Mineshi Sakamoto

Summary

Affiliation: National Institute for Minamata Disease
Country: Japan

Publications

  1. ncbi request reprint Evaluation of changes in methylmercury accumulation in the developing rat brain and its effects: a study with consecutive and moderate dose exposure throughout gestation and lactation periods
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, 4058 18 Hama, Minamata, Kumamoto 867 0008, Japan
    Brain Res 949:51-9. 2002
  2. doi request reprint Stable and episodic/bolus patterns of methylmercury exposure on mercury accumulation and histopathologic alterations in the nervous system
    Mineshi Sakamoto
    National Institute for Minamata Disease, Kumamoto, Japan Universidade Federal do Oeste do ParĂ¡, ICED PPGBIO PPGRNA LABBEX, Santarem, Brazil Electronic address
    Environ Res 152:446-453. 2017
  3. doi request reprint Implications of mercury concentrations in umbilical cord tissue in relation to maternal hair segments as biomarkers for prenatal exposure to methylmercury
    Mineshi Sakamoto
    National Institute for Minamata Disease, Kumamoto 867 0008, Japan Obstetrics and Gynecology, Fukuda Hospital, Kumamoto 860 0004, Japan Electronic address
    Environ Res 149:282-7. 2016
  4. doi request reprint Mercury speciation and selenium in toothed-whale muscles
    Mineshi Sakamoto
    National Institute for Minamata Disease, Hama 4058 18, Minamata, Kumamoto 867 0008, Japan Electronic address
    Environ Res 143:55-61. 2015
  5. doi request reprint Significance of fingernail and toenail mercury concentrations as biomarkers for prenatal methylmercury exposure in relation to segmental hair mercury concentrations
    Mineshi Sakamoto
    Department of Environmental Sciences and Epidemiology, National Institute for Minamata Disease, Minamata, Japan Electronic address
    Environ Res 136:289-94. 2015
  6. doi request reprint Relationships between trace element concentrations in chorionic tissue of placenta and umbilical cord tissue: potential use as indicators for prenatal exposure
    Mineshi Sakamoto
    Department of Environmental Science and Epidemiology, National Institute for Minamata Disease, Minamata, Japan Electronic address
    Environ Int 60:106-11. 2013
  7. doi request reprint Selenomethionine protects against neuronal degeneration by methylmercury in the developing rat cerebrum
    Mineshi Sakamoto
    National Institute for Minamata Disease, Minamata, Kumamoto 867 0008, Japan
    Environ Sci Technol 47:2862-8. 2013
  8. doi request reprint Changes in body burden of mercury, lead, arsenic, cadmium and selenium in infants during early lactation in comparison with placental transfer
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, Minamata, Japan
    Ecotoxicol Environ Saf 84:179-84. 2012
  9. doi request reprint Mercury and docosahexaenoic acid levels in maternal and cord blood in relation to segmental maternal hair mercury concentrations at parturition
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, Minamata, Japan
    Environ Int 44:112-7. 2012
  10. pmc Plasma fatty acid profiles in 37 pairs of maternal and umbilical cord blood samples
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, 4058 18 Hama, 867 0008, Minamata, Kumamoto, Japan
    Environ Health Prev Med 9:67-9. 2004

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Evaluation of changes in methylmercury accumulation in the developing rat brain and its effects: a study with consecutive and moderate dose exposure throughout gestation and lactation periods
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, 4058 18 Hama, Minamata, Kumamoto 867 0008, Japan
    Brain Res 949:51-9. 2002
    ..Thus, although offspring are subjected to consecutive and moderate dose MeHg exposure throughout both the gestation and suckling periods, the risk is especially high during gestation but may decrease during lactation...
  2. doi request reprint Stable and episodic/bolus patterns of methylmercury exposure on mercury accumulation and histopathologic alterations in the nervous system
    Mineshi Sakamoto
    National Institute for Minamata Disease, Kumamoto, Japan Universidade Federal do Oeste do ParĂ¡, ICED PPGBIO PPGRNA LABBEX, Santarem, Brazil Electronic address
    Environ Res 152:446-453. 2017
    ..These results suggest that stable and episodic/bolus patterns of MeHg exposure do not cause differences in Hg accumulation in the blood and brain, or in neurological alterations, when the total doses are the same...
  3. doi request reprint Implications of mercury concentrations in umbilical cord tissue in relation to maternal hair segments as biomarkers for prenatal exposure to methylmercury
    Mineshi Sakamoto
    National Institute for Minamata Disease, Kumamoto 867 0008, Japan Obstetrics and Gynecology, Fukuda Hospital, Kumamoto 860 0004, Japan Electronic address
    Environ Res 149:282-7. 2016
    ..37 and 24.09, respectively. This information will be useful for evaluating maternal MeHg exposure levels in retrospective studies using preserved umbilical cord tissue. ..
  4. doi request reprint Mercury speciation and selenium in toothed-whale muscles
    Mineshi Sakamoto
    National Institute for Minamata Disease, Hama 4058 18, Minamata, Kumamoto 867 0008, Japan Electronic address
    Environ Res 143:55-61. 2015
    ..HgSe was mainly localized in cells near the endomysium using electron probe microanalysis (EPMA). These results suggested that the demethylated MeHg finally deposits within muscle cells of bottlenose dolphin as an inert HgSe. ..
  5. doi request reprint Significance of fingernail and toenail mercury concentrations as biomarkers for prenatal methylmercury exposure in relation to segmental hair mercury concentrations
    Mineshi Sakamoto
    Department of Environmental Sciences and Epidemiology, National Institute for Minamata Disease, Minamata, Japan Electronic address
    Environ Res 136:289-94. 2015
    ..To investigate the appropriateness of mercury (Hg) concentrations in fingernails and toenails at parturition for detecting prenatal exposure to methylmercury (MeHg)...
  6. doi request reprint Relationships between trace element concentrations in chorionic tissue of placenta and umbilical cord tissue: potential use as indicators for prenatal exposure
    Mineshi Sakamoto
    Department of Environmental Science and Epidemiology, National Institute for Minamata Disease, Minamata, Japan Electronic address
    Environ Int 60:106-11. 2013
    ..As an exception, the Cd concentration in placenta showed a moderate but significant correlation (rs=0.41) with that in maternal RBCs, suggesting that the placenta is useful for predicting maternal exposure to Cd during gestation. ..
  7. doi request reprint Selenomethionine protects against neuronal degeneration by methylmercury in the developing rat cerebrum
    Mineshi Sakamoto
    National Institute for Minamata Disease, Minamata, Kumamoto 867 0008, Japan
    Environ Sci Technol 47:2862-8. 2013
    ..These findings serve as a proof that dietary selenium can directly protect neurons against MeHg toxicity in the mammalian brain, especially in the developing cerebrum...
  8. doi request reprint Changes in body burden of mercury, lead, arsenic, cadmium and selenium in infants during early lactation in comparison with placental transfer
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, Minamata, Japan
    Ecotoxicol Environ Saf 84:179-84. 2012
    ..In conclusion, although pregnant women should pay attention to avoid high methylmercury exposure, element exposure through breast-feeding does not pose any great concern in this population...
  9. doi request reprint Mercury and docosahexaenoic acid levels in maternal and cord blood in relation to segmental maternal hair mercury concentrations at parturition
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, Minamata, Japan
    Environ Int 44:112-7. 2012
    ..43) and fourth (r=0.38) 1-cm hair segments, suggesting that maternal and fetal DHA levels reflects maternal fish intake during mid-gestation...
  10. pmc Plasma fatty acid profiles in 37 pairs of maternal and umbilical cord blood samples
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, 4058 18 Hama, 867 0008, Minamata, Kumamoto, Japan
    Environ Health Prev Med 9:67-9. 2004
    ..In order to study the fatty acid transfer from the mother to fetus, their fatty acid profiles were compared by 37 pairs of maternal and umbilical cord plasma specimens obtained from healthy Japanese women at delivery...
  11. pmc High exposure of Chinese mercury mine workers to elemental mercury vapor and increased methylmercury levels in their hair
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, Minamata, Japan
    Environ Health Prev Med 12:66-70. 2007
    ..In addition, the level of methylmercury (MeHg) intake by the workers was estimated from the MeHg concentration in their hair...
  12. doi request reprint Retrospective study on temporal and regional variations of methylmercury concentrations in preserved umbilical cords collected from inhabitants of the Minamata area, Japan
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, 4058 18 Hama, Minamata, Kumamoto 867 0008, Japan
    Ecotoxicol Environ Saf 73:1144-9. 2010
    ..Elevated methylmercury concentrations were first observed in the districts of Minamata, followed by Izumi, Tsunagi and Ashikita, indicating the time-course-dependent regional distributions of methylmercury pollution...
  13. doi request reprint Mercury and heavy metal profiles of maternal and umbilical cord RBCs in Japanese population
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, 4058 18 Hama, Minamata, Kumamoto 867 0008, Japan
    Ecotoxicol Environ Saf 73:1-6. 2010
    ..Hg showed positive correlations with Se in maternal RBCs but not in cord RBCs, and the Se/Hg molar ratio was lower in the latter, suggesting that the protective effects of Se against MeHg are less expected in fetuses than in mothers...
  14. ncbi request reprint Changes in mercury concentrations of segmental maternal hair during gestation and their correlations with other biomarkers of fetal exposure to methylmercury in the Japanese population
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, Kumamoto 867 0008, Japan
    Environ Res 106:270-6. 2008
    ..In addition, the segmental maternal hair throughout gestation is essential to obtain important information on MeHg exposure during the different sensitive windows or bolus MeHg exposure during gestation...
  15. ncbi request reprint Declining Minamata male birth ratio associated with increased male fetal death due to heavy methylmercury pollution
    M Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, Minamata City, Kumamoto, Japan
    Environ Res 87:92-8. 2001
    ..It is possible that male fetuses were more susceptible to the pollution than their female counterparts, and this could be a cause for the lower numbers of male offspring at birth...
  16. ncbi request reprint Dose-dependent effects of methylmercury administered during neonatal brain spurt in rats
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, 4058 18 Hama, Minamata, Kumamoto 867 0008, Japan
    Brain Res Dev Brain Res 152:171-6. 2004
    ..These findings using neonatal rats will be useful for better understanding of the effects of MeHg in the developing human brain during gestation...
  17. ncbi request reprint Declining risk of methylmercury exposure to infants during lactation
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, 4058 18 Hama, Minamata, 867 0008, Kumamoto, Japan
    Environ Res 90:185-9. 2002
    ..9 times of that at birth. Thus, offspring are subjected to MeHg exposure through both the gestation and the breast-feeding periods; the risk is especially high during gestation but may decrease during breast-feeding...
  18. ncbi request reprint Maternal and fetal mercury and n-3 polyunsaturated fatty acids as a risk and benefit of fish consumption to fetus
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, 4058 18 Hama, Minamata, Kumamoto 867 0008, Japan
    Environ Sci Technol 38:3860-3. 2004
    ..Pregnant women in particular need not give up eating fish to obtain such benefits. However, they would do well to at least consume smaller fish, which contain less MeHg, thereby balancing the risks and benefits from fish comsumption...
  19. ncbi request reprint Correlations between mercury concentrations in umbilical cord tissue and other biomarkers of fetal exposure to methylmercury in the Japanese population
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, Kumamoto 867 0008, Japan
    Environ Res 103:106-11. 2007
    ..The findings of this study indicate the significance of cord tissue THg and MeHg as biomarkers for fetal exposure to MeHg at parturition...
  20. ncbi request reprint Mercury concentration in hair samples from Chinese people in coastal cities
    Xiaojie Liu
    National Institute for Minamata Disease, Ministry of the Environment, 4058 18 Hama, Minamata City, Kumamoto 867 0008, Japan
    J Environ Sci (China) 20:1258-62. 2008
    ..Very little females (0.3%) of reproductive age showed hair mercury levels close to 10 microg/g. It was thus concluded that fish consumption was a major current route for mercury exposure in China...
  21. doi request reprint Increased methylmercury toxicity related to obesity in diabetic KK-Ay mice
    Megumi Yamamoto
    Integrated Physiology Section, Department of Basic Medical Science, National Institute for Minamata Disease, Minamata, Kumamoto, Japan
    J Appl Toxicol 34:914-23. 2014
    ..These results indicate that body fat gain in type 2 diabetes mellitus and low mercury accumulation in adipose tissue increased MeHg concentrations in organs and enhanced toxicity in KK-Ay mice at the same dose of MeHg per BW...
  22. ncbi request reprint [Comparison of current activities of daily living (ADL) scores of fetal-type minamata disease patients with their ADL scores 15 years ago and communication disorders of these patients]
    Xiao Jie Liu
    Department of Epidemiology, National Institute for Minamata Disease, Kumamoto, Japan
    Nihon Eiseigaku Zasshi 62:905-10. 2007
    ....
  23. doi request reprint Methylmercury exposure and neurological outcomes in Taiji residents accustomed to consuming whale meat
    Masaaki Nakamura
    Department of Clinical Medicine, National Institute for Minamata Disease, Minamata, Japan Electronic address
    Environ Int 68:25-32. 2014
    ..These findings suggested that sufficient Se intake might be one of causes of the absence of adverse effects of MeHg exposure in this study...
  24. ncbi request reprint Effects of methylmercury on neurodevelopment in Japanese children in relation to the Madeiran study
    Katsuyuki Murata
    Division of Environmental Health Sciences, Department of Social Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Int Arch Occup Environ Health 77:571-9. 2004
    ....
  25. ncbi request reprint Neuronal migration disturbance and consequent cytoarchitecture in the cerebral cortex following transplacental administration of methylmercury
    Akiyoshi Kakita
    The Brain Disease Research Center, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951 8585, Japan
    Acta Neuropathol 104:409-17. 2002
    ..These results suggest that it is the extrinsic circumstances - rather than the timing of neuron generation - that regulates the expression of these proteins...
  26. ncbi request reprint Effects of low dose methylmercury administration during the postnatal brain growth spurt in rats
    Addolorata Coluccia
    Department of Pharmacology and Human Physiology, Medical School, University of Bari, Policlinico, Piazza G Cesare 11, 70124 Bari, Italy
    Neurotoxicol Teratol 29:282-7. 2007
    ..The present results show that low level exposure to MeHg during late brain growth spurt induces subtle and persistent motor and learning deficits, further underlining the serious potential hazard for the exposed children...
  27. ncbi request reprint Methylmercury exposure and health effects in humans: a worldwide concern
    Donna Mergler
    Department of Biological Sciences, Institute for Environmental Sciences, University of Quebec, Montreal, Canada
    Ambio 36:3-11. 2007
    ....
  28. ncbi request reprint Total mercury levels in hair, toenail, and urine among women free from occupational exposure and their relations to renal tubular function
    Tomoko Ohno
    Department of Environmental Health Sciences, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Environ Res 103:191-7. 2007
    ..Also, the following equation may be applicable to the population neither with dental amalgam fillings nor with occupational exposures: [hair mercury (microg/g)]=2.44x[toenail mercury (microg/g)]...
  29. ncbi request reprint Estimation of daily mercury intake from seafood in Japanese women: Akita cross-sectional study
    Yoko Iwasaki
    Environmental Health Department, Ministry of the Environment, Tokyo 100 8975, Japan
    Tohoku J Exp Med 200:67-73. 2003
    ..Daily methylmercury intake in more than 90% of Japanese women may exceed the RfD, and it therefore seems to be far from the present state of Japanese dietary lives...
  30. ncbi request reprint Disruption of postnatal progenitor migration and consequent abnormal pattern of glial distribution in the cerebrum following administration of methylmercury
    Akiyoshi Kakita
    Department of Pathological Neuroscience, Resource Branch for Brain Disease Research CBBR, Brain Research Institute, Niigata University, Asahimachi, Niigata, Japan
    J Neuropathol Exp Neurol 62:835-47. 2003
    ..Thus, exposure to MeHg in the gliogenic period induced irregular distribution of glia as a consequence of abnormal migration of the postnatal progenitors...
  31. ncbi request reprint The Tohoku Study of Child Development: A cohort study of effects of perinatal exposures to methylmercury and environmentally persistent organic pollutants on neurobehavioral development in Japanese children
    Kunihiko Nakai
    Department of Environmental Health Sciences, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    Tohoku J Exp Med 202:227-37. 2004
    ..The results of this cohort study will allow us to evaluate associations between the neurobehavioral development of children and perinatal exposures to MeHg and environmentally POPs in Japan...
  32. ncbi request reprint Subclinical effects of prenatal methylmercury exposure on cardiac autonomic function in Japanese children
    Katsuyuki Murata
    Department of Environmental Health Sciences, Akita University School of Medicine, 010 8543, Akita, Japan
    Int Arch Occup Environ Health 79:379-86. 2006
    ..The subclinical effects of prenatal exposure to methylmercury from fish consumption on the cardiac autonomic function were assessed in 136 Japanese 7-year-old children recruited for this study...
  33. ncbi request reprint [Methylmercury]
    Mineshi Sakamoto
    National Institute for Minamata Disease
    Nihon Rinsho 62:529-32. 2004
  34. ncbi request reprint Effects of mercury vapor exposure on neuromotor function in Chinese miners and smelters
    Toyoto Iwata
    Department of Environmental Health Sciences, Akita University School of Medicine, Akita, 010 8543, Japan
    Int Arch Occup Environ Health 80:381-7. 2007
    ..To clarify the neuromotor effects of occupational exposure to mercury vapor, hand tremor and postural sway were measured in 27 miners and smelters (i.e., exposed workers) and 52 unexposed subjects...
  35. ncbi request reprint Heavy metal contamination status of Japanese cranes (Grus japonensis) in east Hokkaido, Japan--extensive mercury pollution
    Hiroki Teraoka
    Department of Toxicology, School of Veterinary Medicine, Rakuno Gakuen University, Midori cho, Ebetsu 069 8501, Japan
    Environ Toxicol Chem 26:307-12. 2007
    ..Two adult cranes showed extremely high lead levels of more than 30 microg/g in their livers, suggesting lead poisoning. These results have highlighted the widespread and high levels of Hg pollution in Japanese cranes in Hokkaido, Japan...