Mitsuo Saito

Summary

Affiliation: National Institute of Health Sciences
Country: Japan

Publications

  1. ncbi request reprint [Withdrawal of cerivastatin revealed a flaw of post-marketing surveillance system in the United States]
    Mitsuo Saito
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku . 2005
  2. ncbi request reprint [Investigation on new molecular entities of drugs approved in three regions, Japan, U.S. and EU--common and preceding approvals in current 4 years]
    Mitsuo Saito
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku . 2006
  3. ncbi request reprint A literature search on pharmacokinetic drug interactions of statins and analysis of how such interactions are reflected in package inserts in Japan
    M Saito
    Division of Medicinal Safety Science, National Institute of Health Sciences, Kamiyoga, Setagaya Ku, Tokyo, Japan
    J Clin Pharm Ther 30:21-37. 2005
  4. ncbi request reprint Comparison of information on the pharmacokinetic interactions of Ca antagonists in the package inserts from three countries (Japan, USA and UK)
    Mitsuo Saito
    Division of Medicinal Safety Science, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Eur J Clin Pharmacol 61:531-6. 2005
  5. ncbi request reprint Undesirable effects of citrus juice on the pharmacokinetics of drugs: focus on recent studies
    Mitsuo Saito
    Division of Medicinal Safety Science, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Drug Saf 28:677-94. 2005
  6. ncbi request reprint [Introduction of "the manual for handling disorders due to adverse drug reactions"--focus on the antibiotics related severe adverse drug reactions]
    Mitsuo Saito
    Division of Medicinal Safety Science, National Institute of Health Sciences
    Jpn J Antibiot 61:269-88. 2008
  7. ncbi request reprint Neuronal endosomal/lysosomal membrane destabilization activates caspases and induces abnormal accumulation of the lipid secondary messenger ceramide
    Kristen Ditaranto-Desimone
    Dementia Research Program, Nathan Kline Institute, Orangeburg, NY, USA
    Brain Res Bull 59:523-31. 2003
  8. ncbi request reprint Ethanol-induced changes in the content of triglycerides, ceramides, and glucosylceramides in cultured neurons
    Mariko Saito
    Laboratory of Neurobehavior Genetics and the Division of Analytical Psychopharmacology, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Alcohol Clin Exp Res 29:1374-83. 2005
  9. ncbi request reprint Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: consequences to morphology and viability on enzyme suppression in cultured primary neurons
    Neville Marks
    Division of Neurochemistry, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road Orangeburg, NY 10962 USA
    Brain Res 1191:136-47. 2008

Collaborators

  • R Hasegawa
  • N Marks
  • Kristen Ditaranto-Desimone
  • Austin J Yang
  • Gene Dubowchik
  • Martin Berg
  • T L Tekirian
  • Brian Soreghan
  • Stefani Thomas

Detail Information

Publications9

  1. ncbi request reprint [Withdrawal of cerivastatin revealed a flaw of post-marketing surveillance system in the United States]
    Mitsuo Saito
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku . 2005
    ..As for other statins, only limited data was available for the relationship between the dosage and the rate of myopathy. For the safety use of statins, this should be clarified by proper surveillance system...
  2. ncbi request reprint [Investigation on new molecular entities of drugs approved in three regions, Japan, U.S. and EU--common and preceding approvals in current 4 years]
    Mitsuo Saito
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku . 2006
    ..On the other hand, 26 NMEs were solely approved in US and EU during this period. Among 79 NMEs approved in either two or three regions, the number of preceding NMEs was 3 in Japan, 62 in U.S. and 14 in EU...
  3. ncbi request reprint A literature search on pharmacokinetic drug interactions of statins and analysis of how such interactions are reflected in package inserts in Japan
    M Saito
    Division of Medicinal Safety Science, National Institute of Health Sciences, Kamiyoga, Setagaya Ku, Tokyo, Japan
    J Clin Pharm Ther 30:21-37. 2005
    ....
  4. ncbi request reprint Comparison of information on the pharmacokinetic interactions of Ca antagonists in the package inserts from three countries (Japan, USA and UK)
    Mitsuo Saito
    Division of Medicinal Safety Science, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Eur J Clin Pharmacol 61:531-6. 2005
    ..We carried out a literature search to examine and compare the extent to which crucial pharmacokinetic (PK) information is included in package inserts (PIs) in Japan, USA and the UK...
  5. ncbi request reprint Undesirable effects of citrus juice on the pharmacokinetics of drugs: focus on recent studies
    Mitsuo Saito
    Division of Medicinal Safety Science, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Drug Saf 28:677-94. 2005
    ....
  6. ncbi request reprint [Introduction of "the manual for handling disorders due to adverse drug reactions"--focus on the antibiotics related severe adverse drug reactions]
    Mitsuo Saito
    Division of Medicinal Safety Science, National Institute of Health Sciences
    Jpn J Antibiot 61:269-88. 2008
    ..It is needless to say that antibiotics are essential in the modern medical care, close monitoring of the symptom of SAR in untargeted organ is required in use of the antibiotics...
  7. ncbi request reprint Neuronal endosomal/lysosomal membrane destabilization activates caspases and induces abnormal accumulation of the lipid secondary messenger ceramide
    Kristen Ditaranto-Desimone
    Dementia Research Program, Nathan Kline Institute, Orangeburg, NY, USA
    Brain Res Bull 59:523-31. 2003
    ....
  8. ncbi request reprint Ethanol-induced changes in the content of triglycerides, ceramides, and glucosylceramides in cultured neurons
    Mariko Saito
    Laboratory of Neurobehavior Genetics and the Division of Analytical Psychopharmacology, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Alcohol Clin Exp Res 29:1374-83. 2005
    ..Ethanol treatment conditions that induced apoptosis in CGNs and SK-N-SH cells but not in Neuro2a cells were used for these experiments...
  9. ncbi request reprint Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: consequences to morphology and viability on enzyme suppression in cultured primary neurons
    Neville Marks
    Division of Neurochemistry, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road Orangeburg, NY 10962 USA
    Brain Res 1191:136-47. 2008
    ..Pretreatment with GM(1) whose turnover is compromised was protective and pointed to useful therapeutic applications by supplementing existing membrane stores prior to GSC dysfunction...