Katsutaka Oishi

Summary

Affiliation: National Institute of Advanced Industrial Science and Technology
Country: Japan

Publications

  1. ncbi FGF21 is dispensable for hypothermia induced by fasting in mice
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
    Neuro Endocrinol Lett 31:198-202. 2010
  2. doi Feeding cycle-dependent circulating insulin fluctuation is not a dominant Zeitgeber for mouse peripheral clocks except in the liver: Differences between endogenous and exogenous insulin effects
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki 305 8566, Japan Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Chiba 278 8510, Japan Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba 277 0882, Japan Electronic address
    Biochem Biophys Res Commun . 2016
  3. doi Moderately high doses of the artificial sweetener saccharin potentially induce sleep disorders in mice
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba, Japan Electronic address
    Nutrition 32:1159-61. 2016
  4. doi Disrupted light-dark cycle abolishes circadian expression of peripheral clock genes without inducing behavioral arrhythmicity in mice
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki 305 8566, Japan Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Chiba 278 8510, Japan Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba 277 0882, Japan Electronic address
    Biochem Biophys Res Commun 458:256-61. 2015
  5. doi Wheat alkylresorcinols suppress high-fat, high-sucrose diet-induced obesity and glucose intolerance by increasing insulin sensitivity and cholesterol excretion in male mice
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba, Japan Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan
    J Nutr 145:199-206. 2015
  6. doi Disruption of behavioral circadian rhythms induced by psychophysiological stress affects plasma free amino acid profiles without affecting peripheral clock gene expression in mice
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan Electronic address
    Biochem Biophys Res Commun 450:880-4. 2014
  7. pmc Ketogenic diet and fasting induce the expression of cold-inducible RNA-binding protein with time-dependent hypothermia in the mouse liver
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan
    FEBS Open Bio 3:192-5. 2013
  8. pmc Clock mutation affects circadian regulation of circulating blood cells
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology AIST, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    J Circadian Rhythms 4:13. 2006
  9. doi Disrupted daily light-dark cycle induces the expression of hepatic gluconeogenic regulatory genes and hyperglycemia with glucose intolerance in mice
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 432:111-5. 2013
  10. doi The molecular clock regulates circadian transcription of tissue factor gene
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 431:332-5. 2013

Collaborators

Detail Information

Publications69

  1. ncbi FGF21 is dispensable for hypothermia induced by fasting in mice
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
    Neuro Endocrinol Lett 31:198-202. 2010
    ..We recently reported that bezafibrate, a pan-agonist of PPARs, decreases body temperature late at night through hypothalamic neuropeptide Y (NPY) activation and others have shown that mice overexpressing FGF21 are prone to torpor...
  2. doi Feeding cycle-dependent circulating insulin fluctuation is not a dominant Zeitgeber for mouse peripheral clocks except in the liver: Differences between endogenous and exogenous insulin effects
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki 305 8566, Japan Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Chiba 278 8510, Japan Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba 277 0882, Japan Electronic address
    Biochem Biophys Res Commun . 2016
    ....
  3. doi Moderately high doses of the artificial sweetener saccharin potentially induce sleep disorders in mice
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba, Japan Electronic address
    Nutrition 32:1159-61. 2016
    ..Caloric sweeteners such as sugar and honey are replaced in thousands of food products by noncaloric artificial sweeteners (NASs). The aim of the present study was to determine the effects of chronic NAS intake on circadian sleep regulation...
  4. doi Disrupted light-dark cycle abolishes circadian expression of peripheral clock genes without inducing behavioral arrhythmicity in mice
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki 305 8566, Japan Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Chiba 278 8510, Japan Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba 277 0882, Japan Electronic address
    Biochem Biophys Res Commun 458:256-61. 2015
    ..Our findings suggest that disrupted environmental LD cycles abolish the normal oscillation of peripheral clocks and induce internal desynchrony in mammals...
  5. doi Wheat alkylresorcinols suppress high-fat, high-sucrose diet-induced obesity and glucose intolerance by increasing insulin sensitivity and cholesterol excretion in male mice
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba, Japan Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan
    J Nutr 145:199-206. 2015
    ..Epidemiologic studies have shown that the consumption of whole grains can reduce the risk of type 2 diabetes mellitus, cardiovascular disease, and all-cause mortality. However, the underlying mechanisms remain a matter of debate...
  6. doi Disruption of behavioral circadian rhythms induced by psychophysiological stress affects plasma free amino acid profiles without affecting peripheral clock gene expression in mice
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan Electronic address
    Biochem Biophys Res Commun 450:880-4. 2014
    ..These findings suggest that circadian clock gene expression does not always reflect disordered behavior and sleep rhythms and that plasma FFA profiles could serve as a potential biomarker of circadian rhythm disorders. ..
  7. pmc Ketogenic diet and fasting induce the expression of cold-inducible RNA-binding protein with time-dependent hypothermia in the mouse liver
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan
    FEBS Open Bio 3:192-5. 2013
    ..Transient food deprivation also induced time-dependent Cirbp expression with hypothermia in mice. These findings suggest that hypothermia is involved in the increased expression of Cirbp under ketogenic or fasting conditions...
  8. pmc Clock mutation affects circadian regulation of circulating blood cells
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology AIST, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    J Circadian Rhythms 4:13. 2006
    ..Although the number of circulating immune cells is subject to high-amplitude circadian rhythms, the underlying mechanisms are not fully understood...
  9. doi Disrupted daily light-dark cycle induces the expression of hepatic gluconeogenic regulatory genes and hyperglycemia with glucose intolerance in mice
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 432:111-5. 2013
    ..Our findings provide a link between metabolic disorders and environmental photoperiodic cycles in genetically normal animals...
  10. doi The molecular clock regulates circadian transcription of tissue factor gene
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 431:332-5. 2013
    ....
  11. doi Circadian mRNA expression of coagulation and fibrinolytic factors is organ-dependently disrupted in aged mice
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Exp Gerontol 46:994-9. 2011
    ..Aging-dependent constitutive PAI-1 induction in the heart might be a risk factor for cardiovascular diseases that is independent of plasma PAI-1 levels...
  12. doi Low-carbohydrate, high-protein diet affects rhythmic expression of gluconeogenic regulatory and circadian clock genes in mouse peripheral tissues
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Chronobiol Int 29:799-809. 2012
    ..These findings suggest that a HPD not only affects glucose homeostasis, but that it also advances the molecular circadian clock in peripheral tissues...
  13. ncbi Thiazolidinediones are potent inducers of fibroblast growth factor 21 expression in the liver
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Biol Pharm Bull 34:1120-1. 2011
    ....
  14. ncbi Disrupted light-dark cycle induces obesity with hyperglycemia in genetically intact animals
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
    Neuro Endocrinol Lett 30:458-61. 2009
    ..However, whether such disordered phenotypes are due to a loss of circadian clock function within specific metabolically relevant tissues, or the result of disrupted circadian behavioral activities governed by the SCN remains unknown...
  15. ncbi Strain- and tissue-dependent induction of plasminogen activator inhibitor-1 gene expression in fasted mice
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305 8566, Japan
    Biol Pharm Bull 33:530-1. 2010
    ..The effect of FD on plasma PAI-1 levels is also strain-dependent. Genetic background seems to be an important factor that should be considered when investigating thrombosis and fibrinolysis relative to metabolic changes in mice...
  16. doi Ketogenic diet disrupts the circadian clock and increases hypofibrinolytic risk by inducing expression of plasminogen activator inhibitor-1
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305 8566, Japan
    Arterioscler Thromb Vasc Biol 29:1571-7. 2009
    ..We examined circadian changes in plasma PAI-1 and its mRNA expression levels in tissues from mice fed with a KD (KD mice), to evaluate its effects on fibrinolytic functions...
  17. doi Plasminogen activator inhibitor-1 and the circadian clock in metabolic disorders
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki, Japan
    Clin Exp Hypertens 31:208-19. 2009
    ..A series of our recent studies revealed that circadian clock proteins are important for hypofibrinolysis induced by metabolic disorders such as obesity and diabetes...
  18. doi Human connexin31.9, unlike its orthologous protein connexin30.2 in the mouse, is not detectable in the human cardiac conduction system
    Maria M Kreuzberg
    Institute of Genetics, University of Bonn, Bonn, Germany
    J Mol Cell Cardiol 46:553-9. 2009
    ..9 protein, unlike its counterpart in the mouse, is not expressed in detectable quantities and is thus unlikely to contribute to the impulse generation and conduction system or the working myocardium of the human heart...
  19. doi Circadian expression of FGF21 is induced by PPARalpha activation in the mouse liver
    Katsutaka Oishi
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    FEBS Lett 582:3639-42. 2008
    ..These observations suggest that bezafibrate-induced circadian FGF21 expression is due to circadian variations in the responsiveness of the PPARalpha system in the liver...
  20. doi PPARα deficiency augments a ketogenic diet-induced circadian PAI-1 expression possibly through PPARγ activation in the liver
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 401:313-8. 2010
    ..PPARγ activation seems to be involved in KD-induced hypofibrinolysis by augmenting PAI-1 gene expression in the fatty liver...
  21. doi PPARγ activation induces acute PAI-1 gene expression in the liver but not in adipose tissues of diabetic model mice
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Thromb Res 128:e81-5. 2011
    ....
  22. doi Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice
    Katsutaka Oishi
    Biological Clock Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 412:396-400. 2011
    ..The physiological role of the refeeding-induced adipose Fgf21 expression remains to be elucidated...
  23. ncbi Differential effects of physical and psychological stressors on immune functions of rats
    Katsutaka Oishi
    Clock Cell Biology Group, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1, Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Stress 6:33-40. 2003
    ..05), but no effects were found in the psychological stress group. These results underline the importance of distinguishing between physical versus psychological stressors when examining the effects of stress on immune functions...
  24. ncbi Gene- and tissue-specific alterations of circadian clock gene expression in streptozotocin-induced diabetic mice under restricted feeding
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Biochem Biophys Res Commun 317:330-4. 2004
    ....
  25. ncbi PPARalpha is a potential therapeutic target of drugs to treat circadian rhythm sleep disorders
    Hidenori Shirai
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305 8566, Japan
    Biochem Biophys Res Commun 357:679-82. 2007
    ..Our results indicated that PPARalpha is involved in circadian clock control independently of the SCN and that PPARalpha could be a potent target of drugs to treat circadian rhythm sleep disorders including DSPS...
  26. doi PERIOD2 is a circadian negative regulator of PAI-1 gene expression in mice
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
    J Mol Cell Cardiol 46:545-52. 2009
    ..The present findings also suggest that PER2 attenuates obesity-induced hypofibrinolysis by downregulating PAI-1 expression independently of metabolic disorders...
  27. ncbi Functional CLOCK is not involved in the entrainment of peripheral clocks to the restricted feeding: entrainable expression of mPer2 and BMAL1 mRNAs in the heart of Clock mutant mice on Jcl:ICR background
    Katsutaka Oishi
    Clock Cell Biology Group, Institute of Molecular and Cell Biology, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1, Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Biochem Biophys Res Commun 298:198-202. 2002
    ..Thus, the entraining mechanism of peripheral tissues to the RF seems to be different from that to the central clock in the suprachiasmatic nucleus...
  28. ncbi Effect of feeding on peripheral circadian rhythms and behaviour in mammals
    Hisato Kobayashi
    Clock Cell Biology, Institute of Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Genes Cells 9:857-64. 2004
    ..Our data indicate that feeding is an important cue for circadian behaviour rhythms as well as for the photo-entrainment of peripheral clock gene expression...
  29. doi Bezafibrate induces plasminogen activator inhibitor-1 gene expression in a CLOCK-dependent circadian manner
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
    Mol Pharmacol 78:135-41. 2010
    ..The present findings revealed that molecular interaction between the circadian clock and the lipid metabolism regulator affects the bezafibrate-induced gene expression...
  30. ncbi CLOCK regulates the circadian rhythm of kaolin-induced writhing behavior in mice
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Neuroreport 18:1925-8. 2007
    ..Our present study suggested that the circadian variation of the pain sensitivity is governed by the food-entrainable endogenous clock and by the circadian clock molecules in mammals...
  31. ncbi Genome-wide expression analysis reveals 100 adrenal gland-dependent circadian genes in the mouse liver
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, Higashi, Tsukuba, Ibaraki, Japan
    DNA Res 12:191-202. 2005
    ..The present findings suggested that one type of hepatic circadian genes in mice is transcriptionally regulated by core components of the circadian clock, such as CLOCK and BMAL1, and that the other depends on the adrenal gland...
  32. ncbi Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    J Biol Chem 278:41519-27. 2003
    ....
  33. ncbi Tissue-specific augmentation of circadian PAI-1 expression in mice with streptozotocin-induced diabetes
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Thromb Res 114:129-35. 2004
    ..Our results suggest that impairment of the coagulation and fibrinolytic systems induced by diabetes is partly due to impaired circadian PAI-1 fluctuation at the level of mRNA expression...
  34. ncbi Circadian expression of clock genes during ontogeny in the rat heart
    Katsuhiko Sakamoto
    Clock Cell Biology Group, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba 305 8566, Japan
    Neuroreport 13:1239-42. 2002
    ..Judging from mRNA rhythms in the heart, it was probably after P20 that rats established the mature circadian system controlling peripheral rhythms...
  35. ncbi Disrupted fat absorption attenuates obesity induced by a high-fat diet in Clock mutant mice
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    FEBS Lett 580:127-30. 2006
    ..Our results suggest that circadian clock molecules play an important role in lipid homeostasis in mammals...
  36. pmc CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2
    Ryosuke Doi
    Ishida Group of Clock Gene, National Institute of Advanced Industrial Science and Technology, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    J Biol Chem 285:22114-21. 2010
    ..Thus, CLOCK regulates the circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2...
  37. ncbi Bidirectional CLOCK/BMAL1-dependent circadian gene regulation by retinoic acid in vitro
    Hidenori Shirai
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Biochem Biophys Res Commun 351:387-91. 2006
    ..These results suggest that RAs regulate the CLOCK/BMAL1-dependent transcription of circadian genes in a complex manner...
  38. ncbi Differential expressions of mPer1 and mPer2 mRNAs under a skeleton photoperiod and a complete light-dark cycle
    Katsutaka Oishi
    Clock Cell Biology Group, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1, Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Brain Res Mol Brain Res 109:11-7. 2002
    ..Furthermore, we propose that the persistent expression of mPer2 mRNA is required for the entrainment to the SPP...
  39. pmc Molecular characterization of Mybbp1a as a co-repressor on the Period2 promoter
    Yasuhiro Hara
    Clock Cell Biology, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Japan
    Nucleic Acids Res 37:1115-26. 2009
    ..These findings suggest that Mybbp1a and mCRY1 can form complexes on the Per2 promoter that function as negative regulators of Per2 expression...
  40. doi Chronic circadian clock disruption induces expression of the cardiovascular risk factor plasminogen activator inhibitor-1 in mice
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
    Blood Coagul Fibrinolysis 24:106-8. 2013
    ..Chronic circadian clock disruption might induce hypofibrinolysis and increase the risk of cardiovascular events by inducing the PAI-1 gene expression in obese individuals...
  41. ncbi Feeding is not a more potent Zeitgeber than the light-dark cycle in Drosophila
    Katsutaka Oishi
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Neuroreport 15:739-43. 2004
    ..These results suggest that feeding is not a more potent Zeitgeber than the light/dark cycle at either the individual behavioral level or at the peripheral molecular clock levels in Drosophila...
  42. doi The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2
    Kanae Ohsaki
    Clock Cell Biology Research Group, Advanced Industrial Science and Technology, Ibaraki, Japan
    J Biochem 144:609-18. 2008
    ....
  43. doi PPARalpha is involved in photoentrainment of the circadian clock
    Katsutaka Oishi
    Clock Cell Biology Research Group, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
    Neuroreport 19:487-9. 2008
    ..The activity onset was not changed under a short photoperiod (LD 8 : 16) or under constant illumination. These observations suggest that PPARalpha is involved in entrainment of the circadian clock to environmental LD conditions...
  44. pmc CLOCK is involved in the circadian transactivation of peroxisome-proliferator-activated receptor alpha (PPARalpha) in mice
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Biochem J 386:575-81. 2005
    ..These results suggested that CLOCK plays an important role in lipid homoeostasis by regulating the transcription of a key protein, PPARalpha...
  45. ncbi Food deprivation induces adipose plasminogen activator inhibitor-1 (PAI-1) expression without accumulation of plasma PAI-1 in genetically obese and diabetic db/db mice
    Katsutaka Oishi
    Clock Cell Biology Research Group, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1, Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Thromb Haemost 98:864-70. 2007
    ....
  46. ncbi Circadian expression of clock genes is maintained in the liver of Vitamin A-deficient mice
    Hidenori Shirai
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Neurosci Lett 398:69-72. 2006
    ..Our results suggest that dietary Vitamin A is not essential for generating circadian rhythms of peripheral clocks in mammals...
  47. ncbi Differential circadian expression of endothelin-1 mRNA in the rat suprachiasmatic nucleus and peripheral tissues
    Shuji Hanai
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology AIST, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Neurosci Lett 377:65-8. 2005
    ..The results are the first description of the circadian expression of ET-1 mRNA. The diversity of rhythmic expressions among the SCN, whole brain, lungs and heart suggests that ET-1 has different functions in these tissues...
  48. pmc Continuous exposure to a novel stressor based on water aversion induces abnormal circadian locomotor rhythms and sleep-wake cycles in mice
    Koyomi Miyazaki
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Japan
    PLoS ONE 8:e55452. 2013
    ..Circadian gene expression in the liver and muscle was unaltered, indicating that the peripheral clocks in these tissues remained intact...
  49. doi Conserved amino acid residues in C-terminus of PERIOD 2 are involved in interaction with CRYPTOCHROME 1
    Tatsunosuke Tomita
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Biochim Biophys Acta 1803:492-8. 2010
    ..Thus, the conserved amino acid residues of 1179-1198 in PER2 are apparently responsible for binding to CRY1...
  50. ncbi Involvement of circadian clock gene Clock in diabetes-induced circadian augmentation of plasminogen activator inhibitor-1 (PAI-1) expression in the mouse heart
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    FEBS Lett 579:3555-9. 2005
    ..Our results suggested that the circadian clock component, CLOCK, is involved in the diabetes-induced circadian augmentation of PAI-1 expression in the mouse heart...
  51. ncbi Thrombomodulin is a clock-controlled gene in vascular endothelial cells
    Norihiko Takeda
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Biol Chem 282:32561-7. 2007
    ..In conclusion, these data suggest that the peripheral clock in vascular endothelial cells regulates TM gene expression and that the oscillation of TM expression may contribute to the circadian variation of cardiovascular events...
  52. ncbi Bimodal circadian expression of serotonin N-acetyltransferase mRNA in the retina of rats under restricted feeding
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Neurosci Lett 351:21-4. 2003
    ..Our results suggest that NAT mRNA in the rat retina is regulated by at least two circadian oscillatory mechanisms: one is affected by feeding and the other can oscillate independent to the imposed feeding cycles...
  53. doi Short-term feeding at the wrong time is sufficient to desynchronize peripheral clocks and induce obesity with hyperphagia, physical inactivity and metabolic disorders in mice
    Yuki Yasumoto
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan
    Metabolism 65:714-27. 2016
    ..Feeding at unusual times of the day (inactive phase) is thought to be associated with obesity and metabolic disorders in experimental animals and in humans...
  54. doi Dietary heat-killed Lactobacillus brevis SBC8803 promotes voluntary wheel-running and affects sleep rhythms in mice
    Koyomi Miyazaki
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba 305 8566, Japan Electronic address
    Life Sci 111:47-52. 2014
    ..Here we assessed whether a diet supplemented with heat-killed SBC8803 affects circadian locomotor rhythmicity and sleep architecture...
  55. ncbi Harmine lengthens circadian period of the mammalian molecular clock in the suprachiasmatic nucleus
    Daisuke Kondoh
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST
    Biol Pharm Bull 37:1422-7. 2014
    ..Harmine might lengthen the circadian period of the molecular clock by increasing PER2 protein stability in the SCN. ..
  56. ncbi Cloning of Cyc (Bmal1) homolog in Bombyx mori: structural analysis and tissue specific distributions
    Elitza P Markova
    Division of Molecular Science, Graduate School of Science and Technology, Kobe University, 1 1 Rokkodai, Nada, Kobe 657 8501, Japan
    Comp Biochem Physiol B Biochem Mol Biol 134:535-42. 2003
    ..Also no significant day, night time-specific difference in expression of BmCyc gene in the head was detected...
  57. doi The harmala alkaloid harmine is a modulator of circadian Bmal1 transcription
    Yoshiaki Onishi
    Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Higashi 1 1 1, Tsukuba 305 8566, Japan
    Biosci Rep 32:45-52. 2012
    ..These results suggest that harmine extends the circadian period by enhancing RORα function and that harmine is a new candidate that contributes to the control of period length in mammalian cells...
  58. doi Circadian clock in Ciona intestinalis revealed by microarray analysis and oxygen consumption
    Toshifumi Minamoto
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Japan
    J Biochem 147:175-84. 2010
    ..These data suggest that C. intestinalis have a unique molecular circadian clock and the daily environmental change is not such a strong effect for sea squirt in its evolution when compared to vertebrates and insects...
  59. doi Wheat alkylresorcinols reduce micellar solubility of cholesterol in vitro and increase cholesterol excretion in mice
    Kazumasa Horikawa
    a Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Japan
    Nat Prod Res 31:578-582. 2017
    ..These suggest that one underlying mechanism through which ARs suppress diet-induced obesity is by interfering with the micellar cholesterol solubilisation in the digestive tract, which subsequently decreases cholesterol absorption...
  60. pmc Molecular clock regulates daily α1-2-fucosylation of the neural cell adhesion molecule (NCAM) within mouse secondary olfactory neurons
    Daisuke Kondoh
    From the Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba 305 8566, the Department of Basic Veterinary Medicine, Laboratory of Veterinary Anatomy, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080 8555
    J Biol Chem 289:36158-65. 2014
    ..These findings suggest the possibility that the molecular clock is involved in the diurnal regulation of olfaction via α1-2-fucosylation in the olfactory system. ..
  61. doi Impact of denervation-induced muscle atrophy on housekeeping gene expression in mice
    Reiko Nakao
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki, 305 8566, Japan
    Muscle Nerve 51:276-81. 2015
    ..Identification of suitable reference genes that are not affected by experimental conditions is a critical step in accurate normalization of real-time RT-PCR...
  62. ncbi Circadian fluctuations in circulating plasminogen activator inhibitor-1 are independent of feeding cycles in mice
    Katsutaka Oishi
    a Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Chronobiol Int . 2016
    ..6 hours in the livers of DF, compared with NF mice. The day-night feeding cycle is not a critical Zeitgeber for circadian rhythm of circulating PAI-1...
  63. doi Atypical expression of circadian clock genes in denervated mouse skeletal muscle
    Reiko Nakao
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Chronobiol Int 32:486-96. 2015
    ..Our findings revealed that sciatic denervation disrupts the circadian expression of clock and clock-controlled genes either directly or indirectly via muscle atrophy in the gastrocnemius muscles of mice in a gene-specific manner. ..
  64. doi Effect of feeding behavior on circadian regulation of endothelin expression in mouse colon
    Takaharu Kozakai
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki 305 8566, Japan Yamagata University, Faculty of Education, Art and Science, Kojirakawa 1 4 12, Yamagata 990 8560, Japan
    Life Sci 118:232-7. 2014
    ..We investigated the dependence on feeding schedule and biological clock of the regulation of ET-1 gene expression in mouse colon...
  65. doi Dosing schedule-dependent attenuation of dexamethasone-induced muscle atrophy in mice
    Reiko Nakao
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Chronobiol Int 31:506-14. 2014
    ..These results suggest that glucocorticoid-induced muscle atrophy can be attenuated by optimizing the dosing schedule. ..
  66. ncbi Ontogeny of circadian expression of serotonin N-acetyltransferase mRNA in the rat retina
    Katsuhiko Sakamoto
    Clock Cell Biology Group, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba 305 8566, Japan
    Neurosci Lett 317:53-5. 2002
    ....
  67. ncbi [Clock genes and clock-controlled genes in mammals]
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST
    Nihon Rinsho 70:1109-14. 2012
    ..This review summarized the recent information of clock and clock-controlled genes in mammals...
  68. doi Blood coagulation and metabolic profiles in middle-aged male and female ob/ob mice
    Naoki Ohkura
    aMolecular Physiology and Pathology, School of Pharma Sciences, Teikyo University, Tokyo bBiological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Ibaraki cDepartment of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan
    Blood Coagul Fibrinolysis 26:522-6. 2015
    ..These results provided fundamental information about blood coagulation and metabolic features for exploring the function of altered blood coagulation states in ob/ob mice. ..
  69. pmc Free access to a running-wheel advances the phase of behavioral and physiological circadian rhythms and peripheral molecular clocks in mice
    Yuki Yasumoto
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan
    PLoS ONE 10:e0116476. 2015
    ..These findings indicated that endogenous clock-governed voluntary wheel-running activity provides feedback to the central circadian clock that systemically governs behavioral and physiological rhythms. ..