Jun Kanno

Summary

Affiliation: National Institute of Health Sciences
Country: Japan

Publications

  1. ncbi request reprint Oral administration of pentachlorophenol induces interferon signaling mRNAs in C57BL/6 male mouse liver
    Jun Kanno
    Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences, Japan
    J Toxicol Sci 38:643-54. 2013
  2. pmc "Per cell" normalization method for mRNA measurement by quantitative PCR and microarrays
    Jun Kanno
    Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, 1 18 1, Kamiyoga, Tokyo 158 8501, Japan
    BMC Genomics 7:64. 2006
  3. ncbi request reprint Phytoestrogen-low diet for endocrine disruptor studies
    Jun Kanno
    Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    J Agric Food Chem 50:3883-5. 2002
  4. ncbi request reprint Overview: "Children's toxicology", a renovating study field of irreversible "early exposure-delayed effects"
    Jun Kanno
    Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences, Tokyo, Japan
    J Toxicol Sci 34:SP199-200. 2009
  5. ncbi request reprint Thioredoxin overexpression in mice, model of attenuation of oxidative stress, prevents benzene-induced hemato-lymphoid toxicity and thymic lymphoma
    Guang Xun Li
    Division of Cellular and Molecular Toxicology, Biological Safety and Research Center, National Institute of Health Sciences, Tokyo, Japan
    Exp Hematol 34:1687-97. 2006
  6. ncbi request reprint Protective role of connexin 32 in steady-state hematopoiesis, regeneration state, and leukemogenesis
    Yoko Hirabayashi
    Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences, Tokyo, Japan
    Exp Biol Med (Maywood) 232:700-12. 2007
  7. doi request reprint Role of hematopoietic microenvironment in prolonged impairment of B cell regeneration in age-related stromal-cell-impaired SAMP1 mouse: effects of a single dose of 5-fluorouracil
    Isao Tsuboi
    Department of Functional Morphology, Nihon University School of Medicine, 30 1 Ohyaguchikami machi, Itabashiku, Tokyo, Japan
    J Appl Toxicol 28:797-805. 2008
  8. ncbi request reprint Membrane channel connexin 32 maintains Lin(-)/c-kit(+) hematopoietic progenitor cell compartment: analysis of the cell cycle
    Yoko Hirabayashi
    Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences, Tokyo, Japan
    J Membr Biol 217:105-13. 2007
  9. ncbi request reprint Mechanism of benzene-induced hematotoxicity and leukemogenicity: current review with implication of microarray analyses
    Yoko Hirabayashi
    Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Toxicol Pathol 32:12-6. 2004
  10. ncbi request reprint Inflammatory biomarker, neopterin, suppresses B lymphopoiesis for possible facilitation of granulocyte responses, which is severely altered in age-related stromal-cell-impaired mice, SCI/SAM
    Akihiro Minami
    Department of Anatomy, Nihon University School of Medicine, 30 1 Ohyaguchi kamimachi, Tokyo, Japan
    Exp Biol Med (Maywood) 232:134-45. 2007

Detail Information

Publications68

  1. ncbi request reprint Oral administration of pentachlorophenol induces interferon signaling mRNAs in C57BL/6 male mouse liver
    Jun Kanno
    Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences, Japan
    J Toxicol Sci 38:643-54. 2013
    ..PCP might become a hint for developing low molecular weight orally available interferon mimetic drugs following imiquimod and RO4948191 as agonists of toll-like receptor and interferon receptor. ..
  2. pmc "Per cell" normalization method for mRNA measurement by quantitative PCR and microarrays
    Jun Kanno
    Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, 1 18 1, Kamiyoga, Tokyo 158 8501, Japan
    BMC Genomics 7:64. 2006
    ..Since mRNAs are copied from genomic DNA, the simplest way to express mRNA level would be as copy number per template DNA, or more practically, as copy number per cell...
  3. ncbi request reprint Phytoestrogen-low diet for endocrine disruptor studies
    Jun Kanno
    Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    J Agric Food Chem 50:3883-5. 2002
    ....
  4. ncbi request reprint Overview: "Children's toxicology", a renovating study field of irreversible "early exposure-delayed effects"
    Jun Kanno
    Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences, Tokyo, Japan
    J Toxicol Sci 34:SP199-200. 2009
    ..As an overview, toxicology has entered a new phase where children's toxicology becomes a renovating study field of the irreversible "early exposure-delayed effects"...
  5. ncbi request reprint Thioredoxin overexpression in mice, model of attenuation of oxidative stress, prevents benzene-induced hemato-lymphoid toxicity and thymic lymphoma
    Guang Xun Li
    Division of Cellular and Molecular Toxicology, Biological Safety and Research Center, National Institute of Health Sciences, Tokyo, Japan
    Exp Hematol 34:1687-97. 2006
    ....
  6. ncbi request reprint Protective role of connexin 32 in steady-state hematopoiesis, regeneration state, and leukemogenesis
    Yoko Hirabayashi
    Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences, Tokyo, Japan
    Exp Biol Med (Maywood) 232:700-12. 2007
    ..The results indicate that Cx32 in wild-type mice protects HSCs from chemical abrasion and leukemogenic impacts...
  7. doi request reprint Role of hematopoietic microenvironment in prolonged impairment of B cell regeneration in age-related stromal-cell-impaired SAMP1 mouse: effects of a single dose of 5-fluorouracil
    Isao Tsuboi
    Department of Functional Morphology, Nihon University School of Medicine, 30 1 Ohyaguchikami machi, Itabashiku, Tokyo, Japan
    J Appl Toxicol 28:797-805. 2008
    ..An impaired regulation of the expressions of not only positive but also negative regulators after 5-FU treatment was, in part, the cause of the impaired regeneration of CFU-preB cells in SCI mice...
  8. ncbi request reprint Membrane channel connexin 32 maintains Lin(-)/c-kit(+) hematopoietic progenitor cell compartment: analysis of the cell cycle
    Yoko Hirabayashi
    Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences, Tokyo, Japan
    J Membr Biol 217:105-13. 2007
    ..e., being quiescent and noncycling; and once Cx32 is knocked out, these progenitor cells are expected to enter the cell cycle, followed by proliferation and differentiation for maintaining the number of peripheral blood cells...
  9. ncbi request reprint Mechanism of benzene-induced hematotoxicity and leukemogenicity: current review with implication of microarray analyses
    Yoko Hirabayashi
    Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Toxicol Pathol 32:12-6. 2004
    ..Compatible and discriminative gene expression profiling between the p53 knockout mice and wild-type mice was observed after benzene exposure by microarray analyses...
  10. ncbi request reprint Inflammatory biomarker, neopterin, suppresses B lymphopoiesis for possible facilitation of granulocyte responses, which is severely altered in age-related stromal-cell-impaired mice, SCI/SAM
    Akihiro Minami
    Department of Anatomy, Nihon University School of Medicine, 30 1 Ohyaguchi kamimachi, Tokyo, Japan
    Exp Biol Med (Maywood) 232:134-45. 2007
    ....
  11. pmc Benzene-induced hematopoietic neoplasms including myeloid leukemia in Trp53-deficient C57BL/6 and C3H/He mice
    Yasushi Kawasaki
    Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Toxicol Sci 110:293-306. 2009
    ..The detection of AMLs in heterozygous Trp53-deficient mice, even in the C57BL/6 strain, implies that benzene may be a potent inducer of AMLs also in mice with some strain differences...
  12. pmc The OECD program to validate the rat uterotrophic bioassay. Phase 2: coded single-dose studies
    Jun Kanno
    National Institute of Health Sciences, Tokyo, Japan
    Environ Health Perspect 111:1550-8. 2003
    ..These results will be submitted along with other data for independent peer review to provide support for the validation of the uterotrophic bioassay...
  13. doi request reprint Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm-specific enhancer of Mesp2
    Yukuto Yasuhiko
    Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Development 135:3511-9. 2008
    ..These results demonstrate that there is significant evolutionary conservation of Mesp regulatory mechanisms between fish and mice...
  14. ncbi request reprint Exacerbation of benzene pneumotoxicity in connexin 32 knockout mice: enhanced proliferation of CYP2E1-immunoreactive alveolar epithelial cells
    Byung Il Yoon
    Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagayaku, Tokyo 158 8501, Japan
    Toxicology 195:19-29. 2004
    ..But the results did not indicate any enhancement of pulmonary tumorigenesis in the Cx32 KO mice though the number of animals was small...
  15. ncbi request reprint Transcription factors Mesp2 and Paraxis have critical roles in axial musculoskeletal formation
    Yu Takahashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, Setagayaku, Tokyo, Japan
    Dev Dyn 236:1484-94. 2007
    ..The present data strongly suggest that patterning events by bHLH-type transcription factors have deep impacts on regional chondrogenic and myogenic differentiation of somitic cells, mainly by means of control of Pax genes...
  16. doi request reprint Benzene-induced hematopoietic toxicity transmitted by AhR in wild-type mouse and nullified by repopulation with AhR-deficient bone marrow cells: time after benzene treatment and recovery
    Yoko Hirabayashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Chemosphere 73:S290-4. 2008
    ..p. treatment and the i.g. treatment; however, the number of granulo-macrophage colony-forming unit in vitro (CFU-GM) was a common target parameter, the benzene-induced toxicity of which was nullified by the AhR-KO BM cells...
  17. doi request reprint Cellular distributions of molecules with altered expression specific to the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model
    Miwa Takahashi
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Carcinogenesis 29:2218-26. 2008
    ..Selective expression of Tfrc in proliferative lesions suggests an involvement of changes in iron homeostasis during the process of tumor promotion/progression driven by FB or PB...
  18. ncbi request reprint Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation
    Yu Takahashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagayaku, Tokyo 158 8501, Japan
    Dev Biol 304:593-603. 2007
    ..The activation and subsequent suppression of Notch signaling might thus be a crucial event for both stripe pattern formation and boundary formation...
  19. doi request reprint Comparison of murine gene expression profiles between spontaneous and radiation-induced myelogenous leukemias: stochastic and probabilistic expression variances in the former vs radiation-specific expression commonalities in the latter
    Yoko Hirabayashi
    Division of Cellular and Molecular Toxicology, National Center for Biological Safety and Research, National Institute of Health Sciences, Tokyo, Japan
    Exp Hematol 37:195-205. 2009
    ....
  20. pmc Mechanisms of benzene-induced hematotoxicity and leukemogenicity: cDNA microarray analyses using mouse bone marrow tissue
    Byung Il Yoon
    Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, Tokyo, Japan
    Environ Health Perspect 111:1411-20. 2003
    ..Our cDNA microarray data provide valuable information for future investigations of the mechanisms underlying the toxicity and leukemogenicity of benzene...
  21. doi request reprint Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo
    Yu Takahashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagayaku, Tokyo 158 8501, Japan
    Dev Biol 380:172-84. 2013
    ..Therefore, we propose that rostro-caudal patterning of somites is not a prerequisite for metameric patterning of the IVD and VB, but instead required to stimulate IVD differentiation in the caudal half of the sclerotome...
  22. ncbi request reprint Inflammatory biomarker, neopterin, enlarges splenic mast-cell-progenitor pool: prominent impairment of responses in age-related stromal cell-impairment mouse SCI/SAM
    Toshitaka Fukumoto
    Department of Anatomy, Nihon University School of Medicine, 30 1 Ohyaguchi kami machi, Tokyo, Japan
    Int Immunopharmacol 6:1847-58. 2006
    ....
  23. pmc Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression
    Yukuto Yasuhiko
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, Kamiyoga 1 18 1, Setagaya Ku, Tokyo 158 8501, Japan
    Proc Natl Acad Sci U S A 103:3651-6. 2006
    ..This finding uncovers an additional component of the interacting network of various signaling pathways that are involved in somitogenesis...
  24. doi request reprint Increased cellular distribution of vimentin and Ret in the cingulum induced by developmental hypothyroidism in rat offspring maternally exposed to anti-thyroid agents
    Hitoshi Fujimoto
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Reprod Toxicol 34:93-100. 2012
    ..Thus, immunoreactive cells for vimentin and Ret may be quantitatively measurable targets of developmental hypothyroidism in white matter...
  25. ncbi request reprint Acute, subchronic and chronic toxicity studies of a synthetic antioxidant, 2,2'-isobutylidenebis(4,6-dimethylphenol) in rats
    Atsuya Takagi
    Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, Tokyo, Japan
    J Toxicol Sci 30:275-85. 2005
    ..84 mg/kg BW/day) on the basis of induction of thickening of basement membrane in renal tubules at 100 ppm...
  26. pmc Dose-dependent mesothelioma induction by intraperitoneal administration of multi-wall carbon nanotubes in p53 heterozygous mice
    Atsuya Takagi
    Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences, Tokyo, Japan
    Cancer Sci 103:1440-4. 2012
    ....
  27. ncbi request reprint Evaluation of nonthreshold leukemogenic response to methyl nitrosourea in p53-deficient C3H/He mice
    Yoko Hirabayashi
    Cellular and Molecular Toxicology Division, Center for Biological Safety and Research, National Institute of Health Sciences, Tokyo, Japan
    Toxicol Appl Pharmacol 190:251-61. 2003
    ....
  28. ncbi request reprint Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube
    Atsuya Takagi
    Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences, Kamiyoga, Tokyo, Japan
    J Toxicol Sci 33:105-16. 2008
    ....
  29. ncbi request reprint Improved dispersion method of multi-wall carbon nanotube for inhalation toxicity studies of experimental animals
    Yuhji Taquahashi
    Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences, Japan
    J Toxicol Sci 38:619-28. 2013
    ..This method and the chamber with direct injection system would facilitate the inhalation toxicity studies more relevant to human exposure. ..
  30. ncbi request reprint Development of humanized steroid and xenobiotic receptor mouse by homologous knock-in of the human steroid and xenobiotic receptor ligand binding domain sequence
    Katsuhide Igarashi
    Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences, Tokyo, Japan
    J Toxicol Sci 37:373-80. 2012
    ....
  31. ncbi request reprint Senescent B lymphopoiesis is balanced in suppressive homeostasis: decrease in interleukin-7 and transforming growth factor-beta levels in stromal cells of senescence-accelerated mice
    Isao Tsuboi
    Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Exp Biol Med (Maywood) 229:494-502. 2004
    ..Therefore, the acceleration of proliferative signaling and the deceleration of suppressive signaling may both be altered and weakened in a senescent stroma (i.e., homeosuppression)...
  32. ncbi request reprint Mesp1-nonexpressing cells contribute to the ventricular cardiac conduction system
    Satoshi Kitajima
    Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences, Setagaya Ku, Tokyo, Japan
    Dev Dyn 235:395-402. 2006
    ..Furthermore, we indicate a possibility that a population of the cells that contribute to the ventricular CCS might be distinguished at an early stage of development...
  33. pmc Learning and Memory Deficits in Male Adult Mice Treated with a Benzodiazepine Sleep-Inducing Drug during the Juvenile Period
    Yusuke Furukawa
    Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health SciencesTokyo, Japan Department of Comprehensive Pathology, Graduate School, Tokyo Medical and Dental UniversityTokyo, Japan
    Front Neurosci 10:339. 2016
    ..It may need to take an extra care for the prescription of benzodiazepine sleep-inducing drugs to juveniles because it might cause learning and memory deficits. ..
  34. ncbi request reprint Intrauterine environment-genome interaction and children's development (2): Brain structure impairment and behavioral disturbance induced in male mice offspring by a single intraperitoneal administration of domoic acid (DA) to their dams
    Kentaro Tanemura
    Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences, Tokyo, Japan
    J Toxicol Sci 34:SP279-86. 2009
    ....
  35. ncbi request reprint [Twenty-eight day repeated dose oral toxicity test of synergist of a pyrethroid insecticide, 2,3,3,3,2',3',3',3'-Octachlorodipropyl ether (S-421) in rats]
    Yuko Matsushima
    Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, Kamiyoga 1 18 1, Setagaya, Tokyo 158 8501, Japan
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku . 2003
    ..In conclusion, the no-observed-effect levels (NOEL) of S-421 under these conditions was judged to be 40 mg/kg/day...
  36. ncbi request reprint Aryl hydrocarbon receptor mediates benzene-induced hematotoxicity
    Byung Il Yoon
    Division of Cellular and Molecular Toxicology, National Institute of Health Sciences, 1 18 1 Kamiyohga, Setagayaku, Tokyo 158 8501, Japan
    Toxicol Sci 70:150-6. 2002
    ....
  37. ncbi request reprint Glycolytic inhibition by mutation of pyruvate kinase gene increases oxidative stress and causes apoptosis of a pyruvate kinase deficient cell line
    Ken ichi Aisaki
    Cellular and Molecular Toxicology Division, National Institute of Health and Sciences, Tokyo, Japan
    Exp Hematol 35:1190-200. 2007
    ..This study was aimed to elucidate the mechanisms attributing to apoptosis induced by R-PK deficiency...
  38. ncbi request reprint [Gymnema sylvestre leaf extract: a 52-week dietary toxicity study in Wistar rats]
    Yukio Ogawa
    Center for Biological Safety and Research, National Institute of Health Sciences 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Shokuhin Eiseigaku Zasshi 45:8-18. 2004
    ..00% in the diet for 52 weeks. The no-observable-effect level from this study is 1.00% GS, i.e., 504 mg/kg/day for male and 563 mg/kg/day for female as mean daily intake, for 52 weeks...
  39. ncbi request reprint Age/sex dependent and non-monotonous dose-response effect of diethylstilbestrol on the immune functions in mice
    Masanori Utsuyama
    Department of Pathology and Immunology, Aging and Developmental Sciences, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, 113 8519, Tokyo, Japan
    Toxicol Lett 135:145-53. 2002
    ..In conclusion, effect of exogenous estrogens on immune functions should be assessed for all age and sex, and in expectation of non-monotonous dose-response relationship...
  40. ncbi request reprint [Importance of researches on chronic effects by manufactured nanomaterials]
    Akihiko Hirose
    Division of Risk Assessment, National Institute of Health Sciences, Tokyo
    Yakugaku Zasshi 131:195-201. 2011
    ..Therefore, focusing on the toxicological characterization of chronic effects was considered to be most appropriate approach for establishing the risk assessment methods of nanomaterials...
  41. pmc Minichromosome maintenance 2 bound with retroviral Gp70 is localized to cytoplasm and enhances DNA-damage-induced apoptosis
    Shinya Abe
    Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 7:e40129. 2012
    ..Thus, depending on its subcellular localization, MCM2 plays different roles. It participates in DNA replication in the nucleus as shown previously, and enhances apoptosis in the cytoplasm...
  42. doi request reprint The K48-K63 Branched Ubiquitin Chain Regulates NF-κB Signaling
    Fumiaki Ohtake
    Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Tokyo 156 8506, Japan Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences, Tokyo 158 8501, Japan Electronic address
    Mol Cell 64:251-266. 2016
    ....
  43. pmc The OECD program to validate the rat uterotrophic bioassay. Phase 2: dose-response studies
    Jun Kanno
    National Institute of Health Sciences, Tokyo, Japan
    Environ Health Perspect 111:1530-49. 2003
    ..In conclusion, both the intact, immature, and adult OVX versions, and all protocols appear to be reproducible and transferable across laboratories and are able to detect weak estrogen agonists...
  44. doi request reprint Cellular distributions of molecules with altered expression specific to thyroid proliferative lesions developing in a rat thyroid carcinogenesis model
    Gye Hyeong Woo
    Division of Pathology, National Institute of Health Science, Setagaya Ku, Tokyo, Japan
    Cancer Sci 100:617-25. 2009
    ..Decrease of thyroglobulin in Ca may reflect dedifferentiation with progression...
  45. ncbi request reprint Serial transplantation of p53-deficient hemopoietic progenitor cells to assess their infinite growth potential
    Yoko Hirabayashi
    Cellular and Molecular Toxicology Division, Center for Biological Safety Research, National Institute of Health Sciences, 1 18 1 Kamioyhga, Setagayaku, Tokyo 158 8501
    Exp Biol Med (Maywood) 227:474-9. 2002
    ....
  46. doi request reprint Autoimmune regulator, Aire, is a novel regulator of chondrocyte differentiation
    Yuan Si
    Laboratory of Epigenetic Skeletal Diseases, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Biochem Biophys Res Commun 437:579-84. 2013
    ..Taken together, Aire might play a role as an active regulator of chondrocyte differentiation, which leads to new insights into the regulatory mechanisms of chondrocyte differentiation...
  47. ncbi request reprint Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites
    Yu Takahashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagayaku, Tokyo 158 8501, Japan
    Development 132:787-96. 2005
    ....
  48. pmc Ubiquitin acetylation inhibits polyubiquitin chain elongation
    Fumiaki Ohtake
    Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences, Setagaya ku Tokyo, Japan
    EMBO Rep 16:192-201. 2015
    ..These results characterize a mechanism whereby ubiquitin, itself a PTM, is subject to another PTM to modulate mono- and polyubiquitylation, thus adding a new regulatory layer to ubiquitin biology. ..
  49. pmc Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex
    Atsushi Yokoyama
    From the Department of Molecular Endocrinology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan, Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 289:18152-62. 2014
    ..We propose that formation of tissue-specific combinations of coregulator complexes is a critical mechanism for tissue-specific transcriptional regulation. ..
  50. pmc Estrogen receptor α in osteocytes regulates trabecular bone formation in female mice
    Shino Kondoh
    Laboratory of Epigenetic Skeletal Diseases, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    Bone 60:68-77. 2014
    ..These data suggest that ERα in osteocytes has osteoprotective functions in trabecular bone formation through regulating expression of Wnt antagonists, but conversely plays a negative role in cortical bone loss due to unloading. ..
  51. pmc Epigenetic regulation of adipogenesis by PHF2 histone demethylase
    Yosuke Okuno
    Laboratory of Epigenetic Skeletal Diseases, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    Diabetes 62:1426-34. 2013
    ..These findings suggest that PHF2 histone demethylase potentiates adipogenesis through interaction with CEBPA in vivo. Taken together, PHF2 may be a novel therapeutic target in the treatment of obesity and the metabolic syndrome...
  52. doi request reprint Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signalling
    Yusuke Okubo
    Department of Genetics, SOKENDAI, Yata 1111, Shizuoka 411 8540, Japan
    Nat Commun 3:1141. 2012
    ..Collectively, we provide a new model in which Lfng has a crucial role in intercellular coupling of the segmentation clock through a trans-repression mechanism...
  53. ncbi request reprint Assessment of quantitative dual-parameter flow cytometric analysis for the evaluation of testicular toxicity using cyclophosphamide- and ethinylestradiol-treated rats
    Chiaki Katoh
    Department of Preclinical Science, Nippon Roche K K, Research Center, 200 Kajiwara, Kamakura, Kanagawa 247 8530, Japan
    J Toxicol Sci 27:87-96. 2002
    ..These results demonstrate that this method is a very useful and powerful tool to assess testicular toxicity, especially in high-throughput toxicological studies...
  54. ncbi request reprint The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite
    Mitsuru Morimoto
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Development 134:1561-9. 2007
    ..Our study demonstrates that a Ripply2-Mesp2 negative-feedback loop is essential for the periodic generation of the rostro-caudal polarity within a somite...
  55. ncbi request reprint Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts
    Takashi Nakamura
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
    Cell 130:811-23. 2007
    ..Our results support a model in which estrogen regulates the life span of mature osteoclasts via the induction of the Fas/FasL system, thereby providing an explanation for the osteoprotective function of estrogen as well as SERMs...
  56. ncbi request reprint Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates
    Felix Grün
    Department of Developmental and Cell Biology, University of California Irvine, 2113 McGaugh Hall, Irvine, California 92697 2300, USA
    Mol Endocrinol 20:2141-55. 2006
    ..Developmental or chronic lifetime exposure to organotins may therefore act as a chemical stressor for obesity and related disorders...
  57. ncbi request reprint Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse
    Yusuke Watanabe
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Development 133:1625-34. 2006
    ..Our present study thus indicates that the Notch1 signaling pathway plays a suppressive role both in AV myocardial differentiation and the maturation of the ventricular myocardium...
  58. doi request reprint Predominant regeneration of B-cell lineage, instead of myeloid lineage, of the bone marrow after 1 Gy whole-body irradiation in mice: role of differential cytokine expression between B-cell stimulation by IL10, Flt3 ligand and IL7 and myeloid suppression
    Isao Tsuboi
    Department of Functional Morphology, Nihon University School of Medicine, Tokyo 173 8610, Japan
    Radiat Res 170:15-22. 2008
    ....
  59. pmc Premature ovarian failure in androgen receptor-deficient mice
    Hiroko Shiina
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 103:224-9. 2006
    ..Our findings suggest that AR function is required for normal female reproduction, particularly folliculogenesis, and that AR is a potential therapeutic target in POF syndrome...
  60. pmc E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis
    Yasuhiro Nakamura
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8575, Japan
    Am J Pathol 165:2019-31. 2004
    ..E4F1 is therefore considered one of the estrogen-responsive genes involving ER alpha-mediated inhibition of VSMC proliferation and may play an important role in estrogen-related atheroprotection of human aorta...
  61. ncbi request reprint Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling
    Aki Ishikawa
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Mech Dev 121:1443-53. 2004
    ..Collectively, our data suggest that the reciprocal interaction of Notch and Wnt signals, and of their respective negative feedback loops, function to organize the segmentation clock required for somitogenesis...
  62. ncbi request reprint A novel mechanism for polychlorinated biphenyl-induced decrease in serum thyroxine level in rats
    Yoshihisa Kato
    Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa 769 2193, Japan
    Drug Metab Dispos 35:1949-55. 2007
    ....
  63. ncbi request reprint Gene expression profiles in T24 human bladder carcinoma cells by inhibiting an L-type amino acid transporter, LAT1
    Shadi Baniasadi
    National Research Institute of Tuberculosis and Lung Diseases, Shaheed Beheshti University of Medical Science, Tehran, Iran
    Arch Pharm Res 30:444-52. 2007
    ..These data are useful for understanding of intracellular signaling of cell growth inhibition induced by LAT1 inhibitors as candidate for anticancer drug therapy...
  64. ncbi request reprint Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane
    Yasuhiro Miki
    Department of Pathology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8575, Japan
    Bone 40:876-87. 2007
    ..These results indicated that the steroidal aromatase inhibitor, EXE, stimulated hFOB cell proliferation via both AR dependent and independent pathways...
  65. pmc Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
    Frederick S vom Saal
    Reprod Toxicol 24:131-8. 2007
  66. ncbi request reprint Dysplasia and carcinoma development in a repeated dextran sulfate sodium-induced colitis model
    Isao Okayasu
    Department of Pathology, School of Medicine, Kitasato University, Sagamihara Kanagawa, Japan
    J Gastroenterol Hepatol 17:1078-83. 2002
    ..In the present study, a dysplasia-carcinoma sequence in a novel repeated colitis model in mice is documented...
  67. ncbi request reprint Mass distributed clustering: a new algorithm for repeated measurements in gene expression data
    Shinya Matsumoto
    Teradata Division, NCR Japan, Ltd 2 4 1 Shiba koen, Tokyo 105 0011, Japan
    Genome Inform 16:183-94. 2005
    ..This method permits truly unsupervised clustering of the data from DNA microarrays...
  68. ncbi request reprint Intrauterine position and postnatal growth in Sprague-Dawley rats and ICR mice
    Tetsuji Nagao
    Department of Life Science, Faculty of Science and Technology, Kinki University, Kowakae 3 4 1, Higashiosaka, Osaka 577 8502, Japan
    Reprod Toxicol 18:109-20. 2004
    ..The results of this study suggested that the intrauterine position of the embryos/fetuses did not affect the postnatal growth of the reproductive organs, sexual maturation, or behavior in rats and mice...