants and essential hypertension in humans
    Takahiro Ueno
    Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Am J Hypertens 21:691-5. 2008
    ..In this study, therefore, we explored the role of FABP3 genetic variations in essential hypertension (EH) in humans...
  5. ncbi Influence of genetic polymorphisms in oxidative stress related genes and smoking on plasma MDA-LDL, soluble CD40 ligand, E-selectin and soluble ICAM1 levels in patients with coronary artery disease
    Takahiro Ueno
    Department of Medicine, Division of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, Tokyo, Japan
    Med Sci Monit 15:CR341-8. 2009
    ..Previous studies have shown that oxidative stress plays an important role in coronary heart disease. Polymorphisms in key enzymes that regulate oxidative stress may play a role in atherogenicity and were investigated in this study...
  6. ncbi Paraoxonase1 polymorphism Leu-Met55 is associated with cerebral infarction in Japanese population
    Takahiro Ueno
    2nd Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Med Sci Monit 9:CR208-12. 2003
    ..We examined whether these polymorphisms relates with the incidence of cerebral infarction (CI) which is one of the major atherosclerotic disease in Japan...
  7. ncbi Atherogenic dyslipidemia and altered hepatic gene expression in SHRSP.Z-Leprfa/IzmDmcr rats
    Takahiro Ueno
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Itabashi ku, Tokyo 173 8610, Japan
    Int J Mol Med 23:313-20. 2009
    ..Three of ten genes upregulated in liver tissues of SHRSP fatty rats play a role in this metabolic abnormality and are a therapeutic target of this metabolic syndrome...
  8. ncbi Development of a novel gene silencer pyrrole-imidazole polyamide targeting human connective tissue growth factor
    Jian Xin Wan
    Division of Nephrology Hypertension and Endocrinology, Department of Medicine, School of Medicine, Nihon University, Tokyo, Japan
    Biol Pharm Bull 34:1572-7. 2011
    ..The PI polyamide to hCTGF significantly decreased PMA- or TGF-β1-stimulated levels of hCTGF protein in HMCs. These results indicate that the developed synthetic PI polyamide to hCTGF could be a novel gene silencer for fibrotic diseases...
  9. doi Losartan improves the impaired function of endothelial progenitor cells in hypertension via an antioxidant effect
    En Hui Yao
    Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Hypertens Res 30:1119-28. 2007
    ..This is the first report to show that losartan improves the proliferation and function of EPCs in hypertension, suggesting that ARBs are useful to repair hypertensive vascular injuries...
  10. doi A pyrrole-imidazole polyamide targeting transforming growth factor-beta1 inhibits restenosis and preserves endothelialization in the injured artery
    En Hui Yao
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Cardiovasc Res 81:797-804. 2009
    ....
  11. doi Effects of the antioxidative beta-blocker celiprolol on endothelial progenitor cells in hypertensive rats
    En Hui Yao
    Division of Nephrology Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Am J Hypertens 21:1062-8. 2008
    ..EPC function is impaired by oxidative stress. We examined the effects of an antioxidative beta1-adrenoceptor blocker on the number and function of EPCs in hypertensive rats...
  12. ncbi Effects of an ARB on endothelial progenitor cell function and cardiovascular oxidation in hypertension
    Yi Yu
    Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Am J Hypertens 21:72-7. 2008
    ..We investigated the effects of an ARB, candesartan, on EPC function and cardiovascular oxidation in salt-loaded, stroke-prone, spontaneously hypertensive rats (SHR-SP) in vivo...
  13. doi Complement 3 activates the renal renin-angiotensin system by induction of epithelial-to-mesenchymal transition of the nephrotubulus in mice
    Xueli Zhou
    Div of Nephrology, Hypertension, and Endocrinology, Dept of Medicine, Nihon Univ School of Medicine, Tokyo 173 8610, Japan
    Am J Physiol Renal Physiol 305:F957-67. 2013
    ..These data indicate for the first time that C3 may be a primary factor to activate the renal RA systems to induce hypertension...
  14. doi Cardiovascular remodeling and metabolic abnormalities in SHRSP.Z-Lepr(fa)/IzmDmcr rats as a new model of metabolic syndrome
    Takahiro Ueno
    Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Hypertens Res 31:1021-31. 2008
    ..The phenotype of SHRSP fatty is similar to that of human metabolic syndrome, and therefore, studies of these rats may help clarify the molecular mechanisms that underlie metabolic syndrome in humans...
  15. ncbi Development of gene silencing pyrrole-imidazole polyamide targeting the TGF-beta1 promoter for treatment of progressive renal diseases
    Hiroyuki Matsuda
    Department of Internal Medicine, Nihon University School of Medicine, Ooyaguchi kami 30 1, Itabashi ku, Tokyo 173 8610, Japan
    J Am Soc Nephrol 17:422-32. 2006
    ..These results indicate that Py-Im polyamide that targets TGF-beta1 will be a novel gene-silencing agent for the TGF-beta1-associated diseases, including progressive renal diseases...
  16. doi Treatment with valsartan stimulates endothelial progenitor cells and renal label-retaining cells in hypertensive rats
    Yoshinori Yoshida
    Division of Nephrology Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    J Hypertens 29:91-101. 2011
    ..We examined effects of treatment with valsartan on endothelial progenitor cells (EPCs) and renal LRCs in stroke-prone spontaneously hypertensive rats (SHR-SP)...
  17. ncbi Effects of atorvastatin on angiogenesis in hindlimb ischemia and endothelial progenitor cell formation in rats
    Mitsuyasu Matsumura
    Department of Cardiovascular Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 16:319-26. 2009
    ..The function and number of endothelial progenitor cells (EPCs) were investigated in hypertensive rats...
  18. doi Transcriptional inhibition of progressive renal disease by gene silencing pyrrole-imidazole polyamide targeting of the transforming growth factor-β1 promoter
    Hiroyuki Matsuda
    Department of Life Science, Advanced Research Institute of the Sciences and Humanities, Nihon University, Tokyo, Japan
    Kidney Int 79:46-56. 2011
    ..Thus, targeted PI polyamides are potential gene silencers for diseases not treatable by current remedies...
  19. doi Novel gene silencer pyrrole-imidazole polyamide targeting lectin-like oxidized low-density lipoprotein receptor-1 attenuates restenosis of the artery after injury
    En Hui Yao
    Division of Nephrology Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Ooyaguchi kami 30 1, Itabashi ku, Tokyo 173 8610, Japan
    Hypertension 52:86-92. 2008
    ..This novel gene silencer PI polyamide to LOX-1 is, therefore, considered to be a feasible agent for the treatment of in-stent restenosis...
  20. pmc Role of complement 3a in the synthetic phenotype and angiotensin II-production in vascular smooth muscle cells from spontaneously hypertensive rats
    Ying Han
    Division of Nephrology, Hypertension, and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Am J Hypertens 25:284-9. 2012
    ..To evaluate the contribution of complement 3 (C3) or C3a toward these abnormalities in SHR, we examined effects of a C3a receptor inhibitor on proliferation, phenotype, and Ang II-production in VSMCs from SHR and Wistar-Kyoto (WKY) rats...
  21. ncbi Synthetic pyrrole-imidazole polyamide inhibits expression of the human transforming growth factor-beta1 gene
    Yu Mu Lai
    Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    J Pharmacol Exp Ther 315:571-5. 2005
    ..This novel agent will be used for the TGF-beta-related diseases as a gene therapy...
  22. ncbi Chimeric DNA-RNA hammerhead ribozyme targeting transforming growth factor-beta1 mRNA ameliorates renal injury in hypertensive rats
    Yoshiko Tahira
    Department of Medicine, Nihon University School of Medicine, Division of Nephrology and Endocrinology, Tokyo, Japan
    J Hypertens 25:671-8. 2007
    ....
  23. ncbi Development of pyrrole-imidazole polyamide targeting fc receptor common gamma chain for the treatment of immune-complex related renal disease
    Mamiko Kajiwara
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, School of Medicine, Nihon University, 7 7 1 Narashinodai, Funabashi, Chiba 274 8555, Japan
    Biol Pharm Bull 35:2028-35. 2012
    ..PI polyamide targeting the FcRγ gene may be a novel gene regulator for the prevention of lupus nephritis or other immune complex-related disease...
  24. doi Subtype prediction in primary aldosteronism: measurement of circadian variation of adrenocortical hormones and 24-h urinary aldosterone
    Hiroki Kobayashi
    Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Clin Endocrinol (Oxf) 84:814-21. 2016
    ..e. aldosterone, cortisol and ACTH) and a 24-h urinary aldosterone could contribute to the clinical differentiation between unilateral hyperaldosteronism (UHA) and bilateral hyperaldosteronism (BHA)...
  25. doi Role of complement 3a in the growth of mesangial cells from stroke-prone spontaneously hypertensive rats
    Kazuya Ikeda
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Clin Exp Hypertens 36:58-63. 2014
    ..The C3 and C3a receptor system may primarily be involved in the pathogenesis of renal remodeling in hypertensive rats...
  26. doi Protective effects of statin on cardiac fibrosis and apoptosis in adrenomedullin-knockout mice treated with angiotensin II and high salt loading
    Chii Yamamoto
    Division of Life Science, Advanced Research Institute for the Sciences and Humanities, Nihon University Graduate School, Tokyo, Japan
    Hypertens Res 34:348-53. 2011
    ..Thus, statins have potent cardioprotective effects that may be associated with anti-fibrotic, proangiogenic and anti-apoptotic effects in Ang II/salt-loading AM(+/-) mice...
  27. ncbi Appropriate doses of granulocyte-colony stimulating factor reduced atherosclerotic plaque formation and increased plaque stability in cholesterol-fed rabbits
    Taro Matsumoto
    Divsion of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo 173 8610, Japan
    J Atheroscler Thromb 17:84-96. 2010
    ....
  28. doi Reduction of Dimethylnitrosamine-Induced Liver Fibrosis by the Novel Gene Regulator PI Polyamide Targeting Transforming Growth Factor β1 Gene
    Makiko Inami
    Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine
    Biol Pharm Bull 38:1836-42. 2015
    ..The novel gene regulator PI polyamide targeting TGFβ1 may be a feasible therapeutic agent for the treatment of chronic liver disease. ..
  29. doi A novel gene regulator, pyrrole-imidazole polyamide targeting ABCA1 gene increases cholesterol efflux from macrophages and plasma HDL concentration
    Akiko Tsunemi
    Department of Medicine, Division of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, 30 1 Oyaguchi Kami, Itabashi, Tokyo, Japan
    J Mol Med (Berl) 92:509-21. 2014
    ..The designed PI polyamide that targeted ABCA1 successfully increased ABCA1 expression and HDL biogenesis. This novel gene-regulating agent is promising as a useful compound to increase plasma HDL concentration...
  30. doi Effects of an angiotensin II receptor blocker on the impaired function of endothelial progenitor cells in patients with essential hypertension
    Ryo Suzuki
    Division of Nephrology Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Am J Hypertens 27:695-701. 2014
    ..In this study, we investigated basal EPC functions in normotensive control subjects and patients with essential hypertension and the effect of losartan on EPC function in hypertensive patients...
  31. ncbi Complement 3 is involved in changing the phenotype of human glomerular mesangial cells
    Jian Xin Wan
    Department of Medicine, Division of Nephrology and Endocrinology, Nihon University School of Medicine, Tokyo, Japan
    J Cell Physiol 213:495-501. 2007
    ..These results indicate that C3 causes HMCs to convert to the synthetic phenotype and stimulates growth of mesangial cells, suggesting that C3 may play an important role in phenotypic regulation of mesangial cells in renal diseases...
  32. ncbi Complement 3 is involved in the synthetic phenotype and exaggerated growth of vascular smooth muscle cells from spontaneously hypertensive rats
    Zhi Hong Lin
    Second Department of Internal Medicine, Division of Cell Regeneration and Transplantation, Nihon University School of Medicine, Tokyo, Japan
    Hypertension 44:42-7. 2004
    ..C3 is produced only by VSMCs from SHR. Therefore, C3 may be the gene underlying the synthetic phenotype and exaggerated growth of VSMCs from SHR. C3 may be a new target for the treatment of hypertension...
  33. pmc Obesity alters the expression profile of clock genes in peripheral blood mononuclear cells
    Kazunobu Tahira
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Arch Med Sci 7:933-40. 2011
    ..The aim of this study was to investigate the association between the variation in expression profile of clock genes and obesity using peripheral blood mononuclear (PMN) cells...
  34. doi Zinc-finger transcriptional factor Sall1 induces angiogenesis by activation of the gene for VEGF-A
    Chii Yamamoto
    Advanced Research Institute of Science and Humanities, Nihon University, Tokyo, Japan
    Hypertens Res 33:143-8. 2010
    ..These results suggest that Sall1 induces angiogenesis by stimulating VEGF-A promoter activity...
  35. doi Scoring System for the Diagnosis of Bilateral Primary Aldosteronism in the Outpatient Setting before Adrenal Venous Sampling
    Hiroki Kobayashi
    Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Clin Endocrinol (Oxf) . 2016
    ..We aimed to establish new, simple criteria for outpatients to diagnose BHA from PA before AVS...
  36. doi Modulation of the EMT/MET process by pyrrole-imidazole polyamide targeting human transforming growth factor-β1
    Kosuke Saito
    Department of General Medicine, Nihon University School of Medicine, Tokyo, Japan
    Int J Biochem Cell Biol 66:112-20. 2015
    ..These results suggest that PI polyamide targeted to human TGF-β is a novel compound that can control the EMT/MET process of human epithelial cells and enhance the induction of human fibroblasts to iPSCs. ..
  37. pmc Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model
    Jun Igarashi
    Department of General Medicine, Nihon University School of Medicine, Tokyo, Japan
    PLoS ONE 10:e0125295. 2015
    ..PI polyamides targeting hTGF-β1 promoter with solbase ointment will be practical medicines for treating hypertrophic scars after surgical operations and skin burns. ..
  38. doi Complement 3 activates the KLF5 gene in rat vascular smooth muscle cells
    En Hui Yao
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Ooyaguchi kami 30 1, Itabashi ku, Tokyo 173 8610, Japan
    Biochem Biophys Res Commun 367:468-73. 2008
    ..These findings suggest that C3 increases KLF5 promoter activity and gene expression via ERK signaling...
  39. pmc Systematic implantation of dedifferentiated fat cells ameliorated monoclonal antibody 1-22-3-induced glomerulonephritis by immunosuppression with increases in TNF-stimulated gene 6
    Takashi Maruyama
    Division of Nephrology Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Stem Cell Res Ther 6:80. 2015
    ..We established dedifferentiated fat (DFAT) cells that show identical characteristics to MSCs...
  40. ncbi Ubiquitin-positive foam cells are identified in the aortic and mitral valves with atherosclerotic involvement
    Tsutomu Yamada
    Department of Pathology, Nihon University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 16:472-9. 2009
    ....
  41. pmc Anderson's disease/chylomicron retention disease in a Japanese patient with uniparental disomy 7 and a normal SAR1B gene protein coding sequence
    Tomoo Okada
    Department of Pediatrics, Nihon University School of Medicine, 30 1 Oyaguchi Kamicho Itabashi ku, Tokyo 173 8630, Japan
    Orphanet J Rare Dis 6:78. 2011
    ..We describe here a patient with AD/CMRD, a normal SAR1B gene protein coding sequence and maternal uniparental disomy of chromosome 7 (matUPD7)...
  42. doi Development of a chimeric DNA-RNA hammerhead ribozyme targeting SARS virus
    Akiko Fukushima
    Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Intervirology 52:92-9. 2009
    ..To develop an effective and specific medicine targeting the SARS-coronavirus (CoV), a chimeric DNA-RNA hammerhead ribozyme was designed and synthesized using a sequence homologous with the mouse hepatitis virus (MHV)...
  43. doi Nutrition education in Japanese medical schools: a follow-up survey
    Hideo Orimo
    The Japanese Society of Clinical Nutrition, Tokyo, Japan
    Asia Pac J Clin Nutr 22:144-9. 2013
    ..In conclusion, the status of nutrition education in Japan has improved slightly but is still inadequate...
  44. ncbi Rat model of familial combined hyperlipidemia as a result of comparative mapping
    Takahiro Ueno
    Centre de recherche du Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Physiol Genomics 17:38-47. 2004
    ..These data suggest the close relationship between dyslipidemia in HTG rats and human FCHL, establishing a novel animal model for exploration of pathophysiology and therapy based on genomic determinants...
  45. ncbi [Dyslipidemia in renal failure]
    Takayuki Fujioka
    Second Department of Internal Medicine, Nihon University School of Medicine
    Nihon Rinsho 62:118-23. 2004
  46. ncbi Serum apolipoprotein j in health, coronary heart disease and type 2 diabetes mellitus
    Takeshi Kujiraoka
    Department of Advanced Medical Technology and Development, BML Inc, Saitama, Japan
    J Atheroscler Thromb 13:314-22. 2006
    ..These findings suggest that apo J may be anti-atherogenic in humans, and that its concentration is raised by Type 2 diabetes...
  47. ncbi Resolving the composite trait of hypertension into its pharmacogenetic determinants by acute pharmacological modulation of blood pressure regulatory systems
    Takahiro Ueno
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal Hotel Dieu, 3850 Rue Saint Urbain, Montreal, Quebec, Canada
    J Mol Med (Berl) 81:51-60. 2003
    ..This pharmocogenetic approach enabled us to determine the main causative acute BP regulatory systems and should lead to better selection of suitable antihypertensive drugs for individual patients...