Mayumi Iwakawa

Summary

Affiliation: National Institute of Radiological Sciences
Country: Japan

Publications

  1. ncbi request reprint Analysis of non-genetic risk factors for adverse skin reactions to radiotherapy among 284 breast cancer patients
    Mayumi Iwakawa
    RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, Chiba ken 263 8555, Japan
    Breast Cancer 13:300-7. 2006
  2. ncbi request reprint Different radiation susceptibility among five strains of mice detected by a skin reaction
    Mayumi Iwakawa
    Frontier Research Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, Chiba ken 263 8555, Japan
    J Radiat Res 44:7-13. 2003
  3. doi request reprint Expression profiles are different in carbon ion-irradiated normal human fibroblasts and their bystander cells
    Mayumi Iwakawa
    RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba, Japan
    Mutat Res 642:57-67. 2008
  4. ncbi request reprint Strain dependent differences in a histological study of CD44 and collagen fibers with an expression analysis of inflammatory response-related genes in irradiated murine lung
    Mayumi Iwakawa
    RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences, Chiba shi, Japan
    J Radiat Res 45:423-33. 2004
  5. ncbi request reprint The radiation-induced cell-death signaling pathway is activated by concurrent use of cisplatin in sequential biopsy specimens from patients with cervical cancer
    Mayumi Iwakawa
    RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Cancer Biol Ther 6:905-11. 2007
  6. doi request reprint Application of carbon-ion beams or gamma-rays on primary tumors does not change the expression profiles of metastatic tumors in an in vivo murine model
    Tomoaki Tamaki
    RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 74:210-8. 2009
  7. doi request reprint Strain-dependent damage in mouse lung after carbon ion irradiation
    Takashi Moritake
    Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 84:e95-e102. 2012
  8. ncbi request reprint Inter-strain variance in late phase of erythematous reaction or leg contracture after local irradiation among three strains of mice
    Shuhei Noda
    Frontier Research Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, Chiba ken 263 8555, Japan
    Cancer Detect Prev 29:376-82. 2005
  9. doi request reprint The proangiogenic factor ephrin-A1 is up-regulated in radioresistant murine tumor by irradiation
    Kazunori Nojiri
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Exp Biol Med (Maywood) 234:112-22. 2009
  10. ncbi request reprint Upregulation of stress-response genes with cell cycle arrest induced by carbon ion irradiation in multiple murine tumors models
    Kaori Imadome
    RadGenomics Project, National Institute of Radiological Sciences, Inage, Chiba, Japan
    Cancer Biol Ther 7:208-17. 2008

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Analysis of non-genetic risk factors for adverse skin reactions to radiotherapy among 284 breast cancer patients
    Mayumi Iwakawa
    RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, Chiba ken 263 8555, Japan
    Breast Cancer 13:300-7. 2006
    ....
  2. ncbi request reprint Different radiation susceptibility among five strains of mice detected by a skin reaction
    Mayumi Iwakawa
    Frontier Research Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, Chiba ken 263 8555, Japan
    J Radiat Res 44:7-13. 2003
    ....
  3. doi request reprint Expression profiles are different in carbon ion-irradiated normal human fibroblasts and their bystander cells
    Mayumi Iwakawa
    RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba, Japan
    Mutat Res 642:57-67. 2008
    ....
  4. ncbi request reprint Strain dependent differences in a histological study of CD44 and collagen fibers with an expression analysis of inflammatory response-related genes in irradiated murine lung
    Mayumi Iwakawa
    RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences, Chiba shi, Japan
    J Radiat Res 45:423-33. 2004
    ..The expression analysis showed that the several genes are potentially involved in interstrain differences in inflammatory response causing radiation-induced lung fibrosis...
  5. ncbi request reprint The radiation-induced cell-death signaling pathway is activated by concurrent use of cisplatin in sequential biopsy specimens from patients with cervical cancer
    Mayumi Iwakawa
    RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Cancer Biol Ther 6:905-11. 2007
    ..To identify changes in gene expression related to the concurrent use of platinum compounds with radiotherapy, in the treatment of cervical cancer...
  6. doi request reprint Application of carbon-ion beams or gamma-rays on primary tumors does not change the expression profiles of metastatic tumors in an in vivo murine model
    Tomoaki Tamaki
    RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 74:210-8. 2009
    ..To clarify how carbon-ion radiotherapy (C-ion) on primary tumors affects the characteristics of subsequently arising metastatic tumor cells...
  7. doi request reprint Strain-dependent damage in mouse lung after carbon ion irradiation
    Takashi Moritake
    Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 84:e95-e102. 2012
    ..To examine whether inherent factors produce differences in lung morbidity in response to carbon ion (C-ion) irradiation, and to identify the molecules that have a key role in strain-dependent adverse effects in the lung...
  8. ncbi request reprint Inter-strain variance in late phase of erythematous reaction or leg contracture after local irradiation among three strains of mice
    Shuhei Noda
    Frontier Research Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, Chiba ken 263 8555, Japan
    Cancer Detect Prev 29:376-82. 2005
    ..To gain insights into inter-strain differences in radiosensitivity...
  9. doi request reprint The proangiogenic factor ephrin-A1 is up-regulated in radioresistant murine tumor by irradiation
    Kazunori Nojiri
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Exp Biol Med (Maywood) 234:112-22. 2009
    ..Our results suggest that radiotherapy-induced changes in gene expression related with angiogenesis might also modulate microenvironment and influence responsiveness of tumors...
  10. ncbi request reprint Upregulation of stress-response genes with cell cycle arrest induced by carbon ion irradiation in multiple murine tumors models
    Kaori Imadome
    RadGenomics Project, National Institute of Radiological Sciences, Inage, Chiba, Japan
    Cancer Biol Ther 7:208-17. 2008
    ..To elucidate the in vivo biological effects induced by carbon-ion irradiation using comprehensive expression analysis...
  11. ncbi request reprint Fractionated irradiation augments inter-strain variation of skin reactions among three strains of mice
    Toshie Ohta
    Frontier Research Center, National Institute of Radiological Sciences, Chiba ken, Japan
    J Radiat Res 45:515-9. 2004
    ..Our data suggest that genetic factors cause obvious variations in severity of damage and latent period after fractionated irradiation...
  12. doi request reprint Subtypes of cervical adenosquamous carcinomas classified by EpCAM expression related to radiosensitivity
    Kaori Imadome
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Cancer Biol Ther 10:1019-26. 2010
    ..This work provides a novel set of genes that could be used as independent prognostic markers and therapy targets...
  13. doi request reprint Genetic variants of NPAT-ATM and AURKA are associated with an early adverse reaction in the gastrointestinal tract of patients with cervical cancer treated with pelvic radiation therapy
    Atsuko Ishikawa
    RadGenomics Project, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 81:1144-52. 2011
    ..This study sought to associate polymorphisms in genes related to cell cycle regulation or genome maintenance with radiotherapy (RT)-induced an early adverse reaction (EAR) in patients with cervical cancer...
  14. doi request reprint Change in fibroblast growth factor 2 expression as an early phase radiotherapy-responsive marker in sequential biopsy samples from patients with cervical cancer during fractionated radiotherapy
    Miyako Nakawatari
    RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Cancer 116:5082-92. 2010
    ..In the current study, this finding was extended in newly enrolled patients and was investigated further in stromal FGF2 (FGF2-S) expression...
  15. doi request reprint In-gel multiple displacement amplification of long DNA fragments diluted to the single molecule level
    Yuichi Michikawa
    RadGenomics Project, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage, Chiba 263 8555, Japan
    Anal Biochem 383:151-8. 2008
    ..The haplotypes of seven SNPs spanning 240 kb of the DNA surrounding the human ATM gene region on chromosome 11 were determined for 10 individuals, demonstrating the feasibility of this new method...
  16. doi request reprint Combining carbon ion radiotherapy and local injection of α-galactosylceramide-pulsed dendritic cells inhibits lung metastases in an in vivo murine model
    Yu Ohkubo
    RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 78:1524-31. 2010
    ..The antimetastatic efficacy of local combination therapy of carbon ion radiotherapy and immunotherapy was examined by use of an in vivo murine model...
  17. doi request reprint Influence of multiple genetic polymorphisms on genitourinary morbidity after carbon ion radiotherapy for prostate cancer
    Tomo Suga
    RadGenomics Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 72:808-13. 2008
    ..To investigate the genetic risk of late urinary morbidity after carbon ion radiotherapy in prostate cancer patients...
  18. ncbi request reprint Villin1, a novel diagnostic marker for cervical adenocarcinoma
    Etsuko Nakamura
    RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Cancer Biol Ther 8:1146-53. 2009
    ..Our study suggests the existence of a subtype of cervical tumors which are VIL1 positive with poor radioresponse...
  19. ncbi request reprint Chemoradiation-induced expression of fibroblast growth factor-2 and laminin in patients with cervical cancer
    Miyako Nakawatari
    RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Cancer Biol Ther 6:1780-6. 2007
    ..In addition, we sought to examine the predictive value of such changes in expression for disease failure after chemoradiotherapy...
  20. ncbi request reprint Correlation between single nucleotide polymorphisms and jejunal crypt cell apoptosis after whole body irradiation
    Masaru Iwata
    RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences, Japan
    Int J Radiat Biol 83:181-6. 2007
    ..To identify loci concerned with radiosensitivity in a mouse model using single nucleotide polymorphism (SNP) markers...
  21. ncbi request reprint Attenuated lung fibrosis in interleukin 6 knock-out mice after C-ion irradiation to lung
    Tomoko Saito-Fujita
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba
    J Radiat Res 52:270-7. 2011
    ..These results indicated that IL-6 might not be essential for activating macrophages in the late phase, but plays an important role for fibrotic changes of the alveolar wall after irradiation...
  22. ncbi request reprint Haplotype-based analysis of genes associated with risk of adverse skin reactions after radiotherapy in breast cancer patients
    Tomo Suga
    RadGenomics Project, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 69:685-93. 2007
    ..To identify haplotypes of single nucleotide polymorphism markers associated with the risk of early adverse skin reactions (EASRs) after radiotherapy in breast cancer patients...
  23. ncbi request reprint DNA repair capacity measured by high throughput alkaline comet assays in EBV-transformed cell lines and peripheral blood cells from cancer patients and healthy volunteers
    Mayumi Iwakawa
    RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Mutat Res 588:1-6. 2005
    ..7) than in healthy donors (42.9+/-19.6) (P<0.05). We did not observe such differences in the EBV-transformed cell lines. Thus, radiation sensitivity of fresh PB cells measured by the alkaline comet assay was related to cancer status...
  24. ncbi request reprint Gene expression profile changes correlating with radioresistance in human cell lines
    Ken ichi Ishikawa
    RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences, Inage, Chiba, Japan
    Int J Radiat Oncol Biol Phys 65:234-45. 2006
    ..To identify gene expression profiles specific to radioresistance of human cells...
  25. ncbi request reprint Villin1, a diagnostic marker for endometrial adenocarcinoma with high grade nuclear atypia
    Etsuko Nakamura
    RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Cancer Biol Ther 12:181-90. 2011
    ..In addition, VIL1 immunostaining was detected in 25% of endometrial AC cases. These results suggested the existence of an aggressive and VIL1-positive subtype of gynecological tumor...
  26. doi request reprint Gene expression analysis in human malignant melanoma cell lines exposed to carbon beams
    Yoshitaka Matsumoto
    Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Radiat Biol 84:299-314. 2008
    ..To elucidate the molecular changes in response to carbon beams (C-ions) in melanoma...
  27. pmc Visible Genotype Sensor Array
    Yuichi Michikawa
    RadGenomics Project, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, 263 8555, Japan
    Sensors (Basel) 8:2722-2735. 2008
    ..All of the reactions can be performed within one hour using conventional laboratory instruments. This visible genotype sensor array is suitable for "focused genomics" that follows "comprehensive genomics"...
  28. ncbi request reprint Reliable and fast allele-specific extension of 3'-LNA modified oligonucleotides covalently immobilized on a plastic base, combined with biotin-dUTP mediated optical detection
    Yuichi Michikawa
    RadGenomics Project, National Institute of Radiological Sciences, Chiba, Japan
    Anal Sci 22:1537-45. 2006
    ....
  29. pmc Genome wide screen identifies microsatellite markers associated with acute adverse effects following radiotherapy in cancer patients
    Yuichi Michikawa
    RadGenomics Project, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    BMC Med Genet 11:123. 2010
    ..The response of normal tissues in cancer patients undergoing radiotherapy varies, possibly due to genetic differences underlying variation in radiosensitivity...
  30. ncbi request reprint Cyclooxygenase-2 impairs treatment effects of radiotherapy for cervical cancer by inhibition of radiation-induced apoptosis
    Hitoshi Ishikawa
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences NIRS, Chiba, Japan
    Int J Radiat Oncol Biol Phys 66:1347-55. 2006
    ..Cyclooxygenase-2 (COX-2) plays a pivotal role in regulation of radiation-induced apoptosis. The aim of this study was to analyze the relationship between COX-2 expression and postradiotherapy outcomes of patients with cervical cancer...
  31. ncbi request reprint CD44 and Bak expression in IL-6 or TNF-alpha gene knockout mice after whole lung irradiation
    Minako Sakai
    RadGenomics Research Group, National Institute of Radiological Sciences, Inage, Chiba, Japan
    J Radiat Res 49:409-16. 2008
    ..In conclusion, the radioresistant status of IL-6 KO mice in the acute phase of alveolar damage after irradiation suggested an important role for IL-6 in radiation pneumonitis...
  32. ncbi request reprint Radiosensitivity of peripheral blood lymphocytes obtained from patients with cancers of the breast, head and neck or cervix as determined with a micronucleus assay
    Sadayuki Ban
    Frontier Research Center, National Institute of Radiological Sciences NIRS, Chiba, Japan
    J Radiat Res 45:535-41. 2004
    ..Such a classification will be an important initial step to characterize the radiosensitive, radioresistant, or cancer-prone individuals using specific SNP typing...
  33. doi request reprint X-ray irradiation and Rho-kinase inhibitor additively induce invasiveness of the cells of the pancreatic cancer line, MIAPaCa-2, which exhibits mesenchymal and amoeboid motility
    Mayumi Fujita
    RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Cancer Sci 102:792-8. 2011
    ..Simultaneous use of inhibitors, ROCKI and MMPI may be effective in suppressing invasiveness under both X-ray-irradiated and non-irradiated conditions...
  34. doi request reprint Combination effects of distinct cores in 11q13 amplification region on cervical lymph node metastasis of oral squamous cell carcinoma
    Keisuke Sugahara
    RadGenomics Project, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage, Chiba 263 8555, Japan
    Int J Oncol 39:761-9. 2011
    ..0035). Two amplification cores at the 11q13 region may have biological impacts on OSCC cells to spread from the primary site to local lymph nodes. Further study of a larger patient series should be conducted to validate these results...
  35. ncbi request reprint Vascular homeostasis regulators, Edn1 and Agpt2, are upregulated as a protective effect of heat-treated zinc yeast in irradiated murine bone marrow
    Megumi Ueno
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    J Radiat Res 51:519-25. 2010
    ..To elucidate the mechanism underlying the in vivo radioprotection activity by Zn-containing, heat-treated Saccharomyces cerevisiae yeast (Zn-yeast)...
  36. ncbi request reprint Effects of carbon-ion beams on human pancreatic cancer cell lines that differ in genetic status
    Yoshifumi Matsui
    Frontier Research Center, National Institute of Radiological Sciences, Chiba, Japan
    Am J Clin Oncol 27:24-8. 2004
    ..These results suggest that carbon-ion beam therapy is a promising modality. Elucidation of the mechanisms of G2/M arrest and apoptosis may provide clues to enhancing the effects of radiation on pancreatic cancer...
  37. doi request reprint p73 protein expression correlates with radiation-induced apoptosis in the lack of p53 response to radiation therapy for cervical cancer
    Masaru Wakatsuki
    Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Int J Radiat Oncol Biol Phys 70:1189-94. 2008
    ..Here, we investigated whether p73 could compensate for impaired p53 function in apoptosis induced by radiation therapy (RT) for cervical cancer...
  38. ncbi request reprint Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor
    Yoshifumi Matsui
    Department of General Surgery, Shimizu Kousei Hospital, 578 1 Ihara chou Shimizu City, Shizuoka Prefecture, Japan
    Oncol Rep 10:1525-8. 2003
    ..6+/-9.8 at 30 Gy. The present results suggest that Ras signaling pathways are potential targets for manipulation of radiosensitivity, and that induction of an alternative pathway may enhance radiosensitivity of pancreatic cancer...
  39. ncbi request reprint Molecular markers predicting radiotherapy response: report and recommendations from an International Atomic Energy Agency technical meeting
    Catharine M L West
    Academic Department of Radiation Oncology, The University of Manchester, Christie Hospital NHS Trust, Withington, Manchester, UK
    Int J Radiat Oncol Biol Phys 62:1264-73. 2005
    ..A meeting in Amsterdam was organized by the International Atomic Energy Agency to discuss this topic on an international basis...
  40. ncbi request reprint [RadGenomics project]
    Mayumi Iwakawa
    Nihon Igaku Hoshasen Gakkai Zasshi 62:484-9. 2002
    ....
  41. doi request reprint Prediction of lymphatic metastasis based on gene expression profile analysis after brachytherapy for early-stage oral tongue carcinoma
    Hiroshi Watanabe
    Department of Oral Restitution, Tokyo Medical and Dental University, Tokyo, Japan
    Radiother Oncol 87:237-42. 2008
    ..The purpose of this study was to evaluate the predictive ability of lymphatic metastasis after brachytherapy (BRT) for early-stage tongue carcinoma based on gene expression profiling...