Affiliation: National Institute of Infectious Diseases
- Suppression of acute viremia by short-term postexposure prophylaxis of simian/human immunodeficiency virus SHIV-RT-infected monkeys with a novel reverse transcriptase inhibitor (GW420867) allows for development of potent antiviral immune responses resultiK Mori
AIDS Research Center, National Institute of Infectious Diseases, Tokyo Japan
J Virol 74:5747-53. 2000..This model provides a unique means to define mechanisms and correlates of disease protection...
- Induction of protective immunity against pathogenic simian immunodeficiency virus by a foreign receptor-dependent replication of an engineered avirulent virusT Matano
AIDS Research Center, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, 208 0011, Tokyo, Japan
Vaccine 18:3310-8. 2000..This strategy may be useful for development of safe and effective vaccines against various kinds of pathogenic viruses...
- Quintuple deglycosylation mutant of simian immunodeficiency virus SIVmac239 in rhesus macaques: robust primary replication, tightly contained chronic infection, and elicitation of potent immunity against the parental wild-type strainK Mori
AIDS Research Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan
J Virol 75:4023-8. 2001..Thus, the quintuple deglycosylation mutant appeared to represent a novel class of SIV live attenuated vaccine...