Tetsuro Suzuki

Summary

Affiliation: National Institute of Infectious Diseases
Country: Japan

Publications

  1. ncbi request reprint Antiapoptotic regulation by hepatitis C virus core protein through up-regulation of inhibitor of caspase-activated DNase
    Rodolfo Sacco
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Virology 317:24-35. 2003
  2. pmc Identification of basal promoter and enhancer elements in an untranslated region of the TT virus genome
    Tetsuro Suzuki
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Virol 78:10820-4. 2004
  3. ncbi request reprint Hepatitis C viral life cycle
    Tetsuro Suzuki
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Adv Drug Deliv Rev 59:1200-12. 2007
  4. ncbi request reprint [Involvement of nonstructural protein 5A and lipids on production of hepatitis C virus particles]
    Tetsuro Suzuki
    National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo
    Uirusu 58:199-205. 2008
  5. pmc Quantitative detection of hepatitis C virus (HCV) RNA in saliva and gingival crevicular fluid of HCV-infected patients
    Tetsuro Suzuki
    Department of Virology II, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    J Clin Microbiol 43:4413-7. 2005
  6. pmc Involvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A protein
    Hiromichi Hara
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Virol 83:5137-47. 2009
  7. doi request reprint Identification of hepatitis C virus genotype 2a replicon variants with reduced susceptibility to ribavirin
    Su Su Hmwe
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Antiviral Res 85:520-4. 2010
  8. ncbi request reprint Highly attenuated vaccinia virus DIs as a potential SARS vaccine
    Koji Ishii
    National Institute of Infectious Diseases, Tokyo, Japan
    Adv Exp Med Biol 581:593-6. 2006
  9. pmc Production of infectious hepatitis C virus by using RNA polymerase I-mediated transcription
    Takahiro Masaki
    Department of Virology II, National Institute of Infectious Diseases, Shinjuku ku, Tokyo 162 8640, Japan
    J Virol 84:5824-35. 2010
  10. pmc Proteasomal turnover of hepatitis C virus core protein is regulated by two distinct mechanisms: a ubiquitin-dependent mechanism and a ubiquitin-independent but PA28gamma-dependent mechanism
    Ryosuke Suzuki
    Department of Virology II, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    J Virol 83:2389-92. 2009

Detail Information

Publications83

  1. ncbi request reprint Antiapoptotic regulation by hepatitis C virus core protein through up-regulation of inhibitor of caspase-activated DNase
    Rodolfo Sacco
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Virology 317:24-35. 2003
    ....
  2. pmc Identification of basal promoter and enhancer elements in an untranslated region of the TT virus genome
    Tetsuro Suzuki
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Virol 78:10820-4. 2004
    ..Furthermore, a 488-nt region upstream of the basal promoter exhibited enhancer activity, presumably in a cell type-specific manner. This study illustrates some of the mechanisms involved in the transcriptional regulation of TTV...
  3. ncbi request reprint Hepatitis C viral life cycle
    Tetsuro Suzuki
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Adv Drug Deliv Rev 59:1200-12. 2007
    ..This review summarizes our current understanding of genomic organization of HCV, features of the viral protein characteristics, and the viral life cycle...
  4. ncbi request reprint [Involvement of nonstructural protein 5A and lipids on production of hepatitis C virus particles]
    Tetsuro Suzuki
    National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo
    Uirusu 58:199-205. 2008
    ..In addition, cholesterol and sphingolipid on the HCV membrane play a key role in virus internalization. Finally, inhibitors of the sphingolipid biosynthetic pathway efficiently block virion production...
  5. pmc Quantitative detection of hepatitis C virus (HCV) RNA in saliva and gingival crevicular fluid of HCV-infected patients
    Tetsuro Suzuki
    Department of Virology II, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    J Clin Microbiol 43:4413-7. 2005
    ..These findings have important implications for medical personnel and suggest that epidemiological studies designed to understand the significance of the oral route of transmission of HCV are warranted...
  6. pmc Involvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A protein
    Hiromichi Hara
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Virol 83:5137-47. 2009
    ..The CKB-NS4A association is a potential target for the development of a new type of antiviral therapeutic strategy...
  7. doi request reprint Identification of hepatitis C virus genotype 2a replicon variants with reduced susceptibility to ribavirin
    Su Su Hmwe
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Antiviral Res 85:520-4. 2010
    ..The results, in addition to analysis of sequence database, suggest that HCV variants with reduced susceptibility to RBV identified are preferential to genotype 2a...
  8. ncbi request reprint Highly attenuated vaccinia virus DIs as a potential SARS vaccine
    Koji Ishii
    National Institute of Infectious Diseases, Tokyo, Japan
    Adv Exp Med Biol 581:593-6. 2006
  9. pmc Production of infectious hepatitis C virus by using RNA polymerase I-mediated transcription
    Takahiro Masaki
    Department of Virology II, National Institute of Infectious Diseases, Shinjuku ku, Tokyo 162 8640, Japan
    J Virol 84:5824-35. 2010
    ..This Pol I-based HCV expression system will be beneficial for a high-throughput antiviral screening and vaccine discovery programs...
  10. pmc Proteasomal turnover of hepatitis C virus core protein is regulated by two distinct mechanisms: a ubiquitin-dependent mechanism and a ubiquitin-independent but PA28gamma-dependent mechanism
    Ryosuke Suzuki
    Department of Virology II, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    J Virol 83:2389-92. 2009
    ..Our results suggest that turnover of this multifunctional viral protein can be tightly controlled via dual ubiquitin-dependent and -independent proteasomal pathways...
  11. ncbi request reprint Hepatitis C virus core protein activates ERK and p38 MAPK in cooperation with ethanol in transgenic mice
    Takeya Tsutsumi
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Hepatology 38:820-8. 2003
    ....
  12. doi request reprint Trans-encapsidation of hepatitis C virus subgenomic replicon RNA with viral structure proteins
    Koji Ishii
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Biochem Biophys Res Commun 371:446-50. 2008
    ....
  13. pmc Role of the endoplasmic reticulum-associated degradation (ERAD) pathway in degradation of hepatitis C virus envelope proteins and production of virus particles
    Mohsan Saeed
    Department of Virology II, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    J Biol Chem 286:37264-73. 2011
    ..A co-immunoprecipitation assay showed that EDEM orthologs do not bind with JEV envelope protein. These findings highlight the crucial role of the ERAD pathway in the life cycle of specific viruses...
  14. doi request reprint Dynamic behavior of hepatitis C virus quasispecies in a long-term culture of the three-dimensional radial-flow bioreactor system
    Kyoko Murakami
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Virol Methods 148:174-81. 2008
    ..Thus, this HCV infection model in the RFB system should be useful for investigating the dynamic behavior of HCV quasispecies in cultured cells and evaluating anti-HCV compounds...
  15. pmc Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles
    Takahiro Masaki
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Virol 82:7964-76. 2008
    ..These results suggest that NS5A plays a key role in regulating the early phase of HCV particle formation by interacting with core protein and that its C-terminal serine cluster is a determinant of the NS5A-core interaction...
  16. pmc Critical role of virion-associated cholesterol and sphingolipid in hepatitis C virus infection
    Hideki Aizaki
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Virol 82:5715-24. 2008
    ....
  17. doi request reprint Cellular vimentin content regulates the protein level of hepatitis C virus core protein and the hepatitis C virus production in cultured cells
    Yuko Nitahara-Kasahara
    Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Toyama, Shinjuku ku, Tokyo, Japan
    Virology 383:319-27. 2009
    ..HCV production was also affected by cellular vimentin content. Our findings together suggest that modulation of hepatic vimentin expression might enable the control of HCV production...
  18. ncbi request reprint [Advances in research on HCV replication and virion formation]
    Tetsuro Suzuki
    Department of Virology II, National Institute of Infectious, Diseases, Japan
    Uirusu 60:87-92. 2010
    ..Involvement of lipid droplet, lipid metabolism and the viral nonstructural proteins in the production of the infectious particles has also been revealed...
  19. pmc Evaluation of hepatitis C virus core antigen assays in detecting recombinant viral antigens of various genotypes
    Mohsan Saeed
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    J Clin Microbiol 47:4141-3. 2009
    ..Quantitation of the antigen is improved by using a distinct anticore antibody with a different epitope...
  20. pmc RNA polymerase activity and specific RNA structure are required for efficient HCV replication in cultured cells
    Asako Murayama
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    PLoS Pathog 6:e1000885. 2010
    ..In conclusion, N3H, high polymerase activity, enhanced kissing-loop interactions, and optimal viral RNA structure in the 3'UTR were required for J6CF replication in cultured cells...
  21. doi request reprint Chaperonin TRiC/CCT participates in replication of hepatitis C virus genome via interaction with the viral NS5B protein
    Yasushi Inoue
    Department of Virology II, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    Virology 410:38-47. 2011
    ....
  22. pmc Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS2
    Ryosuke Suzuki
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    PLoS Pathog 9:e1003589. 2013
    ....
  23. doi request reprint E6AP ubiquitin ligase mediates ubiquitin-dependent degradation of peroxiredoxin 1
    Junichi Nasu
    Department of Virology II, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    J Cell Biochem 111:676-85. 2010
    ..Our findings raise a possibility that E6AP may play a role in regulating Prx1-dependent intracellular oxidative signal transduction pathways...
  24. ncbi request reprint Hepatitis C virus core protein exerts an inhibitory effect on suppressor of cytokine signaling (SOCS)-1 gene expression
    Hideyuki Miyoshi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Hepatol 43:757-63. 2005
    ..We studied the effect of the core protein of hepatitis C virus (HCV) on the expression of SOCS-1 gene...
  25. ncbi request reprint Transcriptomic comparison of human hepatoma Huh-7 cell clones with different hepatitis C virus replication efficiencies
    Yasushi Inoue
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Jpn J Infect Dis 60:173-8. 2007
    ..The genes identified in this study should be examined further to determine their roles in HCV RNA replication. The Huh-7 subclones identified in this study provide a tool for identifying novel host factors involved in viral replication...
  26. ncbi request reprint Down-regulation of the internal ribosome entry site (IRES)-mediated translation of the hepatitis C virus: critical role of binding of the stem-loop IIId domain of IRES and the viral core protein
    Takashi Shimoike
    Department of Virology II, National Institute of Infectious Diseases, Musashi Murayama, Tokyo 208 0011, Japan
    Virology 345:434-45. 2006
    ..We propose a model in which competitive binding of the core protein for the IRES and 40S ribosomal subunit regulates HCV translation...
  27. pmc Identification and characterization of the human inhibitor of caspase-activated DNase gene promoter
    Kazuhiko Omata
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo, Japan
    Apoptosis 13:929-37. 2008
    ..Structural analysis of the human ICAD promoter and identification of factors which regulate its activity might further our understanding of the biological role of ICAD with respect to regulation of apoptosis and cancer development...
  28. pmc Antiviral activity of glycyrrhizin against hepatitis C virus in vitro
    Yoshihiro Matsumoto
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    PLoS ONE 8:e68992. 2013
    ..Finally, we demonstrated that combination treatment with GL augmented IFN-induced reduction of virus in the HCVcc system. GL is identified as a novel anti-HCV agent that targets infectious virus particle release. ..
  29. ncbi request reprint Production and release of infectious hepatitis C virus from human liver cell cultures in the three-dimensional radial-flow bioreactor
    Hideki Aizaki
    Department of Virology II, National Institute of Infectious Diseases, Shinjuku ku, Tokyo 162 8640, Japan
    Virology 314:16-25. 2003
    ..It will also accelerate research into the pathogenicity of HCV, as well as the development of prophylactic agents and new therapy...
  30. pmc The NS3 helicase and NS5B-to-3'X regions are important for efficient hepatitis C virus strain JFH-1 replication in Huh7 cells
    Asako Murayama
    Department of Virology II, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku, Tokyo 162 8640, Japan
    J Virol 81:8030-40. 2007
    ..In conclusion, the JFH-1 NS3 helicase and NS5B-to-3'X regions are important for efficient replication and virus particle formation of HCV genotype 2a strains...
  31. ncbi request reprint Alteration of intrahepatic cytokine expression and AP-1 activation in transgenic mice expressing hepatitis C virus core protein
    Takeya Tsutsumi
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Virology 304:415-24. 2002
    ..Thus, the altered in vivo expression of cytokines with AP-1 activation in consequence to the core protein expression may contribute to hepatocarcinogenesis in persistent HCV infection...
  32. doi request reprint Identification of annexin A1 as a novel substrate for E6AP-mediated ubiquitylation
    Tetsu Shimoji
    Department of Virology II, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    J Cell Biochem 106:1123-35. 2009
    ..Our findings raise the possibility that E6AP may play a role in controlling the diverse functions of annexin A1 through the ubiquitin-proteasome pathway...
  33. pmc All-trans retinoic acid down-regulates human albumin gene expression through the induction of C/EBPbeta-LIP
    Takahiro Masaki
    Department of Virology II, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    Biochem J 397:345-53. 2006
    ....
  34. doi request reprint Selective estrogen receptor modulators inhibit hepatitis C virus infection at multiple steps of the virus life cycle
    Yuko Murakami
    Department of Bioactive Molecules, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    Microbes Infect 15:45-55. 2013
    ..Taken together, SERMs seemed to target multiple steps of HCV viral life cycle: attachment, entry, replication, and post replication events. SERMs may be potential candidates for the treatment of HCV infection...
  35. doi request reprint Trans-complemented hepatitis C virus particles as a versatile tool for study of virus assembly and infection
    Ryosuke Suzuki
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Virology 432:29-38. 2012
    ..These results demonstrate that our plasmid-based system for efficient production of HCVtcp is beneficial for studying HCV life cycles, particularly in viral assembly and infection...
  36. pmc Visualization and measurement of ATP levels in living cells replicating hepatitis C virus genome RNA
    Tomomi Ando
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    PLoS Pathog 8:e1002561. 2012
    ..ATeam may be a powerful tool for the study of energy metabolism during replication of the viral genome...
  37. doi request reprint Virological characterization of the hepatitis C virus JFH-1 strain in lymphocytic cell lines
    Kyoko Murakami
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Gen Virol 89:1587-92. 2008
    ..Our results suggest that lymphocytic cells can support HCV JFH-1 translation and polyprotein processing, but may lack some host factors essential for HCV JFH-1 infection and replication...
  38. doi request reprint Hepatitis C virus RNA replication in human stellate cells regulates gene expression of extracellular matrix-related molecules
    Noriyuki Watanabe
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Biochem Biophys Res Commun 407:135-40. 2011
    ..The HCV RNA-replicating hepatic stellate cell line isolated in this study will be useful for investigating hepatic stellate cell functions and HCV replication machinery...
  39. ncbi request reprint [Hepatitis C virus replication associated with lipid rafts]
    Hideki Aizaki
    Department of Virology II, National Institute of Infectious Diseases, Shinjuku ku, Tokyo 162 8640, Japan
    Seikagaku 78:321-6. 2006
  40. doi request reprint Structural requirements of virion-associated cholesterol for infectivity, buoyant density and apolipoprotein association of hepatitis C virus
    Mami Yamamoto
    Department of Virology II, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo, Japan
    J Gen Virol 92:2082-7. 2011
    ..We also provide evidence that virion-associated cholesterol contributes to the interaction between HCV particles and apolipoprotein E. The molecular basis for the effects of different sterols on HCV infectivity is discussed...
  41. ncbi request reprint Proteomic profiling of lipid droplet proteins in hepatoma cell lines expressing hepatitis C virus core protein
    Shigeko Sato
    Department of Biochemistry and Cell Biology and Department of Virology II, National Institute of Infectious Diseases, Tokyo 162 8640
    J Biochem 139:921-30. 2006
    ..These results suggest that lipid droplets containing HCV core protein may participate in the RNA metabolism of the host and/or HCV, affecting the pathopoiesis and/or virus replication/production in HCV-infected cells...
  42. doi request reprint Pathogenesis of lipid metabolism disorder in hepatitis C: polyunsaturated fatty acids counteract lipid alterations induced by the core protein
    Hideyuki Miyoshi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Hepatol 54:432-8. 2011
    ..Experimental studies have revealed that the core protein of hepatitis C virus (HCV) induces steatosis...
  43. ncbi request reprint CYP3A4 inducible model for in vitro analysis of human drug metabolism using a bioartificial liver
    Tohru Iwahori
    Department of Biochemistry, The Jikei University School of Medicine, Tokyo, Japan
    Hepatology 37:665-73. 2003
    ..In conclusion, the bioartificial liver composed of human functional HCC cell line was useful in studying drug interactions during induction of human CYP3A4...
  44. ncbi request reprint Expression profiling of liver cell lines expressing entire or parts of hepatitis C virus open reading frame
    Hideki Aizaki
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Hepatology 36:1431-8. 2002
    ..In conclusion, functional genomic approaches comparing expression among the different cell lines expressing parts of the HCV genome may promote our understanding of the molecular basis of pathogenicity of HCV infection...
  45. ncbi request reprint Enhancement of de novo fatty acid biosynthesis in hepatic cell line Huh7 expressing hepatitis C virus core protein
    Masayoshi Fukasawa
    Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Tokyo, Japan
    Biol Pharm Bull 29:1958-61. 2006
    ..Up-regulation of de novo fatty acid biosynthesis by HCV core protein may affect cellular lipid metabolism, resulting in neutral lipid accumulation in HCV-infected cells...
  46. ncbi request reprint Production of infectious hepatitis C virus particles in three-dimensional cultures of the cell line carrying the genome-length dicistronic viral RNA of genotype 1b
    Kyoko Murakami
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Virology 351:381-92. 2006
    ..We conclude that the replicon-based 3D culture system allows the production of infectious HCV particles. This system is a valuable tool in studies of HCV morphogenesis in a natural host cell environment...
  47. doi request reprint Biological properties of purified recombinant HCV particles with an epitope-tagged envelope
    Hitoshi Takahashi
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Biochem Biophys Res Commun 395:565-71. 2010
    ..Purified HCV particle-immunization induced both an anti-E2 and an anti-FLAG antibody response in immunized mice. This strategy may contribute to future detailed analysis of HCV particle structure and to HCV vaccine development...
  48. pmc E6AP ubiquitin ligase mediates ubiquitylation and degradation of hepatitis C virus core protein
    Masayuki Shirakura
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Virol 81:1174-85. 2007
    ..We propose that the E6AP-mediated ubiquitin-proteasome pathway may affect the production of HCV particles through controlling the amounts of viral nucleocapsid protein...
  49. doi request reprint Replication of hepatitis C virus genotype 3a in cultured cells
    Mohsan Saeed
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Gastroenterology 144:56-58.e7. 2013
    ..We identified cell culture-adaptive mutations that increased colony formation multiple-fold. We have therefore established a genotype 3a replicon system that can be used to study this HCV genotype...
  50. pmc In vivo adaptation of hepatitis C virus in chimpanzees for efficient virus production and evasion of apoptosis
    Mohsan Saeed
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Hepatology 54:425-33. 2011
    ..Furthermore, the cells harboring this strain displayed lower susceptibility to the apoptosis induced by tumor necrosis factor α or Fas ligand compared with the cells replicating JFH-1/wt...
  51. ncbi request reprint Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity
    Takeya Tsutsumi
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Hepatology 35:937-46. 2002
    ..In conclusion, these results suggest that modulation of RXRalpha-controlled gene expression via interaction with the core protein contributes to the pathogenesis of HCV infection...
  52. doi request reprint Enhanced expression of lymphomagenesis-related genes in peripheral blood B cells of chronic hepatitis C patients
    Masahiko Ito
    Department of Research on Blood and Biological Products, National Institute of Infectious Diseases, Musashi Murayama shi, Tokyo 208 0011, Japan
    Clin Immunol 135:459-65. 2010
    ..These results suggest a possible relationship between chronic HCV infection and B-lymphomagenesis...
  53. pmc Nonstructural 5A Protein of Hepatitis C Virus Interferes with Toll-Like Receptor Signaling and Suppresses the Interferon Response in Mouse Liver
    Takeya Tsutsumi
    Department of Internal Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    PLoS ONE 12:e0170461. 2017
    ....
  54. doi request reprint Single-domain intrabodies against hepatitis C virus core inhibit viral propagation and core-induced NFκB activation
    Ryosuke Suzuki
    1 Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    J Gen Virol 97:887-92. 2016
    ..Furthermore, intrabody expression suppressed HCV core-induced NFκB promoter activity. These intrabodies may therefore serve as tools for elucidating the role of core in HCV pathogenesis. ..
  55. pmc Prolactin Regulatory Element Binding Protein Is Involved in Hepatitis C Virus Replication by Interaction with NS4B
    Lingbao Kong
    Department of Virology II, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    J Virol 90:3093-111. 2016
    ..Furthermore, PREB was induced by HCV infection in vitro and in vivo. Our findings provide new insights into HCV host cofactors...
  56. doi request reprint Alternative endocytosis pathway for productive entry of hepatitis C virus
    Mami Matsuda
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    J Gen Virol 95:2658-67. 2014
    ..Collectively, these data indicated that HCV entered different target cells through different entry routes. ..
  57. pmc Targeting cellular squalene synthase, an enzyme essential for cholesterol biosynthesis, is a potential antiviral strategy against hepatitis C virus
    Kyoko Saito
    Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Tokyo, Japan
    J Virol 89:2220-32. 2015
    ..Collectively, our findings highlight the importance of the cholesterol biosynthetic pathway in HCV production and implicate SQS as a potential target for antiviral strategies against HCV...
  58. pmc Molecular determinants for subcellular localization of hepatitis C virus core protein
    Ryosuke Suzuki
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo, Japan 162 8640
    J Virol 79:1271-81. 2005
    ..Differences in the cellular trafficking of HCV core protein, achieved and maintained by multiple targeting functions as mentioned above, may in part regulate the diverse range of biological roles of the core protein...
  59. ncbi request reprint A cell-based, microplate colorimetric screen identifies 7,8-benzoflavone and green tea gallate catechins as inhibitors of the hepatitis C virus
    Hidesuke Fukazawa
    Department of Bioactive Molecules, National Institute of Infectious Diseases, Tokyo, Japan
    Biol Pharm Bull 35:1320-7. 2012
    ..This assay is simple, reliable and cost-effective; does not require any specially engineered cell lines or viruses; and should be useful in the identification of compounds with anti-HCV activity...
  60. doi request reprint Identification of bisindolylmaleimides and indolocarbazoles as inhibitors of HCV replication by tube-capture-RT-PCR
    Yuko Murakami
    Department of Bioactive Molecules, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    Antiviral Res 83:112-7. 2009
    ..These series of compounds represent new classes of inhibitors that may warrant further development...
  61. ncbi request reprint [Development of HCV infection system and HCV-RNA replication system]
    Kyoko Murakami
    Department of Virology II, National Institute of Infectious Diseases
    Nihon Rinsho 62:111-5. 2004
  62. ncbi request reprint Molecular biology of hepatitis C virus
    Tetsuro Suzuki
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Tokyo, Japan
    J Gastroenterol 42:411-23. 2007
    ..This review summarizes the current knowledge of cell culture systems for HCV research and recent advances in the investigation of the molecular virology of HCV...
  63. doi request reprint Seroprevalence of trichodysplasia spinulosa-associated polyomavirus in Japan
    Hitomi Fukumoto
    Department of Pathology, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan Department of Dermatology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    J Clin Virol 65:76-82. 2015
    ..To date, serological analyses have revealed that TSV infection is common among adults in the general population of Europe and Australia. However, there have been no reports of TSV in Asia...
  64. ncbi request reprint Reduction of hepatitis C virus NS5A phosphorylation through its interaction with amphiphysin II
    Atsuko Masumi
    Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo, Japan
    Biochem Biophys Res Commun 336:572-8. 2005
    ..In vitro kinase assays demonstrated that its interaction with amphiphysin II inhibits phosphorylation of NS5A. These results suggest that amphiphysin II participates in the HCV life cycle by modulating the phosphorylation of NS5A...
  65. doi request reprint Retinoids and rexinoids inhibit hepatitis C virus independently of retinoid receptor signaling
    Yuko Murakami
    Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Tokyo 162 8640, Japan Electronic address
    Microbes Infect 16:114-22. 2014
    ..These series of compounds warrant further investigation as new class of HCV drugs, for the clinical translation of our observation may lead to increased anti-HCV efficacy. ..
  66. ncbi request reprint Outbreak of hepatitis C virus infection in an outpatient clinic
    Takashi Ishikawa
    Department of Internal Medicine, University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 20:1087-93. 2005
    ..Six were outpatients of the clinic, which is located near the hospital. An extensive survey of clinic outpatients conducted by the local health department revealed six more new acute hepatitis cases during this period...
  67. ncbi request reprint [Mechanism of HCV-RNA replication]
    Hideki Aizaki
    Department of Virology II, National Institute of Infectious Diseases
    Nihon Rinsho 62:81-4. 2004
  68. ncbi request reprint [Replication of hepatitis delta virus]
    Tetsuro Suzuki
    Department of Virology II, National Institute of Infectious Diseases
    Nihon Rinsho 62:393-7. 2004
  69. ncbi request reprint GBV-B as a pleiotropic virus: distribution of GBV-B in extrahepatic tissues in vivo
    Koji Ishii
    Department of Virology II, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Microbes Infect 9:515-21. 2007
    ..These results indicate that GBV-B as well as HCV is a pleiotropic virus in vivo...
  70. ncbi request reprint Induction of protective immunity against severe acute respiratory syndrome coronavirus (SARS-CoV) infection using highly attenuated recombinant vaccinia virus DIs
    Koji Ishii
    Department of Virology II, National Institute of Infectious Diseases, Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Virology 351:368-80. 2006
    ..Thus, replication-deficient DIs constructs hold promise for the development of a safe and potent SARS vaccine...
  71. pmc Rapid genome sequencing of RNA viruses
    Tetsuya Mizutani
    Department of Virology 1, National Institute of Infectious Diseases, Musashimurayama City, Tokyo, Japan
    Emerg Infect Dis 13:322-4. 2007
    ..This method affords new opportunities to address the challenges of unknown or untypeable emerging viruses...
  72. pmc Critical role of PA28gamma in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis
    Kohji Moriishi
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 104:1661-6. 2007
    ..These findings suggest that PA28gamma plays a crucial role in the development of liver pathology induced by HCV infection...
  73. pmc Proteasome activator PA28gamma-dependent nuclear retention and degradation of hepatitis C virus core protein
    Kohji Moriishi
    Research Center for Emerging Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita Shi, Osaka 565 0871, Japan
    J Virol 77:10237-49. 2003
    ..Overexpression of PA28gamma enhanced the proteolysis of the HCV core protein. Thus, the nuclear retention and stability of the HCV core protein is regulated via a PA28gamma-dependent pathway through which HCV pathogenesis may be exerted...
  74. pmc Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication
    Shuhei Taguwa
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    J Virol 82:2631-41. 2008
    ..These results suggest that hB-ind1 plays a crucial role in HCV RNA replication and the propagation of JFH1 virus through interaction with viral and host proteins...
  75. pmc Involvement of the PA28gamma-dependent pathway in insulin resistance induced by hepatitis C virus core protein
    Hironobu Miyamoto
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Virol 81:1727-35. 2007
    ..These results suggest that the HCV core protein suppresses insulin signaling through a PA28gamma-dependent pathway...
  76. pmc Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90
    Toru Okamoto
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    EMBO J 25:5015-25. 2006
    ..These results suggest that the complex consisting of NS5A, FKBP8, and Hsp90 plays an important role in HCV RNA replication...
  77. pmc Oligomerization of hepatitis C virus core protein is crucial for interaction with the cytoplasmic domain of E1 envelope protein
    Kousuke Nakai
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, 3 1, Yamadaoka, Suita, Osaka 565 0871, Japan
    J Virol 80:11265-73. 2006
    ..Taken together, our studies suggest that interaction between the self-oligomerized HCV core and the E1 glycoprotein is mediated through the cytoplasmic loop present in a polytopic form of the E1 glycoprotein...
  78. pmc A single-amino-acid mutation in hepatitis C virus NS5A disrupting FKBP8 interaction impairs viral replication
    Toru Okamoto
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, 3 1, Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    J Virol 82:3480-9. 2008
    ..These results suggest that specific interaction of NS5A with FKBP8 in the cytoplasmic compartment plays a crucial role in the replication of HCV...
  79. pmc Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B
    Itsuki Hamamoto
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, 3 1, Yamadaoka, Suita, Osaka 565 0871, Japan
    J Virol 79:13473-82. 2005
    ..These results suggest that VAP-B, in addition to VAP-A, plays an important role in the replication of the HCV genome...
  80. ncbi request reprint Differential cellular gene expression induced by hepatitis B and C viruses
    Motoyuki Otsuka
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 300:443-7. 2003
    ..Combined, these microarray results shed new light on the effects of HBV proteins on cellular gene expression and on the differences in the pathogenic activities of these two hepatitis viruses...
  81. pmc Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus
    Craig R Brunetti
    BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada N6G 2V4
    J Virol 77:13335-47. 2003
    ..Finally, we summarize the predicted immunomodulatory protein repertoire in the Yatapoxvirus genus as a whole...
  82. ncbi request reprint Overexpression of hepatitis C virus NS5A protein induces chromosome instability via mitotic cell cycle dysregulation
    Kwan Hyuck Baek
    Research Institute, National Cancer Center, Goyang, South Korea
    J Mol Biol 359:22-34. 2006
    ....
  83. pmc Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation
    Kiyoko Okamoto
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    J Virol 82:8349-61. 2008
    ..These results suggest that intramembrane processing of HCV core protein by SPP is required for the localization of the HCV core protein in the DRM and for viral propagation...