M Makino

Summary

Affiliation: National Institute of Infectious Diseases
Country: Japan

Publications

  1. ncbi request reprint Substrate-bound fibronectin enhances scavenger receptor activity of macrophages by calcium signaling
    M Beppu
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan
    Arch Biochem Biophys 390:243-52. 2001
  2. ncbi request reprint Aggregation of mycobacteria caused by disruption of fibronectin-attachment protein-encoding gene
    Yuji Miyamoto
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aobacho, Higashimurayama, Tokyo 189 0002, Japan
    FEMS Microbiol Lett 236:227-34. 2004
  3. pmc Identification of an Immunomodulating Agent from Mycobacterium leprae
    Yumi Maeda
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aobacho, Higashimurayama, Tokyo 189 0002, Japan
    Infect Immun 73:2744-50. 2005
  4. ncbi request reprint Immunostimulatory activity of major membrane protein-II from Mycobacterium leprae
    Masahiko Makino
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aobacho, Higashimurayama, Tokyo 189 0002, Japan
    Cell Immunol 233:53-60. 2005
  5. pmc Structural analysis and biosynthesis gene cluster of an antigenic glycopeptidolipid from Mycobacterium intracellulare
    Nagatoshi Fujiwara
    Department of Host Defense, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Bacteriol 190:3613-21. 2008
  6. pmc Polyclonal activation of naïve T cells by urease deficient-recombinant BCG that produced protein complex composed of heat shock protein 70, CysO and major membrane protein-II
    Yumiko Tsukamoto
    Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aobacho, Higashimurayama, Tokyo 189 0002, Japan
    BMC Infect Dis 14:179. 2014
  7. ncbi request reprint [Development of a novel recombinant BCG for tuberculosis vaccine]
    Masahiko Makino
    Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 82:107-10. 2013
  8. pmc An in vitro model of Mycobacterium leprae induced granuloma formation
    Hongsheng Wang
    Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 12 Jiangwangmiao Road, Nanjing 210042, China
    BMC Infect Dis 13:279. 2013
  9. ncbi request reprint [Current advances in leprosy research activities]
    Masahiko Makino
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo 189 0002, Japan
    Nihon Hansenbyo Gakkai Zasshi 74:3-22. 2005
  10. ncbi request reprint Association of CD40 ligand expression on HTLV-I-infected T cells and maturation of dendritic cells
    M Makino
    Division of Human Retrovirus, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan
    Scand J Immunol 54:574-81. 2001

Detail Information

Publications55

  1. ncbi request reprint Substrate-bound fibronectin enhances scavenger receptor activity of macrophages by calcium signaling
    M Beppu
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan
    Arch Biochem Biophys 390:243-52. 2001
    ....
  2. ncbi request reprint Aggregation of mycobacteria caused by disruption of fibronectin-attachment protein-encoding gene
    Yuji Miyamoto
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aobacho, Higashimurayama, Tokyo 189 0002, Japan
    FEMS Microbiol Lett 236:227-34. 2004
    ..These results indicate that the FAP affects the cell surface properties, and its deletion lead to enhanced aggregation of the M. smegmatis...
  3. pmc Identification of an Immunomodulating Agent from Mycobacterium leprae
    Yumi Maeda
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aobacho, Higashimurayama, Tokyo 189 0002, Japan
    Infect Immun 73:2744-50. 2005
    ..Taken together, MMP-II can be recognized as an immunomodulating protein in terms of activation of antigen-presenting cells and innate immunity...
  4. ncbi request reprint Immunostimulatory activity of major membrane protein-II from Mycobacterium leprae
    Masahiko Makino
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aobacho, Higashimurayama, Tokyo 189 0002, Japan
    Cell Immunol 233:53-60. 2005
    ..These results suggest that memory T cells from PB leprosy are primed with MMP-II prior to the manifestation of the disease, and MMP-II is highly antigenic in terms of activation of adaptive immunity...
  5. pmc Structural analysis and biosynthesis gene cluster of an antigenic glycopeptidolipid from Mycobacterium intracellulare
    Nagatoshi Fujiwara
    Department of Host Defense, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Bacteriol 190:3613-21. 2008
    ..253 containing gtfB-drrC of M. intracellulare serotype 16, and the transformant produced serotype 16 GPL. Together, the ORFs of this serotype 16-specific gene cluster are responsible for the biosynthesis of serotype 16 GPL...
  6. pmc Polyclonal activation of naïve T cells by urease deficient-recombinant BCG that produced protein complex composed of heat shock protein 70, CysO and major membrane protein-II
    Yumiko Tsukamoto
    Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aobacho, Higashimurayama, Tokyo 189 0002, Japan
    BMC Infect Dis 14:179. 2014
    ....
  7. ncbi request reprint [Development of a novel recombinant BCG for tuberculosis vaccine]
    Masahiko Makino
    Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 82:107-10. 2013
    ..The effect of BCG-DHTM as a vaccine for tuberculosis is not fully convincing and need the improvement, however, our strategy in the development of new recombinant BCG for tuberculosis seems to provide useful tool...
  8. pmc An in vitro model of Mycobacterium leprae induced granuloma formation
    Hongsheng Wang
    Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 12 Jiangwangmiao Road, Nanjing 210042, China
    BMC Infect Dis 13:279. 2013
    ..In the pathogenesis of leprosy, granulomas play a key role, however, the mechanisms of the formation and maintenance of M. leprae granulomas are still not clearly understood...
  9. ncbi request reprint [Current advances in leprosy research activities]
    Masahiko Makino
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo 189 0002, Japan
    Nihon Hansenbyo Gakkai Zasshi 74:3-22. 2005
    ..Leprosy caused by M. leprae is still unclear on various aspects including transmission, immunology, nerve damage etc. Here we introduce the recent advances in the field of basic leprosy research...
  10. ncbi request reprint Association of CD40 ligand expression on HTLV-I-infected T cells and maturation of dendritic cells
    M Makino
    Division of Human Retrovirus, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan
    Scand J Immunol 54:574-81. 2001
    ..The CD40L+ T-cell-induced maturation was blocked by anti-CD40L antibody. Therefore, the lack of CD40L expression on HTLV-I-infected T cells may be associated with the development of ATL...
  11. ncbi request reprint Impaired maturation and function of dendritic cells by mycobacteria through IL-1beta
    Masahiko Makino
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Eur J Immunol 36:1443-52. 2006
    ..Therefore, production of IL-1beta by mycobacteria-infected antigen-presenting cells counteracts effective stimulation of innate and adaptive immune responses...
  12. ncbi request reprint GM-CSF-mediated T-cell activation by macrophages infected with recombinant BCG that secretes major membrane protein-II of Mycobacterium leprae
    Masahiko Makino
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    FEMS Immunol Med Microbiol 55:39-46. 2009
    ..leprae was inhibited in a GM-CSF-dependent manner when the precursor monocytes were infected with BCG-SM. BCG inducing GM-CSF production was effective in macrophage-mediated T-cell activation partially through IL-10 inhibition...
  13. ncbi request reprint [Identification of an immunodominant antigen of Mycobacterium leprae and its application for the development of protective measures]
    Masahiko Makino
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Japan
    Nihon Hansenbyo Gakkai Zasshi 75:279-83. 2006
    ..leprae. Then, we constructed a recombinant BCG secreting MMP-II. The recombinant BCG strongly stimulated both naive CD4+ and naive CD8+ T cells, and seemed to be a useful immunostimulatory agent...
  14. pmc Immunostimulatory activity of recombinant Mycobacterium bovis BCG that secretes major membrane protein II of Mycobacterium leprae
    Masahiko Makino
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aobacho, Higashimurayama, Tokyo 189 0002, Japan
    Infect Immun 74:6264-71. 2006
    ..Taken together, these results indicate that BCG capable of secreting the immunodominant Ag is more potent in the stimulation of T cells...
  15. ncbi request reprint Contribution of GM-CSF on the enhancement of the T cell-stimulating activity of macrophages
    Masahiko Makino
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aobacho, Higashimurayama, Tokyo 189 0002, Japan
    Microbes Infect 9:70-7. 2007
    ..leprae, Major Membrane Protein-II on their surface. These results indicate that GM-CSF, but not M-CSF, contributes to the up-regulation of the T cell-stimulating activity of M. leprae-infected macrophages...
  16. pmc Marked suppression of T cells by a benzothiophene derivative in patients with human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis
    M Makino
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    Clin Diagn Lab Immunol 6:316-22. 1999
    ..CI-959-A showed little toxicity toward lymphoma or HTLV-I-infected T-cell lines or toward monocytes and cultured DCs. These results suggest that CI-959-A might be a potent anti-HAM/TSP agent...
  17. pmc Mycobacterium leprae infection in monocyte-derived dendritic cells and its influence on antigen-presenting function
    Ken Hashimoto
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
    Infect Immun 70:5167-76. 2002
    ..M. leprae is a unique pathogen which remains resistant to DC-mediated T-cell immunity, at least in the early stages of infection...
  18. pmc Potent and selective inhibition of human immunodeficiency virus type 1 transcription by piperazinyloxoquinoline derivatives
    M Baba
    Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Sakuragaoka, Japan
    Antimicrob Agents Chemother 41:1250-5. 1997
    ..It was not inhibitory to HIV-1 Tat or the cellular transcription factors NF-kappaB and Sp1, suggesting that the piperazinyloxoquinoline derivatives are a group of HIV-1 transcription inhibitors with a unique mechanism of action...
  19. pmc Inhibition of the multiplication of Mycobacterium leprae by vaccination with a recombinant M. bovis BCG strain that secretes major membrane protein II in mice
    Y Maeda
    Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo 189 0002, Japan
    Clin Vaccine Immunol 16:1399-404. 2009
    ..BCG-SM inhibited the multiplication of M. leprae in the footpads of C57BL/6J mice more efficiently than BCG-pMV. These results indicate that a BCG strain that secretes MMP-II could be a better vaccine candidate for leprosy...
  20. ncbi request reprint Enhanced activation of T lymphocytes by urease-deficient recombinant bacillus Calmette-Guérin producing heat shock protein 70-major membrane protein-II fusion protein
    Tetsu Mukai
    Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    J Immunol 185:6234-43. 2010
    ..leprae than vector control BCG. These results indicate that the triple combination of HSP70, MMP-II, and urease depletion may provide a useful tool for inducing better activation of naive T cells...
  21. ncbi request reprint CD4+ T-cell activation by antigen-presenting cells infected with urease-deficient recombinant Mycobacterium bovis bacillus Calmette-Guérin
    Tetsu Mukai
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    FEMS Immunol Med Microbiol 53:96-106. 2008
    ..C57BL/6 mice intradermally inoculated with BCG-Delta UT more efficiently produced memory T cells that responded to recall antigen. Therefore, the depletion of urease from BCG is useful for the activation of T cells...
  22. ncbi request reprint Assessment of cell mediated immunogenicity of Mycobacterium leprae-derived antigens
    Yumi Maeda
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama, 189 0002, Tokyo, Japan
    Cell Immunol 222:69-77. 2003
    ..Furthermore, the intracellular perforin production in CD8(+) T cells was up-regulated in an Ag-dose dependent manner. These results suggest that M. leprae membrane Ags might be useful as the vaccinating agents against leprosy...
  23. pmc The role of human T-lymphotropic virus type 1 (HTLV-1)-infected dendritic cells in the development of HTLV-1-associated myelopathy/tropical spastic paraparesis
    M Makino
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    J Virol 73:4575-81. 1999
    ..These results suggest that DCs are susceptible to HTLV-1 infection and that their cognate interaction with T cells may contribute to the development of HAM/TSP...
  24. ncbi request reprint Production of functionally deficient dendritic cells from HTLV-I-infected monocytes: implications for the dendritic cell defect in adult T cell leukemia
    M Makino
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Virology 274:140-8. 2000
    ..These results suggest that HTLV-I-infected monocytes cannot properly differentiate to DCs and that this might be one of the important mechanisms producing dysfunctional DCs in ATL patients...
  25. ncbi request reprint Induction of cross-priming of naive CD8+ T lymphocytes by recombinant bacillus Calmette-Guerin that secretes heat shock protein 70-major membrane protein-II fusion protein
    Tetsu Mukai
    Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    J Immunol 183:6561-8. 2009
    ..These results indicate that BCG-70M activated DC, CD4(+) T cells, and CD8(+) T cells, and the combination of HSP70 and MMP-II may be useful for inducing better T cell activation...
  26. pmc Characterization of the fucosylation pathway in the biosynthesis of glycopeptidolipids from Mycobacterium avium complex
    Yuji Miyamoto
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aobacho, Higashimurayama, Tokyo 189 0002, Japan
    J Bacteriol 189:5515-22. 2007
    ..Our findings may contribute to the clarification of the complex glycosylation pathways involved in forming the oligosaccharide portion of GPLs from the M. avium complex, which are structurally distinct...
  27. pmc Identification and characterization of the genes involved in glycosylation pathways of mycobacterial glycopeptidolipid biosynthesis
    Yuji Miyamoto
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aobacho, Higashimurayama, Tokyo 189 0002, Japan
    J Bacteriol 188:86-95. 2006
    ..Our findings propose that both M. smegmatis and M. avium have the common glycosylation pathway in the early steps of GPL biosynthesis but differ at the later stages...
  28. ncbi request reprint Inhibition of human immunodeficiency virus type 1 replication and cytokine production by fluoroquinoline derivatives
    M Baba
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima 890, Japan
    Mol Pharmacol 53:1097-103. 1998
    ....
  29. ncbi request reprint Role of the polypeptide region of a 33kDa mycobacterial lipoprotein for efficient IL-12 production
    Yasuko Yamashita
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aobacho, Higashimurayama, Tokyo 189 0002, Japan
    Cell Immunol 229:13-20. 2004
    ..Therefore, both peptide regions of LpK and lipid residues are necessary for efficient IL-12 production...
  30. ncbi request reprint IL-12 and IL-18 synergistically induce the bactericidal activity of murine peritoneal cells against M. leprae
    H Nomaguchi
    Leprosy Research Center, National Institute Infectious Diseases, 4 2 1 Aobacho, Higashimurayama shi, Tokyo 189 0002, Japan
    Nihon Hansenbyo Gakkai Zasshi 70:113-9. 2001
    ..IL-12 and IL-18 induced host cell death through NK-cells and T-cells. Therefore. IL-12 and IL-18 play an important role on direct killing of intracellular M. leprae and on indirect killing of them through inducing host cell death...
  31. pmc The Mycobacterium avium complex gtfTB gene encodes a glucosyltransferase required for the biosynthesis of serovar 8-specific glycopeptidolipid
    Yuji Miyamoto
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo 189 0002, Japan
    J Bacteriol 190:7918-24. 2008
    ..Our findings might provide a clue to understanding the biosynthetic regulation that modulates the biological functions of GPLs in MAC...
  32. pmc Serological diagnosis of leprosy in patients in vietnam by enzyme-linked immunosorbent assay with Mycobacterium leprae-derived major membrane protein II
    Masanori Kai
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama, Tokyo 189 0002, Japan
    Clin Vaccine Immunol 15:1755-9. 2008
    ..Overall, the epidemiological study conducted in Vietnam suggests that serological testing with MMP-II would be beneficial in detecting leprosy...
  33. ncbi request reprint Analysis of drug-resistant strains of Mycobacterium leprae in an endemic area of Vietnam
    Masanori Kai
    Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
    Clin Infect Dis 52:e127-32. 2011
    ..However, the rate of reduction has decelerated over the years, giving early detection of Mycobacterium leprae and epidemiological study of relapse renewed relevance in attempts to eliminate the disease...
  34. ncbi request reprint Temperature dependency for survival of Mycobacterium leprae in macrophages
    Yasuo Fukutomi
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1, Aoba cho, Higashimurayama shi, Tokyo 189 0002, Japan
    Nihon Hansenbyo Gakkai Zasshi 78:7-16. 2009
    ..However, the viability of M. leprae was almost lost within 2 weeks if cultured at 37 degrees C. These data suggest that temperature is a crucial factor for the survival of M. leprae in host cells...
  35. pmc Multiple cases of cutaneous Mycobacterium massiliense infection in a "hot spa" in Japan
    Kazue Nakanaga
    Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama shi, Tokyo 189 0002, Japan
    J Clin Microbiol 49:613-7. 2011
    ..This is the first known report of cutaneous M. massiliense infections that could not be attributed to a prior invasive procedure. This is also the first report of M. massiliense infection in Japan...
  36. pmc Mutation analysis of the Mycobacterium leprae folP1 gene and dapsone resistance
    Noboru Nakata
    Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Antimicrob Agents Chemother 55:762-6. 2011
    ..This study confirmed that point mutations at codon 53 or 55 of the M. leprae folP1 gene result in dapsone resistance...
  37. pmc Novel rhamnosyltransferase involved in biosynthesis of serovar 4-specific glycopeptidolipid from Mycobacterium avium complex
    Yuji Miyamoto
    Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aobacho, Higashimurayama, Tokyo 189 0002, Japan
    J Bacteriol 192:5700-8. 2010
    ..These findings may provide clues to understanding the biological role of serovar 4-specific GPL in MAC pathogenicity and may also provide new insights into glycosyltransferase, which generates structural and functional diversity of GPLs...
  38. ncbi request reprint Detection of serum antibodies to M. leprae major membrane protein-II in leprosy patients from Indonesia
    Mochammad Hatta
    Department of Microbiology, Faculty of Medicine, Molecular Biology and Immunology Laboratory, Hasanuddin University, KM 10, Kampus Tamalanrea, Makassar, Indonesia
    Lepr Rev 80:402-9. 2009
    ..We previously showed that antibodies to Major Membrane Protein-II (MMP-II) derived from Mycobacterium leprae could be used to diagnose leprosy in Japan...
  39. ncbi request reprint [Forefront of vaccine development: tuberculosis and leprosy]
    Toshiki Tamura
    Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 78:271-6. 2009
    ..These results suggest that Th1 immune response induced by Peptide-25 plays an important role in the induction of functional activation of CD8+ cytotoxic T cells...
  40. ncbi request reprint Identification of trehalose dimycolate (cord factor) in Mycobacterium leprae
    Masanori Kai
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama shi, Tokyo 189 0002, Japan
    FEBS Lett 581:3345-50. 2007
    ..For the first time, MALDI-TOF mass analyses showed the presence of TDM in M. leprae...
  41. ncbi request reprint Evaluation of major membrane protein-II as a tool for serodiagnosis of leprosy
    Yumi Maeda
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    FEMS Microbiol Lett 272:202-5. 2007
    ..These percentage values were significantly higher than these values obtained for existing phenolic glycolipid-I based methods, suggesting that MMP-II antibody detection would facilitate the diagnosis of leprosy...
  42. ncbi request reprint High-level expression of pseudogenes in Mycobacterium leprae
    Koichi Suzuki
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    FEMS Microbiol Lett 259:208-14. 2006
    ..Although M. leprae has an exceptional number and proportion of pseudogenes among species, our results suggest that some of the M. leprae pseudogenes are not just 'decayed' genes, but may have a functional role...
  43. ncbi request reprint Identification of Mycobacterium species by comparative analysis of the dnaA gene
    Tetsu Mukai
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases NIID, Higashimurayama, Tokyo, Japan
    FEMS Microbiol Lett 254:232-9. 2006
    ..These results demonstrate that the variable sequences in the dnaA gene were species specific and were sufficient for the development of an accurate and rapid diagnosis of Mycobacterium species...
  44. ncbi request reprint Studies of lipoproteins of Mycobacterium leprae
    Yumi Maeda
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama, Tokyo 189 0002, Japan
    Nihon Hansenbyo Gakkai Zasshi 73:15-21. 2004
    ..leprae LpK is involved in protective immunity against leprosy. Pursuit of such lipoproteins may reveal insights into the pathogenesis of the disease...
  45. pmc Novel 33-kilodalton lipoprotein from Mycobacterium leprae
    Yumi Maeda
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo 189 0002, Japan
    Infect Immun 70:4106-11. 2002
    ..The studies imply that M. leprae LpK is involved in protective immunity against leprosy and may be a candidate for vaccine design...
  46. ncbi request reprint Characteristic mutations found in the ML0411 gene of Mycobacterium leprae isolated in Northeast Asian countries
    M Kai
    Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama, Tokyo 189 0002, Japan Electronic address
    Infect Genet Evol 19:200-4. 2013
    ..leprae TN ML0411 type of SNPs. These results demonstrate the existence of M. leprae strains in Northeast Asian region having characteristic SNP patterns...
  47. ncbi request reprint Upregulation of T-cell-stimulating activity of mycobacteria-infected macrophages
    H Kimura
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Scand J Immunol 60:278-86. 2004
    ..These results suggest that the induction of phenotypic changes in macrophages can lead to the upregulation of host defence activity against M. leprae...
  48. ncbi request reprint Fusion of mature dendritic cells and human T-lymphotropic virus type I infected T cells: its efficiency as an antigen-presenting cell
    Satoshi Shimokubo
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, 189 0002, Japan
    Virology 301:13-20. 2002
    ..The results suggest that fusion DC-T cells produce functionally competent Ag-presenting cells and may be a likely candidate for immunotherapeutic use...
  49. ncbi request reprint Complete inhibition of viral breakthrough by combination of MKC-442 with AZT during a long-term culture of HIV-1 infected cells
    M Okamoto
    Division of Human Retroviruses, Faculty of Medicine, Kagoshima University 8 35 1, Japan
    Antiviral Res 31:69-77. 1996
    ....
  50. ncbi request reprint Prognostic significance of reverse transcriptase-polymerase chain reaction measurement of carcinoembryonic antigen mRNA levels in tumor drainage blood and peripheral blood of patients with colorectal carcinoma
    T Taniguchi
    First Department of Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
    Cancer 89:970-6. 2000
    ..The objective of this study was to assess the prognostic value of detecting circulating tumor cells in the tumor drainage blood and peripheral blood of patients with colorectal carcinoma...
  51. pmc Immunostimulatory activity of major membrane protein II from Mycobacterium tuberculosis
    Yumiko Tsukamoto
    Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aobacho, Higashimurayama, Tokyo 189 0002, Japan
    Clin Vaccine Immunol 18:235-42. 2011
    ..These results indicate that M. tuberculosis-derived MMP, as a sole protein or as part of a fusion protein, may be useful for developing new vaccinating agents against tuberculosis...
  52. ncbi request reprint Induction of mucosal IgA following intravaginal administration of inactivated HIV-1-capturing nanospheres in mice
    Masaki Kawamura
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    J Med Virol 66:291-8. 2002
    ..Thus, HIV-NS may have great potential as a prophylactic HIV-1 vaccine and should be examined further for its efficacy in non-human primates...
  53. ncbi request reprint Overexpression of interleukin-15 prevents the development of murine retrovirus-induced acquired immunodeficiency syndrome
    Masayuki Umemura
    Laboratory of Host Defense, Research Institute for Disease Mechanism and Control, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    FASEB J 16:1755-63. 2002
    ..These results indicate that IL-15 prevents the progression of MAIDS and may provide insight into an immunotherapeutic approach using the IL-15 gene for controlling retrovirus-induced immunodeficiency...
  54. ncbi request reprint Active surveillance of leprosy contacts in country with low prevalence rate
    Masanori Kai
    Int J Lepr Other Mycobact Dis 72:50-3. 2004
    ..These results indicate that serological analysis of patient contacts might be useful to find out high risk individuals, and there are M. leprae strains resistant to chemotherapeutic agents in Pakistan...
  55. pmc Use of protein antigens for early serological diagnosis of leprosy
    Malcolm S Duthie
    Infectious Disease Research Institute, 1124 Columbia St, Suite 400, Seattle, WA 98104, USA
    Clin Vaccine Immunol 14:1400-8. 2007
    ..A serological diagnostic test capable of identifying and allowing treatment of early-stage leprosy could reduce transmission, prevent functional disabilities and stigmatizing deformities, and facilitate leprosy eradication...