T Horio

Summary

Affiliation: National Cardiovascular Center
Country: Japan

Publications

  1. ncbi request reprint Diagnostic value of carotid intima-media thickness and plaque score for predicting target organ damage in patients with essential hypertension
    S Takiuchi
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Japan
    J Hum Hypertens 18:17-23. 2004
  2. doi request reprint Chronic kidney disease as an independent risk factor for new-onset atrial fibrillation in hypertensive patients
    Takeshi Horio
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Japan
    J Hypertens 28:1738-44. 2010
  3. doi request reprint Association of insulin-like growth factor-1 receptor gene polymorphisms with left ventricular mass and geometry in essential hypertension
    T Horio
    Division of Hypertension and Nephrology, Department of Medicine, Suita, Osaka, Japan
    J Hum Hypertens 24:320-6. 2010
  4. ncbi request reprint Pioglitazone-induced insulin sensitization improves vascular endothelial function in nondiabetic patients with essential hypertension
    Takeshi Horio
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Japan
    Am J Hypertens 18:1626-30. 2005
  5. ncbi request reprint Pioglitazone improves left ventricular diastolic function in patients with essential hypertension
    Takeshi Horio
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Japan
    Am J Hypertens 18:949-57. 2005
  6. ncbi request reprint Production and autocrine/paracrine effects of endogenous insulin-like growth factor-1 in rat cardiac fibroblasts
    Takeshi Horio
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, 5 7 1, Fujishirodai, Suita, Osaka 565 8565, Japan
    Regul Pept 124:65-72. 2005
  7. ncbi request reprint Influence of low high-density lipoprotein cholesterol on left ventricular hypertrophy and diastolic function in essential hypertension
    Takeshi Horio
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Am J Hypertens 16:938-44. 2003
  8. ncbi request reprint Gene expression, secretion, and autocrine action of C-type natriuretic peptide in cultured adult rat cardiac fibroblasts
    Takeshi Horio
    Department of Medicine, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    Endocrinology 144:2279-84. 2003
  9. ncbi request reprint Cardiac production and secretion of adrenomedullin are increased in heart failure
    T Nishikimi
    Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
    Hypertension 30:1369-75. 1997
  10. ncbi request reprint Role of increased circulating and renal adrenomedullin in rats with malignant hypertension
    T Nishikimi
    Research Institute, Fujishirodai, Suita, Osaka 565, Japan
    Am J Physiol Regul Integr Comp Physiol 281:R2079-87. 2001

Collaborators

Detail Information

Publications90

  1. ncbi request reprint Diagnostic value of carotid intima-media thickness and plaque score for predicting target organ damage in patients with essential hypertension
    S Takiuchi
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Japan
    J Hum Hypertens 18:17-23. 2004
    ..Max-IMT is suggested to be the most reliable and simplest parameter for predicting hypertensive target organ damage including microangiopathy in patients with essential hypertension...
  2. doi request reprint Chronic kidney disease as an independent risk factor for new-onset atrial fibrillation in hypertensive patients
    Takeshi Horio
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Japan
    J Hypertens 28:1738-44. 2010
    ..However, the association between CKD and the onset of AF has not been fully elucidated. The present study assessed the hypothesis that CKD may influence the onset of AF in hypertensives...
  3. doi request reprint Association of insulin-like growth factor-1 receptor gene polymorphisms with left ventricular mass and geometry in essential hypertension
    T Horio
    Division of Hypertension and Nephrology, Department of Medicine, Suita, Osaka, Japan
    J Hum Hypertens 24:320-6. 2010
    ....
  4. ncbi request reprint Pioglitazone-induced insulin sensitization improves vascular endothelial function in nondiabetic patients with essential hypertension
    Takeshi Horio
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Japan
    Am J Hypertens 18:1626-30. 2005
    ..The present study assessed the hypothesis that primary treatment of insulin resistance may reverse endothelial dysfunction in hypertensive subjects...
  5. ncbi request reprint Pioglitazone improves left ventricular diastolic function in patients with essential hypertension
    Takeshi Horio
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Japan
    Am J Hypertens 18:949-57. 2005
    ..The present study assessed the hypothesis that primary treatment of insulin resistance may reverse such cardiac changes in hypertensive patients...
  6. ncbi request reprint Production and autocrine/paracrine effects of endogenous insulin-like growth factor-1 in rat cardiac fibroblasts
    Takeshi Horio
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, 5 7 1, Fujishirodai, Suita, Osaka 565 8565, Japan
    Regul Pept 124:65-72. 2005
    ..Cardiac IGF-1 may function as an endogenous modulator of cardiac hypertrophy or remodeling...
  7. ncbi request reprint Influence of low high-density lipoprotein cholesterol on left ventricular hypertrophy and diastolic function in essential hypertension
    Takeshi Horio
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Am J Hypertens 16:938-44. 2003
    ..Although low high-density lipoprotein (HDL) cholesterol is well known to be a major risk factor for coronary heart disease, it is unclear whether HDL cholesterol plays a role in hypertensive heart disease...
  8. ncbi request reprint Gene expression, secretion, and autocrine action of C-type natriuretic peptide in cultured adult rat cardiac fibroblasts
    Takeshi Horio
    Department of Medicine, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    Endocrinology 144:2279-84. 2003
    ..CNP produced by cardiac fibroblasts may play a role as an autocrine regulator against excessive cardiac fibrosis...
  9. ncbi request reprint Cardiac production and secretion of adrenomedullin are increased in heart failure
    T Nishikimi
    Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
    Hypertension 30:1369-75. 1997
    ..Human failing heart actually secretes AM into the circulation, and the regulation of AM secretion appears to differ from that of atrial natriuretic peptide...
  10. ncbi request reprint Role of increased circulating and renal adrenomedullin in rats with malignant hypertension
    T Nishikimi
    Research Institute, Fujishirodai, Suita, Osaka 565, Japan
    Am J Physiol Regul Integr Comp Physiol 281:R2079-87. 2001
    ....
  11. ncbi request reprint Effects of adrenomedullin on cultured rat cardiac myocytes and fibroblasts
    T Horio
    Division of Hypertension, Department of Medicine, National Cardiovascular Center, 5 7 1, Fujishirodai, Suita, Japan
    Eur J Pharmacol 382:1-9. 1999
    ....
  12. ncbi request reprint Effect of adrenomedullin on cAMP and cGMP levels in rat cardiac myocytes and nonmyocytes
    T Nishikimi
    Division of Hypertension, Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
    Eur J Pharmacol 353:337-44. 1998
    ..These results suggest that myocytes and nonmyocytes secrete adrenomedullin and that adrenomedullin increases cAMP levels possibly via different receptors in myocytes and nonmyocytes...
  13. ncbi request reprint Reverse white-coat effect as an independent risk for left ventricular concentric hypertrophy in patients with treated essential hypertension
    M Tomiyama
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Japan
    J Hum Hypertens 21:212-9. 2007
    ..Our findings demonstrate that reverse white-coat effect is an independent risk factor for LV hypertrophy, especially concentric hypertrophy, in treated hypertensive patients...
  14. ncbi request reprint Association of single nucleotide polymorphisms in endothelin family genes with the progression of atherosclerosis in patients with essential hypertension
    H Yasuda
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    J Hum Hypertens 21:883-92. 2007
    ..Of the endothelin-related genes, EDNRB-rs5351 was the most susceptible SNP associated with atherosclerosis in male hypertensives, and the genetic background may be involved in the progression of atherosclerosis in EHT patients...
  15. ncbi request reprint Inhibitory regulation of hypertrophy by endogenous atrial natriuretic peptide in cultured cardiac myocytes
    T Horio
    Division of Hypertension, Department of Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Hypertension 35:19-24. 2000
    ..ANP may play a role as an autocrine factor in the regulation of cardiac myocyte growth...
  16. ncbi request reprint Cause of residual hypertension after adrenalectomy in patients with primary aldosteronism
    Y Horita
    Departments of Medicine, Pathology, and Cardiovascular Surgery, Division of Hypertension and Nephrology, National Cardiovascular Center, Osaka, Japan
    Am J Kidney Dis 37:884-9. 2001
    ..In conclusion, severity of glomerulosclerosis and arteriolosclerosis and LVM are related to blood pressure after adrenalectomy in patients with PA...
  17. ncbi request reprint Alterations of intrarenal adrenomedullin and its receptor system in heart failure rats
    F Yoshihara
    Research Institute, National Cardiovascular Center, Osaka, Japan
    Hypertension 37:216-22. 2001
    ..The present findings suggest that increased renal AM levels in decompensated heart failure, presumably due to increased AM production in renal tubules, in part, are involved in the regulation of sodium excretion...
  18. ncbi request reprint Evaluation of intrarenal hemodynamics by Doppler ultrasonography for renoprotective effect of angiotensin receptor blockade
    C Ogata
    Department of Medicine, Division of Hypertension and Nephrology, National Cardiovascular Center, Osaka, Japan
    Clin Nephrol 64:352-7. 2005
    ..The aim of this study was to evaluate the intrarenal hemodynamic change with ARB by renal Doppler ultrasonography (RDU) and to assess the mechanism of ARB in patients with hypertension...
  19. ncbi request reprint Left ventricular diastolic dysfunction in patients with chronic renal failure: impact of diabetes mellitus
    J Miyazato
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Diabet Med 22:730-6. 2005
    ..The present study was designed to investigate the impact of diabetic nephropathy on LV diastolic dysfunction, independent of LV hypertrophy, in CRF patients...
  20. ncbi request reprint The active molecular form of plasma adrenomedullin is extracted in the pulmonary circulation in patients with mitral stenosis: possible role of adrenomedullin in pulmonary hypertension
    T Nishikimi
    Department of Medicine, National Cardiovascular Center, 5 7 1, Fujishirodai, Suita, Osaka 565 8565, Japan
    Clin Sci (Lond) 100:61-6. 2001
    ....
  21. ncbi request reprint Molecular forms of plasma and urinary adrenomedullin in normal, essential hypertension and chronic renal failure
    T Nishikimi
    Research Institute, National Cardiovascular Centre, Osaka, Japan
    J Hypertens 19:765-73. 2001
    ....
  22. doi request reprint C-type natriuretic peptide is a Schwann cell-derived factor for development and function of sensory neurones
    I Kishimoto
    Department of Biochemistry, National Cardiovascular Center Research Institute, Suita City, Osaka, Japan
    J Neuroendocrinol 20:1213-23. 2008
    ..Taken together, these results suggest that CNP is derived from Schwann cells and plays an important role for the development and function of nociceptive sensory neurones...
  23. ncbi request reprint Evaluation of apoptotic cells induced by ultraviolet light B radiation in epidermal sheets stained by the TUNEL technique
    H Okamoto
    Department of Dermatology, Kansai Medical University, Moriguchi, Osaka, Japan
    J Invest Dermatol 113:802-7. 1999
    ....
  24. ncbi request reprint Effects of roxithromycin on adhesion molecules expressed on endothelial cells of the dermal microvasculature
    H Akamatsu
    Department of Dermatology, Kansai Medical University, Moriguchi, Osaka, Japan
    J Int Med Res 29:523-7. 2001
    ..We conclude that roxithromycin may exert its anti-inflammatory action by inhibition of the in vivo expression of adhesion molecules on dermal microvascular endothelial cells...
  25. ncbi request reprint Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heart
    T Nishikimi
    Research Institute, National Cardiovascular Center, Suita, Osaka 565, Japan
    Am J Physiol Heart Circ Physiol 279:H3031-9. 2000
    ....
  26. ncbi request reprint Concentration of roxithromycin in the lesions of acne vulgaris
    H Akamatsu
    Department of Dermatology, Kansai Medical University, Moriguchi, Osaka, Japan
    J Int Med Res 29:537-40. 2001
    ..The mean concentration of roxithromycin in the lesions was 0.54 microgram/ml. These results suggest that roxithromycin accumulates at therapeutic levels in the pilosebaceous system...
  27. ncbi request reprint Detection of action, inhibition and augmentation spectra in solar urticaria
    H Miyauchi
    Department of Dermatology, Kansai Medical University, Osaka, Japan
    Dermatology 191:286-91. 1995
    ..The action spectrum of solar urticaria varies among cases. In addition, light spectra outside the activating wavelengths can influence the wheal formation in selected patients...
  28. ncbi request reprint The effect of antibiotics on the production of superantigen from Staphylococcus aureus isolated from atopic dermatitis
    Y Adachi
    Department of Dermatology, Kansai Medical University, Osaka, Japan
    J Dermatol Sci 28:76-83. 2002
    ..These results suggested that the suppressive effects of antimicrobial agents that act as inhibitors of protein synthesis on superantigen production from S. aureus may be useful in the treatment of atopic dermatitis...
  29. ncbi request reprint DNA-dependent protein kinase catalytic subunit is cleaved during UV-induced apoptosis
    T Itoh
    Department of Dermatology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi, 570 8506, Osaka, Japan
    J Dermatol Sci 25:72-7. 2001
    ..Although apoptosis was not completely blocked by the caspase-3 inhibitor, the cleavage of the DNA-PKcs was blocked. These results indicate that DNA-PKcs is cleaved by the caspase-3 for UVB-induced apoptosis in HaCaT cells...
  30. ncbi request reprint Comprehensive analysis of 28 patients with latex allergy and prevalence of latex sensitization among hospital personnel
    K Mitsuya
    Department of Dermatology, Kansai Medical University, Moriguchi, Osaka, Japan
    J Dermatol 28:405-12. 2001
    ..The prevalence of latex allergy was found to be 4.6%. This indicates that not only dermatologists but also all hospital workers should be aware of this type of allergy...
  31. ncbi request reprint Protective effects of sunscreening agents on photocarcinogenesis, photoaging, and DNA damage in XPA gene knockout mice
    S Horiki
    Department of Dermatology, Kansai Medical University, 10 15, Fumizono cho, Moriguchi, Osaka, 570 8506, Japan
    Arch Dermatol Res 292:511-8. 2000
    ..The XPA model mouse is a useful animal for the evaluation of the photoprotective ability of sunscreens because photoresponses, even chronic changes, can be easily and quickly induced experimentally...
  32. ncbi request reprint Photobiologic and photoimmunologic characteristics of XPA gene-deficient mice
    T Horio
    Department of Dermatology, Kansai Medical University, Moriguchi, Osaka, Japan
    J Investig Dermatol Symp Proc 6:58-63. 2001
    ..Our experimental data indicate that cancer development in XP patients involves not only mutagenesis due to the defect in DNA repair, but also the enhanced UV-immunosuppression and intensified impairment of natural killer function...
  33. ncbi request reprint UV-induced skin carcinogenesis in xeroderma pigmentosum group A (XPA) gene-knockout mice with nucleotide excision repair-deficiency
    K Tanaka
    Institute for Molecular and Cellular Biology, Osaka University, 1 3 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Mutat Res 477:31-40. 2001
    ..4) The UVB-induced immunosuppression was greatly enhanced in the XPA-knockout mice. It is possible that an enhanced impairment of the immune system by UVB irradiation is involved in the high incidence of skin cancer in XP...
  34. ncbi request reprint Association of genetic polymorphisms of endothelin-converting enzyme-1 gene with hypertension in a Japanese population and rare missense mutation in preproendothelin-1 in Japanese hypertensives
    Mariko Banno
    Research Institute, National Cardiovascular Center, Suita, Japan
    Hypertens Res 30:513-20. 2007
    ..Taken together, these findings reveal that the EDN-ECE pathway is an important system involved in essential hypertension in Japanese...
  35. ncbi request reprint Adrenomedullin inhibits doxorubicin-induced cultured rat cardiac myocyte apoptosis via a cAMP-dependent mechanism
    Takeshi Tokudome
    Research Institute, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    Endocrinology 143:3515-21. 2002
    ..AM, as an autocrine factor, may play a protective role against cardiomyocyte injury by doxorubicin...
  36. ncbi request reprint Uric acid, left ventricular mass index, and risk of cardiovascular disease in essential hypertension
    Yoshio Iwashima
    Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Hypertension 47:195-202. 2006
    ..The association between UA and CVD events may be introduced in part because of a direct association of UA with LVMI...
  37. ncbi request reprint A novel missense mutation, F826Y, in the mineralocorticoid receptor gene in Japanese hypertensives: its implications for clinical phenotypes
    Kei Kamide
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Hypertens Res 28:703-9. 2005
    ....
  38. ncbi request reprint Clinical implications of assessing coronary flow velocity reserve and plasma endothelin-1 in hypertensive patients
    Hideki Fujii
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Hypertens Res 28:911-6. 2005
    ..The link between these two parameters may play a role in the genesis of chest pain in hypertensive patients without CAD...
  39. ncbi request reprint Renal function in patients with abdominal aortic aneurysm. Comparison with hypertensive patients
    Satoko Nakamura
    Division of Hypertension and Nephrology, Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Kidney Blood Press Res 29:67-73. 2006
    ..The present study was designed to evaluate and compare renal function and risk factors of AAA patients with those of hypertensive patients...
  40. ncbi request reprint Genetic variations of HSD11B2 in hypertensive patients and in the general population, six rare missense/frameshift mutations
    Kei Kamide
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Hypertens Res 29:243-52. 2006
    ..Taken together, our results indicate that missense mutations in HSD11B2 do not substantially contribute to essential hypertension in Japanese...
  41. ncbi request reprint Masked hypertension and target organ damage in treated hypertensive patients
    Mari Tomiyama
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Japan
    Am J Hypertens 19:880-6. 2006
    ..However, it remains to be elucidated how masked hypertension modifies target organ damage in treated hypertensive patients...
  42. ncbi request reprint Reverse white-coat effect as an independent risk for microalbuminuria in treated hypertensive patients
    Toako Kato
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Nephrol Dial Transplant 22:911-6. 2007
    ..The present study assessed the hypothesis that this phenomenon may specifically associate with microalbuminuria, a marker of early renal damage, in treated hypertension...
  43. ncbi request reprint Association of genetic polymorphisms of ACADSB and COMT with human hypertension
    Kei Kamide
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    J Hypertens 25:103-10. 2007
    ..We examined the association of human homologues of these genes with human hypertension...
  44. ncbi request reprint Effect of early nephrology referral on the initiation of hemodialysis and survival in patients with chronic kidney disease and cardiovascular diseases
    Satoko Nakamura
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Japan
    Circ J 71:511-6. 2007
    ..The impact of early referral on the timing of hemodialysis (HD) and mortality in the patients with CKD and cardiovascular diseases (CVD) was evaluated in this present study...
  45. ncbi request reprint Midregional proadrenomedullin reflects cardiac dysfunction in haemodialysis patients with cardiovascular disease
    Fumiki Yoshihara
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    Nephrol Dial Transplant 22:2263-8. 2007
    ..Objectives. We evaluated whether midregional proadrenomedullin reflects cardiac dysfunction, systemic inflammation or blood volume in haemodialysis patients...
  46. ncbi request reprint Fasting plasma glucose is an independent determinant of left ventricular diastolic dysfunction in nondiabetic patients with treated essential hypertension
    Junko Miyazato
    Department of Medicine, National Cardiovascular Center, Suita, Japan
    Hypertens Res 25:403-9. 2002
    ....
  47. ncbi request reprint Possible involvement of oxidative stress in hypoxia-induced adrenomedullin secretion in cultured rat cardiomyocytes
    Fumiki Yoshihara
    Research Institute, National Cardiovascular Center, 5 7 1 Fujishirodai, Osaka 565 8565, Suita, Japan
    Eur J Pharmacol 436:1-6. 2002
    ..Adrenomedullin secreted from myocytes may play a cell protective role in an autocrine manner...
  48. ncbi request reprint Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats
    Daryl O Schwenke
    Department of Biochemistry, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Endocrinology 149:237-44. 2008
    ..These results demonstrate the therapeutic benefits of ghrelin for impeding the pathogenesis of pulmonary hypertension and right ventricular hypertrophy, particularly in subjects prone to CH (e.g. pulmonary disorders)...
  49. ncbi request reprint Brain natriuretic peptide in hemodialysis patients: predictive value for hemodynamic change during hemodialysis and cardiac function
    Tetsutaro Matayoshi
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Am J Nephrol 28:122-7. 2008
    ..The aim of the present study is to examine the predictive value of BNP for blood pressure (BP) fall during HD and cardiac function...
  50. ncbi request reprint Ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction
    Takeshi Soeki
    National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita City, Osaka 565 8565, Japan
    Am J Physiol Heart Circ Physiol 294:H426-32. 2008
    ..01). In conclusion, these data suggest the potential usefulness of ghrelin as a new cardioprotective hormone early after MI...
  51. ncbi request reprint The incidence and risk factors of renal artery stenosis in patients with severe carotid artery stenosis
    Satoko Nakamura
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Japan
    Hypertens Res 30:839-44. 2007
    ..The RAS risk factors were the presence of other CVDs, renal dysfunction, and smoking. Since RAS is an underlying cause of hypertension and renal failure, it is important to consider the presence of RAS in patients with severe CAS...
  52. ncbi request reprint Relationship between insulin resistance and the renin-angiotensin system: analysis for patients with essential and renovascular hypertension
    Tetsutaro Matayoshi
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    Clin Exp Hypertens 29:479-87. 2007
    ..However, there was no significant relationship between PRA and indices of insulin resistance and hyperinsulinemia in patients with RVHT. In conclusion, the systemic RAS may modulate insulin sensitivity in EHT patients...
  53. ncbi request reprint Protein tyrosine kinase 2beta as a candidate gene for hypertension
    Kei Kamide
    Divisions of Hypertension, National Cardiovascular Center, Suita, Osaka, Japan
    Pharmacogenet Genomics 17:931-9. 2007
    ..Thus, a haplotype in PTK2B may play a role in essential hypertension in Japanese...
  54. doi request reprint Decreased coronary flow reserve in haemodialysis patients
    Shinnichiro Niizuma
    Division of Hypertension and Nephrology, National Cardiovascular Center, Fujishirodai 5 7 1, Suita 565 8565, Japan
    Nephrol Dial Transplant 23:2324-8. 2008
    ..Coronary flow reserve (CFR) reflects the functional capacity of microcirculation to adapt to blood demand during increased cardiac work...
  55. doi request reprint Pulmonary venous flow and risk of cardiovascular disease in essential hypertension
    Yoshio Iwashima
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Japan
    J Hypertens 26:798-805. 2008
    ..The prognostic significance of the pulmonary venous flow in essential hypertensive patients was investigated...
  56. doi request reprint C-reactive protein, left ventricular mass index, and risk of cardiovascular disease in essential hypertension
    Yoshio Iwashima
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 30:1177-85. 2007
    ..37, 95% CI: 1.02-1.85, p=0.025). Our findings demonstrate that the CRP level is independently associated with LVMI, and suggest that measurement of CRP may provide clinically important prognostic information to supplement LVH...
  57. doi request reprint Masked hypertension: subtypes and target organ damage
    Yuhei Kawano
    Division of Hypertension and Nephrology, National Cardiovascular Center, Osaka, Japan
    Clin Exp Hypertens 30:289-96. 2008
    ..It is important to identify individuals with masked hypertension, to evaluate them with including the search for the subtype, and to treat each patient appropriately according to the cause of this condition...
  58. doi request reprint Associations of hypertension and its complications with variations in the xanthine dehydrogenase gene
    Jin Yang
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Hypertens Res 31:931-40. 2008
    ..0006). Our results suggest that genetic variations in XDH contribute partly to hypertension and its complications, including atherosclerosis and CKD...
  59. ncbi request reprint Relationship between home blood pressure and longitudinal changes in target organ damage in treated hypertensive patients
    Sei Tsunoda
    Department of Medicine, National Cardiovascular Center, Suita, Japan
    Hypertens Res 25:167-73. 2002
    ..In conclusion, Home BP was more effective than clinic BP as a predictor of changes in left ventricular hypertrophy in treated hypertensive patients. Home BP should be controlled to below 135/85 mmHg to prevent cardiac hypertrophy...
  60. ncbi request reprint Influence of plasma aldosterone on left ventricular geometry and diastolic function in treated essential hypertension
    Yoshio Iwashima
    Department of Medicine, National Cardiovascular Center, Suita, Japan
    Hypertens Res 25:49-56. 2002
    ....
  61. ncbi request reprint Endothelin a receptor blockade and endothelin B receptor blockade improve hypokalemic nephropathy by different mechanisms
    Shin Ichi Suga
    National Cardiovascular Center Research Institute, Department of Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Am Soc Nephrol 14:397-406. 2003
    ..Thus, ETA as well as ETB blockade may be renoprotective in hypokalemic nephropathy...
  62. ncbi request reprint Identification of gene polymorphism in lipocalin-type prostaglandin D synthase and its association with carotid atherosclerosis in Japanese hypertensive patients
    Yoshikazu Miwa
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Biochem Biophys Res Commun 322:428-33. 2004
    ..71 (95% CI: 0.58-0.88)]. Our results suggested that 4111 A>C polymorphism in the L-PGDS gene contributes to the development of carotid atherosclerosis in Japanese hypertensive patients...
  63. ncbi request reprint Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Circulation 108:889-95. 2003
    ..We investigated whether transplantation of vasodilator gene-transduced EPCs ameliorates monocrotaline (MCT)-induced pulmonary hypertension in rats...
  64. ncbi request reprint Efficacy of screening for primary aldosteronism by adrenocortical scintigraphy without discontinuing antihypertensive medication
    Hajime Nakahama
    Division of Hypertension and Nephrology, National Cardiovascular Center, Fujishirodai 5 7 1, Suita 565 8565, Osaka, Japan
    Am J Hypertens 16:725-8. 2003
    ..We examined the efficacy of adrenocortical scintigraphy performed without modification of antihypertensive medications...
  65. ncbi request reprint Microalbuminuria and cardiovascular events in elderly hypertensive patients without previous cardiovascular complications
    Satoko Nakamura
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Osaka, Japan
    Hypertens Res 26:603-8. 2003
    ..05). The results indicated that, in elderly hypertensive patients without previous cardiovascular complications, microalbuminuria can be a predictor of cardiovascular events irrespective of conventional BP control...
  66. ncbi request reprint The effect of pituitary adenylate cyclase activating polypeptide on cultured rat cardiocytes as a cardioprotective factor
    Hirofumi Sano
    National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Regul Pept 109:107-13. 2002
    ..On the other hand, PACAP inhibited the protein synthesis and DNA synthesis of the nonmyocytes. These indicate that PACAP might be involved in the regulation of cardiac hypertrophy and fibrosis as a cardioprotective factor...
  67. ncbi request reprint Effects of the creation of arteriovenous fistula for hemodialysis on cardiac function and natriuretic peptide levels in CRF
    Yoshio Iwashima
    Department of Medicine, Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    Am J Kidney Dis 40:974-82. 2002
    ..However, the influence of an arteriovenous (AV) fistula on cardiac function has not been fully elucidated. The present study investigated serial changes in cardiac function and hormonal levels after the AV fistula operation...
  68. ncbi request reprint Carotid intima-media thickness is correlated with impairment of coronary flow reserve in hypertensive patients without coronary artery disease
    Shin Takiuchi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 26:945-51. 2003
    ..These associations may explain the links between cardiac and cerebrovascular involvements in patients with hypertension...
  69. ncbi request reprint Association between left ventricular diastolic dysfunction and renal hemodynamic change in patients with treated essential hypertension
    Chinami Ogata
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Japan
    Hypertens Res 26:971-8. 2003
    ....
  70. ncbi request reprint Ventricular nonmyocytes inhibit doxorubicin-induced myocyte apoptosis: involvement of endogenous endothelin-1 as a paracrine factor
    Takeshi Tokudome
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, 5 7 1, Fujishirodai, Suita, Osaka 565 8565, Japan
    Endocrinology 145:2458-66. 2004
    ..The present findings demonstrate that cardiac nonmyocytes inhibit DOX-induced myocyte apoptosis, at least in part, via ET-1 secretion-mediated CREB activation independent of the decrease in oxidative stress...
  71. ncbi request reprint Inhibitory effect of C-type natriuretic peptide (CNP) on cultured cardiac myocyte hypertrophy: interference between CNP and endothelin-1 signaling pathways
    Takeshi Tokudome
    Research Institute, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    Endocrinology 145:2131-40. 2004
    ....
  72. ncbi request reprint Plasma adrenomedullin concentration is increased in patients with peripheral arterial occlusive disease associated with vascular inflammation
    Yoshihiko Suzuki
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, 5 7 1, Fujishirodai, Suita, Osaka 565 8565, Japan
    Regul Pept 118:99-104. 2004
    ..An increased production of AM in PAOD may play a protective role against advanced atherosclerosis with an inflammatory signature...
  73. ncbi request reprint Close association of endothelial dysfunction with insulin resistance and carotid wall thickening in hypertension
    Masaaki Suzuki
    Department of Gastroenterology and Metabolic Diseases, Osaka Prefectural General Hospital, 3 1 56 Mandai Higashi, Sumiyoshi ku, Osaka 558 8558, Japan
    Am J Hypertens 17:228-32. 2004
    ..Endothelial dysfunction has been regarded as an early stage in the atherosclerotic process. Endothelial dysfunction and insulin resistance were observed in hypertensive subjects and were associated with carotid wall thickening...
  74. ncbi request reprint Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes
    Kei Kamide
    Division of Hypertension and Nephrology, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Hypertens 17:446-9. 2004
    ..The objective of this study was to test whether more subtle changes of WNK4 could be implicated in hypertension or renal failure...
  75. ncbi request reprint Direct effects of high glucose and insulin on protein synthesis in cultured cardiac myocytes and DNA and collagen synthesis in cardiac fibroblasts
    Takeshi Tokudome
    Research Institute, National Cardiovascular Center, Suita, Japan
    Metabolism 53:710-5. 2004
    ..Insulin regulates myocyte protein synthesis and fibroblast DNA synthesis through different intracellular mechanisms...
  76. ncbi request reprint Six missense mutations of the epithelial sodium channel beta and gamma subunits in Japanese hypertensives
    Kei Kamide
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Hypertens Res 27:333-8. 2004
    ..Thus, further investigation of these mutations, including functional analyses, will be needed...
  77. ncbi request reprint Adiponectin and inflammatory markers in peripheral arterial occlusive disease
    Yoshio Iwashima
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Japan
    Atherosclerosis 188:384-90. 2006
    ..Adiponectin concentration could be a marker of the existence of atherosclerosis, and measurement of its concentration may be helpful in assessment of the progress of atherosclerosis...
  78. ncbi request reprint Diagnostic and prognostic value of plasma brain natriuretic peptide in non-dialysis-dependent CRF
    Yoichi Takami
    Department of Medicine, Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    Am J Kidney Dis 44:420-8. 2004
    ..This study is designed to clarify the diagnostic and prognostic value of plasma BNP level in patients with CRF...
  79. ncbi request reprint Plasma asymmetric dimethylarginine and coronary and peripheral endothelial dysfunction in hypertensive patients
    Shin Takiuchi
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    Am J Hypertens 17:802-8. 2004
    ..We hypothesized that changes in serum asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, and concomitant insulin resistance may be underlying factors connecting the two pathologic alterations...
  80. ncbi request reprint [Cardioprotective effects of natriuretic peptides]
    Takeshi Horio
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center
    Nihon Rinsho 62:65-8. 2004
  81. ncbi request reprint Plasma atrial natriuretic peptide concentration inversely correlates with left atrial collagen volume fraction in patients with atrial fibrillation: plasma ANP as a possible biochemical marker to predict the outcome of the maze procedure
    Fumiki Yoshihara
    National Cardiovascular Center Research Institute, Suita, Japan
    J Am Coll Cardiol 39:288-94. 2002
    ..We hypothesized that the plasma atrial natriuretic peptide (ANP) level reflects atrial degenerative change and may predict the outcome of the maze procedure...
  82. ncbi request reprint Upregulation of intracardiac adrenomedullin and its receptor system in rats with volume overload-induced cardiac hypertrophy
    Fumiki Yoshihara
    Division of Hypertension and Nephrology, National Cardiovascular Center, Fujishirodai, Suita, Osaka 565 8565, Japan
    Regul Pept 127:239-44. 2005
    ..42). These results suggest that intracardiac adrenomedullin and its receptor system are upregulated and may participate in the regulation of cardiac remodeling in volume overload-induced cardiac hypertrophy...
  83. ncbi request reprint Chronic administration of adrenomedullin attenuates the hypertension and increases renal nitric oxide synthase in Dahl salt-sensitive rats
    Fumiki Yoshihara
    Division of Hypertension and Nephrology, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Regul Pept 128:7-13. 2005
    ..These results suggest that adrenomedullin infusion has beneficial effects on this hypertension probably in part through restored renal NOS expression in DS rats...
  84. ncbi request reprint Response of adrenomedullin system to cytokine in cardiac fibroblasts-role of adrenomedullin as an antifibrotic factor
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Cardiovasc Res 66:104-13. 2005
    ..We studied the effects of interleukin 1-beta (IL-1beta) on the adrenomedullin system in cardiac fibroblasts and also examined the pathophysiological significance of such effects...
  85. ncbi request reprint The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics
    Tetsutaro Matayoshi
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Hypertens Res 27:821-33. 2004
    ..Both newly detected TSC C1784T and ADRB3 T727C are gene polymorphisms susceptible to the antihypertensive effect of TZDs in patients with EHT. Thus, the prediction of BP reduction by TZDs may be possible by evaluating these two SNPs...
  86. ncbi request reprint Insertion/deletion polymorphism in clusterin gene influences serum lipid levels and carotid intima-media thickness in hypertensive Japanese females
    Yoshikazu Miwa
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Biochem Biophys Res Commun 331:1587-93. 2005
    ..In conclusion, the clusterin gene polymorphism may contribute to the serum lipid levels and the progression of carotid atherosclerosis in hypertensive Japanese females...
  87. ncbi request reprint Calcineurin-nuclear factor of activated T cells pathway-dependent cardiac remodeling in mice deficient in guanylyl cyclase A, a receptor for atrial and brain natriuretic peptides
    Takeshi Tokudome
    Department of Biochemistry, Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
    Circulation 111:3095-104. 2005
    ..In this study, we examined the role of calcineurin, a calcium-dependent phosphatase, in cardiac remodeling in GCA-knockout (GCA-KO) mice...
  88. ncbi request reprint Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population
    Jin Yang
    Divisions of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    J Hypertens 23:1497-505. 2005
    ..We studied whether genetic variations in RGS2 are implicated in hypertension or other phenotypes in Japanese hypertensive individuals and the general population...
  89. ncbi request reprint Cerivastatin, a hydroxymethylglutaryl coenzyme A reductase inhibitor, inhibits cardiac myocyte hypertrophy induced by endothelin
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Eur J Pharmacol 453:175-81. 2002
    ..These results suggest that cerivastatin directly attenuates cardiac hypertrophy induced by endothelin in cultured rat myocytes partly by inhibition of the Rho pathway...
  90. ncbi request reprint Adrenomedullin reflects cardiac dysfunction, excessive blood volume, and inflammation in hemodialysis patients
    Fumiki Yoshihara
    Division of Hypertension and Nephrology, National Cardiovascular Center, National Cardiovascular Center Research Institute, Osaka, Japan
    Kidney Int 68:1355-63. 2005
    ....