Yumiko Saga

Summary

Affiliation: National Institute of Genetics
Country: Japan

Publications

  1. doi request reprint CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways
    Rie Saba
    Division of Mammalian Development, Genetic Strains Research Center, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan Electronic address
    Dev Biol 389:173-81. 2014
  2. doi request reprint The oscillation of Notch activation, but not its boundary, is required for somite border formation and rostral-caudal patterning within a somite
    Masayuki Oginuma
    Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Development 137:1515-22. 2010
  3. ncbi request reprint The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite
    Mitsuru Morimoto
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Development 134:1561-9. 2007
  4. ncbi request reprint Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2
    Hiroki Kokubo
    Division of Mammalian Development, National Institute of Genetics, 1111 Yata, Mishima Shizuoka 411 8540, Japan
    Development 134:747-55. 2007
  5. ncbi request reprint Functional redundancy among Nanos proteins and a distinct role of Nanos2 during male germ cell development
    Atsushi Suzuki
    Department of Genetics, National Institute of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Development 134:77-83. 2007
  6. doi request reprint The repression of Notch signaling occurs via the destabilization of mastermind-like 1 by Mesp2 and is essential for somitogenesis
    Nobuo Sasaki
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Development 138:55-64. 2011
  7. ncbi request reprint Implication of nanos2-3'UTR in the expression and function of nanos2
    Masayuki Tsuda
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Mech Dev 123:440-9. 2006
  8. doi request reprint NANOS2 promotes male germ cell development independent of meiosis suppression
    Rie Saba
    Division of Mammalian Development, Genetic Strains Research Center, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Dev Biol 385:32-40. 2014
  9. doi request reprint The RNA-binding protein NANOS2 is required to maintain murine spermatogonial stem cells
    Aiko Sada
    Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Science 325:1394-8. 2009
  10. doi request reprint Notch signaling is required for the maintenance of enteric neural crest progenitors
    Yoshiaki Okamura
    Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Development 135:3555-65. 2008

Collaborators

Detail Information

Publications39

  1. doi request reprint CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways
    Rie Saba
    Division of Mammalian Development, Genetic Strains Research Center, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan Electronic address
    Dev Biol 389:173-81. 2014
    ....
  2. doi request reprint The oscillation of Notch activation, but not its boundary, is required for somite border formation and rostral-caudal patterning within a somite
    Masayuki Oginuma
    Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Development 137:1515-22. 2010
    ..This indicates that the initial somite pattern can be defined as a direct output of the segmentation clock...
  3. ncbi request reprint The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite
    Mitsuru Morimoto
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Development 134:1561-9. 2007
    ..Our study demonstrates that a Ripply2-Mesp2 negative-feedback loop is essential for the periodic generation of the rostro-caudal polarity within a somite...
  4. ncbi request reprint Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2
    Hiroki Kokubo
    Division of Mammalian Development, National Institute of Genetics, 1111 Yata, Mishima Shizuoka 411 8540, Japan
    Development 134:747-55. 2007
    ..Furthermore, we find that the expression of Hesr1 and Hesr2 is independent of Notch2 signaling. Taken together, our data demonstrate that Hesr1 and Hesr2 play crucial roles in AV boundary formation through the suppression of Tbx2...
  5. ncbi request reprint Functional redundancy among Nanos proteins and a distinct role of Nanos2 during male germ cell development
    Atsushi Suzuki
    Department of Genetics, National Institute of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Development 134:77-83. 2007
    ..Our present findings thus indicate that there are redundant functions of the Nanos proteins in early PGC development, but that Nanos2 has a distinct function during male germ cell development in the mouse...
  6. doi request reprint The repression of Notch signaling occurs via the destabilization of mastermind-like 1 by Mesp2 and is essential for somitogenesis
    Nobuo Sasaki
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Development 138:55-64. 2011
    ..Surprisingly, this function of Mesp2 is found to be independent of its function as a transcription factor. Together, these data demonstrate that Mesp2 is a novel component involved in the suppression of Notch target genes...
  7. ncbi request reprint Implication of nanos2-3'UTR in the expression and function of nanos2
    Masayuki Tsuda
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Mech Dev 123:440-9. 2006
    ....
  8. doi request reprint NANOS2 promotes male germ cell development independent of meiosis suppression
    Rie Saba
    Division of Mammalian Development, Genetic Strains Research Center, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Dev Biol 385:32-40. 2014
    ..These results suggest that NANOS2 is not merely a suppressor of meiosis, but instead plays pivotal roles in the sexual differentiation of male germ cells. ..
  9. doi request reprint The RNA-binding protein NANOS2 is required to maintain murine spermatogonial stem cells
    Aiko Sada
    Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Science 325:1394-8. 2009
    ..Thus, NANOS2 is a key stem cell regulator that is expressed in self-renewing spermatogonial stem cells and maintains the stem cell state during murine spermatogenesis...
  10. doi request reprint Notch signaling is required for the maintenance of enteric neural crest progenitors
    Yoshiaki Okamura
    Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Development 135:3555-65. 2008
    ....
  11. doi request reprint Mesp2 and Tbx6 cooperatively create periodic patterns coupled with the clock machinery during mouse somitogenesis
    Masayuki Oginuma
    Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka, Japan
    Development 135:2555-62. 2008
    ..Taken together, we conclude that Mesp2 is the final output signal by which the temporal information from the segmentation clock is translated into segmental patterning during mouse somitogenesis...
  12. pmc Nanos2 suppresses meiosis and promotes male germ cell differentiation
    Atsushi Suzuki
    Department of Genetics, SOKENDAI, Mishima, Shizuoka 411 8540, Japan
    Genes Dev 22:430-5. 2008
    ..We also demonstrate that Nanos2 activates a male-specific genetic program, which is supported by the inhibition of meiosis and the induction of male-type differentiation in female germ cells following the forced expression of Nanos2...
  13. doi request reprint Pofut1 is required for the proper localization of the Notch receptor during mouse development
    Yoshiaki Okamura
    Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Mech Dev 125:663-73. 2008
    ..We propose that altered trafficking pathways may account for the abnormal accumulation of the Notch1 receptor in the endoplasmic reticulum in Pofut1-null mouse embryos...
  14. ncbi request reprint Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse
    Yusuke Watanabe
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Development 133:1625-34. 2006
    ..Our present study thus indicates that the Notch1 signaling pathway plays a suppressive role both in AV myocardial differentiation and the maturation of the ventricular myocardium...
  15. ncbi request reprint Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system
    Hiroki Kokubo
    Division of Mammalian Development, National Institute of Genetics, Mishima, Shizuoka, Japan
    Dev Biol 278:301-9. 2005
    ..Taken together, our results demonstrate a requirement for hesr1 and hesr2 in mediating Notch signaling in the developing cardiac and vascular systems...
  16. doi request reprint Ectopic retinoic acid signaling affects outflow tract cushion development through suppression of the myocardial Tbx2-Tgfβ2 pathway
    Masahide Sakabe
    Division of Mammalian Development, National Institute of Genetics, 1111 Yata Mishima, Shizuoka 411 8540, Japan
    Development 139:385-95. 2012
    ..These data suggest that RA signaling participates in the Tbx2 transcriptional mechanism during OFT development and that the Tbx2-Tgfβ2 cascade is one of the key pathways involved in inducing the TGA phenotype...
  17. pmc Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells
    Mitsuru Morimoto
    Division of Mammalian Development, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Development 139:4365-73. 2012
    ..These results suggest that two different assemblies of Notch receptors coordinate the numbers and distribution of the major epithelial cell types in the conducting airway during lung organogenesis...
  18. pmc Notch signaling in Sertoli cells regulates cyclical gene expression of Hes1 but is dispensable for mouse spermatogenesis
    Kazuteru Hasegawa
    Division of Mammalian Development, National Institute of Genetics, Mishima, Shizuoka, Japan
    Mol Cell Biol 32:206-15. 2012
    ..Our results thus indicate that Notch signaling regulates cyclical gene expression in Sertoli cells but is dispensable for mouse spermatogenesis. This highlights the evolutionary divergences in regulation of germ cell development...
  19. ncbi request reprint Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2
    Yoshiro Nakajima
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Development 133:2517-25. 2006
    ..In addition, ectopic Mesp2 expression induces abnormally epithelialized structures, which support to the idea that Mesp2 induces the formation of segmental borders by activating genes that play roles in cellular epithelialization...
  20. pmc The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice
    Makoto Kiso
    Division of Mammalian Development and Mammalian Genetics, National Institute of Genetics, Mishima, Shizuoka, Japan
    Proc Natl Acad Sci U S A 106:9292-7. 2009
    ..These results indicate that Sox21 is a master regulator of hair shaft cuticle differentiation and shed light on the possible causes of human hair disorders...
  21. doi request reprint Hesr2 knockout mice develop aortic valve disease with advancing age
    Hiroki Kokubo
    Division of Mammalian Development, National Institute of Genetics, Shizuoka, Japan
    Arterioscler Thromb Vasc Biol 33:e84-92. 2013
    ..However, the pathological mechanisms underlying these diseases are largely unknown. Our aim is to identify the role of the hairy and enhancer of split-related (Hesr)-2 gene in the adult heart...
  22. doi request reprint Identification of presomitic mesoderm (PSM)-specific Mesp1 enhancer and generation of a PSM-specific Mesp1/Mesp2-null mouse using BAC-based rescue technology
    Masayuki Oginuma
    Department of Genetics, SOKENDAI, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Mech Dev 125:432-40. 2008
    ..This successfully rescued gastrulation defects due to the lack of the early mesoderm in the dKO mouse and we thereby obtained a PSM-specific Mesp1/Mesp2-null mouse showing a lack of segmented somites...
  23. doi request reprint Mouse germ cell development during embryogenesis
    Yumiko Saga
    Division of Mammalian Development, National Institute of Genetics, Graduate University for Advanced Studies SOKENDAI, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Curr Opin Genet Dev 18:337-41. 2008
    ..In this review, the process of germ cell development in the mouse is discussed with a particular focus on the functions of the key proteins, Blimp1, Nanos, and Dead end1...
  24. ncbi request reprint Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis
    Mitsuru Morimoto
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Dev Biol 300:687-98. 2006
    ..Moreover, we have found that somitogenesis in the early stages is more susceptible to changes in the Mesp gene dosage, indicating that a threshold level of Mesp activity must be required for the progression of normal somitogenesis...
  25. ncbi request reprint The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity
    Mitsuru Morimoto
    Division of Mammalian Development, National Institute of Genetics, Mishima, Japan
    Nature 435:354-9. 2005
    ..We propose that the oscillation of Notch activity is arrested and translated in the wavefront by Mesp2...
  26. doi request reprint Retinoic acid signaling in Sertoli cells regulates organization of the blood-testis barrier through cyclical changes in gene expression
    Kazuteru Hasegawa
    Division of Mammalian Development, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Development 139:4347-55. 2012
    ..Taken together, our data suggest that the cyclical activation of RA signaling in Sertoli cells during stages VII-XII contributes to a periodic organization of the BTB through changes in stage-dependent gene expression...
  27. doi request reprint Function of Nanos2 in the male germ cell lineage in mice
    Yumiko Saga
    National Institute of Genetics, Graduate University for Advanced Studies, SOKENDAI, Yata, Mishima, Shizuoka, Japan
    Cell Mol Life Sci 67:3815-22. 2010
    ..It has also been shown that the Nanos2 interacts with protein components of the deadenylation complex involved in the initial step of the RNA degradation pathway...
  28. ncbi request reprint Mesp-family genes are required for segmental patterning and segmental border formation
    Yumiko Saga
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Adv Exp Med Biol 638:113-23. 2008
    ..In this process, Mesp2, another basic HLH protein plays a critical role. Genetic evidence is provided how Mesp2 regulates Notch signaling to establish segmental identity in the anterior PSM...
  29. doi request reprint RNA Binding Protein Nanos2 Organizes Post-transcriptional Buffering System to Retain Primitive State of Mouse Spermatogonial Stem Cells
    Zhi Zhou
    Division of Mammalian Development, Genetic Strains Research Center, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Dev Cell 34:96-107. 2015
    ..This mechanism links mRNA turnover to mTORC1 signaling through Nanos2-containing mRNPs and establishes a post-transcriptional buffering system to facilitate SSC homeostasis in the fluctuating environment within the seminiferous tubule...
  30. doi request reprint Sexual development of mouse germ cells: Nanos2 promotes the male germ cell fate by suppressing the female pathway
    Yumiko Saga
    Division of Mammalian Development, National Institute of Genetics, and Department of Genetics, SOKENDAI, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Dev Growth Differ 50:S141-7. 2008
    ....
  31. doi request reprint Guidepost neurons for the lateral olfactory tract: expression of metabotropic glutamate receptor 1 and innervation by glutamatergic olfactory bulb axons
    Tatsumi Hirata
    Division of Brain Function, National Institute of Genetics, Yata, Mishima, Shizuoka, Japan
    Dev Neurobiol 72:1559-76. 2012
    ..Together with the finding that lot cells themselves are glutamatergic excitatory neurons, our results provide another notable example of precocious interactions between the projecting axons and their intermediate targets...
  32. doi request reprint The mechanism of somite formation in mice
    Yumiko Saga
    Division of Mammalian Development, National Institute of Genetics and Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Curr Opin Genet Dev 22:331-8. 2012
    ..Particular attention is paid to the interplay between two the distinct signaling pathways of Notch and FGF and the Mesp2 transcription factor acting as an effector molecule during mouse somitogenesis...
  33. ncbi request reprint Segmental border is defined by the key transcription factor Mesp2, by means of the suppression of Notch activity
    Yumiko Saga
    Division of Mammalian Development, National Institute of Genetics, and Department of Genetics, SOKENDAI, Mishima, Japan
    Dev Dyn 236:1450-5. 2007
    ..During this process, Mesp2, another basic HLH protein, plays a critical role in the anterior PSM. In this review, I further clarify the dynamic processes leading to segmental border formation in the developing mouse embryo...
  34. pmc Dazl is a target RNA suppressed by mammalian NANOS2 in sexually differentiating male germ cells
    Yuzuru Kato
    Division of Mammalian Development, Genetic Strains Research Center, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Nat Commun 7:11272. 2016
    ..We propose a dual system of NANOS2-mediated suppression of Dazl expression as a pivotal molecular mechanism promoting sexual differentiation of XY germ cells...
  35. ncbi request reprint Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling
    Aki Ishikawa
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Mech Dev 121:1443-53. 2004
    ..Collectively, our data suggest that the reciprocal interaction of Notch and Wnt signals, and of their respective negative feedback loops, function to organize the segmentation clock required for somitogenesis...
  36. doi request reprint FGF8-FGFR1 signaling acts as a niche factor for maintaining undifferentiated spermatogonia in the mouse
    Kazuteru Hasegawa
    Division of Mammalian Development, National Institute of Genetics, Mishima, Shizuoka, Japan
    Biol Reprod 91:145. 2014
    ..Taken together, our data suggest that FGF signaling is an important component of the testicular niche and has a unique function for maintaining undifferentiated spermatogonia. ..
  37. ncbi request reprint Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction
    Hiroki Kokubo
    Division of Mammalian Development, National Institute of Genetics, Mishima, Japan
    Circ Res 95:540-7. 2004
    ..Because of the unique spectrum of cardiac anomalies expressed by hesr2-null mice, they represent a useful model system for elucidating the genetic basis of heart dysfunction...
  38. pmc The synchrony and cyclicity of developmental events
    Yumiko Saga
    Mammalian Development Laboratory, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Cold Spring Harb Perspect Biol 4:a008201. 2012
    ..The interplay between signaling molecules that provides positional information and the transcription factors that respond to such positional cues are critical to the role of the segmentation clock and are discussed...
  39. ncbi request reprint Conserved role of nanos proteins in germ cell development
    Masayuki Tsuda
    Division of Mammalian Development, National Institute of Genetics, SOKENDAI, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Science 301:1239-41. 2003
    ..Hence, although mice and flies differ in their mechanisms for germ cell specification, there seems to be conserved function for nanos proteins among invertebrates and vertebrates...