National Institute of Infectious Diseases

Summary

Organization: National Institute of Infectious Diseases
Country: Japan

Top Publications

  1. pmc Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes
    Jun ichi Wachino
    Department of Bacteriology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    Antimicrob Agents Chemother 54:3061-4. 2010
  2. ncbi [Preparedness and international contribution on H5N1 highly pathogenic avian influenza and pandemic-influenza]
    Takato Odagiri
    Laboratory of Influenza Viruses, Department of Virology 3, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashi Murayama, Tokyo 208 0011, Japan
    Uirusu 56:77-84. 2006
  3. ncbi Folate intakes and folate biomarker profiles of pregnant Japanese women in the first trimester
    N Mito
    Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan
    Eur J Clin Nutr 61:83-90. 2007
  4. pmc The GrlR-GrlA regulatory system coordinately controls the expression of flagellar and LEE-encoded type III protein secretion systems in enterohemorrhagic Escherichia coli
    Sunao Iyoda
    Department of Bacteriology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    J Bacteriol 188:5682-92. 2006
  5. ncbi First detection of Rickettsia in soft-bodied ticks associated with seabirds, Japan
    Hiroki Kawabata
    Department of Bacteriology, National Institute of Infectious Diseases, Shinjoku ku, Tokyo 162 8640, Japan
    Microbiol Immunol 50:403-6. 2006
  6. ncbi Regulation of p90RSK phosphorylation by SARS-CoV infection in Vero E6 cells
    Tetsuya Mizutani
    Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashimurayama, Tokyo 208 0011, Japan
    FEBS Lett 580:1417-24. 2006
  7. ncbi Identification of Mycobacterium species by comparative analysis of the dnaA gene
    Tetsu Mukai
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases NIID, Higashimurayama, Tokyo, Japan
    FEMS Microbiol Lett 254:232-9. 2006
  8. ncbi The establishment of a HeLa cell demonstrating rapid mitogen-activated protein kinase phosphorylation in response to 1alpha,25-dihydroxyvitamin D3 by stable transfection of a chick skeletal muscle cDNA library
    Jun Yamauchi
    Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan
    Biosci Biotechnol Biochem 70:312-5. 2006
  9. ncbi Double-stranded RNA stimulates chemokine expression in microglia through vacuolar pH-dependent activation of intracellular signaling pathways
    Kazuo Nakamichi
    Department of Virology 1, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan
    J Neurochem 95:273-83. 2005
  10. ncbi [Current topics on SARS coronavirus]
    Tetsuya Mizutani
    Virology 1, Gakuen 4 7 1, Musashimurayama City, Tokyo 208 0011, Japan
    Uirusu 54:97-105. 2004

Detail Information

Publications62

  1. pmc Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes
    Jun ichi Wachino
    Department of Bacteriology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    Antimicrob Agents Chemother 54:3061-4. 2010
    ....
  2. ncbi [Preparedness and international contribution on H5N1 highly pathogenic avian influenza and pandemic-influenza]
    Takato Odagiri
    Laboratory of Influenza Viruses, Department of Virology 3, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashi Murayama, Tokyo 208 0011, Japan
    Uirusu 56:77-84. 2006
    ..Furthermore, international supports to the affected countries for development and improvement of diagnostic system are required in the public health aspect...
  3. ncbi Folate intakes and folate biomarker profiles of pregnant Japanese women in the first trimester
    N Mito
    Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan
    Eur J Clin Nutr 61:83-90. 2007
    ..To assess the status of dietary folate intake, serum and red blood cell (RBC) folate, and related nutritional biomarkers in healthy Japanese women in early pregnancy...
  4. pmc The GrlR-GrlA regulatory system coordinately controls the expression of flagellar and LEE-encoded type III protein secretion systems in enterohemorrhagic Escherichia coli
    Sunao Iyoda
    Department of Bacteriology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    J Bacteriol 188:5682-92. 2006
    ..The fact that an EHEC strain constitutively expressing FlhD/FlhC cannot adhere to HeLa cells leads us to hypothesize that GrlA-dependent repression of the flagellar regulon is important for efficient cell adhesion of EHEC to host cells...
  5. ncbi First detection of Rickettsia in soft-bodied ticks associated with seabirds, Japan
    Hiroki Kawabata
    Department of Bacteriology, National Institute of Infectious Diseases, Shinjoku ku, Tokyo 162 8640, Japan
    Microbiol Immunol 50:403-6. 2006
    ..capensis in the U.S.A. This suggested that an environmental circulation had consisted among microorganisms, ticks and long distance migratory seabirds around the Pacific Ocean...
  6. ncbi Regulation of p90RSK phosphorylation by SARS-CoV infection in Vero E6 cells
    Tetsuya Mizutani
    Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashimurayama, Tokyo 208 0011, Japan
    FEBS Lett 580:1417-24. 2006
    ..These results indicated that phosphorylation status of p90RSK by SARS-CoV infection is different from that by stimulation of EGF. This is the first detailed report regarding regulation of p90RSK phosphorylation by virus infection...
  7. ncbi Identification of Mycobacterium species by comparative analysis of the dnaA gene
    Tetsu Mukai
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases NIID, Higashimurayama, Tokyo, Japan
    FEMS Microbiol Lett 254:232-9. 2006
    ..These results demonstrate that the variable sequences in the dnaA gene were species specific and were sufficient for the development of an accurate and rapid diagnosis of Mycobacterium species...
  8. ncbi The establishment of a HeLa cell demonstrating rapid mitogen-activated protein kinase phosphorylation in response to 1alpha,25-dihydroxyvitamin D3 by stable transfection of a chick skeletal muscle cDNA library
    Jun Yamauchi
    Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan
    Biosci Biotechnol Biochem 70:312-5. 2006
    ..These cell lines have the potential to be a good tool for further investigation of rapid non-genomic mechanism activated by 1,25-(OH)2D3...
  9. ncbi Double-stranded RNA stimulates chemokine expression in microglia through vacuolar pH-dependent activation of intracellular signaling pathways
    Kazuo Nakamichi
    Department of Virology 1, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan
    J Neurochem 95:273-83. 2005
    ..Taken together, these results suggest that the recognition of dsRNA structure selectively induces the CXCL10 and CCL5 responses in microglia through vacuolar pH-dependent activation of NF-kappaB and MAPK signaling pathways...
  10. ncbi [Current topics on SARS coronavirus]
    Tetsuya Mizutani
    Virology 1, Gakuen 4 7 1, Musashimurayama City, Tokyo 208 0011, Japan
    Uirusu 54:97-105. 2004
    ..Topics of the research on the present SARS-research field are development of vaccine, inspecting of medicine and establishment of diagnostic method. Here, the newest information is offered about these researches...
  11. ncbi Porphyrias in Japan: compilation of all cases reported through 2002
    Masao Kondo
    Division of Applied Nutrition, National Institute of Health and Nutrition, Tokyo, Japan
    Int J Hematol 79:448-56. 2004
    ....
  12. ncbi Hypermethylation of the CpG island of connexin 32, a candiate tumor suppressor gene in renal cell carcinomas from hemodialysis patients
    Tomohiro Yano
    Department of Food Science Research for Health, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Cancer Lett 208:137-42. 2004
    ..These results suggest that Cx32 is a promising tumor suppressor gene relating to the early stage of renal carcinogenesis in the hemodialysis patients...
  13. ncbi Transgenic tobacco cells producing the human monoclonal antibody to hepatitis B virus surface antigen
    Akira Yano
    Department of Oral Health, National Institute of Public Health, Tokyo, Japan
    J Med Virol 73:208-15. 2004
    ..The results of this study point to the feasibility of producing MAbs to HBsAg in plants as an alternative to HBIg...
  14. ncbi Cold-induced thermogenesis mediated by GABA in the preoptic area of anesthetized rats
    Toshimasa Osaka
    National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku 162 8636, Japan
    Am J Physiol Regul Integr Comp Physiol 287:R306-13. 2004
    ..These results suggest that GABA and GABA(A) receptors in the POA mediate cold information arising from the skin for eliciting cold-induced thermogenesis...
  15. ncbi Plasmid pBP136 from Bordetella pertussis represents an ancestral form of IncP-1beta plasmids without accessory mobile elements
    Kazunari Kamachi
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Musashimurayma, Tokyo 208 0011, Japan
    Microbiology 152:3477-84. 2006
    ....
  16. ncbi [Novel chemical mediators in the resolution of inflammation]
    Makoto Arita
    Tanpakushitsu Kakusan Koso 52:348-54. 2007
  17. ncbi An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation
    Shinji Miura
    Nutritional Science Program, National Institute of Health and Nutrition, 1 23 1, Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Endocrinology 148:3441-8. 2007
    ..These data indicate that up-regulation of PGC-1alpha expression in skeletal muscle by exercise is mediated, at least in part, by beta-ARs activation. Among ARs, beta2-AR may mediate an increase in PGC-1alpha by exercise...
  18. doi Predicting VO(2max) with an objectively measured physical activity in Japanese men
    Zhen Bo Cao
    Health Promotion and Exercise Program, National Institute of Health and Nutrition, Shinjuku ku, Tokyo, Japan
    Eur J Appl Physiol 109:465-72. 2010
    ..This study demonstrated that combining SC with VPA, but not with MVPA, was useful in predicting VO(2max) variance and improved the ability of the regression models to accurately predict VO(2max)...
  19. ncbi [Forefront of vaccine development: tuberculosis and leprosy]
    Toshiki Tamura
    Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 78:271-6. 2009
    ..These results suggest that Th1 immune response induced by Peptide-25 plays an important role in the induction of functional activation of CD8+ cytotoxic T cells...
  20. doi Differential susceptibility of peripheral blood CD5+ and CD5- B cells to apoptosis in chronic hepatitis C patients
    Toshiaki Mizuochi
    Department of Research on Blood and Biological Products, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    Biochem Biophys Res Commun 389:512-5. 2009
    ..The rationale for the differential susceptibility of distinct B cell subsets in CHC is also discussed with regard to extrahepatic manifestations associated with chronic HCV infection...
  21. pmc Two-step conformational changes in a coronavirus envelope glycoprotein mediated by receptor binding and proteolysis
    Shutoku Matsuyama
    Department of Virology III, National Institute of Infectious Diseases, 4 7 1 Gakuen Musashi Murayama, Tokyo 208 0011, Japan
    J Virol 83:11133-41. 2009
    ..These results suggest that trypsin suffices for the induction of membrane fusion of receptor-primed S protein, but an additional unidentified cellular factor is required to trigger membrane fusion by CPL...
  22. doi Effects of summer training camp on serum opsonic activity and plasma cytokine levels in female long-distance runners
    Takashi Kumae
    Health Promotion and Exercise Program, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Luminescence 24:438-43. 2009
    ..According to the results of peak time and peak height of LmCL, SOA seems to increase at first qualitatively and then quantitatively during the summer camp. The increased SOA level may compensate for the decrease in neutrophil activity...
  23. doi Virulence and pathophysiology of the Congo Basin and West African strains of monkeypox virus in non-human primates
    Masayuki Saijo
    Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases NIID, 4 7 1 Gakuen, Musashimurayama, Tokyo 208 0011, Japan
    J Gen Virol 90:2266-71. 2009
    ..Zr-599 affected respiratory, genito-urinary and gastrointestinal tract organs more severely than Liberia. Zr-599 was more virulent than Liberia and one of the factors might be the difference in organ tropism...
  24. doi Heat loss responses and blockade of prostaglandin E2-induced thermogenesis elicited by alpha1-adrenergic activation in the rostromedial preoptic area
    T Osaka
    Health Promotion and Exercise Program, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku 162 8636, Japan
    Neuroscience 162:1420-8. 2009
    ..These results demonstrate that NA in the rostromedial POA exerts alpha(1)-adrenoceptor-mediated hypothermic effects and opposes PGE(2)-induced fever...
  25. doi Application of lambda Red recombination system to Vibrio cholerae genetics: simple methods for inactivation and modification of chromosomal genes
    Shouji Yamamoto
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    Gene 438:57-64. 2009
    ..Use of the techniques presented here should prompt rapid and efficient mutagenesis/modification of V. cholerae chromosomal genes...
  26. doi Self-assembly of sapovirus recombinant virus-like particles from polyprotein in mammalian cells
    Tomoichiro Oka
    Department of Virology II, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashi Murayama, Tokyo 208 0011, Japan
    Microbiol Immunol 53:49-52. 2009
    ....
  27. doi Imported infectious diseases and surveillance in Japan
    Kiyosu Taniguchi
    Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    Travel Med Infect Dis 6:349-54. 2008
    ..However, further timely investigation for unusual increase in infectious diseases is needed...
  28. pmc Antigenic diversity of human sapoviruses
    Grant S Hansman
    National Institute of Infectious Diseases, Tokyo, Japan
    Emerg Infect Dis 13:1519-25. 2007
    ..Conversely, an antigen ELISA showed that VLPs of SaV in all human genogroups were antigenically distinct. These findings indicate a likely correspondence between SaV antigenicity and VP1 genogrouping and genotyping...
  29. ncbi [Sendai viral infection and host innate immunity]
    Atsushi Kato
    Tanpakushitsu Kakusan Koso 52:1194-9. 2007
  30. pmc Human sapovirus in clams, Japan
    Grant S Hansman
    National Institute of Infectious Diseases, Tokyo, Japan
    Emerg Infect Dis 13:620-2. 2007
    ..Closely matching sequences have been detected in stool specimens from patients with gastroenteritis in Japan, which indicates a possible food-to-human transmission link...
  31. ncbi Improvement of DNA vaccine immunogenicity by a dual antigen expression system
    Shin Sasaki
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama, Tokyo 189 0002, Japan
    Biochem Biophys Res Commun 315:38-43. 2004
    ..We concluded that increasing the number of antigen expression cassettes in a vaccine construct improved antigen expression in the transduced tissue, which induced stronger DNA-raised immune responses...
  32. pmc Two cases of fatal necrotizing fasciitis caused by Photobacterium damsela in Japan
    Kunikazu Yamane
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo, Japan
    J Clin Microbiol 42:1370-2. 2004
    ..Both cases occurred in fishermen who became sick after fishing. They developed multiple organ failure within 20 to 36 h from the onset of initial symptoms despite intensive chemotherapy and surgical treatments...
  33. ncbi Analysis of the canine IgE-binding epitope on the major allergen (Cry j 1) of Japanese cedar pollen with anti-Cry j 1 monoclonal antibodies
    M Sakaguchi
    Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan
    Vet Immunol Immunopathol 78:35-43. 2001
    ..In three dogs, IgE recognized EP-4 which is a heat-stable epitope. EP-5 is a predominant allergic epitope for dogs and some, but not all, dogs have IgE reaction patterns to the epitopes similar to those of humans...
  34. ncbi A flagellar gene fliZ regulates the expression of invasion genes and virulence phenotype in Salmonella enterica serovar Typhimurium
    S Iyoda
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Toyama 1 23 1 Shinjuku ku, 162 8640, Japan
    Microb Pathog 30:81-90. 2001
    ..These results indicate that the fliZ gene product positively regulates the invasion genes and is necessary for expression of full virulence...
  35. pmc Trends in antimicrobial-drug resistance in Japan
    Y Arakawa
    National Institute of Infectious Diseases, Tokyo, Japan
    Emerg Infect Dis 6:572-5. 2000
    ..However, several of these microorganisms have recently developed resistance against many antimicrobial drugs...
  36. pmc Angiotensin-converting enzyme inhibitor captopril prevents activation-induced apoptosis by interfering with T cell activation signals
    C Odaka
    Department of Bacterial and Blood Products, National Institute of Infectious Diseases, Tokyo, Japan
    Clin Exp Immunol 121:515-22. 2000
    ..Captopril has been reported to induce systemic lupus erythematosus syndrome, and our findings may be useful for elucidating the mechanism of captopril-induced autoimmunity...
  37. ncbi Transcriptional regulation of HIV-1 LTR during antigen-dependent activation of primary T cells by dendritic cells
    Y Tsunetsugu-Yokota
    Department of Immunology, AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    J Leukoc Biol 67:432-40. 2000
    ..Our results suggest that additional cofactors distinct from IL-2-inducing signaling molecules are important for LTR activation during antigen-dependent T cell activation...
  38. ncbi Chromatid break rejoining and exchange aberration formation following gamma-ray exposure: analysis in G2 human fibroblasts by chemically induced premature chromosome condensation
    E Gotoh
    Division of Genetic Resources, National Institute of Infectious Diseases, Tokyo, Japan
    Int J Radiat Biol 75:1129-35. 1999
    ..To analyse the kinetics of chromatid break induction, rejoining, and misrejoining after y-irradiation in G2 phase human cells using premature chromosome condensation induced by calyculin A...
  39. ncbi Cloning and characterization of a gene encoding phosphatidyl inositol-specific phospholipase C from Trypanosoma cruzi
    T Nozaki
    Department of Parasitology, National Institute of Infectious Diseases, Tokyo, Japan
    Mol Biochem Parasitol 102:283-95. 1999
    ..The yeast-expressed T. cruzi PLC showed an absolute Ca2+ dependence which was similar to mammalian PLC isoforms: the half-maximal activity at 0.5-1 x 10(-5) M Ca2+ and the maximal activity at 1-2 x 10(-4) M Ca2+...
  40. ncbi Genomic structure and chromosome location of RPL27A/Rpl27a, the genes encoding human and mouse ribosomal protein L27A
    J Kusuda
    Division of Genetic Resources, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    Cytogenet Cell Genet 85:248-51. 1999
    ..Fluorescence in situ hybridization (FISH) analysis localized the mouse intron-containing Rpl27a to chromosome 7E2-F1 syntenic to human chromosome 11p15, where human RPL27A was located...
  41. ncbi Rubella virus genome diagnosis during pregnancy and mechanism of congenital rubella
    S Katow
    Department of Viral Disease and Vaccine Control, National Institute of Infectious Diseases, Musashi Murayama, Tokyo, Japan
    Intervirology 41:163-9. 1998
    ..A phylogenetic tree of 61 virus isolates suggested no difference of virulence/teratogenicity among the virus isolates...
  42. ncbi Selective effects of genistein, a soybean isoflavone, on B-lymphopoiesis and bone loss caused by estrogen deficiency
    Y Ishimi
    Department of Food Science, The National Institute of Health and Nutrition, Tokyo, Japan
    Endocrinology 140:1893-900. 1999
    ..Phytoestrogens may be useful for preventing bone loss caused by estrogen deficiency in females...
  43. ncbi Binding of human cytomegalovirus to sulfated glucuronyl glycosphingolipids and their inhibitory effects on the infection
    K Ogawa-Goto
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Japan
    J Gen Virol 79:2533-41. 1998
    ..These results clearly show that HCMV recognizes and binds to the sulfated carbohydrate structure in SGGL and also suggest that binding of HCMV to the specific sugar structure may play an important role in HCMV infection...
  44. ncbi Structure and expression of a cyst specific protein of Acanthamoeba castellanii
    Y Hirukawa
    Division of Radiological Protection and Biology, National Institute of Infectious Diseases, Shinjuku ku, Tokyo 162, Japan
    Biochim Biophys Acta 1398:47-56. 1998
    ..RNA blot analysis showed that the expression of CSP21 mRNA was restricted within early stages of encystment, suggesting that the biosynthesis of CSP21 is regulated at mRNA level...
  45. pmc Development of normal mice from metaphase I oocytes fertilized with primary spermatocytes
    A Ogura
    Department of Veterinary Science, National Institute of Infectious Diseases, 1 23 1, Toyama, Shinjuku, Tokyo 162, Japan
    Proc Natl Acad Sci U S A 95:5611-5. 1998
    ..Two pups (one male and one female) were proven to be fertile. This finding provides direct evidence that the nuclei of male germ cells acquire the ability to fertilize oocytes before the first meiotic division...
  46. ncbi Sequence analysis, gene expression, and chromosomal assignment of mouse Borg4 gene and its human orthologue
    N Osada
    Division of Genetic Resources, National Institute of Infectious Diseases, Tokyo, Japan
    J Hum Genet 45:374-7. 2000
    ..By fluorescence in situ hybridization, mouse Borg4 and the putative human orthologue have been assigned to mouse chromosome 11E and human chromosome 17q24-25, which has been described as syntenic to the mouse region...
  47. ncbi Electron microscopic study of persistent dengue virus infection: analysis using a cell line persistently infected with Dengue-2 virus
    T Takasaki
    Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan
    Intervirology 44:48-54. 2001
    ..It is likely that persistent infection is maintained mainly by the division of infected cells without cytopathic effect by dengue-2 virus...
  48. ncbi [Clinical leprosy in Japan]
    N Ishii
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases NIID, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 70:145-9. 2001
    ..Recently, diagnostic guides including information about network systems have become available in book stores. It is possible to obtain all kinds of information about leprosy from the network systems...
  49. ncbi Collaborative study: Standardization of Japanese reference diphtheria and tetanus toxoids, (adsorbed, lot 2), for potency determination of diphtheria-tetanus- acellular pertussis combined vaccine
    Masaaki Iwaki
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208 0011, Japan
    Jpn J Infect Dis 56:183-5. 2003
  50. ncbi Influence of the origin and level of dietary protein on TBI-induced oxidative damage in mice
    Sung Jae Shin
    Department of Food Science Research for Health, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Int J Vitam Nutr Res 73:297-302. 2003
    ..Mice fed a low-protein diet became susceptible to TBI-induced oxidative damage regardless of the origin of protein. Vitamin C and E values of the soybean protein group were markedly lower than those of the casein group...
  51. ncbi Effect of dietary DHA on DHA levels in retinal rod outer segments in young versus mature rats
    Chieko Nishizawa
    Division of Food Science, Independent Administrative Institution, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Int J Vitam Nutr Res 73:259-65. 2003
    ..Our findings indicate that mature rats maintain a constant level of DHA in the ROS membranes even after being directly supplemented with high doses of DHA...
  52. ncbi Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism
    Kentaro Hanada
    Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 1 23 1, Toyama, Shinjuku, Tokyo 162 8640, Japan
    Biochim Biophys Acta 1632:16-30. 2003
    ..Specific missense mutations in the human LCB1 gene cause hereditary sensory neuropathy type I, an autosomal dominantly inherited disease, and these mutations confer dominant-negative effects on SPT activity...
  53. ncbi Biosynthetic regulation and intracellular transport of phosphatidylserine in mammalian cells
    Osamu Kuge
    Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640
    J Biochem 133:397-403. 2003
    ..Here we describe the current understanding of the regulation of PtdSer biosynthesis and the transport of PtdSer from the ER to the mitochondria in mammalian cells...
  54. ncbi Bone marrow transplantation in a child with Wiskott-Aldrich syndrome latently infected with acyclovir-resistant (ACV(r)) herpes simplex virus type 1: emergence of foscarnet-resistant virus originating from the ACV(r) virus
    Masayuki Saijo
    Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan
    J Med Virol 68:99-104. 2002
    ..This is the first report on the clinical course of a BMT-associated ACV(r) HSV-1 infection that subsequently developed resistance to foscarnet as well...
  55. ncbi High genomic diversity of enterohemorrhagic Escherichia coli isolates in Japan and its applicability for the detection of diffuse outbreak
    Jun Terajima
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    Jpn J Infect Dis 55:19-22. 2002
    ..Based on the diversity of genotypes among the isolates of enterohemorrhagic E. coli O157:H7/- in Japan, we suggest the presence of a few other possible diffuse outbreaks due to the organisms, showing indistinguishable genotypes...
  56. ncbi Analytical method of measuring tea catechins in human plasma by solid-phase extraction and HPLC with electrochemical detection
    K Umegaki
    The National Institute of Health and Nutrition, Tokyo, Japan
    J Nutr Sci Vitaminol (Tokyo) 47:402-8. 2001
    ..The concentration of total catechins (free+conjugated forms) in plasma increased up to 2 h after the intake...
  57. pmc Selective amplification of tyv (rfbE), prt (rfbS), viaB, and fliC genes by multiplex PCR for identification of Salmonella enterica serovars Typhi and Paratyphi A
    Kenji Hirose
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    J Clin Microbiol 40:633-6. 2002
    ..The results showed that all the clinical isolates examined of Salmonella serovars Typhi and Paratyphi A were accurately identified by this assay...
  58. ncbi Immunologic characterization of HIV-specific DNA vaccine
    N Ishii
    Leprosy Research Center, National Institute of Infectious Diseases, Higashi murayama, Tokyo, Japan
    J Investig Dermatol Symp Proc 6:76-80. 2001
    ..Therefore, topical administration of DNA vaccine is an effective route, and may be very useful for the prevention of infectious diseases...
  59. ncbi Expression of p53 and human herpesvirus-8 (HHV-8)-encoded latency-associated nuclear antigen with inhibition of apoptosis in HHV-8-associated malignancies
    H Katano
    Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
    Cancer 92:3076-84. 2001
    ..Recently, the binding of LANA to p53 was demonstrated in vitro. In the current study, the authors investigated the association between p53 and LANA expression with apoptosis in HHV-8-associated malignancies in vivo...
  60. pmc Improved method for detection of Vibrio parahaemolyticus in seafood
    Y Hara-Kudo
    Department of Biomedical Food Research, National Institute of Infectious Diseases, Shinjuku ku, Tokyo 162 8640, Japan
    Appl Environ Microbiol 67:5819-23. 2001
    ..parahaemolyticus. Our findings suggest that this new enrichment and isolation scheme is more sensitive and accurate for identifying V. parahaemolyticus in seafood samples than previously used methods...
  61. ncbi Inhibition of expression of ornithine decarboxylase by c-myc antisense oligonucleotide at the promotion stage of lung tumorigenesis in mice
    T Yano
    Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan
    Jpn J Pharmacol 87:90-2. 2001
    ..Overall, it is possible that the induction of ODC in the carcinogenic process of lung is regulated at its transcriptional level...
  62. ncbi Acquired fusion activity of a murine coronavirus MHV-2 variant with mutations in the proteolytic cleavage site and the signal sequence of the S protein
    Y K Yamada
    Division of Experimental Animal Research, National Institute of Health, 4 7 1 Gakuen, Musashimurayama, Tokyo, Japan
    Virology 227:215-9. 1997
    ..This conclusion differs from studies on the activity of syncytium formation by the S proteins of fusogenic MHV-JHM and -A59 strains. Possible reasons for these differences in fusion activity are discussed...