Kazuhiko Nakayama

Summary

Country: Japan

Publications

  1. ncbi request reprint Possible alteration of tryptophan metabolism following repeated administration of sertraline in the rat brain
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Brain Res Bull 59:293-7. 2003
  2. ncbi request reprint [Mechanism of action of new generation antidepressants under development in Japan: focusing on dopamine neurotransmission]
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 29:99-108. 2009
  3. ncbi request reprint Mirtazapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Brain Res Bull 63:237-41. 2004
  4. ncbi request reprint Effect of paroxetine on extracellular serotonin and dopamine levels in the prefrontal cortex
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, 3 25 8 Nishishimbashi, Minato ku, Tokyo 105 8461, Japan
    Naunyn Schmiedebergs Arch Pharmacol 365:102-5. 2002
  5. ncbi request reprint Diurnal rhythm in extracellular levels of 5-hydroxyindoleacetic acid in the medial prefrontal cortex of freely moving rats: an in vivo microdialysis study
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, Nishishinbashi 3 19 18, Minato ku, Tokyo 105 8471, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 26:1383-8. 2002
  6. doi request reprint Association between neurotrophin-3 polymorphisms and executive function in Japanese patients with amnestic mild cognitive impairment and mild Alzheimer disease
    Nobuyuki Kobayashi
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 34:190-7. 2012
  7. pmc Genetic Association between Presenilin 2 Polymorphisms and Alzheimer's Disease and Dementia of Lewy Body Type in a Japanese Population
    Ayako Suzuki
    Departments of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Dis Extra 6:90-7. 2016
  8. pmc Usefulness of DNA Methylation Levels in COASY and SPINT1 Gene Promoter Regions as Biomarkers in Diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment
    Nobuyuki Kobayashi
    Department of Virology, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 11:e0168816. 2016
  9. pmc Development of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimer's Disease and Amnesic Mild Cognitive Impairment
    Nobuyuki Kobayashi
    Department of Virology, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 11:e0146449. 2016
  10. doi request reprint Genetic association between APOA1 and APOD polymorphisms and Alzheimer's disease in a Japanese population
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    J Neural Transm (Vienna) 120:1599-603. 2013

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Possible alteration of tryptophan metabolism following repeated administration of sertraline in the rat brain
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Brain Res Bull 59:293-7. 2003
    ..In conclusion, the data show that the increase in tryptophan levels and the decrease in 5-HT turnover in rat brain are attenuated by repeated treatment of sertraline...
  2. ncbi request reprint [Mechanism of action of new generation antidepressants under development in Japan: focusing on dopamine neurotransmission]
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 29:99-108. 2009
    ..Clinically, mirtazapine shows an earlier onset of action and a sedative effect. Bupropion is a DA and NA reuptake inhibitor, and is considered useful to activate DA neurons...
  3. ncbi request reprint Mirtazapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Brain Res Bull 63:237-41. 2004
    ..These results indicate that mirtazapine induces the enhancement of the output of cortical dopamine mediated via blockade of alpha(2)-adrenergic receptors and facilitation of post-synaptic 5-HT(1A) function...
  4. ncbi request reprint Effect of paroxetine on extracellular serotonin and dopamine levels in the prefrontal cortex
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, 3 25 8 Nishishimbashi, Minato ku, Tokyo 105 8461, Japan
    Naunyn Schmiedebergs Arch Pharmacol 365:102-5. 2002
    ..These results suggest that the increase in extracellular dopamine concentration in the mPFC elicited by paroxetine is the result of stimulation of 5-HT(3) receptors by the extracellular accumulation of 5-HT in the mPFC...
  5. ncbi request reprint Diurnal rhythm in extracellular levels of 5-hydroxyindoleacetic acid in the medial prefrontal cortex of freely moving rats: an in vivo microdialysis study
    Kazuhiko Nakayama
    Department of Psychiatry, Jikei University School of Medicine, Nishishinbashi 3 19 18, Minato ku, Tokyo 105 8471, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 26:1383-8. 2002
    ....
  6. doi request reprint Association between neurotrophin-3 polymorphisms and executive function in Japanese patients with amnestic mild cognitive impairment and mild Alzheimer disease
    Nobuyuki Kobayashi
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 34:190-7. 2012
    ....
  7. pmc Genetic Association between Presenilin 2 Polymorphisms and Alzheimer's Disease and Dementia of Lewy Body Type in a Japanese Population
    Ayako Suzuki
    Departments of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Dis Extra 6:90-7. 2016
    ..Nonsynonymous polymorphisms in the PSEN2 gene showed Lewy body dementia (LBD) phenotypes clinically. Therefore, we aimed to investigate whether PSEN2 gene polymorphisms were associated with AD or LBD...
  8. pmc Usefulness of DNA Methylation Levels in COASY and SPINT1 Gene Promoter Regions as Biomarkers in Diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment
    Nobuyuki Kobayashi
    Department of Virology, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 11:e0168816. 2016
    ..In conclusion, DNA methylation levels in the COASY and SPINT1 promoter regions were considered to potentially be a convenient and useful biomarker for diagnosis of AD and aMCI...
  9. pmc Development of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimer's Disease and Amnesic Mild Cognitive Impairment
    Nobuyuki Kobayashi
    Department of Virology, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 11:e0146449. 2016
    ..0001, ANCOVA). No association was found between methylation levels and APOE genotype. NCAPH2/LMF2 methylation levels were considered to potentially be a convenient and useful biomarker for diagnosis of AD and aMCI. ..
  10. doi request reprint Genetic association between APOA1 and APOD polymorphisms and Alzheimer's disease in a Japanese population
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    J Neural Transm (Vienna) 120:1599-603. 2013
    ..Our results suggest that the variation of the APOD gene modifies the risk for AD. Further association studies for APOD 3' UTR polymorphisms with other ethnic groups would be needed. ..
  11. doi request reprint Association between executive dysfunction and hippocampal volume in Alzheimer's disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
    Int Psychogeriatr 23:764-71. 2011
    ..The aim of the present study was to evaluate how the hippocampal volume influences executive function as a non-memory cognitive function...
  12. doi request reprint Association between BDNF polymorphism (Val66Met) and executive function in patients with amnestic mild cognitive impairment or mild Alzheimer disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 33:266-72. 2012
    ....
  13. doi request reprint Association between the catechol-O-methyltransferase polymorphism Val158Met and Alzheimer's disease in a Japanese population
    Nobuto Shibata
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Int J Geriatr Psychiatry 30:927-33. 2015
    ..A functional COMT polymorphism, Val158Met (rs4680 G > A), affects the onset of AD and is associated with alcohol dependence through dopamine receptor sensitivity in the prefrontal cortex...
  14. doi request reprint Mirtazapine improves visual hallucinations in Parkinson's disease: a case report
    Kenji Tagai
    Department of Psychiatry, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, Japan
    Psychogeriatrics 13:103-7. 2013
    ..Mirtazapine improved the patient's refractory psychotic symptoms, especially her visual hallucinations, without worsening her motor symptoms. ..
  15. doi request reprint Association between nerve growth factor gene polymorphism and executive dysfunction in Japanese patients with early-stage Alzheimer's disease and amnestic mild cognitive impairment
    Tomoyuki Nagata
    Division of Molecular Genetics, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 32:379-86. 2011
    ....
  16. doi request reprint Correlation between a reduction in Frontal Assessment Battery scores and delusional thoughts in patients with Alzheimer's disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Kashiwa, Chiba, Japan
    Psychiatry Clin Neurosci 63:449-54. 2009
    ....
  17. doi request reprint Increase in the IgG avidity index due to herpes simplex virus type 1 reactivation and its relationship with cognitive function in amnestic mild cognitive impairment and Alzheimer's disease
    Nobuyuki Kobayashi
    Department of Virology, The Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo 105 8461, Japan
    Biochem Biophys Res Commun 430:907-11. 2013
    ....
  18. doi request reprint Differentiation between amnestic-mild cognitive impairment and early-stage Alzheimer's disease using the Frontal Assessment Battery test
    Ayumi Yamao
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
    Psychogeriatrics 11:235-41. 2011
    ..The aim of the present cross-sectional study is to evaluate executive dysfunction using the Frontal Assessment Battery (FAB) screening test in two groups and to investigate the interaction with other cognitive impairments...
  19. doi request reprint Mirtazapine in combination with perospirone synergistically enhances dopamine release in the rat prefrontal cortex via 5-HT1A receptor activation
    Michiaki Morita
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Psychiatry Clin Neurosci 65:246-53. 2011
    ..The purpose of this study was to elucidate the mechanism underlying the clinical efficacy of mirtazapine-perospirone combination therapy for treatment-resistant depression in a rat model...
  20. doi request reprint Genetic association between RAGE polymorphisms and Alzheimer's disease and Lewy body dementias in a Japanese cohort: a case-control study
    Yoshihide Takeshita
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    Int J Geriatr Psychiatry . 2016
    ..Therefore, we aimed to investigate whether RAGE gene polymorphisms were associated with AD and LBDs...
  21. doi request reprint Psychosocial or clinico-demographic factors related to neuropsychiatric symptoms in patients with Alzheimer's disease needing interventional treatment: analysis of the CATIE-AD study
    Tomoyuki Nagata
    Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan
    Int J Geriatr Psychiatry . 2016
    ..These clusters were classified from 12 Neuropsychiatric Inventory (NPI) subscores in our previous study using the Clinical Antipsychotic Trials of Intervention Effectiveness-Alzheimer's Disease (CATIE-AD) dataset...
  22. doi request reprint Plasma BDNF levels are correlated with aggressiveness in patients with amnestic mild cognitive impairment or Alzheimer disease
    Tomoyuki Nagata
    Department of Psychiatry, The Jikei University School of Medicine, 3 25 8 Nishishimbashi, Minato ku, Tokyo, 105 8471, Japan
    J Neural Transm (Vienna) 121:433-41. 2014
    ..The plasma BDNF level was robustly correlated with aggressiveness, implying that the plasma BDNF level might be useful as a behavioral state marker in patients with AD or A-MCI. ..
  23. doi request reprint Non-pharmacological management for patients with frontotemporal dementia: a systematic review
    Shunichiro Shinagawa
    Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA
    J Alzheimers Dis 45:283-93. 2015
    ..These limitations warrant well-designed large-scale research to examine effects of non-pharmacological interventions on behavioral symptoms of FTD. ..
  24. doi request reprint Association between brain-derived neurotrophic factor (BDNF) gene polymorphisms and executive function in Japanese patients with Alzheimer's disease
    Tomoyuki Nagata
    Division of Molecular Genetics, Institute of DNA Medicine, Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Psychogeriatrics 11:141-9. 2011
    ....
  25. doi request reprint Executive Dysfunction Correlated With 2-Year Treatment Response in Patients With Late-Life Undifferentiated Somatoform Disorders
    Keisuke Inamura
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan Electronic address
    Psychosomatics 57:378-89. 2016
    ..Treatment strategies for late-life SDs require these etiological factors to be considered. We hypothesized that the treatment response in patients with late-life SDs was associated with executive dysfunction...
  26. doi request reprint DNA methylation in the NCAPH2/LMF2 promoter region is associated with hippocampal atrophy in Alzheimer's disease and amnesic mild cognitive impairment patients
    Shunichiro Shinagawa
    Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan Electronic address
    Neurosci Lett 629:33-7. 2016
    ..Our results suggest that DNA methylation in the NCAPH2/LMF2 promoter region is associated with hippocampal atrophy through apoptosis. ..
  27. doi request reprint Cognitive Dysfunction in Patients With Late-Life Somatic Symptom Disorder: A Comparison According to Disease Severity
    Keisuke Inamura
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan KI, TN, Kazutaka Nukariya Electronic address
    Psychosomatics 56:486-94. 2015
    ..However, the details of the cognitive dysfunction that occur in late-life SSD are still unknown...
  28. doi request reprint Genetic Association Between KIBRA Polymorphism and Alzheimer's Disease with in a Japanese Population
    Eri Kawai
    Department of Psychiatry, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Neuromolecular Med 17:170-7. 2015
    ..The SPECT study revealed hyperperfusion in the C allele carrier group was detected in the right inferior frontal gyrus compared with the T/T group. KIBRA rs17070145 affects specific phenotypes of patients with AD. ..
  29. doi request reprint Classification of Neuropsychiatric Symptoms Requiring Antipsychotic Treatment in Patients with Alzheimer's Disease: Analysis of the CATIE-AD Study
    Tomoyuki Nagata
    Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan
    J Alzheimers Dis 50:839-45. 2016
    ..The clinical rating scales with structured questionnaires have been useful to evaluate neuropsychiatric symptoms (NPSs) of patients with dementia over the past twenty year...
  30. doi request reprint Correlation between cognition and symptomatic severity in patients with late-life somatoform disorders
    Keisuke Inamura
    a Department of Psychiatry, Kashiwa Hospital, Jikei University School of Medicine, Chiba, Japan
    Aging Ment Health 19:169-74. 2015
    ..The aim of the present study was to evaluate how cognition is correlated with the severity of late-life SDs from a neuropsychological viewpoint...
  31. doi request reprint Relationship of frontal lobe dysfunction and aberrant motor behaviors in patients with Alzheimer's disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
    Int Psychogeriatr 22:463-9. 2010
    ....
  32. doi request reprint Correlation between both morphologic and functional changes and anxiety in Alzheimer's disease
    Kenji Tagai
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Disord 38:153-60. 2014
    ..Although anxiety symptoms are often observed in Alzheimer's disease (AD), little attention has been paid to this symptom compared with other neuropsychiatric symptoms...
  33. doi request reprint Facilitation of intracranial self-stimulation behavior in rats by environmental stimuli associated with nicotine
    Michio Itasaka
    Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8510, Japan Department of Psychology, Graduate School of Humanities, Senshu University, 2 1 1, Higashi mita, Tama ku, Kawasaki shi, Kanagawa, 214 8580, Japan
    Physiol Behav 107:277-82. 2012
    ..The present results demonstrate that nicotine-conditioned contextual stimuli may affect the mesolimbic dopamine system through ICSS threshold lowering effect...
  34. ncbi request reprint [Psychophysiological evaluations of clinical efficacy in outpatients: Morita therapy for psychophysiological insomnia]
    Wataru Yamadera
    Department of Psychiatry, Jikei University School of Medicine
    Seishin Shinkeigaku Zasshi 107:341-51. 2005
    ..This finding suggested that Morita therapy on outpatients with PPI was effective in helping subjects accept their insomnia and lied a constructive life...
  35. ncbi request reprint Clonazepam for chemotherapy-induced nausea and vomiting (CINV)
    Minako Koga
    Department of Psychiatry, Machida Municipal Hospital, Machida shi, Tokyo, 194 0023, Japan
    Anticancer Res 28:2433-6. 2008
    ..A 51-year-old woman experienced refractory chemotherapy-induced nausea and vomiting (CINV) in spite of extensive antiemetic therapy, including 5-HT3 antagonists, corticosteroids, dopamine antagonists and antihistamines...
  36. doi request reprint Human herpesvirus 6 and 7 are biomarkers for fatigue, which distinguish between physiological fatigue and pathological fatigue
    Ryo Aoki
    Department of Psychiatry, The Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo 105 8461, Japan Electronic address
    Biochem Biophys Res Commun 478:424-30. 2016
    ..Thus, HHV-6 and HHV-7 would be useful biomarkers for distinguishing between physiological and pathological fatigue. Our findings suggest a fundamentally new approach to evaluating fatigue and preventing fatigue-related diseases. ..
  37. doi request reprint A case in which mirtazapine reduced auditory hallucinations in a patient with Parkinson disease
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Int Psychogeriatr 25:1199-201. 2013
    ..The present case suggests the effectiveness of MRZ for the treatment of refractory AHs in patients with PD...
  38. doi request reprint Managing abnormal eating behaviours in frontotemporal lobar degeneration patients with topiramate
    Shunichiro Shinagawa
    Department of Psychiatry, Jikei University School of Medicine, Minato ku, Tokyo, Japan
    Psychogeriatrics 13:58-61. 2013
    ..Topiramate was effective, especially for compulsive eating, in cases with distinct lobar atrophy, but not for all abnormal eating behaviours...
  39. pmc Age-Related Association between Apolipoprotein E ε4 and Cognitive Function in Japanese Patients with Alzheimer's Disease
    Tomoyuki Nagata
    Division of Molecular Genetics, Institute of DNA Medicine, Tokyo, Japan Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Dement Geriatr Cogn Dis Extra 3:66-73. 2013
    ..In the present study, we investigated whether apolipoprotein E (APOE) polymorphisms influenced the cognitive function of Japanese patients with Alzheimer's disease (AD) at certain ages...
  40. ncbi request reprint Anorexia nervosa with chronic episodes for more than 30 years in a patient with a comorbid schizotypal personality disorder
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Psychiatry Clin Neurosci 61:434-6. 2007
    ..She was treated with low-dose antipsychotics, and her impulsive behavior improved. The patient's SPD was considered to have had a psychopathological contribution to her chronic episodes of anorexia nervosa...
  41. doi request reprint Classifying eating-related problems among institutionalized people with dementia
    Shunichiro Shinagawa
    Department of Psychiatry, Jikei University School of Medicine, Tokyo
    Psychiatry Clin Neurosci 70:175-81. 2016
    ..The aim of this study was to develop a possible classification of eating-related problems and to reveal the background factors affecting each of these problems across various conditions causing dementia...
  42. pmc Predisposition for borderline personality disorder with comorbid major depression is associated with that for polycystic ovary syndrome in female Japanese population
    Satoshi Kawamura
    Department of Psychiatry, Tokyo Jikei University School of Medicine, Tokyo, Japan
    Neuropsychiatr Dis Treat 7:655-62. 2011
    ..5273). In conclusion, the predisposition for BPD with MDD is associated with that for PCOS, in the female Japanese population. An elevated serum IL-6 level is considered to be a possible biomarker of BPD with MDD...
  43. ncbi request reprint Effectiveness of carbamazepine for benzodiazepine-resistant impulsive aggression in a patient with frontal infarctions
    Tomoyuki Nagata
    Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Kashiwa, Chiba, Japan
    Psychiatry Clin Neurosci 61:695-7. 2007
    ..The efficacy of CBZ treatment in this patient suggests a method for controlling benzodiazepine-resistant impulsive aggression...
  44. doi request reprint Clinical efficacy of individual cognitive behavior therapy for psychophysiological insomnia in 20 outpatients
    Miki Sato
    Department of Psychiatry, Jikei University School of Medicine, Jikei University School of Medicine, Tokyo, Japan
    Psychiatry Clin Neurosci 64:187-95. 2010
    ..9 years, and the mean duration of insomnia morbidity was 8.9 years. Each received individual combined CBT treatments consisting of stimulus control, sleep reduction, cognitive therapy and sleep hygiene education over a period of 1 month...
  45. doi request reprint Psychosis in frontotemporal dementia
    Shunichiro Shinagawa
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan
    J Alzheimers Dis 42:485-99. 2014
    ..It is suggested that a possible overlap exists between FTD and schizophrenia. This potential overlap indicates a vulnerability to psychosis due to brain systems and pathways shared by these disorders. ..
  46. pmc Longitudinal Changes in the Government-Certified Index Stage and Requisite Costs for Long-Term Care Insurance System among the Community-Dwelling Demented Elderly in Japan
    Shunichiro Shinagawa
    Department of Psychiatry, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Int J Alzheimers Dis 2013:164919. 2013
    ..VaD subjects required higher costs than AD subjects in the total certified period and in GCI stage 5. Conclusion. Our results indicate that causes of dementia can have an impact on the requisite costs for the LTC insurance...
  47. doi request reprint A comparison of family care infrastructure for demented elderly in inner cities and regional areas in Japan
    Shunichiro Shinagawa
    Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Psychogeriatrics 12:159-64. 2012
    ..We aimed to compare the family caregiving infrastructure of demented elderly visiting a memory clinic...
  48. doi request reprint Usefulness of pharmacist-assisted screening and psychiatric referral program for outpatients with cancer undergoing chemotherapy
    Tatsuhiko Ito
    Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan
    Psychooncology 20:647-54. 2011
    ..We introduced a clinical screening program utilizing the Distress and Impact Thermometer (DIT) to identify MDD and AD in cancer outpatients receiving chemotherapy. This study assessed the usefulness of the screening program...
  49. pmc Decreases in brain reward function reflect nicotine- and methamphetamine-withdrawal aversion in rats
    Hisatsugu Miyata
    Department of Psychiatry, Jikei University School of Medicine, Tokyo 105 8461, Japan
    Curr Neuropharmacol 9:63-7. 2011
    ....
  50. ncbi request reprint [Case of prolonged recovery from serotonin syndrome caused by paroxetine]
    Yusuke Ochiai
    Department of Psychiatry, Jikei University School of Medicine
    Seishin Shinkeigaku Zasshi 105:1532-8. 2003
    ..Therefore, when serotonin syndrome is suspected, prompt discontinuation of the suspected causative medication, followed by close monitoring of the pharmacokinetics is warranted...
  51. ncbi request reprint [Psychiatry and sleep disorders--delirium]
    Hiroshi Ito
    Seishin Shinkeigaku Zasshi 108:1217-21. 2006
  52. ncbi request reprint Serotonin transporter binding in patients with mood disorders: a PET study with [11C](+)McN5652
    Tetsuya Ichimiya
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Biol Psychiatry 51:715-22. 2002
    ..The aim of this study was to examine whether 5-HTT binding was altered in patients with mood disorders using positron emission tomography (PET)...
  53. ncbi request reprint Decreased dopamine D2 receptor binding in the anterior cingulate cortex in schizophrenia
    Tetsuya Suhara
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, 9 1, Anagawa 4 chome, Inage Ku, Chiba shi, 263 8555 Japan
    Arch Gen Psychiatry 59:25-30. 2002
    ..On the other hand, a number of studies have reported abnormalities in the cerebral cortex of schizophrenia. The aim of this study was to examine the extrastriatal D2 receptors of patients with schizophrenia...