Kazuyuki Ueno

Summary

Affiliation: National Hospital Organization
Country: Japan

Publications

  1. ncbi request reprint Evaluation of mexiletine clearance in a Japanese population
    Kazuyuki Ueno
    Department of Pharmacy, National Cardiovascular Center, 5 7 1, Fujishiridai, Suita City, Osaka 565 8565, Japan
    Ann Pharmacother 36:241-5. 2002
  2. ncbi request reprint Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Circulation 110:3674-9. 2004
  3. ncbi request reprint Relationship between serum aprindine concentration and neurologic side effects in Japanese
    Yoshimasa Tsuchishita
    Department of Pharmacy, Maizuru Kyosai Hospital, Federation of National Public Services and Affiliated Mutual Associations, Japan
    Biol Pharm Bull 32:637-9. 2009
  4. doi request reprint Decreased vancomycin clearance in patients with congestive heart failure
    Yuko Shimamoto
    Department of Pharmacy, National Hospital Organization Osaka National Hospital, Osaka, Japan
    Eur J Clin Pharmacol 69:449-57. 2013
  5. ncbi request reprint Lack of interaction between amiodarone and mexiletine in cardiac arrhythmia patients
    Emi Yonezawa
    Department of Pharmacy, National Cardiovascular Center, Suita City, Osaka, Japan
    J Clin Pharmacol 42:342-6. 2002
  6. ncbi request reprint Effects of serum concentrations of disopyramide and its metabolite mono-N-dealkyldisopyramide on the anticholinergic side effects associated with disopyramide
    Yoshimasa Tsuchishita
    Department of Pharmacy, Maizuru Kyosai Hospital, Federation of National Public Services and Affiliated Mutual Associations, Kyoto, Japan
    Biol Pharm Bull 31:1368-70. 2008
  7. ncbi request reprint Impairment of mycophenolate mofetil absorption by calcium polycarbophil
    Ryuji Kato
    Department of Pharmacy, Yokkaichi Social Insurance Hospital, Mie, Japan
    J Clin Pharmacol 42:1275-80. 2002
  8. ncbi request reprint Effect of clarithromycin on steady-state digoxin concentrations
    Hideko Tanaka
    Department of Pharmacy, National Cardiovascular Center, Osaka, Japan
    Ann Pharmacother 37:178-81. 2003
  9. ncbi request reprint [A case in which tofisopam was effective for treatment of paroxysmal supraventricular tachycardia]
    Ryuji Kato
    Department of Pharmacy, Yokkaichi Social Insurance Hospital, 10 8 Hazuyama cho, Yokkaichi City 510 0016, Japan
    Yakugaku Zasshi 123:365-8. 2003
  10. ncbi request reprint Intravenous administration of nifekalant hydrochloride for the prevention of ischemia-induced ventricular tachyarrhythmia in patients with renal failure undergoing hemodialysis
    Masafumi Myoishi
    Division of Cardiology, National Cardiovascular Center, Osaka, Japan
    Circ J 67:898-900. 2003

Collaborators

  • Kazuya Ooi
  • Noritoshi Nagaya
  • Ryuji Kato
  • Yuko Shimamoto
  • Satoshi Yasuda
  • Takuma Shirasaka
  • Masafumi Kitakaze
  • Yoritaka Otsuka
  • Takashi Kurita
  • K Komamura
  • A Ohtsu
  • K Sai
  • Tsuyoshi Fukuda
  • S Ozawa
  • H Minami
  • Yasuo Ohno
  • K Sugai
  • Keiko Maekawa
  • Su Ryang Kim
  • Tomohide Tamura
  • Shiro Kamakura
  • Kyoko Fukumoto
  • Jun Ichi Sawada
  • Yoshiro Saito
  • Mayumi Saeki
  • Yoshimasa Tsuchishita
  • Akiko Soyama
  • Naoyuki Kamatani
  • Masaaki Kusumoto
  • Nobumitsu Hanioka
  • Kana Matsumoto
  • Mariko Kobayashi
  • Takashi Kobayashi
  • Hitonobu Tomoike
  • Asami Kashima
  • Narihiro Minami
  • Yu ichi Goto
  • Masaaki Katoh
  • Hideo Kimura
  • Kazuhiko Tanaka
  • Hiromi Fukushima-Uesaka
  • Hideto Jinno
  • Toshiharu Nakajima
  • Yutaka Kitamura
  • Hirohisa Saito
  • Takahiro Nakamura
  • Kouichi Kurose
  • Masafumi Myoishi
  • Hideko Tanaka
  • Kunio Miyatake
  • Emi Yonezawa
  • Takashi Kubo
  • Atsuko Miyajima
  • Yoshihito Okumura
  • Keita Saito
  • Hiroyuki Hichiya
  • Shizuo Narimatsu
  • Kanako Tachibana
  • Taisuke Ohtsuki
  • Mamiko Tanemura
  • Osamu Saitoh
  • Mitsuru Kawai
  • Chieko Suzuki
  • Miho Funahashi
  • Teiichi Ohnuma
  • Toshiko Tanaka-Kagawa
  • Nagahiro Saijo
  • Kisho Shiseki
  • Kenji Matsumoto
  • Akiko Ohno
  • Noboru Yamamoto
  • Teruhiko Yoshida
  • Kuniaki Shirao
  • Sotaro Hanai
  • Hidemi Watanabe
  • Mayumi Kodama
  • Masahiro Tohkin
  • Norie Murayama
  • Isao Morii
  • Nahoko Kaniwa
  • Kazuhiro Satomi
  • Hiroshi Nonogi
  • Shunichi Miyazaki
  • Atsushi Kawamura
  • Kohji Yoneda
  • Yoshiaki Katayama
  • Hiroshi Hashimoto
  • Miho Tachibana

Detail Information

Publications25

  1. ncbi request reprint Evaluation of mexiletine clearance in a Japanese population
    Kazuyuki Ueno
    Department of Pharmacy, National Cardiovascular Center, 5 7 1, Fujishiridai, Suita City, Osaka 565 8565, Japan
    Ann Pharmacother 36:241-5. 2002
    ..To evaluate mexiletine clearance in a Japanese population and to clarify the roles of CYP2D6 and CYP1A2 in mexiletine disposition...
  2. ncbi request reprint Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Circulation 110:3674-9. 2004
    ..We investigated the effects of ghrelin on left ventricular (LV) function, exercise capacity, and muscle wasting in patients with chronic heart failure (CHF)...
  3. ncbi request reprint Relationship between serum aprindine concentration and neurologic side effects in Japanese
    Yoshimasa Tsuchishita
    Department of Pharmacy, Maizuru Kyosai Hospital, Federation of National Public Services and Affiliated Mutual Associations, Japan
    Biol Pharm Bull 32:637-9. 2009
    ..In conclusion, serum aprindine concentration should be maintained under approximately 1 microg/ml in Japanese patients to prevent neurologic side effects...
  4. doi request reprint Decreased vancomycin clearance in patients with congestive heart failure
    Yuko Shimamoto
    Department of Pharmacy, National Hospital Organization Osaka National Hospital, Osaka, Japan
    Eur J Clin Pharmacol 69:449-57. 2013
    ..The purpose of this study was to evaluate the influence of CHF on the clearance of vancomycin, a glycopeptide antibacterial agent...
  5. ncbi request reprint Lack of interaction between amiodarone and mexiletine in cardiac arrhythmia patients
    Emi Yonezawa
    Department of Pharmacy, National Cardiovascular Center, Suita City, Osaka, Japan
    J Clin Pharmacol 42:342-6. 2002
    ..There was no significant difference in CL(MEX)/F of the MEX group and the MEX + AMD group. The results suggest that the pharmacokinetics of mexiletine is not affected by amiodarone in patients with cardiac arrhythmias...
  6. ncbi request reprint Effects of serum concentrations of disopyramide and its metabolite mono-N-dealkyldisopyramide on the anticholinergic side effects associated with disopyramide
    Yoshimasa Tsuchishita
    Department of Pharmacy, Maizuru Kyosai Hospital, Federation of National Public Services and Affiliated Mutual Associations, Kyoto, Japan
    Biol Pharm Bull 31:1368-70. 2008
    ....
  7. ncbi request reprint Impairment of mycophenolate mofetil absorption by calcium polycarbophil
    Ryuji Kato
    Department of Pharmacy, Yokkaichi Social Insurance Hospital, Mie, Japan
    J Clin Pharmacol 42:1275-80. 2002
    ..Therefore, it appears clear that the concomitant administration of mycophenolate mofetil and calcium polycarbophil should be avoided...
  8. ncbi request reprint Effect of clarithromycin on steady-state digoxin concentrations
    Hideko Tanaka
    Department of Pharmacy, National Cardiovascular Center, Osaka, Japan
    Ann Pharmacother 37:178-81. 2003
    ..To evaluate the magnitude and dose-relatedness of the effect of clarithromycin on the pharmacokinetics of digoxin, and to compare the effects of clarithromycin with those of P-glycoprotein inhibitors...
  9. ncbi request reprint [A case in which tofisopam was effective for treatment of paroxysmal supraventricular tachycardia]
    Ryuji Kato
    Department of Pharmacy, Yokkaichi Social Insurance Hospital, 10 8 Hazuyama cho, Yokkaichi City 510 0016, Japan
    Yakugaku Zasshi 123:365-8. 2003
    ..These results suggest that tofisopam overcame the existing imbalance of the sympathetic and vagus nervous system. In this case report, it is suggested that tofisopam is effective for the treatment of PSVT...
  10. ncbi request reprint Intravenous administration of nifekalant hydrochloride for the prevention of ischemia-induced ventricular tachyarrhythmia in patients with renal failure undergoing hemodialysis
    Masafumi Myoishi
    Division of Cardiology, National Cardiovascular Center, Osaka, Japan
    Circ J 67:898-900. 2003
    ..Because NIF is not dialyzed, dose adjustment at relatively low concentrations was required, with monitoring of the QT interval...
  11. ncbi request reprint Effects of adrenomedullin inhalation on hemodynamics and exercise capacity in patients with idiopathic pulmonary arterial hypertension
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Circulation 109:351-6. 2004
    ..Accordingly, we investigated the effects of AM inhalation on pulmonary hemodynamics and exercise capacity in patients with idiopathic pulmonary arterial hypertension...
  12. ncbi request reprint Effect of congestive heart failure on mexiletine pharmacokinetics in a Japanese population
    Mariko Kobayashi
    Department of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
    Biol Pharm Bull 29:2267-9. 2006
    ..The goal of this study was to evaluate the influence of congestive heart failure (CHF) on the clearance of mexiletine...
  13. ncbi request reprint Pharmacokinetic characteristics of amiodarone in long-term oral therapy in Japanese population
    Asami Kashima
    Department of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences Niigata 950 2081, Japan
    Biol Pharm Bull 28:1934-8. 2005
    ..These results suggest that the individual variation in pharmacokinetics of amiodarone is comparatively small, which might be sufficient to decide that the maintenance dose was the same one (200 mg/d) in long-term oral amiodarone therapy...
  14. ncbi request reprint Sequence-based analysis of the CYP2D6*36-CYP2D6*10 tandem-type arrangement, a major CYP2D6*10 haplotype in the Japanese population
    Akiko Soyama
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Drug Metab Pharmacokinet 21:208-16. 2006
    ..This sequence information is an important addition to the CYP2D6 sequence data that was obtained by the human genome project...
  15. ncbi request reprint Effect of amiodarone on the serum concentration/dose ratio of metoprolol in patients with cardiac arrhythmia
    Kyoko Fukumoto
    Department of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences
    Drug Metab Pharmacokinet 21:501-5. 2006
    ..Therefore, careful monitoring of metoprolol concentrations/bioactivity of CYP2D6 is required in the context of co-administration of amiodarone and metoprolol...
  16. ncbi request reprint Catalytic roles of CYP2D6.10 and CYP2D6.36 enzymes in mexiletine metabolism: in vitro functional analysis of recombinant proteins expressed in Saccharomyces cerevisiae
    Nobumitsu Hanioka
    Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    Biochem Pharmacol 71:1386-95. 2006
    ..10. The same tendency was also observed in kinetic analysis for bufuralol 1''-hydroxylation as a representative CYP2D6 probe. These findings suggest that CYP2D6*36 has a more drastic impact on mexiletine metabolism than CYP2D6*10...
  17. ncbi request reprint Stereoselective effect of amiodarone on the pharmacokinetics of racemic carvedilol
    Kyoko Fukumoto
    Department of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Drug Metab Pharmacokinet 20:423-7. 2005
    ..54+/-1.73 ng/mL versus 3.03+/-0.670 ng/mL, P<0.001). These results suggest that metabolism of S-carvedilol was markedly inhibited by coadministration of amiodarone...
  18. ncbi request reprint Effect of protein binding of pilsicainide on the pharmacokinetics
    Kyoko Fukumoto
    Department of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Drug Metab Pharmacokinet 20:183-6. 2005
    ..These results suggest C/D is increased in patients with high CRP levels because of binding of pilsicainide to protein, resulting decreased clearance...
  19. ncbi request reprint Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population
    Akiko Soyama
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 20:24-33. 2005
    ..Our findings provide fundamental and useful information for genotyping CYP1A2 in the Japanese, and probably Asian populations...
  20. ncbi request reprint UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer
    Kimie Sai
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Clin Pharmacol Ther 75:501-15. 2004
    ....
  21. ncbi request reprint Single nucleotide polymorphisms and haplotype frequencies of CYP3A5 in a Japanese population
    Mayumi Saeki
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Hum Mutat 21:653. 2003
    ..Our findings suggest that CYP3A5*3 is the major defective allele and that other functional exonic SNPs are rare in the Japanese...
  22. ncbi request reprint Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population
    Hiromi Fukushima-Uesaka
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Hum Mutat 23:100. 2004
    ..Our findings provide fundamental and useful information for genotyping CYP3A4 (and CYP3A5) in the Japanese, and probably Asian populations...
  23. ncbi request reprint Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan
    Kimie Sai
    Project Team for Pharmacogenetics, Division of Xenobiotic Metabolism and Disposition, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Pharmacogenetics 13:741-57. 2003
    ..These findings suggest that the P-glycoprotein encoded by ABCB1/MDR1 in the proximal tubules plays a substantial role in renal exclusion of drugs and, moreover, that block-haplotyping is valuable for pharmacogenetic studies...
  24. ncbi request reprint Comprehensive UGT1A1 genotyping in a Japanese population by pyrosequencing
    Mayumi Saeki
    Project Team for Pharmacogenetics, Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Clin Chem 49:1182-5. 2003
  25. ncbi request reprint Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population
    Mayumi Saeki
    Project Team for Pharmacogenetics, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Drug Metab Dispos 32:1048-54. 2004
    ..Our findings provide fundamental and useful information for genotyping UGT2B4 and UGT2B7 in the Japanese, and probably other populations...