Kunimasa Arima

Summary

Affiliation: National Center Hospital for Mental
Country: Japan

Publications

  1. ncbi request reprint Cerebral arterial pathology of CADASIL and CARASIL (Maeda syndrome)
    Kunimasa Arima
    Department of Laboratory Medicine, National Center Hospital for Mental, Nervous and Muscular Disorders, Kodaira, Tokyo, Japan
    Neuropathology 23:327-34. 2003
  2. doi request reprint Phosphorylated Syk expression is enhanced in Nasu-Hakola disease brains
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University Department of Clinical Neuropathology, Tokyo, Japan
    Neuropathology 32:149-57. 2012
  3. doi request reprint Failure to confirm an association between Epsin 4 and schizophrenia in a Japanese population
    Misty Richards
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Neural Transm (Vienna) 115:1347-54. 2008
  4. pmc Effects of the CACNA1C risk allele on neurocognition in patients with schizophrenia and healthy individuals
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Sci Rep 2:634. 2012
  5. doi request reprint Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan Department of Psychiatry, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    J Psychiatr Res 47:401-6. 2013
  6. doi request reprint Negative correlation between cerebrospinal fluid oxytocin levels and negative symptoms of male patients with schizophrenia
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Schizophr Res 139:201-6. 2012
  7. doi request reprint Immunohistochemical characterization of CD33 expression on microglia in Nasu-Hakola disease brains
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Tokyo, Japan
    Neuropathology 35:529-37. 2015
  8. doi request reprint Association of plasma IL-6 and soluble IL-6 receptor levels with the Asp358Ala polymorphism of the IL-6 receptor gene in schizophrenic patients
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Psychiatr Res 45:1439-44. 2011
  9. doi request reprint Benzodiazepines, benzodiazepine-like drugs, and typical antipsychotics impair manual dexterity in patients with schizophrenia
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan Department of Psychiatry, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Psychiatr Res 49:37-42. 2014
  10. doi request reprint Possible association of the semaphorin 3D gene (SEMA3D) with schizophrenia
    Takashi Fujii
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    J Psychiatr Res 45:47-53. 2011

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Cerebral arterial pathology of CADASIL and CARASIL (Maeda syndrome)
    Kunimasa Arima
    Department of Laboratory Medicine, National Center Hospital for Mental, Nervous and Muscular Disorders, Kodaira, Tokyo, Japan
    Neuropathology 23:327-34. 2003
    ..The authors suggest that CARASIL be referred to as 'Maeda syndrome' or 'CARASIL (Maeda syndrome)' to avoid confusion with CADASIL...
  2. doi request reprint Phosphorylated Syk expression is enhanced in Nasu-Hakola disease brains
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University Department of Clinical Neuropathology, Tokyo, Japan
    Neuropathology 32:149-57. 2012
    ..These observations indicate that neuronal expression of pSyk was greatly enhanced in the cerebral cortex and the hippocampus of NHD brains, possibly via non-TREM2/DAP12 signaling pathways involved in Syk activation...
  3. doi request reprint Failure to confirm an association between Epsin 4 and schizophrenia in a Japanese population
    Misty Richards
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Neural Transm (Vienna) 115:1347-54. 2008
    ..Our results suggest that the examined region of Epsin 4 does not have a major influence on susceptibility to schizophrenia in Japanese...
  4. pmc Effects of the CACNA1C risk allele on neurocognition in patients with schizophrenia and healthy individuals
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Sci Rep 2:634. 2012
    ..These results add to the literature suggesting that rs1006737 may be associated with schizophrenia through its detrimental effect on endophenotypic traits...
  5. doi request reprint Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan Department of Psychiatry, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    J Psychiatr Res 47:401-6. 2013
    ..The present findings suggest that IL-6 of central origin is associated with the pathophysiology of schizophrenia and MDD, although confounding effect of smoking status can not be entirely excluded...
  6. doi request reprint Negative correlation between cerebrospinal fluid oxytocin levels and negative symptoms of male patients with schizophrenia
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Schizophr Res 139:201-6. 2012
    ..Previous studies also suggest altered oxytocin function in patients with schizophrenia and depression. However, few studies have examined the central oxytocin levels in these disorders...
  7. doi request reprint Immunohistochemical characterization of CD33 expression on microglia in Nasu-Hakola disease brains
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Tokyo, Japan
    Neuropathology 35:529-37. 2015
    ..These results do not support the view that CD33-expressing microglia play a central role in the development of leukoencephalopathy in NHD brains. ..
  8. doi request reprint Association of plasma IL-6 and soluble IL-6 receptor levels with the Asp358Ala polymorphism of the IL-6 receptor gene in schizophrenic patients
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Psychiatr Res 45:1439-44. 2011
    ..Increased IL-6 levels without alterations in sIL-6R levels may result in excessive IL-6 signaling in schizophrenia...
  9. doi request reprint Benzodiazepines, benzodiazepine-like drugs, and typical antipsychotics impair manual dexterity in patients with schizophrenia
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan Department of Psychiatry, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Psychiatr Res 49:37-42. 2014
    ..Psychiatrists should be aware that some psychotropic medications may enhance the disability caused by the impairment of dexterity in patients with schizophrenia. ..
  10. doi request reprint Possible association of the semaphorin 3D gene (SEMA3D) with schizophrenia
    Takashi Fujii
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    J Psychiatr Res 45:47-53. 2011
    ..Our findings provide strong evidence that SEMA3D confers susceptibility to schizophrenia, which could contribute to the neurodevelopmental impairments in the disorder...
  11. pmc Association study of the vesicular monoamine transporter 1 (VMAT1) gene with schizophrenia in a Japanese population
    Misty Richards
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, 187 8502, Japan
    Behav Brain Funct 2:39. 2006
    ..3, a locus with strong evidence of linkage with schizophrenia. A recent study reported that a non-synonymous single nucleotide polymorphism (SNP) of the gene (Pro4Thr) was associated with schizophrenia...
  12. doi request reprint Neuromyelitis optica/Devic's disease: gene expression profiling of brain lesions
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Tokyo, Japan
    Neuropathology 28:561-76. 2008
    ..These results suggest that profound activation of the macrophage-mediated proinflammatory immune mechanism plays a pivotal role in development of NMO brain lesions...
  13. doi request reprint Clinical impact of (11)C-Pittsburgh compound-B positron emission tomography carried out in addition to magnetic resonance imaging and single-photon emission computed tomography on the diagnosis of Alzheimer's disease in patients with dementia and mild cog
    Yoshie Omachi
    Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan
    Psychiatry Clin Neurosci 69:741-51. 2015
    ....
  14. doi request reprint Expression of Ca²⁺-dependent activator protein for secretion 2 is increased in the brains of schizophrenic patients
    Kotaro Hattori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi cho, Kodaira, Tokyo, 187 8502 Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1738-43. 2011
    ..Chronic risperidone treatment did not alter the expression of CADPS2 in frontal cortex of mice. The observed increase in the expression of CADPS2 may be related to the impaired synaptic function in schizophrenia...
  15. doi request reprint Relationship between apathy and diffusion tensor imaging metrics of the brain in Alzheimer's disease
    Miho Ota
    Department of Radiology, Musashi Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Int J Geriatr Psychiatry 27:722-6. 2012
    ..In this study, we examined the association between apathy and white matter integrity using diffusion tensor imaging (DTI)...
  16. pmc PLD3 is accumulated on neuritic plaques in Alzheimer's disease brains
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji, Pharmaceutical University, 2 522 1 Noshio, Kiyose 204 8588, Tokyo, Japan
    Alzheimers Res Ther 6:70. 2014
    ..However, the precise cellular location and distribution of PLD3 in AD brains remain largely unknown...
  17. ncbi request reprint Extensive loss of arterial medial smooth muscle cells and mural extracellular matrix in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL)
    Takashi Oide
    Department of Laboratory Medicine, Musashi Hospital, National Center of Neurology and Psychiatry, Kodaira, Japan
    Neuropathology 28:132-42. 2008
    ..We speculate that the abnormalities in the ECM are causatively related to the SMC degeneration, since the ECM is a crucial signal determining the biophysiological properties of arterial SMCs...
  18. doi request reprint Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions
    Aiko Izumi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Neuropsychopharmacology 33:3237-45. 2008
    ..016) and verbal IQ (P<0.001). Genetic variation of the hNP gene may contribute to molecular mechanisms of bipolar disorder and some aspects of memory and intelligence...
  19. pmc Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau
    Sayuri Taniguchi-Watanabe
    Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, 2 1 6 Kamikitazawa, Setagaya Ku, Tokyo, 156 8506, Japan
    Acta Neuropathol 131:267-80. 2016
    ..These unique assembled tau cores may be used to classify and diagnose disease strains. Based on these results, we propose a new clinicopathological classification of tauopathies based on the biochemical properties of tau. ..
  20. pmc Bioinformatics Data Mining Approach Suggests Coexpression of AGTPBP1 with an ALS-linked Gene C9orf72
    Shouta Kitano
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan
    J Cent Nerv Syst Dis 7:15-26. 2015
    ..However, at present, the physiological function of C9orf72 remains largely unknown...
  21. pmc LC3, an autophagosome marker, is expressed on oligodendrocytes in Nasu-Hakola disease brains
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Tokyo, Japan
    Orphanet J Rare Dis 9:68. 2014
    ..At present, the molecular mechanism responsible for development of leukoencephalopathy in NHD brains remains totally unknown...
  22. pmc Molecular network analysis suggests aberrant CREB-mediated gene regulation in the Alzheimer disease hippocampus
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Noshio, Kiyose, Tokyo, Japan
    Dis Markers 27:239-52. 2009
    ....
  23. doi request reprint Neurodegenerative changes in patients with clinical history of bipolar disorders
    Ayako Shioya
    Department of Pathology and Laboratory Medicine, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan
    Neuropathology 35:245-53. 2015
    ..The patients who died in/after their 70s demonstrated AGs similar to controls, except for the patient with CBD. Our data provides potentiality that neurodegenerative diseases may be an underlying pathology in certain cases of BPD. ..
  24. pmc Close association of water channel AQP1 with amyloid-beta deposition in Alzheimer disease brains
    Tamako Misawa
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo, 204 8588, Japan
    Acta Neuropathol 116:247-60. 2008
    ..These observations suggest the possible association of astrocytic AQP1 with Abeta deposition in AD brains...
  25. doi request reprint Postmortem findings in a patient with cerebral amyloid angiopathy actively treated with corticosteroid
    Kazuko Machida
    Department of Medicine Neurology and Rheumatology, Kodaira, Japan
    Amyloid 19:47-52. 2012
    ..Comparing the previous biopsy findings with those at autopsy, the total disappearance of the inflammatory cell infiltration and diminishing of the cerebrovascular amyloid deposits were noted...
  26. doi request reprint Activation of microglia/macrophages expressing phosphorylated S6 ribosomal protein in a case of hemimegalencephaly with progressive calcification and atrophy
    Yutaka Nonoda
    Department of Child Neurology, National Center Hospital of Neurology and Psychiatry, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi cho, Kodaira, Tokyo 187 8551, Japan
    J Neurol Sci 287:52-9. 2009
    ..The cellular mechanism and significance of P-S6-specific activation of the mTOR cascade in HME, particularly in the inflammatory cell lineage, should be explored further...
  27. ncbi request reprint Three-repeat Tau 69 is a major tau isoform in laser-microdissected Pick bodies
    Takuya Ohkubo
    Second Department of Physiology, Tokyo Medical University, Tokyo, Japan
    Amyloid 13:1-5. 2006
    ..Such a combination of morphological and biochemical techniques significantly complements the existing histopathological methods...
  28. doi request reprint Concordance between (99m)Tc-ECD SPECT and 18F-FDG PET interpretations in patients with cognitive disorders diagnosed according to NIA-AA criteria
    Kimiteru Ito
    Department of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan
    Int J Geriatr Psychiatry 29:1079-86. 2014
    ....
  29. doi request reprint Misfolded SOD1 forms high-density molecular complexes with synaptic molecules in mutant SOD1-linked familial amyotrophic lateral sclerosis cases
    Toshiyuki Araki
    Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    J Neurol Sci 314:92-6. 2012
    ..These results suggest that inhibition of synaptic release mechanism by association of misfolded SOD1 with synaptic molecules plays a role in the dysfunction of FALS...
  30. doi request reprint Immunohistochemical characterization of microglia in Nasu-Hakola disease brains
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University Department of Clinical Neuropathology, Tokyo, Japan
    Neuropathology 31:363-75. 2011
    ....
  31. doi request reprint Diffusion abnormality in posterior cingulate fiber tracts in Alzheimer's disease: tract-specific analysis
    Yasuhiro Nakata
    Department of Radiology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Radiat Med 26:466-73. 2008
    ..The aim of this study was to determine diffusion abnormalities in the posterior cingulate fiber tracts (PCFTs) in patients with Alzheimer's disease (AD) by diffusion tensor tractography (DTT)...
  32. doi request reprint TDP-43 dimerizes in human cells in culture
    Yuki Shiina
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, 2 522 1 Noshio Kiyose, Tokyo, 204 8588, Japan
    Cell Mol Neurobiol 30:641-52. 2010
    ..These results suggest that the 86-kDa band represents dimerized TDP-43 expressed constitutively in normal cells under physiological conditions...
  33. ncbi request reprint Failure to confirm an association between the PLXNA2 gene and schizophrenia in a Japanese population
    Takashi Fujii
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:873-7. 2007
    ..Furthermore, haplotype-based analyses did not provide evidence for an association. These results suggest that PLXNA2 may not play a major role in the development of schizophrenia in our Japanese sample...
  34. doi request reprint Absence of small-vessel abnormalities in alternating hemiplegia of childhood
    Masayuki Sasaki
    Department of Child Neurology, National Center of Neurology and Psychiatry NCNP, 4 1 1 Ogawahigashi cho, Kodaira, Tokyo 187 8551, Japan
    Brain Dev 33:390-3. 2011
    ..To investigate whether Japanese patients with alternating hemiplegia of childhood (AHC) have the similar small-vessel abnormalities in skin reported in European patients with AHC...
  35. ncbi request reprint Autotaxin expression is enhanced in frontal cortex of Alzheimer-type dementia patients
    Ken Umemura
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Neurosci Lett 400:97-100. 2006
    ..These observations suggest that expression of the autotaxin gene and cell signaling by lysophosphatidic acid may be involved in the pathology of ATD, and that this cell signaling pathway may be a potential target of treatments for ATD...
  36. ncbi request reprint Ultrastructural characteristics of tau filaments in tauopathies: immuno-electron microscopic demonstration of tau filaments in tauopathies
    Kunimasa Arima
    Department of Laboratory Medicine, Musashi Hospital, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8551, Japan
    Neuropathology 26:475-83. 2006
    ..In this study, the 3-repeat tau or 4-repeat tau epitope was detected in situ at the ultrastructural level in abnormal tubules in representative pathological lesions in Pick's disease, PSP and corticobasal degeneration...
  37. ncbi request reprint Human astrocytes express 14-3-3 sigma in response to oxidative and DNA-damaging stresses
    Jun ichi Satoh
    Department of Bioinformatics and Neuroinformatics, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo, Japan
    Neurosci Res 56:61-72. 2006
    ..These observations suggest that 14-3-3sigma might serve as a marker of oxidative and DNA-damaging stresses inducing the mitotic checkpoint dysfunction in reactive astrocytes under pathological conditions...
  38. ncbi request reprint Arterial changes in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in relation to pathogenesis of diffuse myelin loss of cerebral white matter: examination of cerebral medullary arteries by reconstruct
    Riki Okeda
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Stroke 33:2565-9. 2002
    ..We sought to examine the precise extent and severity of changes in the cerebral arteries in an autopsy case of CADASIL in relation to pathogenesis of the diffuse myelin loss...
  39. ncbi request reprint [Research resource network and Parkinson disease brain bank donor registration program in Japan]
    Kunimasa Arima
    Department of Psychiatry, National Center of Neurology and Psychiatry Hospital, Ogawa higashi machi, Kadaira shi, Tokyo, Japan
    Brain Nerve 62:1025-34. 2010
    ..Autopsies have been performed for 2 of these donors. To promote brain banking activities,it is necessary to establish legal and ethical guidelines for the use of autopsied materials in biomedical research...
  40. ncbi request reprint Coexistence of familial transthyretin amyloidosis ATTR Val30Met and spinocerebellar ataxia type 1 in a Japanese family--a follow-up autopsy report
    Takashi Oide
    Department of Laboratory Medicine, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan
    Amyloid 11:191-9. 2004
    ....
  41. ncbi request reprint Autosomal dominant leukoencephalopathy with mild clinical symptoms due to cerebrovascular dysfunctions: a new disease entity?
    Shinichi Hirabayashi
    Department of Neurology, Nagano Children s Hospital, Azumino, Nagano, Japan
    Brain Dev 30:146-50. 2008
    ..Further accumulation of similar cases is necessary to establish the possibility of a new familial leukoencephalopathy...