Affiliation: Nagoya University
- Mechanism of systemically injected interferon-alpha impeding monoamine biosynthesis in rats: role of nitric oxide as a signal crossing the blood-brain barrierTomitsune Kitagami
Department of Biochemistry, Nagoya University Graduate School of Medicine, Tsuruma cho, Showa Ku, Nagoya 466, Japan
Brain Res 978:104-14. 2003..As a result, nitric oxide induced by the intramuscular injection of IFN-alpha was found to cross the blood-brain barrier and suppress both tetrahydrobiopterin biosynthesis and dopamine production in the amygdala and raphe areas...