Hidehiro Iida

Summary

Affiliation: National Cardiovascular Center
Country: Japan

Publications

  1. doi request reprint Absolute quantitation of myocardial blood flow with (201)Tl and dynamic SPECT in canine: optimisation and validation of kinetic modelling
    Hidehiro Iida
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Fujishiro dai, Suita City, Osaka 565 8565, Japan
    Eur J Nucl Med Mol Imaging 35:896-905. 2008
  2. pmc Imaging of the appearance time of cerebral blood using [15O]H2O PET for the computation of correct CBF
    Nobuyuki Kudomi
    Department of Medical Physics, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    EJNMMI Res 3:41. 2013
  3. pmc Three-dimensional brain phantom containing bone and grey matter structures with a realistic head contour
    Hidehiro Iida
    Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, Suita City, Osaka, Japan
    Ann Nucl Med 27:25-36. 2013
  4. pmc F-18 fluorodeoxyglucose uptake and water-perfusable tissue fraction in assessment of myocardial viability
    Hidehiro Iida
    Turku PET Center, Turku University Central Hospital, 20520, Turku, Finland
    Ann Nucl Med 26:644-55. 2012
  5. doi request reprint Multicenter evaluation of a standardized protocol for rest and acetazolamide cerebral blood flow assessment using a quantitative SPECT reconstruction program and split-dose 123I-iodoamphetamine
    Hidehiro Iida
    Dual Table Autoradiography SPECT Research Group in Japan, Osaka, Japan
    J Nucl Med 51:1624-31. 2010
  6. ncbi request reprint Quantification in SPECT cardiac imaging
    Hidehiro Iida
    National Cardiovascular Center, Research Institute, Suita City, Osaka, Japan
    J Nucl Med 44:40-2. 2003
  7. pmc Effects of patient movement on measurements of myocardial blood flow and viability in resting ¹⁵O-water PET studies
    Kazuhiro Koshino
    Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    J Nucl Cardiol 19:524-33. 2012
  8. pmc Measurement of density and affinity for dopamine D(2) receptors by a single positron emission tomography scan with multiple injections of [(11)C]raclopride
    Yoko Ikoma
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Osaka 565 8565, Japan
    J Cereb Blood Flow Metab 30:663-73. 2010
  9. ncbi request reprint Separation of input function for rapid measurement of quantitative CMRO2 and CBF in a single PET scan with a dual tracer administration method
    Nobuyuki Kudomi
    Department of Investigative Radiology, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, 5 7 1, Fujishirodai, Suita, Osaka 565 8565, Japan
    Phys Med Biol 52:1893-908. 2007
  10. doi request reprint The use of magnetic resonance cell tracking to monitor endothelial progenitor cells in a rat hindlimb ischemic model
    Carlos A Agudelo
    Department of Biomedical Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Biomaterials 33:2439-48. 2012

Detail Information

Publications82

  1. doi request reprint Absolute quantitation of myocardial blood flow with (201)Tl and dynamic SPECT in canine: optimisation and validation of kinetic modelling
    Hidehiro Iida
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Fujishiro dai, Suita City, Osaka 565 8565, Japan
    Eur J Nucl Med Mol Imaging 35:896-905. 2008
    ..This study is intended to validate a kinetic modelling approach for in vivo quantitative estimation of regional myocardial blood flow (MBF) and volume of distribution of 201Tl using dynamic SPECT...
  2. pmc Imaging of the appearance time of cerebral blood using [15O]H2O PET for the computation of correct CBF
    Nobuyuki Kudomi
    Department of Medical Physics, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    EJNMMI Res 3:41. 2013
    ..We estimated brain ATB in an image-based fashion to correct CBF by accounting for differences in computed CBF values using three different analyses: ARG and BFM with and without fixing the partition coefficient...
  3. pmc Three-dimensional brain phantom containing bone and grey matter structures with a realistic head contour
    Hidehiro Iida
    Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, Suita City, Osaka, Japan
    Ann Nucl Med 27:25-36. 2013
    ..This study examined the feasibility of using this phantom for evaluating PET/SPECT images...
  4. pmc F-18 fluorodeoxyglucose uptake and water-perfusable tissue fraction in assessment of myocardial viability
    Hidehiro Iida
    Turku PET Center, Turku University Central Hospital, 20520, Turku, Finland
    Ann Nucl Med 26:644-55. 2012
    ..This study aimed to directly compare these two independent methods in assessing myocardial viability in patients with abnormal wall motion...
  5. doi request reprint Multicenter evaluation of a standardized protocol for rest and acetazolamide cerebral blood flow assessment using a quantitative SPECT reconstruction program and split-dose 123I-iodoamphetamine
    Hidehiro Iida
    Dual Table Autoradiography SPECT Research Group in Japan, Osaka, Japan
    J Nucl Med 51:1624-31. 2010
    ..This study was aimed at validating this technique at different institutions with a variety of SPECT devices and imaging protocols...
  6. ncbi request reprint Quantification in SPECT cardiac imaging
    Hidehiro Iida
    National Cardiovascular Center, Research Institute, Suita City, Osaka, Japan
    J Nucl Med 44:40-2. 2003
  7. pmc Effects of patient movement on measurements of myocardial blood flow and viability in resting ¹⁵O-water PET studies
    Kazuhiro Koshino
    Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    J Nucl Cardiol 19:524-33. 2012
    ..This study was aimed at evaluating the effects of such movement on myocardial blood flow (MBF) and perfusable tissue fraction (PTF) measurements in intravenous ¹⁵O-water PET...
  8. pmc Measurement of density and affinity for dopamine D(2) receptors by a single positron emission tomography scan with multiple injections of [(11)C]raclopride
    Yoko Ikoma
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Osaka 565 8565, Japan
    J Cereb Blood Flow Metab 30:663-73. 2010
    ..Estimated B(max) and K(d) values of D(2) receptors in normal or partially dopamine-depleted striatum were comparable to the previously reported values...
  9. ncbi request reprint Separation of input function for rapid measurement of quantitative CMRO2 and CBF in a single PET scan with a dual tracer administration method
    Nobuyuki Kudomi
    Department of Investigative Radiology, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, 5 7 1, Fujishirodai, Suita, Osaka 565 8565, Japan
    Phys Med Biol 52:1893-908. 2007
    ..We concluded that the present calculation based methods could be of use for quantitatively calculating CBF and CMRO(2) with the DARG approach...
  10. doi request reprint The use of magnetic resonance cell tracking to monitor endothelial progenitor cells in a rat hindlimb ischemic model
    Carlos A Agudelo
    Department of Biomedical Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Biomaterials 33:2439-48. 2012
    ..Compared to the commonly used particle type of MRI contrast agents, the system described in this study is expected to be invaluable to help clarifying the process of stem cell transplantation therapy...
  11. ncbi request reprint Parametric imaging of myocardial blood flow with 15O-water and PET using the basis function method
    Hiroshi Watabe
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Osaka, Japan
    J Nucl Med 46:1219-24. 2005
    ..The basis function method linearizes the solution of the 1-tissue-compartment model, which results in a computationally much faster method than the conventional nonlinear least-squares fitting method in estimating the parameters...
  12. doi request reprint A physiologic model for recirculation water correction in CMRO2 assessment with 15O2 inhalation PET
    Nobuyuki Kudomi
    Department of Investigative Radiology, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    J Cereb Blood Flow Metab 29:355-64. 2009
    ..Also, k was correlated with BMRO(2), suggesting that k can be determined from BMRO(2). The present model and simplified procedure can be used to assess CMRO(2) for a wide range of conditions and species...
  13. pmc Rapid quantitative CBF and CMRO(2) measurements from a single PET scan with sequential administration of dual (15)O-labeled tracers
    Nobuyuki Kudomi
    Department of Investigative Radiology, National Cerebral and Cardiovascular Center, Research Institute, Suita, Osaka, Japan
    J Cereb Blood Flow Metab 33:440-8. 2013
    ..The DBFM method enables accurate assessment of CBF and CMRO(2) without additional CBV scan within significantly shortened examination period, in clinical settings...
  14. ncbi request reprint Rapid quantitative measurement of CMRO(2) and CBF by dual administration of (15)O-labeled oxygen and water during a single PET scan-a validation study and error analysis in anesthetized monkeys
    Nobuyuki Kudomi
    Department of Investigative Radiology, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Fujishirodai, Suita, Osaka, Japan
    J Cereb Blood Flow Metab 25:1209-24. 2005
    ..These results show that this fast technique has an ability for accurate assessment of CBF/CMRO(2) and also allows multiple assessment at different physiologic conditions...
  15. doi request reprint Three-dimensional quantitation of regional cerebral blood flow in mice using a high-resolution pinhole SPECT system and 123I-iodoamphetamine
    Tsutomu Zeniya
    Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Nucl Med Biol 38:1157-64. 2011
    ....
  16. ncbi request reprint Accelerated 3D-OSEM image reconstruction using a Beowulf PC cluster for pinhole SPECT
    Tsutomu Zeniya
    Department of Investigative Radiology, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, 565 8565, Japan
    Ann Nucl Med 21:537-43. 2007
    ..To reduce the long reconstruction time, we parallelized the two-orbit pinhole 3D-OSEM reconstruction process by using a Beowulf personal computer (PC) cluster...
  17. doi request reprint Evaluation of utility of asymmetric index for count-based oxygen extraction fraction on dual-tracer autoradiographic method for chronic unilateral brain infarction
    Katsuhiro Iwanishi
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Ann Nucl Med 23:533-9. 2009
    ..In this paper, we evaluated feasibility of the non-invasive count-based method with the DARG protocol...
  18. ncbi request reprint A new reconstruction strategy for image improvement in pinhole SPECT
    Tsutomu Zeniya
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, 565 8565, Suita, Osaka, Japan
    Eur J Nucl Med Mol Imaging 31:1166-72. 2004
    ..This system may be of use in quantitative assessment of bio-physiological functions in small animals...
  19. doi request reprint The leptomeningeal ivy sign on fluid-attenuated inversion recovery images in moyamoya disease: positron emission tomography study
    Yasuyuki Kaku
    Department of Neurosurgery, National Cerebral and Cardiovascular Center, Suita, Japan
    Cerebrovasc Dis 36:19-25. 2013
    ..However, a decreased vascular reserve is not concrete. The purpose of this study was to evaluate the correlation between ivy sign proliferation and the findings of 15O gas positron emission tomography (PET)...
  20. doi request reprint Quantitative assessment of regional cerebral blood flow by dynamic susceptibility contrast-enhanced MRI, without the need for arterial blood signals
    Jun Ichiro Enmi
    Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita City, Osaka 565 8565, Japan
    Phys Med Biol 57:7873-92. 2012
    ..83, p < 0.01) for the conventional method. The contrasts in CBF images from our method were the same as those from the conventional method. These findings suggest the feasibility of assessing CBF without arterial blood signals...
  21. ncbi request reprint Long-term effect of motor cortical repetitive transcranial magnetic stimulation [correction]
    Takuya Hayashi
    Department of Investigative Radiology, Research Institute, National Cardiovascular Centre, Suita, Osaka, Japan
    Ann Neurol 56:77-85. 2004
    ..The results demonstrate that motor rTMS has a long-term lasting effect on motor-related regions and distant limbic-related areas via functional connections...
  22. doi request reprint Three-dimensional SPECT reconstruction with transmission-dependent scatter correction
    Antti Sohlberg
    National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Ann Nucl Med 22:549-56. 2008
    ....
  23. ncbi request reprint Use of a compact pixellated gamma camera for small animal pinhole SPECT imaging
    Tsutomu Zeniya
    Department of Investigative Radiology, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Osaka, Japan
    Ann Nucl Med 20:409-16. 2006
    ..This study was aimed at evaluating the basic performance of the detection system and the feasibility of small animal SPECT imaging...
  24. ncbi request reprint Dependency of energy and spatial distributions of photons on edge of object in brain SPECT
    Hossain M Deloar
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Ann Nucl Med 17:99-106. 2003
    ..The aim of this study was to investigate the dependency of CSW on the spatial and energy distribution of radioisotope to predict the edges of objects...
  25. doi request reprint Influence of residual oxygen-15-labeled carbon monoxide radioactivity on cerebral blood flow and oxygen extraction fraction in a dual-tracer autoradiographic method
    Katsuhiro Iwanishi
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka, 565 8565, Japan
    Ann Nucl Med 23:363-71. 2009
    ....
  26. ncbi request reprint A theoretical model of oxygen delivery and metabolism for physiologic interpretation of quantitative cerebral blood flow and metabolic rate of oxygen
    Takuya Hayashi
    Department of Investigative Radiology, Research Institute of National Cardiovascular Center, Hospital of National Cardiovascular Center, Fujishirodai, Suita, Osaka, Japan
    J Cereb Blood Flow Metab 23:1314-23. 2003
    ....
  27. pmc Cerebral blood flow and metabolism of hyperperfusion after cerebral revascularization in patients with moyamoya disease
    Yasuyuki Kaku
    Department of Neurosurgery, National Cerebral and Cardiovascular Center, Osaka, Japan
    J Cereb Blood Flow Metab 32:2066-75. 2012
    ..05). This study revealed that symptomatic hyperperfusion in MMD is characterized by temporary increases in CBF >100% over preoperative values caused by prolonged recovery of increased CBV...
  28. doi request reprint Parametric renal blood flow imaging using [15O]H2O and PET
    Nobuyuki Kudomi
    Turku PET Centre, University of Turku, Turku, Finland
    Eur J Nucl Med Mol Imaging 36:683-91. 2009
    ..ml/ml) to be negligible. The aim of this study was to develop a method for calculating parametric images of RBF (K(1), k(2)) as well as V(A) without fixing the partition coefficient by the basis function method (BFM)...
  29. doi request reprint Quantitative evaluation of changes in binding potential with a simplified reference tissue model and multiple injections of [11C]raclopride
    Yoko Ikoma
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Neuroimage 47:1639-48. 2009
    ..An advantage of the proposed method is the shortened scan period for the quantitative assessment of the BP(ND) change for neurotransmitter competition studies...
  30. ncbi request reprint Performance of list mode data acquisition with ECAT EXACT HR and ECAT EXACT HR+ positron emission scanners
    Hiroshi Watabe
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Ann Nucl Med 20:189-94. 2006
    ..31 Mbytes/ s were generated for 37 MBq injections. Our results suggest that careful attention must be paid to the protocol of the list mode data acquisition in order to obtain the highest performance of the PET scanner...
  31. doi request reprint Development of motion correction technique for cardiac (15)O-water PET study using an optical motion tracking system
    Kazuhiro Koshino
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Ann Nucl Med 24:1-11. 2010
    ..We developed a motion correction system using an optical motion-tracking device to detect a subject's global movement for cardiac study...
  32. pmc Adequacy of a compartment model for CMRO₂ quantitation using ¹⁵O-labeled oxygen and PET: a clearance measurement of ¹⁵O-radioactivity following intracarotid bolus injection of ¹⁵O-labeled oxyhemoglobin on Macaca fascicularis
    Hidehiro Iida
    Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, Suita City, Osaka, Japan
    J Cereb Blood Flow Metab 34:1434-9. 2014
    ..However, it should be noted that more data are necessary to unequivocally confirm the result. ..
  33. doi request reprint Experimental pig model of old myocardial infarction with long survival leading to chronic left ventricular dysfunction and remodeling as evaluated by PET
    Noboru Teramoto
    Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
    J Nucl Med 52:761-8. 2011
    ..The aim of this study was to evaluate the pathophysiologic status of a pig model of old MI using a series of PET studies...
  34. doi request reprint Monte Carlo estimation of scatter effects on quantitative myocardial blood flow and perfusable tissue fraction using 3D-PET and (15)O-water
    Yoshiyuki Hirano
    Department of Bio medical Imaging, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
    Phys Med Biol 57:7481-92. 2012
    ..From the simulation results, we concluded that quantitative MBF is less affected by scatter and absorption in 3D-PET using (15)O-water. However, scatter correction is essential for accurate PTF...
  35. doi request reprint Use of a clinical MRI scanner for preclinical research on rats
    Akihide Yamamoto
    Department of Investigative Radiology, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Radiol Phys Technol 2:13-21. 2009
    ..11 +/- 2.85%, and the MTT was 1.29 +/- 0.40 s in the Pt region and 2.32 +/- 0.17 s in the HT region. A single dose of Gd-DTPA enabled the assessment of AIF within MCA territory and of quantitative CBF in rats...
  36. ncbi request reprint System design and development of a pinhole SPECT system for quantitative functional imaging of small animals
    Toshiyuki Aoi
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Ann Nucl Med 20:245-51. 2006
    ....
  37. doi request reprint Quantification of myocardial blood flow using (201)Tl SPECT and population-based input function
    Kazuhiro Koshino
    Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka, 565 8565, Japan
    Ann Nucl Med 28:917-25. 2014
    ..This study aimed to validate the quantification of MBF using (201)Tl cardiac SPECT based on a population-averaged input function (STD-IF) and one-point blood sample technique...
  38. ncbi request reprint Quantitative mapping of basal and vasareactive cerebral blood flow using split-dose 123I-iodoamphetamine and single photon emission computed tomography
    Kyeong Min Kim
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita City, Osaka, 565 8565, Japan
    Neuroimage 33:1126-35. 2006
    ..Repeat assessment of quantitative CBF from a single session of scans with split-dose IMP is accurate, and may be applied to clinical research for assessing vascular reactivity in patients with chronic cerebral vascular disease...
  39. doi request reprint Implantation study of small-caliber "biotube" vascular grafts in a rat model
    Masashi Yamanami
    Division of Medical Engineering and Materials, National Cerebral and Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka, 565 8565, Japan
    J Artif Organs 16:59-65. 2013
    ..Biotubes could be used as small-caliber vascular prostheses that greatly facilitate the healing process and exhibit excellent biocompatibility in vascular regenerative medicine...
  40. ncbi request reprint [Estimation of the arterial blood radioactivity concentration using the whole body-to-arterial blood partition coefficients and the cross-calibration factor in 123I-iodoamphetamine SPECT--towards a noninvasive clinical protocol with the QSPECT-DTARG metho
    Hidehiro Iida
    Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute
    Kaku Igaku 49:49-58. 2012
    ..This feature may allow a large scale multi-center investigation, which may contribute to improve the non-invasive protocol...
  41. ncbi request reprint Body-contour versus circular orbit acquisition in cardiac SPECT: assessment of defect detectability with channelized Hotelling observer
    Antti Sohlberg
    aNational Cardiovascular Center Research Institute, Osaka, Japan bMolecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Nucl Med Commun 28:937-42. 2007
    ..Even though body-contour orbits can improve resolution of reconstructed images their effect on lesion detection is not well known...
  42. ncbi request reprint Comparison of multi-ray and point-spread function based resolution recovery methods in pinhole SPECT reconstruction
    Antti Sohlberg
    National Cardiovascular Center Research Institute, Suita City, Osaka, Japan
    Nucl Med Commun 27:823-7. 2006
    ..This paper investigates the benefits of two resolution recovery methods, multi-ray and point-spread function based, in pinhole SPECT by comparing them to uncorrected reconstruction...
  43. pmc Quantitative assessment of rest and acetazolamide CBF using quantitative SPECT reconstruction and sequential administration of (123)I-iodoamphetamine: comparison among data acquired at three institutions
    Miho Yamauchi
    Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka, 565 8565, Japan
    Ann Nucl Med 28:836-50. 2014
    ..This study was intended to generate a normal database and to investigate its inter-institutional consistency...
  44. doi request reprint Validity of using a 3-dimensional PET scanner during inhalation of 15O-labeled oxygen for quantitative assessment of regional metabolic rate of oxygen in man
    Yuki Hori
    Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, Suita City, Osaka, Japan
    Phys Med Biol 59:5593-609. 2014
    ..This study also suggested the feasibility of using a state-of-the-art 3D PET scanner in the quantitative PET imaging during inhalation of 15O labeled oxygen...
  45. ncbi request reprint Evaluation of a commercial PET tomograph-based system for the quantitative assessment of rCBF, rOEF and rCMRO2 by using sequential administration of 15O-labeled compounds
    Miho Shidahara
    Department of Investigative Radiology, National Cardio Vascular Center, Research Institute, Suita, Osaka, Japan
    Ann Nucl Med 16:317-27. 2002
    ..This suggested the need for a dynamic acquisition of a sinogram with a short interval. The proposed strategy provided an accurate quantification of CBF and OEF by PET with 15O-tracers...
  46. ncbi request reprint (18)F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study
    Mikako Ogawa
    Department of Investigative Radiology, Research Institute, National Cardiovascular Center, Suita, Japan
    J Nucl Med 45:1245-50. 2004
    ..Furthermore, PET imaging of vulnerable plaques was performed with an animal model of atherosclerosis, Watanabe heritable hyperlipidemic (WHHL) rabbits...
  47. doi request reprint Slowly progressive neuronal death associated with postischemic hyperperfusion in cortical laminar necrosis after high-flow bypass for a carotid intracavernous aneurysm
    Koji Iihara
    Department of Neurosurgery, National Cardiovascular Center, Osaka, Japan
    J Neurosurg 112:1254-9. 2010
    ..This report illustrates, for the first time, dynamic neuroradiological correlations between slowly progressive neuronal death shown by (123)I-IMZ SPECT and cortical laminar necrosis on MR imaging in human stroke...
  48. ncbi request reprint Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities
    Kyeong Min Kim
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita City, Osaka 565 8565, Japan
    J Nucl Med 44:512-9. 2003
    ..In this work, we evaluated the accuracy gained from a method of transmission-dependent convolution subtraction (TDCS) in the quantitation of activity that is highly concentrated in the striatum (STR)...
  49. doi request reprint Cerebral blood flow and metabolism associated with cerebral microbleeds in small vessel disease
    Tetsuya Hashimoto
    Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka, 565 8565, Japan
    Ann Nucl Med 30:494-500. 2016
    ..We investigated the relationships between CMBs, and CBF and metabolism in symptomatic small vessel disease...
  50. ncbi request reprint Endogenous dopamine release induced by repetitive transcranial magnetic stimulation over the primary motor cortex: an [11C]raclopride positron emission tomography study in anesthetized macaque monkeys
    Takashi Ohnishi
    Department of Investigative Radiology, National Cardio Vascular Center Research Institute, Osaka, Japan
    Biol Psychiatry 55:484-9. 2004
    ....
  51. pmc Preserved acetazolamide reactivity in lacunar patients with severe white-matter lesions: 15O-labeled gas and H2O positron emission tomography studies
    Tomohisa Nezu
    Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan
    J Cereb Blood Flow Metab 32:844-50. 2012
    ..5±17.2%, P=0.524). Lacunar patients with severe WMLs exhibited reduced CBF and CMRO(2), and increased OEF in the centrum semiovale. The ACZ reactivity was preserved in both patients with severe and mild WMLs in each site of the brain...
  52. doi request reprint Monte Carlo simulation of scintillation photons for the design of a high-resolution SPECT detector dedicated to human brain
    Yoshiyuki Hirano
    Department of Bio medical Imaging, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Ann Nucl Med 26:214-21. 2012
    ....
  53. doi request reprint Impaired myocardium regeneration with skeletal cell sheets--a preclinical trial for tissue-engineered regeneration therapy
    Shigeru Miyagawa
    Division of Cardiovascular Surgery, Department of Surgery, Faculty of Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Transplantation 90:364-72. 2010
    ..We hypothesized that autologous skeletal cell (SC) sheets regenerate the infract myocardium in porcine heart as a preclinical trial...
  54. ncbi request reprint Development of a hyperpolarized 129Xe system on 3T for the rat lungs
    Hiroshi Sato
    Department of Investigative Radiology, Research Institute of National Cardiovascular Center, Suita Osaka, Japan
    Magn Reson Med Sci 3:1-9. 2004
    ..We developed a hyperpolarized 129Xe experimental system using a 3T MRI scanner that yields sufficient volume and polarization and quantitatively analyzed the dissolved-phase 129Xe signal in the rat lungs...
  55. ncbi request reprint [Development of method to estimate delay time for arterial imput function with [15O]CO2-PET study using sinogram data and attenuation map]
    Hiroshi Watabe
    Department of Investigative Radiology, National Cardiovascular Center Research Institute
    Kaku Igaku 41:17-23. 2004
    ..The present method can eliminate the effect of the radioactivity outside of the brain on the sinogram data and estimate the delay time accurately and fast enough for clinical use...
  56. doi request reprint Long-term/bioinert labeling of rat mesenchymal stem cells with PVA-Gd conjugates and MRI monitoring of the labeled cell survival after intramuscular transplantation
    Yoichi Tachibana
    Department of Biomedical Engineering and Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka 565 8565, Japan
    Bioconjug Chem 25:1243-51. 2014
    ..Our cell survival tracking system would be a very powerful tool to this end and would be applicable in clinical cell therapies. ..
  57. doi request reprint Hyperthyroidism increases brown fat metabolism in humans
    Minna Lahesmaa
    Turku PET Centre M L, J O, M S, J C H, A K, K A V, p n, University of Turku, 20520 Turku, Finland Division of Endocrinology C S J, Department of Medicine, University of Helsinki and Helsinki University Hospital, 00014 Helsinki, Finland Department of Endocrinology M S, P J and Department of Nuclear Medicine T N, Turku University Hospital, 20520 Turku, Finland Department of Investigative Radiology H I, National Cerebral and Cardiovascular Center Research Institute, Osaka 565 8565, Japan Department of Medical Physics N K, Faculty of Medicine, Kagawa University, Kagawa 760 0016, Japan and Medical Genetics S E, Department of Medical Biochemistry, University of Gothenburg, 411 37 Gothenburg, Sweden
    J Clin Endocrinol Metab 99:E28-35. 2014
    ..Thyroid hormones are important regulators of brown adipose tissue (BAT) development and function. In rodents, BAT metabolism is up-regulated by thyroid hormones...
  58. pmc Breath-hold CT attenuation correction for quantitative cardiac SPECT
    Kazuhiro Koshino
    Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    EJNMMI Res 2:33. 2012
    ..The purpose of this study was to investigate the effects of respiratory phase during breath-hold CT acquisition on attenuation correction of cardiac SPECT imaging...
  59. doi request reprint Long-term in vivo magnetic resonance imaging tracking of endothelial progenitor cells transplanted in rat ischemic limbs and their angiogenic potential
    Carlos A Agudelo
    Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Tissue Eng Part A 17:2079-89. 2011
    ..Dex-DOTA-Gd3(+) was found to efficiently label EPCs over a long duration without significant cytotoxicity. This provides an MR signal sufficient for tracking the EPCs intramuscularly injected into the limb...
  60. ncbi request reprint Evaluation of penetration and scattering components in conventional pinhole SPECT: phantom studies using Monte Carlo simulation
    Hossain M Deloar
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka, 565 8565, Japan
    Phys Med Biol 48:995-1008. 2003
    ..Object scatter correction for all radionuclides used in this study is necessary and correction for the penetration contribution is necessary for all radionuclides but 201Tl...
  61. pmc PET quantification of cerebral oxygen metabolism in small animals
    Takashi Temma
    Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    ScientificWorldJournal 2014:159103. 2014
    ..Herein, we introduce an intravenous administration method using two types of injectable (15)O-O2 and an (15)O-O2 gas inhalation method through an airway placed in the trachea, which enables oxygen metabolism measurements in rats. ..
  62. pmc Substantial Reduction of Parenchymal Cerebral Blood Flow in Mice with Bilateral Common Carotid Artery Stenosis
    Yorito Hattori
    Department of Stroke and Cerebrovascular Diseases, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
    Sci Rep 6:32179. 2016
    ..These results suggest that the BCAS model reliably replicates chronic cerebral hypoperfusion. ..
  63. doi request reprint 3-Tesla magnetic resonance angiographic assessment of a tissue-engineered small-caliber vascular graft implanted in a rat
    Masashi Yamanami
    Department of Bioengineering, Advanced Biomedical Engineering Center, National Cardiovascular Center Research Institute, Osaka, Japan
    J Biomed Mater Res B Appl Biomater 92:156-60. 2010
    ....
  64. ncbi request reprint Activation of the anterior cingulate gyrus by 'Green Odor': a positron emission tomography study in the monkey
    Tetsuya Sasabe
    Department of Oral Physiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Chem Senses 28:565-72. 2003
    ..These findings suggest that the increase of rCBF in the anterior cingulate gyrus by the odor of hexenol/hexenal may contribute the healing effects of this mixture observed in the monkey...
  65. ncbi request reprint Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction
    Munehisa Shimamura
    Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Osaka, Japan
    Hypertension 47:742-51. 2006
    ..Our results also provide evidence for the feasibility of gene therapy in the chronic stage of cerebral infarction...
  66. doi request reprint Design and characterization of a polymeric MRI contrast agent based on PVA for in vivo living-cell tracking
    Yoichi Tachibana
    Department of Biomedical Engineering, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Suita 565 8565, Japan
    Contrast Media Mol Imaging 5:309-17. 2010
    ..After cell labeling, signal enhancement of cells was observed in vitro and in vivo. These results indicate that Gd-PVA can visualize only the living cells in vivo for a long period of time, even in areas deep within large animal bodies...
  67. doi request reprint Intraperitoneal and intravenous deliveries are not comparable in terms of drug efficacy and cell distribution in neonatal mice with hypoxia-ischemia
    Makiko Ohshima
    Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
    Brain Dev 37:376-86. 2015
    ..The objective of our study is to clarify the differences in the therapeutic effects of drugs and in the distribution of infused cells after an IP or IV injection in animals with brain injury...
  68. doi request reprint Microstructural abnormalities in white matter and their effect on depressive symptoms after stroke
    Fumihiko Yasuno
    Department of Psychiatry, Nara Medical University, 840 Shijocho, Kashihara, Nara 634 8522, Japan Department of Investigative Radiology, National Cerebral and Cardiovascular Center, Suita, Japan Electronic address
    Psychiatry Res 223:9-14. 2014
    ..Regional white matter damage may reflect abnormalities in neuroanatomical pathways related to the pathophysiology of depression. ..
  69. ncbi request reprint A coil for magnetic stimulation of the macaque monkey brain
    Yukio Nonaka
    Neurology Division, Nihon Kohden Corporation, Tokyo, Japan
    Suppl Clin Neurophysiol 56:75-80. 2003
  70. ncbi request reprint Regional changes in human cerebral blood flow during dipyridamole stress: neural activation in the thalamus and prefrontal cortex
    Hiroshi Ito
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan
    Neuroimage 16:788-93. 2002
    ....
  71. ncbi request reprint Development of a practical image-based scatter correction method for brain perfusion SPECT: comparison with the TEW method
    Miho Shidahara
    Department of Brain Science and Molecular Imaging, National Center for Geriatrics and Gerontology Research Institute, 36 3, Gengo Morioka cho, Obu, Aichi, 474 8522, Japan
    Eur J Nucl Med Mol Imaging 32:1193-8. 2005
    ..The purpose of this study was to validate this method by means of phantom simulations and human studies with 99mTc-labeled tracers, based on comparison with the conventional triple energy window (TEW) method...
  72. ncbi request reprint Validation of the dual-table autoradiographic method to quantify two sequential rCBFs in a single SPET session with N-isopropyl-[123I] p-iodoamphetamine
    Sadahiko Nishizawa
    Biomedical Imaging Research Center, Fukui Medical University, Fukui, Japan
    Eur J Nucl Med Mol Imaging 30:943-50. 2003
    ..0% and 6.3%, respectively. The dual-table ARG method can be reliably used to quantify rCBF before and after an ACZ challenge with a 40-min scan protocol and continuous arterial blood sampling for several minutes...
  73. ncbi request reprint Understanding of cerebral energy metabolism by dynamic living brain slice imaging system with [18F]FDG
    Mikako Ogawa
    Photon Medical Research Center, Hamamatsu University School of Medicine, Laboratory of Genome Bio Photonics, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Neurosci Res 52:357-61. 2005
    ....
  74. ncbi request reprint Estimation of oxygen metabolism in a rat model of permanent ischemia using positron emission tomography with injectable15O-O2
    Takashi Temma
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    J Cereb Blood Flow Metab 26:1577-83. 2006
    ..Injectable (15)O-O(2) could be used to reliably estimate oxygen metabolism in an infarction rat model with positron emission tomography...
  75. ncbi request reprint Development of injectable O-15 oxygen and estimation of rat OEF
    Yasuhiro Magata
    Laboratory of Genome Bio Photonics, Photon Medical Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Cereb Blood Flow Metab 23:671-6. 2003
    ..57 +/- 0.13). This method is useful to study the CMRO(2) and OEF in small animals using an animal positron emission tomography system. It may accelerate the basic research of several cerebral perfusion diseases...
  76. ncbi request reprint Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380 SPET
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 0135, USA
    Eur J Nucl Med Mol Imaging 30:1620-9. 2003
    ..These results demonstrate the feasibility of quantifying high-affinity type nAChRs using [123I]5-I-A-85380 in humans and support the use of VT' measured by bolus studies...
  77. ncbi request reprint Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [123I]epidepride SPET
    Masahiro Fujita
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, West Haven, CT, USA
    Eur J Nucl Med Mol Imaging 31:644-54. 2004
    ..It is concluded that SC is required for accurate quantification of distribution volumes of receptor ligands in SPET studies...
  78. ncbi request reprint Accelerated median root prior reconstruction for pinhole single-photon emission tomography (SPET)
    Antti Sohlberg
    Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, PO Box 1777 FIN 70211, Kuopio, Finland
    Phys Med Biol 48:1957-69. 2003
    ..The results showed that the accelerated PH-MRP algorithm was very robust. It provided visually pleasing images with lower noise level than the FBP or OS-EM and with smaller bias and sharper edges than the conventional Bayesian methods...
  79. ncbi request reprint Left atrial versus left ventricular input function for quantification of the myocardial blood flow with nitrogen-13 ammonia and positron emission tomography
    Jens D Hove
    Department of Cardiology, Medical Department B, The Heart Center, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Eur J Nucl Med Mol Imaging 31:71-6. 2004
    ..Spillover of activity from the left ventricular wall to the blood time-activity curve is of importance in hyperaemic flow studies using (13)NH(3). Application of a left atrial input function is a possible solution to these issues...
  80. ncbi request reprint The effect of nitroglycerin on myocardial blood flow in various segments characterized by rest-redistribution thallium SPECT
    Eiji Tadamura
    Department of Nuclear Medicine and Diagnostic Imaging, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Nucl Med 44:745-51. 2003
    ..The purpose of the study was to evaluate the effect of nitroglycerin (NTG) on myocardial blood flow (MBF) and coronary vascular resistance (CVR) in various segments characterized by rest-redistribution (201)Tl SPECT...
  81. ncbi request reprint Consensus nomenclature for in vivo imaging of reversibly binding radioligands
    Robert B Innis
    National Institute of Mental Health, Molecular Imaging Branch, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 27:1533-9. 2007
    ..An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands...
  82. ncbi request reprint [Estimation and optimization of the use of standard arterial input function for split-dose administration of N-isopropyl-p[123I]iodoamphetamine]
    Rei Kurisu
    Department of Radiology, Sapporo Azabu Neurosurgical Hospital
    Kaku Igaku 39:13-20. 2002
    ....