Koji Yamamoto

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint [Required laboratory examination and blood transfusion therapy in massive hemorrhage during surgery]
    Koji Yamamoto
    Department of Transfusion Medicine, Nagoya University Hospital, Nagoya 466 8550, Japan
    Rinsho Byori 59:678-83. 2011
  2. pmc Fibrinogen concentrate administration attributes to significant reductions of blood loss and transfusion requirements in thoracic aneurysm repair
    Koji Yamamoto
    Department of Transfusion Medicine, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya 466 8560, Japan
    J Cardiothorac Surg 9:90. 2014
  3. ncbi request reprint Expression of transforming growth factor-beta and tumor necrosis factor-alpha in the plasma and tissues of mice with lupus nephritis
    K Yamamoto
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Lab Invest 80:1561-70. 2000
  4. ncbi request reprint Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly
    Koji Yamamoto
    Department of Transfusion Medicine, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya 466 8550, Japan
    Cardiovasc Res 66:276-85. 2005
  5. ncbi request reprint Obesity enhances the induction of plasminogen activator inhibitor-1 by restraint stress: a possible mechanism of stress-induced renal fibrin deposition in obese mice
    K Yamamoto
    Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan
    J Thromb Haemost 3:1495-502. 2005
  6. ncbi request reprint Intravenous immunoglobulin therapy for acquired coagulation inhibitors: a critical review
    Koji Yamamoto
    Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan
    Int J Hematol 85:287-93. 2007
  7. ncbi request reprint Molecular evaluation of endothelial progenitor cells in patients with ischemic limbs: therapeutic effect by stem cell transplantation
    Koji Yamamoto
    Department of Transfusion Medicine, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya 466 8550, Japan
    Arterioscler Thromb Vasc Biol 24:e192-6. 2004
  8. pmc Aging accelerates endotoxin-induced thrombosis : increased responses of plasminogen activator inhibitor-1 and lipopolysaccharide signaling with aging
    Koji Yamamoto
    First Department of Internal Medicine, Nagoya University School of Medicine, Showa, Japan
    Am J Pathol 161:1805-14. 2002
  9. ncbi request reprint Aging and obesity augment the stress-induced expression of tissue factor gene in the mouse
    Koji Yamamoto
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Blood 100:4011-8. 2002
  10. ncbi request reprint Increased expression of plasminogen activator inhibitor-1 with fibrin deposition in a murine model of aging, "Klotho" mouse
    Kyosuke Takeshita
    First Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsurumai, Showa, Nagoya 466 8550, Japan
    Semin Thromb Hemost 28:545-54. 2002

Detail Information

Publications56

  1. ncbi request reprint [Required laboratory examination and blood transfusion therapy in massive hemorrhage during surgery]
    Koji Yamamoto
    Department of Transfusion Medicine, Nagoya University Hospital, Nagoya 466 8550, Japan
    Rinsho Byori 59:678-83. 2011
    ..This treatment should help to improve the prognosis of patients in surgery, and also to decrease the use of blood products...
  2. pmc Fibrinogen concentrate administration attributes to significant reductions of blood loss and transfusion requirements in thoracic aneurysm repair
    Koji Yamamoto
    Department of Transfusion Medicine, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya 466 8560, Japan
    J Cardiothorac Surg 9:90. 2014
    ..There are increasing reports suggesting that fibrinogen concentrate may be effective in controlling perioperative bleeding and reducing transfusion requirements...
  3. ncbi request reprint Expression of transforming growth factor-beta and tumor necrosis factor-alpha in the plasma and tissues of mice with lupus nephritis
    K Yamamoto
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Lab Invest 80:1561-70. 2000
    ..The fact that TGF-beta is specifically induced in the kidney whereas TNF-alpha increases in a variety of tissues, supports the hypothesis that the renal specificity of this disorder reflects the abnormal expression of TGF-beta...
  4. ncbi request reprint Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly
    Koji Yamamoto
    Department of Transfusion Medicine, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya 466 8550, Japan
    Cardiovasc Res 66:276-85. 2005
    ..Further studies on the genetic mechanism of aging-associated PAI-1 induction will be necessary to define the basis for cardiovascular aging in relation to thrombosis...
  5. ncbi request reprint Obesity enhances the induction of plasminogen activator inhibitor-1 by restraint stress: a possible mechanism of stress-induced renal fibrin deposition in obese mice
    K Yamamoto
    Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan
    J Thromb Haemost 3:1495-502. 2005
    ..We have begun to investigate the expression of a primary inhibitor of fibrinolysis, plasminogen activator inhibitor-1 (PAI-1), in association with tissue thrombosis, using restraint-stressed obese mice...
  6. ncbi request reprint Intravenous immunoglobulin therapy for acquired coagulation inhibitors: a critical review
    Koji Yamamoto
    Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan
    Int J Hematol 85:287-93. 2007
    ..IVIG therapy thus may be considered one choice for treating acquired coagulation inhibitors, although its efficacy improves when used in combination with immunosuppressive agents...
  7. ncbi request reprint Molecular evaluation of endothelial progenitor cells in patients with ischemic limbs: therapeutic effect by stem cell transplantation
    Koji Yamamoto
    Department of Transfusion Medicine, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya 466 8550, Japan
    Arterioscler Thromb Vasc Biol 24:e192-6. 2004
    ..It is also important to evaluate endothelial progenitor cell (EPC) contents in different stem cell sources to choose the best material for therapeutic angiogenesis...
  8. pmc Aging accelerates endotoxin-induced thrombosis : increased responses of plasminogen activator inhibitor-1 and lipopolysaccharide signaling with aging
    Koji Yamamoto
    First Department of Internal Medicine, Nagoya University School of Medicine, Showa, Japan
    Am J Pathol 161:1805-14. 2002
    ....
  9. ncbi request reprint Aging and obesity augment the stress-induced expression of tissue factor gene in the mouse
    Koji Yamamoto
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Blood 100:4011-8. 2002
    ..These results suggest that the induction of TF gene may increase the risk of stress-associated thrombosis in older and obese subjects and that TNF-alpha may be involved...
  10. ncbi request reprint Increased expression of plasminogen activator inhibitor-1 with fibrin deposition in a murine model of aging, "Klotho" mouse
    Kyosuke Takeshita
    First Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsurumai, Showa, Nagoya 466 8550, Japan
    Semin Thromb Hemost 28:545-54. 2002
    ..These observations suggest that in the process of aging the PAI-1 gene expression is increased, contributing to the development of thrombosis...
  11. pmc Plasminogen activator inhibitor-1 is a major stress-regulated gene: implications for stress-induced thrombosis in aged individuals
    Koji Yamamoto
    First Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsurumai, Showa, Nagoya 466 8550, Japan
    Proc Natl Acad Sci U S A 99:890-5. 2002
    ..These results suggest that the large induction of PAI-1 by stress increases the risk for thrombosis in the older populations, and that the adipose tissue may be involved...
  12. pmc Increased expression of plasminogen activator inhibitor-1 in cardiomyocytes contributes to cardiac fibrosis after myocardial infarction
    Kyosuke Takeshita
    Department of Cardiology, Nagoya University Graduate School of Medicine, Showa, Japan
    Am J Pathol 164:449-56. 2004
    ....
  13. doi request reprint Ablation of angiotensin IV receptor attenuates hypofibrinolysis via PAI-1 downregulation and reduces occlusive arterial thrombosis
    Yasushi Numaguchi
    Department of Medical Science of Proteases, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 8550, Japan
    Arterioscler Thromb Vasc Biol 29:2102-8. 2009
    ....
  14. pmc Stress augments insulin resistance and prothrombotic state: role of visceral adipose-derived monocyte chemoattractant protein-1
    Yasuhiro Uchida
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Diabetes 61:1552-61. 2012
    ..Stress evoked adipose inflammation to increase coagulation factors and impair insulin sensitivity through adipose-derived MCP-1...
  15. pmc Pitavastatin-induced angiogenesis and arteriogenesis is mediated by Notch1 in a murine hindlimb ischemia model without induction of VEGF
    Ryosuke Kikuchi
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Lab Invest 91:691-703. 2011
    ..Taken together, pitavastatin activates Notch1 through Akt-dependent stimulation of γ-secretase in endothelial cells, and thereby increases vasculogenesis without VEGF induction...
  16. pmc Angiotensin II receptor blocker ameliorates stress-induced adipose tissue inflammation and insulin resistance
    Motoharu Hayashi
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    PLoS ONE 9:e116163. 2014
    ..Our results suggests that irbesartan treatment exerts additive benefits for glucose metabolism in hypertensive patients with mental stress. ..
  17. doi request reprint Platelet activation and induction of tissue factor in acute and chronic atrial fibrillation: involvement of mononuclear cell-platelet interaction
    Mutsuharu Hayashi
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Thromb Res 128:e113-8. 2011
    ..The aim of this study was to analyze platelet activation and tissue factor (TF) induction in mononuclear cells (MNCs) and granulocytes downstream of cell-cell interactions in AF patients...
  18. ncbi request reprint Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and stress-induced thrombus formation in heterozygous antithrombin-deficient mice
    Masamitsu Yanada
    First Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Blood 99:2455-8. 2002
    ..The AT+/- mouse thus is a useful model for studying the effect of environmental or genetic risk factors on thrombogenesis...
  19. ncbi request reprint Recurrent intramural hematoma of the small intestine in a severe hemophilia A patient with a high titer of factor VIII inhibitor: a case report and review of the literature
    Akira Katsumi
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 84:166-9. 2006
    ..Cases of intramural hematoma of the gastrointestinal tract among hemophilia patients are also reviewed...
  20. doi request reprint Dipeptidyl peptidase- IV inhibitor alogliptin improves stress-induced insulin resistance and prothrombotic state in a murine model
    Maimaiti Yisireyili
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Psychoneuroendocrinology 73:186-195. 2016
    ..We tested the hypothesis that alogliptin, a dipeptidyl peptidase-4 inhibitor, can ameliorate the biological effects of chronic stress in mice...
  21. doi request reprint Functional difference between membrane-bound and soluble human thrombomodulin
    Yuko Miwa
    1 Department of Transplant Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan 2 Prime Tech Ltd, Tsuchiura, Japan 3 Department of Developmental Biology, National Institute of Agrobiological Sciences, Tsukuba, Japan 4 Department of Transfusion Medicine, Nagoya University School of Medicine, Nagoya, Japan 5 Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan 6 Department Animal Science and Resources, Nihon University of College of Bioresource Sciences, Fujisawa, Japan 7 Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Transplantation 99:702-9. 2015
    ..The purpose of this study is to examine the functional difference in endothelial cells between membrane-bound hTM (MB-hTM) and S-hTM and to elucidate effective strategy using both types of hTM...
  22. pmc Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis
    Takayuki Nakayama
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Int J Hematol 87:363-70. 2008
    ..We observed that NMC4 also inhibited VWF interaction with sulfatides in a dose-dependent manner. Thus, we conclude that VWF binding sites of sulfatide overlap those of platelet GPIb and botrocetin...
  23. pmc Adipose tissue-derived mesenchymal stem cells facilitate hematopoiesis in vitro and in vivo: advantages over bone marrow-derived mesenchymal stem cells
    Norihiko Nakao
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Pathol 177:547-54. 2010
    ..Secondary transplantation experiments showed that ADSCs exerted favorable effects on long-term HSCs. These results suggest that ADSCs can be a promising therapeutic alternative to BMSCs...
  24. ncbi request reprint Molecular basis of antithrombin deficiency in four Japanese patients with antithrombin gene abnormalities including two novel mutations
    Mayu Kyotani
    Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Hematol 82:702-5. 2007
    ....
  25. ncbi request reprint Disseminated intravascular coagulation in acute leukemia: clinical and laboratory features at presentation
    Masamitsu Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Eur J Haematol 77:282-7. 2006
    ..Although there are two major scoring systems for the clinical diagnosis of disseminated intravascular coagulation (DIC), the validity of these systems for leukemia-associated DIC remains to be confirmed...
  26. pmc Recovery of flow-mediated vasodilatation after repetitive measurements is involved in early vascular impairment: comparison with indices of vascular tone
    Hatsumi Inaba
    Department of Clinical Laboratory, Nagoya University Hospital, Nagoya, Japan
    PLoS ONE 9:e83977. 2014
    ..The findings demonstrated the reproducibility of FMTD-R and FMTD measurements, and that FMTD-R might be involved in arterial stiffness and early vascular impairment in the healthy subjects. ..
  27. doi request reprint Potential value of human thrombomodulin and DAF expression for coagulation control in pig-to-human xenotransplantation
    Yuko Miwa
    Department of Applied Immunology, Nagoya University School of Medicine, Nagoya, Japan
    Xenotransplantation 17:26-37. 2010
    ..The purpose of this study was to elucidate the protective effects on the coagulation system of the expression of human TM and decay accelerating factor (hDAF) (for inhibition of complement activation) in pig endothelial cells...
  28. doi request reprint A combination therapy of gemcitabine with immunotherapy for patients with inoperable locally advanced pancreatic cancer
    Yoshiki Hirooka
    Department of Endoscopy, Nagoya University, Nagoya City, Japan
    Pancreas 38:e69-74. 2009
    ....
  29. ncbi request reprint Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice
    Tadashi Matsushita
    Department of Hematology, Nagoya University Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 325:1163-71. 2004
    ..Such observation may parallel the diverse expression of Alport's manifestations of human individuals with MYH9 disorders and suggest the limited requirement of the gene for maintenance and function of specific organs...
  30. pmc gamma-Secretase inhibitor reduces diet-induced atherosclerosis in apolipoprotein E-deficient mice
    Toru Aoyama
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Biochem Biophys Res Commun 383:216-21. 2009
    ..These results provided new insight into the anti-atherogenic properties of GSI in Apo E(-/-) mice fed Western diet...
  31. doi request reprint Plasminogen activator inhibitor-1 in aging
    Koji Yamamoto
    Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan
    Semin Thromb Hemost 40:652-9. 2014
    ..In this review, we highlight the role of PAI-1 in the pathophysiology of aging and aging-associated disorders. ..
  32. ncbi request reprint Identification of protein Salpha gene mutations including four novel mutations in eight unrelated patients with protein S deficiency
    Hiromi Okada
    Department of Medical Technology, Nagoya University School of Health Sciences, Nagoya, Japan
    Br J Haematol 126:219-25. 2004
    ..These data implied that unknown factor(s) other than the 732A-->G mutation itself might influence phenotypic expression of PS status in different individuals...
  33. ncbi request reprint [Thrombotic tendency and laboratory medicine in metabolic syndrome]
    Koji Yamamoto
    Department of Transfusion Medicine, Nagoya University Hospital, Nagoya 466 8560
    Rinsho Byori 55:952-61. 2007
    ..Each pathology included in metabolic syndrome could stimulate PAI-1 expression, and thus, PAI-1 would be a good marker of progression of metabolic syndrome itself and of risk for thrombotic cardiovascular diseases as well...
  34. doi request reprint Comparison of the efficacy of ribavirin plus peginterferon alfa-2b for chronic hepatitis C infection in patients with and without coagulation disorders
    Takashi Honda
    Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Med Virol 85:228-34. 2013
    ..In conclusion, combination therapy for chronic hepatitis C was comparably effective between patients with and without coagulation disorders and did not result in adverse bleeding...
  35. doi request reprint Donor screening algorithm for exclusion of thrombophilia during evaluation of living donor liver transplantation
    Hayato Ogawa
    Department ofTransplant Surgery, Nagoya University Hospital, Nagoya, Japan
    Clin Transplant 25:277-82. 2011
    ..In conclusion, we were able to detect thrombophilia and avoid donor thrombosis using additional screening criteria and our novel algorithm...
  36. ncbi request reprint The relationship between variables of 123-I-metaiodobenzylguanidine cardiac imaging and clinical status of the patients with diastolic heart failure
    Masato Sugiura
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Int J Cardiol 113:223-8. 2006
    ..The status of cardiac sympathetic nerve activity in patients with diastolic heart failure has not been fully understood. 123-I-metaiodobenzylguanidine cardiac images are valuable for evaluating cardiac sympathetic nerve activity...
  37. ncbi request reprint Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression
    Kyosuke Takeshita
    Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circulation 109:1776-82. 2004
    ..Homozygous mutant mice with a defect of klotho gene expression (kl/kl) show multiple age-related disorders and premature death from unknown causes...
  38. ncbi request reprint [Molecular mechanisms of thrombogenesis and vascular pathologies in vivo]
    Koji Yamamoto
    Rinsho Ketsueki 45:347-54. 2004
  39. ncbi request reprint Attenuated stress-induced catecholamine release in mice lacking the vasopressin V1b receptor
    Shuji Itoh
    Research Institute of Pharmacological and Therapeutical Development, Otsuka Pharmaceutical, Ltd, 463 10, Kagasuno, Kawauchi cho, Tokushima 771 0192, Japan
    Am J Physiol Endocrinol Metab 291:E147-51. 2006
    ..Taken together, these findings suggest that, in addition to the previously elucidated effect on the hypothalamic-pituitary-adrenal axis, vasopressin activity via V(1b) receptors regulates stress-induced catecholamine release...
  40. ncbi request reprint Safety and efficacy of autologous progenitor cell transplantation for therapeutic angiogenesis in patients with critical limb ischemia
    Masahiro Kajiguchi
    Department of Cardiology, Nagoya University Graduate School of Medicine, Japan
    Circ J 71:196-201. 2007
    ..However, because one-third of treated patients fail to respond, the present study was an exploration of the characteristics of responders and non-responders to this treatment regimen...
  41. ncbi request reprint Alteration of integrins under hypoxic stress in early placenta and choriocarcinoma cell line BeWo
    Takayuki Iwaki
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Gynecol Obstet Invest 57:196-203. 2004
    ..These results suggest that hypoxic stress regulates the synthesis of integrin and fibronectin mRNAs in early placenta...
  42. ncbi request reprint Enzyme immunoassay for measurement of murine plasminogen activator inhibitor-1, employing a specific antibody produced by the DNA vaccine method
    Takayuki Yamada
    Department of Medical Technology, Nagoya University School of Health Sciences, 1 1 20 Daiko Minami, Higashi, Nagoya 461 8673, Japan
    Thromb Res 111:285-91. 2003
    ..This approach might also be useful for immunological investigation of other coagulation factors and related proteins...
  43. ncbi request reprint Subectodermal microfibrillar bundles are organized into a distinct parallel array in the developing chick limb bud
    Keitaro Isokawa
    Department of Anatomy, Nihon University School of Dentistry, Tokyo 101 8310, Japan
    Anat Rec A Discov Mol Cell Evol Biol 279:708-19. 2004
    ..These fibers could be developmentally linked to oxytalan fibers, which are known to be present in the papillary dermis in mature cutaneous tissue...
  44. ncbi request reprint Correlates of serum high-density lipoprotein cholesterol: a community-based study of middle-aged and older men and women in Japan
    Dalei Chi
    Department of Informatics, School of Medicine, Mie University, Tsu, Japan
    Asia Pac J Public Health 15:17-22. 2003
    ..We suggested that efforts to reduce coronary heart disease risks focus on weight control and good daily lifestyles in middle-aged and older Japanese population...
  45. ncbi request reprint Synthesis and structure-activity relationships of potent 3- or 4-substituted-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors
    Hiroshi Fukushima
    Medicinal Research Laboratories, Taisho Pharmaceutical Co Ltd, 1 403 Yoshino cho, Kita ku, Saitama shi, Saitama 331 9530, Japan
    Bioorg Med Chem 12:6053-61. 2004
    ..We report here on the synthesis and biological data of the aforementioned derivatives...
  46. ncbi request reprint Ribavirin and use of clotting factors in patients with hemophilia and chronic hepatitis C
    Takashi Honda
    JAMA 293:1190-2. 2005
  47. ncbi request reprint Activation of signal transducer and activator transcription 3 and expression of suppressor of cytokine signal 1 during liver regeneration in rats
    Shigeru Sakuda
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
    J Hepatol 36:378-84. 2002
    ..The aims of this study were to identify STAT3-activated cells and to clarify the expression of suppressor of cytokine signal (SOCS), a negative feedback molecule of STAT3, after PH...
  48. ncbi request reprint [Preparation and characterization of (5-methyl-2-oxo-1,3-dioxol-4-yl) methyl thiamine sulfides]
    Tetsuro Uchida
    Department of Chemistry, Nagaoka University of Technology, Nagaoka City, Japan
    Yakugaku Zasshi 126:179-86. 2006
    ..Thus it was shown that the promoiety should be also used for improvement of poor oral absorption of drugs with a mercapto group, in addition to the absorption of drugs with carboxyl, amino, and hydroxyl groups...
  49. ncbi request reprint Analysis of expression profiles of islet-associated transcription and growth factors during beta-cell neogenesis from duct cells in partially duct-ligated mice
    Ming Li
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Pancreas 27:345-55. 2003
    ..Beta-cell neogenesis from pancreatic duct cells has been reported to occur in duct-ligated rat. Nevertheless, detailed process of this phenomenon has not been clarified...
  50. ncbi request reprint Clinical protocol for angiogenesis by intramyocardial injection of autologous bone marrow mononuclear cells in patients with severe coronary artery disease: TACT-NAGOYA-HEART
    Hideo Izawa
    Department of Cardiology, Nagoya University Graduate School of Medicine, Japan
    Circ J 70:1180-3. 2006
    ..Intramyocardial injection of autologous bone marrow mononuclear cells (ABMMCs) has been shown to induce neovascularization of ischemic myocardium...
  51. ncbi request reprint Elevated expression of O-GlcNAc-modified proteins and O-GlcNAc transferase in corneas of diabetic Goto-Kakizaki rats
    Yoshihiro Akimoto
    Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Invest Ophthalmol Vis Sci 44:3802-9. 2003
    ....
  52. pmc Unphosphorylated twitchin forms a complex with actin and myosin that may contribute to tension maintenance in catch
    Daisuke Funabara
    Graduate School of Bioresources, Mie University, Tsu, Mie 514 8507, Japan
    J Exp Biol 210:4399-410. 2007
    ..25 nm and it is suggested that the D2 site aligns with the myosin heads. It is proposed that the complex formed with the dephosphorylated D2 site of twitchin, F-actin and myosin represents a component of the mechanical linkage in catch...
  53. ncbi request reprint NF-kappaB activation in non-parenchymal liver cells after partial hepatectomy in rats: possible involvement in expression of heparin-binding epidermal growth factor-like growth factor
    Shigeru Sakuda
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, 565 0871 Osaka, Japan
    J Hepatol 36:527-33. 2002
    ..The aims of this study were to identify NF-B-activated cells and to clarify their involvement in HB-EGF expression after PH...
  54. doi request reprint Synthesis and structure-activity relationships of potent 4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors
    Hiroshi Fukushima
    Medicinal Chemistry Laboratories, Taisho Pharmaceutical Co, Ltd, 1 403, Yoshino cho, Kita ku, Saitama shi, Saitama 331 9530, Japan
    Bioorg Med Chem 16:4093-106. 2008
    ..We report the identification of a potent and stable DPP-IV inhibitor (TS-021) with a long-term persistent plasma drug concentration and a potent antihyperglycemic activity...
  55. ncbi request reprint Synthesis and structure-activity relationships of potent 1-(2-substituted-aminoacetyl)-4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors
    Hiroshi Fukushima
    Medicinal Chemistry Laboratories, Taisho Pharmaceutical Co, Ltd, Saitama, Japan
    Chem Pharm Bull (Tokyo) 56:1110-7. 2008
    ..An L-tert-butylglycine derivative was found to be a stable and potent DPP-IV inhibitor that exhibits a glucose lowering effect in vivo. Here, we report the synthesis of and biological data on the aforementioned derivatives...
  56. ncbi request reprint Effect of ribavirin, in combination with interferon in patients with hepatitis C, on the bleeding risk associated with selective serotonin reuptake inhibitors
    Takashi Honda
    J Clin Psychiatry 69:679-80. 2008