Hiroshi Furukawa

Summary

Affiliation: National Hospital Organization
Country: Japan

Publications

  1. pmc Association of increased frequencies of HLA-DPB1*05:01 with the presence of anti-Ro/SS-A and anti-La/SS-B antibodies in Japanese rheumatoid arthritis and systemic lupus erythematosus patients
    Hiroshi Furukawa
    Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan
    PLoS ONE 8:e53910. 2013
  2. doi request reprint Association of a single nucleotide polymorphism in the SH2D1A intronic region with systemic lupus erythematosus
    H Furukawa
    Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Japan
    Lupus 22:497-503. 2013
  3. doi request reprint Genome, epigenome and transcriptome analyses of a pair of monozygotic twins discordant for systemic lupus erythematosus
    Hiroshi Furukawa
    Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan
    Hum Immunol 74:170-5. 2013
  4. pmc Association of human leukocyte antigen with interstitial lung disease in rheumatoid arthritis: a protective role for shared epitope
    Hiroshi Furukawa
    Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Kanagawa, Japan
    PLoS ONE 7:e33133. 2012
  5. pmc TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study
    Aya Kawasaki
    Molecular and Genetic Epidemiology Laboratory, Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Japan
    Arthritis Res Ther 13:R41. 2011
  6. pmc Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study
    Aya Kawasaki
    Molecular and Genetic Epidemiology Laboratory, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Arthritis Res Ther 12:R174. 2010
  7. doi request reprint Neutrophil CD64 is upregulated in RA patients with lymphoma but not in other solid cancers
    Akiko Komiya
    a Department of Clinical Laboratory, Sagamihara National Hospital, National Hospital Organization, Kanagawa, Japan
    Mod Rheumatol 26:216-23. 2016
  8. pmc Serum biomarker analysis of collagen disease patients with acute-onset diffuse interstitial lung disease
    Shomi Oka
    Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, 18 1 Sakuradai, Minami Ku, Sagamihara, Kanagawa, 252 0392, Japan
    BMC Immunol 14:9. 2013
  9. pmc Protective effect of the HLA-DRB1*13:02 allele in Japanese rheumatoid arthritis patients
    Shomi Oka
    Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan
    PLoS ONE 9:e99453. 2014
  10. doi request reprint Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-alpha
    Atsuhiko Hikita
    Department of Pathomechanisms, Clinical Research Center, National Hospital Organization Sagamihara Hospital, Sagamihara, Kanagawa 228 8522, Japan
    Biochem Cell Biol 87:581-93. 2009

Collaborators

Detail Information

Publications17

  1. pmc Association of increased frequencies of HLA-DPB1*05:01 with the presence of anti-Ro/SS-A and anti-La/SS-B antibodies in Japanese rheumatoid arthritis and systemic lupus erythematosus patients
    Hiroshi Furukawa
    Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan
    PLoS ONE 8:e53910. 2013
    ..Here, we investigated associations of HLA class II alleles with the presence of anti-Ro/SS-A or anti-La/SS-B antibodies in RA...
  2. doi request reprint Association of a single nucleotide polymorphism in the SH2D1A intronic region with systemic lupus erythematosus
    H Furukawa
    Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Japan
    Lupus 22:497-503. 2013
    ..65, 95% CI 1.28-5.46). Functional evaluation of rs2049995 showed that reporter gene activity was increased 1.9-fold for the susceptible allele compared with the resistant allele. An intronic SNP of SH2D1A is associated with SLE...
  3. doi request reprint Genome, epigenome and transcriptome analyses of a pair of monozygotic twins discordant for systemic lupus erythematosus
    Hiroshi Furukawa
    Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan
    Hum Immunol 74:170-5. 2013
    ..There were no genomic differences between monozygotic twins discordant for SLE, but epigenomic and gene expression differences were detected. These findings provide information for better understanding of SLE pathogenesis...
  4. pmc Association of human leukocyte antigen with interstitial lung disease in rheumatoid arthritis: a protective role for shared epitope
    Hiroshi Furukawa
    Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Kanagawa, Japan
    PLoS ONE 7:e33133. 2012
    ..In this study, we investigated the association of HLA class II alleles with ILD in RA...
  5. pmc TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study
    Aya Kawasaki
    Molecular and Genetic Epidemiology Laboratory, Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Japan
    Arthritis Res Ther 13:R41. 2011
    ..To test whether additional polymorphisms contribute to SLE in Japanese, we systematically analyzed the association of TLR7 with SLE in a Japanese female population...
  6. pmc Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study
    Aya Kawasaki
    Molecular and Genetic Epidemiology Laboratory, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Arthritis Res Ther 12:R174. 2010
    ..In this study, we investigated whether the association of TNIP1 with SLE was replicated in a Japanese population. In addition, association of TNIP1 with RA was also examined...
  7. doi request reprint Neutrophil CD64 is upregulated in RA patients with lymphoma but not in other solid cancers
    Akiko Komiya
    a Department of Clinical Laboratory, Sagamihara National Hospital, National Hospital Organization, Kanagawa, Japan
    Mod Rheumatol 26:216-23. 2016
    ..To evaluate the utility of quantifying CD64 expression on neutrophils in rheumatoid arthritis patients with malignancy, especially its diagnostic role in lymphoma...
  8. pmc Serum biomarker analysis of collagen disease patients with acute-onset diffuse interstitial lung disease
    Shomi Oka
    Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, 18 1 Sakuradai, Minami Ku, Sagamihara, Kanagawa, 252 0392, Japan
    BMC Immunol 14:9. 2013
    ..The prognosis of acute-onset diffuse ILD (AoDILD) occurring in collagen disease patients is very poor. Here, we investigated serum biomarker profiles of AoDILD to find markers predicting outcome in patients with collagen diseases...
  9. pmc Protective effect of the HLA-DRB1*13:02 allele in Japanese rheumatoid arthritis patients
    Shomi Oka
    Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan
    PLoS ONE 9:e99453. 2014
    ..87×10(-5), Pc = 0.0026, OR 0.26, 95%CI 0.12-0.56). Thus, this study identified a negative association of DRB1*13:02 with Japanese RA; our findings support the protective role of DRB1*13:02 in the pathogenesis of ACPA-positive RA...
  10. doi request reprint Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-alpha
    Atsuhiko Hikita
    Department of Pathomechanisms, Clinical Research Center, National Hospital Organization Sagamihara Hospital, Sagamihara, Kanagawa 228 8522, Japan
    Biochem Cell Biol 87:581-93. 2009
    ....
  11. pmc Human leukocyte antigens and systemic lupus erythematosus: a protective role for the HLA-DR6 alleles DRB1*13:02 and *14:03
    Hiroshi Furukawa
    Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan
    PLoS ONE 9:e87792. 2014
    ..To the best of our knowledge, this is the first report of a protective association between the carrier frequencies of HLA-DRB1*13:02 and *14:03 and SLE in the Japanese population...
  12. doi request reprint αvβ5 integrin promotes dedifferentiation of monolayer-cultured articular chondrocytes
    Naoshi Fukui
    National Hospital Organization Sagamihara Hospital, Sagamihara, Japan
    Arthritis Rheum 63:1938-49. 2011
    ..Although the involvement of integrins has been suggested, the exact mechanisms of the change have not been determined. This study was undertaken to clarify the mechanisms underlying the loss of chondrocyte phenotype early after plating...
  13. doi request reprint Diffuse chronic leptomeningitis with seropositive rheumatoid arthritis: report of a case successfully treated as rheumatoid leptomeningitis
    Kota Shimada
    Department of Rheumatology, National Hospital Organization Sagamihara Hospital, 18 1 Sakura dai, Sagamihara, Kanagawa, 228 8522, Japan
    Mod Rheumatol 19:556-62. 2009
    ..Her IgG-index, serum levels of soluble interleukin-2 receptor and ferritin, and cerebrospinal level of interleukin-6 paralleled her clinical course...
  14. doi request reprint Human leukocyte antigen polymorphisms and personalized medicine for rheumatoid arthritis
    Hiroshi Furukawa
    Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan
    J Hum Genet 60:691-6. 2015
    ..Understanding the role of HLA as the most important genetic factor relevant to RA susceptibility may help in determining its pathogenesis and pave the way to personalized medicine. ..
  15. doi request reprint Neutrophil CD64 for monitoring the activity of nontuberculous mycobacteria infection in patients with rheumatoid arthritis
    Akiko Komiya
    Department of Clinical Laboratory, Sagamihara National Hospital, National Hospital Organization, Kanagawa, Japan
    Mod Rheumatol 24:770-4. 2014
    ..To evaluate the utility of neutrophil CD64 as a marker for monitoring the activity of nontuberculous mycobacteria (NTM) infection in patients with rheumatoid arthritis (RA)...
  16. pmc Incidence of Symptomatic Vertebral Fractures Among Newly Diagnosed Autoimmune Diseases Initiating Glucocorticoid Therapy
    Kiyoshi Migita
    From the Department of General Internal Medicine and Rheumatology, Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki KM, NI, SI, YJ, YI, YT, CK Japanese National Hospital Organization NHO EBM Study Group for Adverse Effects of Corticosteroid Therapy J NHOSAC, Hikarigaoka, Meguro, Tokyo KM Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki AK and Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara, Japan HF, St
    Medicine (Baltimore) 94:e875. 2015
    ..There is a need for further, even longer-term, prospective studies subjected patients with autoimmune disease, including ILD, under GC treatment...
  17. doi request reprint Zonal gene expression of chondrocytes in osteoarthritic cartilage
    Naoshi Fukui
    Clinical Research Center, National Hospital Organization Sagamihara Hospital, Kanagawa, Japan
    Arthritis Rheum 58:3843-53. 2008
    ..To determine the chondrocyte metabolism in respective zones of osteoarthritic (OA) cartilage...