Akihide Ryo

Summary

Affiliation: National Institute of Infectious Diseases
Country: Japan

Publications

  1. ncbi request reprint Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration
    Yih Cherng Liou
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 424:556-61. 2003
  2. pmc SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag
    Akihide Ryo
    Department of Pathology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Proc Natl Acad Sci U S A 105:294-9. 2008
  3. doi request reprint Identification of phosphorylated proteins involved in the oncogenesis of prostate cancer via Pin1-proteomic analysis
    Kanji Endoh
    Drug Discovery Research Center, Taiho Pharmaceutical Co, Ltd, Tsukuba, Japan
    Prostate 72:626-37. 2012
  4. doi request reprint Pinning down HER2-ER crosstalk in SMRT regulation
    Akihide Ryo
    AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Trends Biochem Sci 34:162-5. 2009
  5. doi request reprint Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 Gag
    Mayuko Nishi
    AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo, Japan
    FEBS Lett 583:1243-50. 2009
  6. doi request reprint Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu
    Kei Miyakawa
    Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236 0004, Japan
    Sci Signal 5:ra73. 2012
  7. ncbi request reprint A suppressive role of the prolyl isomerase Pin1 in cellular apoptosis mediated by the death-associated protein Daxx
    Akihide Ryo
    Department of Pathology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    J Biol Chem 282:36671-81. 2007
  8. doi request reprint DNA vaccine expressing HIV-1 gp120/immunoglobulin fusion protein enhances cellular immunity
    Masaru Shimada
    Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Vaccine 28:4920-7. 2010
  9. pmc The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions
    Ayumi Kudoh
    Department of Microbiology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
    Retrovirology 11:9. 2014
  10. pmc ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction
    Kei Miyakawa
    Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236 0004, Japan
    Nat Commun 6:6945. 2015

Detail Information

Publications33

  1. ncbi request reprint Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration
    Yih Cherng Liou
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 424:556-61. 2003
    ..Thus, Pin1 is pivotal in protecting against age-dependent neurodegeneration, providing insight into the pathogenesis and treatment of Alzheimer's disease and other tauopathies...
  2. pmc SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag
    Akihide Ryo
    Department of Pathology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Proc Natl Acad Sci U S A 105:294-9. 2008
    ..These results together indicate that SOCS1 is a crucial host factor that regulates the intracellular dynamism of HIV-1 Gag and could therefore be a potential new therapeutic target for AIDS and its related disorders...
  3. doi request reprint Identification of phosphorylated proteins involved in the oncogenesis of prostate cancer via Pin1-proteomic analysis
    Kanji Endoh
    Drug Discovery Research Center, Taiho Pharmaceutical Co, Ltd, Tsukuba, Japan
    Prostate 72:626-37. 2012
    ..Although Pin1 has been shown to be involved in cell transformation and the maintenance of the malignant phenotype in prostate cancer, its specific substrates during these processes have not yet been determined...
  4. doi request reprint Pinning down HER2-ER crosstalk in SMRT regulation
    Akihide Ryo
    AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Trends Biochem Sci 34:162-5. 2009
    ..Pin1 functions downstream of HER2, positioning it as an important modulator of the crosstalk between ER and growth factor signaling...
  5. doi request reprint Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 Gag
    Mayuko Nishi
    AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo, Japan
    FEBS Lett 583:1243-50. 2009
    ..We thus propose that the microtubule network plays a role in SOCS1-mediated HIV-1 Gag transport and virus particle formation...
  6. doi request reprint Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu
    Kei Miyakawa
    Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236 0004, Japan
    Sci Signal 5:ra73. 2012
    ..Together, these results suggest that SCYL2 serves as a regulatory factor for Vpu, reducing the extent of Vpu phosphorylation and consequently enhancing BST2-mediated viral restriction...
  7. ncbi request reprint A suppressive role of the prolyl isomerase Pin1 in cellular apoptosis mediated by the death-associated protein Daxx
    Akihide Ryo
    Department of Pathology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    J Biol Chem 282:36671-81. 2007
    ....
  8. doi request reprint DNA vaccine expressing HIV-1 gp120/immunoglobulin fusion protein enhances cellular immunity
    Masaru Shimada
    Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Vaccine 28:4920-7. 2010
    ..These results demonstrate that covalent antigen modification with an Ig sequence can modulate antigen-specific cellular immune responses. The approach may be useful for vaccine development...
  9. pmc The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions
    Ayumi Kudoh
    Department of Microbiology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
    Retrovirology 11:9. 2014
    ..In our present study, we identified this kinase using a proteomic approach and further delineate its role in HIV-1 replication...
  10. pmc ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction
    Kei Miyakawa
    Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236 0004, Japan
    Nat Commun 6:6945. 2015
    ..This study thus demonstrates a distinct function of ASK1 in restoring the host antiviral system that can be enhanced by AZT treatment. ..
  11. pmc A distinct role for Pin1 in the induction and maintenance of pluripotency
    Mayuko Nishi
    Department of Microbiology, Yokohama City University School of Medicine, Kanazawa Ku, Yokohama, Japan
    J Biol Chem 286:11593-603. 2011
    ..These data suggest that the manipulation of Pin1 function could be a potential strategy for the stable induction and proliferation of human iPS cells...
  12. pmc BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction
    Kei Miyakawa
    AIDS Research Center, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    PLoS Pathog 5:e1000700. 2009
    ....
  13. pmc Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell
    Mayuko Nishi
    Department of Microbiology, Yokohama City University School of Medicine, Yokohama, Japan
    Oncotarget 5:8665-80. 2014
    ..Furthermore, our current study identified WA as a putative drug candidate for abrogating the stemness and tumor initiating ability of CSCs. ..
  14. doi request reprint Relationship between phosphorylation of sperm-specific antigen and prognosis of lung adenocarcinoma
    Akiko Okayama
    Yokohama City University, Graduate School of Medical Life Science and Advanced Medical Research Center, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    J Proteomics 139:60-6. 2016
    ..Therefore, we suggest that phosphorylation of this protein indicates its role as a potential biomarker and new therapeutic target...
  15. pmc Molecular dissection of HBV evasion from restriction factor tetherin: A new perspective for antiviral cell therapy
    Kei Miyakawa
    Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236 0004, Japan
    Oncotarget 6:21840-52. 2015
    ..In addition, strategies to augment the antiviral activity of tetherin by impeding tetherin-HBs interactions may be viable as a therapeutic intervention against HBV. ..
  16. doi request reprint Identification of Tyrosine-Phosphorylated Proteins Upregulated during Epithelial-Mesenchymal Transition Induced with TGF-β
    Akiko Okayama
    Yokohama City University, Advanced Medical Research Center, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    J Proteome Res 14:4127-36. 2015
    ..Tyrosine phosphorylations of these proteins represent possible candidates of prognostic prediction markers for lung adenocarcinoma. ..
  17. doi request reprint Follicular dendritic cells activate HIV-1 replication in monocytes/macrophages through a juxtacrine mechanism mediated by P-selectin glycoprotein ligand 1
    Kenji Ohba
    AIDS Research Center, National Institute of Infectious Diseases, Toyama, Shinjyuku ku, Tokyo, Japan
    J Immunol 183:524-32. 2009
    ..We have thus elucidated a novel regulatory mechanism in which FDCs are a potent positive bystander that facilitates HIV-1 replication in adjacent infected monocytic cells via a juxtacrine signaling mechanism...
  18. doi request reprint Proteomic analysis of proteins related to prognosis of lung adenocarcinoma
    Akiko Okayama
    Graduate School of Medical Life Science and Advanced Medical Research Center, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    J Proteome Res 13:4686-94. 2014
    ....
  19. ncbi request reprint Prolyl-isomerase Pin1 accumulates in lewy bodies of parkinson disease and facilitates formation of alpha-synuclein inclusions
    Akihide Ryo
    Department of Pathology, Yokohama City University School of Medicine, Japan
    J Biol Chem 281:4117-25. 2006
    ..These results indicate that Pin1-mediated prolyl-isomerization plays a pivotal role in a post-translational modification pathway for alpha-synuclein aggregation and in the resultant Lewy body formations in PD...
  20. doi request reprint Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity
    Tatsuma Ban
    Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Immunity 45:319-32. 2016
    ..Our results reveal a role for Lyn as a specific suppressor of the TLR-MyD88-IRF5 pathway and illustrate the importance of fine-tuning IRF5 activity for the maintenance of immune homeostasis. ..
  21. pmc Thymic alterations in GM2 gangliosidoses model mice
    Seiichi Kanzaki
    Department of Pathology, Yokohama City University School of Medicine, Yokohama, Japan
    PLoS ONE 5:. 2010
    ..We have previously found that the progressive neurologic disease induced in Hexb(-/-) mice, an animal model for Sandhoff disease, is associated with the production of pathogenic anti-glycolipid autoantibodies...
  22. doi request reprint Molecular evolution of the hypervariable region of the attachment glycoprotein gene in human respiratory syncytial virus subgroup B genotypes BA9 and BA10
    Koo Nagasawa
    Department of Pediatrics, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba shi, Chiba 260 8677, Japan Infectious Disease Surveillance Center, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    Infect Genet Evol 36:217-23. 2015
    ..The results suggested that the recently prevalent HRSV-B genotypes BA9 and BA10 evolved uniquely, leading to epidemics of HRSV-B worldwide over a 15-year period. ..
  23. doi request reprint Anti-interleukin-5 and multiple autoantibodies are associated with human atherosclerotic diseases and serum interleukin-5 levels
    Tomoaki Ishigami
    Yokohama City University Graduate School of Medicine, Department of Medical Science and Cardio renal Medicine, 3 9, Fukuura, Kanazawa Ku, Yokohama City, Kanagawa Ken, 236 0004, Japan
    FASEB J 27:3437-45. 2013
    ..940. Our results provide important clues to understanding the role of autoantibody-mediated immune reactions in human atherosclerosis and suggest novel therapeutic opportunities for management of the disease...
  24. doi request reprint The prolyl isomerase Pin1 stabilizes the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein and promotes malignant transformation
    Soo Jin Jeong
    AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Biochem Biophys Res Commun 381:294-9. 2009
    ..Our current study demonstrates an important role for Pin1 in the post-translational regulation of Tax and suggests that the targeting of Pin1 may offer a new insight into the pathogenesis of HTLV-1 related diseases...
  25. ncbi request reprint Stable suppression of tumorigenicity by Pin1-targeted RNA interference in prostate cancer
    Akihide Ryo
    Department of Pathology, Yokohama City University School of Medicine, Yokohama, Japan
    Clin Cancer Res 11:7523-31. 2005
    ..In the present study, we sought to determine the potential of Pin1-targeted gene silencing in inhibiting cellular growth and tumorigenicity in prostate cancer...
  26. pmc Molecular evolution of haemagglutinin (H) gene in measles virus
    Hirokazu Kimura
    1 Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Musashimurayama shi, Tokyo 208 0011, Japan 2 Department of Molecular Biodefence Research, Yokohama City University Graduate School of Medicine, Yokohama shi, Kanagawa 236 0004, Japan
    Sci Rep 5:11648. 2015
    ..Based on the molecular evolution of H gene, an ancestor MeV of the 24 genotypes emerged about 100 years ago and the structure of H protein has been well conserved...
  27. doi request reprint IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils
    Daisuke Kurotaki
    Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Nat Commun 5:4978. 2014
    ..Thus, IRF8 not only bestows monocyte and DC differentiation potential upon mononuclear phagocyte progenitors but also restrains these progenitors from differentiating into neutrophils. ..
  28. pmc Molecular evolution of the VP1, VP2, and VP3 genes in human rhinovirus species C
    Makoto Kuroda
    Pathogen Genomics Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Sci Rep 5:8185. 2015
    ..These results suggested that HRV-C may have an old history and unique antigenicity as an agent of various ARI. ..
  29. pmc Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)
    Koichi Watashi
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Hepatology 59:1726-37. 2014
    ..CsA inhibited the binding between NTCP and large envelope protein in vitro. Evaluation of CsA analogs identified a compound with higher anti-HBV potency, having a median inhibitory concentration <0.2 μM...
  30. doi request reprint Molecular and enzymatic characterization of XMRV protease by a cell-free proteolytic analysis
    Satoko Matsunaga
    Department of Microbiology, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    J Proteomics 75:4863-73. 2012
    ..This system may provide an attractive means for analyzing the function of retrovirus proteases and provide a technology platform for drug screening...
  31. pmc Low-intensity pulsed ultrasound activates the phosphatidylinositol 3 kinase/Akt pathway and stimulates the growth of chondrocytes in three-dimensional cultures: a basic science study
    Ryohei Takeuchi
    Department of Orthopaedic Surgery, Yokohama City University School of Medicine, Yokohama City, Kanagawa, Japan
    Arthritis Res Ther 10:R77. 2008
    ....
  32. doi request reprint Co-administration of viral vector-based vaccines suppresses antigen-specific effector CD8 T cells
    Sayaka Yashima
    Department of Molecular Biodefence Research, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Vaccine 28:3257-64. 2010
    ..This viral interference may involve soluble factor(s), secreted by virus-infected cells. Our study may help in designing a vaccination regimen and in investigating viral interference...
  33. ncbi request reprint Activation of Galectin-1 gene in human hepatocellular carcinoma involves methylation-sensitive complex formations at the transcriptional upstream and downstream elements
    Nobuo Kondoh
    Department of Biochemistry II, National Defense Medical College, Saitama 359 8513, Japan
    Int J Oncol 23:1575-83. 2003
    ..Thus, the specific interaction of methylation-sensitive factors to the upstream and downstream elements may be essential for the activation of the Gal-1 gene in HCC cells...