Aya Naiki-Ito

Summary

Affiliation: Nagoya City University
Country: Japan

Publications

  1. doi Gap junction dysfunction reduces acetaminophen hepatotoxicity with impact on apoptotic signaling and connexin 43 protein induction in rat
    Aya Naiki-Ito
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Toxicol Pathol 38:280-6. 2010
  2. doi Expression of glutathione peroxidase 2 is associated with not only early hepatocarcinogenesis but also late stage metastasis
    Shugo Suzuki
    Department of Experimental Pathology, Graduate School of Medicine, Nagoya City University, Nagoya, Japan
    Toxicology 311:115-23. 2013
  3. doi Organ specific Gst-pi expression of the metastatic androgen independent prostate cancer cells in nude mice
    Taku Naiki
    Department of Experimental Pathology and Tumor Biology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan
    Prostate 72:533-41. 2012
  4. doi Induction of apoptosis in the LNCaP human prostate carcinoma cell line and prostate adenocarcinomas of SV40T antigen transgenic rats by the Bowman-Birk inhibitor
    Mingxi Tang
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Pathol Int 59:790-6. 2009
  5. doi Apocynin, an NADPH oxidase inhibitor, suppresses rat prostate carcinogenesis
    Shugo Suzuki
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan Pathology Division, Nagoya City East Medical Center, Nagoya, Japan
    Cancer Sci 104:1711-7. 2013
  6. doi Silencing of connexin 43 suppresses invasion, migration and lung metastasis of rat hepatocellular carcinoma cells
    Kumiko Ogawa
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Cancer Sci 103:860-7. 2012
  7. doi GPX2 overexpression is involved in cell proliferation and prognosis of castration-resistant prostate cancer
    Taku Naiki
    Department of Experimental Pathology and Tumor Biology and Department of Nephro Urology, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku 467 8601, Nagoya, Japan
    Carcinogenesis 35:1962-7. 2014
  8. ncbi Gpx2 is an overexpressed gene in rat breast cancers induced by three different chemical carcinogens
    Aya Naiki-Ito
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya, Japan
    Cancer Res 67:11353-8. 2007
  9. doi Tranilast suppresses prostate cancer growth and osteoclast differentiation in vivo and in vitro
    Shinya Sato
    Department of Experimental Pathology and Tumor Biology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan
    Prostate 70:229-38. 2010
  10. pmc Preventive Effects of Fermented Brown Rice and Rice Bran against Prostate Carcinogenesis in TRAP Rats
    Toshiya Kuno
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Nutrients 8:. 2016

Collaborators

Detail Information

Publications23

  1. doi Gap junction dysfunction reduces acetaminophen hepatotoxicity with impact on apoptotic signaling and connexin 43 protein induction in rat
    Aya Naiki-Ito
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Toxicol Pathol 38:280-6. 2010
    ..Moreover, gap junctional functions of Cx32 can play important roles in removing damaged hepatocytes by apoptosis for liver tissue homeostasis...
  2. doi Expression of glutathione peroxidase 2 is associated with not only early hepatocarcinogenesis but also late stage metastasis
    Shugo Suzuki
    Department of Experimental Pathology, Graduate School of Medicine, Nagoya City University, Nagoya, Japan
    Toxicology 311:115-23. 2013
    ..Together with immunohistochemical findings of elevated expression in rat and also human liver lesions, the results point to important roles in hepatocarcinogenesis. ..
  3. doi Organ specific Gst-pi expression of the metastatic androgen independent prostate cancer cells in nude mice
    Taku Naiki
    Department of Experimental Pathology and Tumor Biology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan
    Prostate 72:533-41. 2012
    ....
  4. doi Induction of apoptosis in the LNCaP human prostate carcinoma cell line and prostate adenocarcinomas of SV40T antigen transgenic rats by the Bowman-Birk inhibitor
    Mingxi Tang
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Pathol Int 59:790-6. 2009
    ..These in vivo and in vitro results suggest that BBI possesses chemopreventive activity associated with induction of Cx43 expression and apoptosis...
  5. doi Apocynin, an NADPH oxidase inhibitor, suppresses rat prostate carcinogenesis
    Shugo Suzuki
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan Pathology Division, Nagoya City East Medical Center, Nagoya, Japan
    Cancer Sci 104:1711-7. 2013
    ..These data suggest that apocynin possesses chemopreventive potential against prostate cancer. ..
  6. doi Silencing of connexin 43 suppresses invasion, migration and lung metastasis of rat hepatocellular carcinoma cells
    Kumiko Ogawa
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Cancer Sci 103:860-7. 2012
    ....
  7. doi GPX2 overexpression is involved in cell proliferation and prognosis of castration-resistant prostate cancer
    Taku Naiki
    Department of Experimental Pathology and Tumor Biology and Department of Nephro Urology, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku 467 8601, Nagoya, Japan
    Carcinogenesis 35:1962-7. 2014
    ..These findings suggest that GPX2 is a prognostic marker in CRPC and affects proliferation of prostate cancer under androgen depletion partially through protection against ROS signaling. ..
  8. ncbi Gpx2 is an overexpressed gene in rat breast cancers induced by three different chemical carcinogens
    Aya Naiki-Ito
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya, Japan
    Cancer Res 67:11353-8. 2007
    ..Thus, these data suggested that GPX2 may be involved in mammary carcinogenesis and cell proliferation in both rats and humans, indicating that GPX2 may be a novel target for the prevention and therapy of breast cancer...
  9. doi Tranilast suppresses prostate cancer growth and osteoclast differentiation in vivo and in vitro
    Shinya Sato
    Department of Experimental Pathology and Tumor Biology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan
    Prostate 70:229-38. 2010
    ..The present study was conducted to assess suppressive effects of Tranilast on prostate cancer growth and osteoclast differentiation in vivo and in vitro...
  10. pmc Preventive Effects of Fermented Brown Rice and Rice Bran against Prostate Carcinogenesis in TRAP Rats
    Toshiya Kuno
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Nutrients 8:. 2016
    ..These results indicate that FBRA controls tumor growth by activating pathways responsive to energy deprivation and suggest that FBRA has translational potential for the prevention of human prostate cancer. ..
  11. pmc Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis
    Hiroyuki Kato
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Oncotarget 7:2009-21. 2016
    ..These findings suggest that Cx32 dysfunction like in chronic liver disease promoted EtOH-associated hepatocarcinogenesis through dysregulation of Erk-Dusp1 signaling. ..
  12. doi Ellagic acid, a component of pomegranate fruit juice, suppresses androgen-dependent prostate carcinogenesis via induction of apoptosis
    Aya Naiki-Ito
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Prostate 75:151-60. 2015
    ..PFJ and EA have been reported to suppress various cancers, including prostate cancer. However, their chemopreventive effects on development and progression of prostate cancer using in vivo models have not been established yet...
  13. doi Purple corn color inhibition of prostate carcinogenesis by targeting cell growth pathways
    Ne Long
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Cancer Sci 104:298-303. 2013
    ..The results suggested that cyanidin-3-glucoside and pelargonidin-3-glucoside are the active compounds...
  14. doi Age-dependent carcinogenic susceptibility in rat liver is related to potential of gap junctional intercellular communication
    Aya Naiki-Ito
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Toxicol Pathol 40:715-21. 2012
    ..These results suggest that a decline of hepatic intercellular communication through gap junction results in increased susceptibility to DEN-induced hepatocarcinogenesis in aged rats...
  15. pmc NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses prostate cancer without adverse effect
    Toshiki Etani
    Department of Nephro urology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan
    Oncotarget 6:2865-78. 2015
    ..In conclusion, NCL1 effectively suppressed prostate cancer growth without adverse events. We suggest that NCL1 is a potential therapeutic agent for hormone-resistant prostate cancer. ..
  16. pmc Pioglitazone, a Peroxisome Proliferator-Activated Receptor γ Agonist, Suppresses Rat Prostate Carcinogenesis
    Shugo Suzuki
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Int J Mol Sci 17:. 2016
    ..These data suggest that PGZ possesses a chemopreventive potential for prostate cancer...
  17. doi Napsin A is a specific marker for ovarian clear cell adenocarcinoma
    Yoriko Yamashita
    1 Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan 2 Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Mod Pathol 28:111-7. 2015
    ..Therefore, we propose that napsin A is another sensitive and specific marker for distinguishing ovarian clear cell tumors (especially adenocarcinomas) from other ovarian tumors. ..
  18. doi 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis is not enhanced by CYP1A inducers, alpha- and beta-naphthoflavone: relationship to intralobular distribution of CYP1A expression
    Shugo Suzuki
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Toxicol Pathol 38:583-91. 2010
    ..This difference in intralobular distribution of CYP1A might be related to the fact that MeIQx hepatocarcinogenesis was not modified by the two CYP1A inducers...
  19. doi Histone Deacetylase Inhibition in Prostate Cancer Triggers miR-320-Mediated Suppression of the Androgen Receptor
    Shinya Sato
    Department of Epigenomics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Cancer Res 76:4192-204. 2016
    ..OBP-801 may be a potent AR-targeting therapeutic reagent in AR-positive prostate cancer regardless of androgen dependency. Cancer Res; 76(14); 4192-204. ©2016 AACR. ..
  20. pmc Pain-reducing anesthesia prevents oxidative stress in human term placenta
    Yoko Tsuzuki
    Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan Department of Anesthesiology and Resuscitation, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Clin Biochem Nutr 58:156-60. 2016
    ..128) for HNE staining. Our results suggest that although the role of oxidative stress and its influences on fetal state in the placenta in labor remains unclear, it seems to be lessened by epidural anesthesia. ..
  21. pmc Chemopreventive effect of resveratrol and apocynin on pancreatic carcinogenesis via modulation of nuclear phosphorylated GSK3β and ERK1/2
    Akihisa Kato
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Oncotarget 6:42963-75. 2015
    ..Taken together, the present study indicates that RV and AC have potential as chemopreventive agents for pancreatic cancer...
  22. pmc Glutathione S-transferase Pi mediates proliferation of androgen-independent prostate cancer cells
    Naomi Hokaiwado
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Carcinogenesis 29:1134-8. 2008
    ..These findings suggest that GST-pi might play important roles in proliferation of androgen-independent human prostate cancer cells...
  23. pmc Giant Retroperitoneal Mucinous Tumor Supportively Diagnosed as a Dedifferentiated Liposarcoma by Fluorescence In Situ Hybridization of MDM2 Gene
    Taku Naiki
    Department of Nephro urology, Graduate School of Medical Sciences, Nagoya City University, Mizuho ku 467 8601, Nagoya, Japan
    ISRN Urol 2011:261735. 2011
    ..We experienced a case of a giant retroperitoneal dedifferentiated liposarcoma. FISH analysis was useful for the diagnosis and determination of the therapeutic strategy...