Takeshi Kobayashi

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint Targeting hyperthermia for renal cell carcinoma using human MN antigen-specific magnetoliposomes
    M Shinkai
    Department of Biotechnology, Graduate School of Engineering, Nagoya University, Furo, Chikusa ku, Nagoya 464 8603
    Jpn J Cancer Res 92:1138-45. 2001
  2. ncbi request reprint Novel methodology for fabrication of tissue-engineered tubular constructs using magnetite nanoparticles and magnetic force
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Nagoya, Japan
    Tissue Eng 11:1553-61. 2005
  3. ncbi request reprint Construction and harvest of multilayered keratinocyte sheets using magnetite nanoparticles and magnetic force
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Nagoya, Japan
    Tissue Eng 10:873-80. 2004
  4. ncbi request reprint Heat immunotherapy using magnetic nanoparticles and dendritic cells for T-lymphoma
    Kouji Tanaka
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    J Biosci Bioeng 100:112-5. 2005
  5. ncbi request reprint Antitumor effects of combined therapy of recombinant heat shock protein 70 and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Nagoya 464 8603, Japan
    Cancer Immunol Immunother 53:26-32. 2004
  6. ncbi request reprint Magnetite nanoparticle-loaded anti-HER2 immunoliposomes for combination of antibody therapy with hyperthermia
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Chikusa ku, Furo cho, 464 8603, Japan
    Cancer Lett 212:167-75. 2004
  7. ncbi request reprint Heat shock protein 70 gene therapy combined with hyperthermia using magnetic nanoparticles
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Nagoya 464 8603, Japan
    Cancer Gene Ther 10:918-25. 2003
  8. ncbi request reprint Intratumoral injection of immature dendritic cells enhances antitumor effect of hyperthermia using magnetic nanoparticles
    Kouji Tanaka
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya, Japan
    Int J Cancer 116:624-33. 2005
  9. ncbi request reprint The effect of RGD peptide-conjugated magnetite cationic liposomes on cell growth and cell sheet harvesting
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Nagoya 464 8603, Japan
    Biomaterials 26:6185-93. 2005
  10. ncbi request reprint Magnetic force-based mesenchymal stem cell expansion using antibody-conjugated magnetoliposomes
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Nagoya 464 8603, Japan
    J Biomed Mater Res B Appl Biomater 75:320-7. 2005

Detail Information

Publications39

  1. ncbi request reprint Targeting hyperthermia for renal cell carcinoma using human MN antigen-specific magnetoliposomes
    M Shinkai
    Department of Biotechnology, Graduate School of Engineering, Nagoya University, Furo, Chikusa ku, Nagoya 464 8603
    Jpn J Cancer Res 92:1138-45. 2001
    ..These results indicate the G250-FMLs could target renal cell carcinoma cells in vitro and in vivo, and are efficiently applicable to the hyperthermic treatment of carcinoma...
  2. ncbi request reprint Novel methodology for fabrication of tissue-engineered tubular constructs using magnetite nanoparticles and magnetic force
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Nagoya, Japan
    Tissue Eng 11:1553-61. 2005
    ....
  3. ncbi request reprint Construction and harvest of multilayered keratinocyte sheets using magnetite nanoparticles and magnetic force
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Nagoya, Japan
    Tissue Eng 10:873-80. 2004
    ..These results suggest that this novel methodology using magnetite nanoparticles and magnetic force, which we have termed "magnetic force-based tissue engineering" (Mag-TE), is a promising approach for tissue engineering...
  4. ncbi request reprint Heat immunotherapy using magnetic nanoparticles and dendritic cells for T-lymphoma
    Kouji Tanaka
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    J Biosci Bioeng 100:112-5. 2005
    ..5% (1/8) in the case of mice treated by hyperthermia alone. This novel cancer therapy, which we have termed "heat immunotherapy", may be applicable to patients with advanced malignancies...
  5. ncbi request reprint Antitumor effects of combined therapy of recombinant heat shock protein 70 and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Nagoya 464 8603, Japan
    Cancer Immunol Immunother 53:26-32. 2004
    ..It was also found that systemic antitumor immunity was induced in the cured mice. This study suggests that novel combined therapy using exogenous HSP70 and hyperthermia has great potential in cancer treatment...
  6. ncbi request reprint Magnetite nanoparticle-loaded anti-HER2 immunoliposomes for combination of antibody therapy with hyperthermia
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Chikusa ku, Furo cho, 464 8603, Japan
    Cancer Lett 212:167-75. 2004
    ..5 degrees C under an alternating magnetic field, resulting in strong cytotoxic effects. These results suggest that this novel therapeutic tool is applicable to treatment of HER2-overexpressing cancer...
  7. ncbi request reprint Heat shock protein 70 gene therapy combined with hyperthermia using magnetic nanoparticles
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Nagoya 464 8603, Japan
    Cancer Gene Ther 10:918-25. 2003
    ..This study demonstrates that this novel therapeutic strategy combining the use of hsp70 gene therapy and hyperthermia using MCLs may be applicable to patients with advanced malignancies...
  8. ncbi request reprint Intratumoral injection of immature dendritic cells enhances antitumor effect of hyperthermia using magnetic nanoparticles
    Kouji Tanaka
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya, Japan
    Int J Cancer 116:624-33. 2005
    ..This study has important implications for the application of MCL-induced hyperthermia plus DC therapy in patients with advanced malignancies as a novel cancer therapy...
  9. ncbi request reprint The effect of RGD peptide-conjugated magnetite cationic liposomes on cell growth and cell sheet harvesting
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Nagoya 464 8603, Japan
    Biomaterials 26:6185-93. 2005
    ..These results suggest that this novel methodology using RGD-MCLs and magnetic force, which we have termed 'magnetic force-based tissue engineering (Mag-TE)', is a promising approach for tissue engineering...
  10. ncbi request reprint Magnetic force-based mesenchymal stem cell expansion using antibody-conjugated magnetoliposomes
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Nagoya 464 8603, Japan
    J Biomed Mater Res B Appl Biomater 75:320-7. 2005
    ..These results suggest that this AML culture method can rapidly and efficiently expand a small number of MSCs into numbers suitable for clinical application...
  11. ncbi request reprint Anticancer effect and immune induction by hyperthermia of malignant melanoma using magnetite cationic liposomes
    Masataka Suzuki
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya, Japan
    Melanoma Res 13:129-35. 2003
    ..These results suggest that hyperthermia using MCLs is an effective therapy for melanoma, since this treatment can kill the tumour cells not only by heat but also by inducing an immune response...
  12. ncbi request reprint Time-course data analysis of gene expression profiles reveals purR regulon concerns in organic solvent tolerance in Escherichia coli
    Kazunori Shimizu
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    J Biosci Bioeng 99:72-4. 2005
    ..It was found that the purR regulon plays an important role in the organic solvent tolerance (OST) of E. coli...
  13. ncbi request reprint Multiple fuzzy neural network system for outcome prediction and classification of 220 lymphoma patients on the basis of molecular profiling
    Tatsuya Ando
    Department of Biotechnology, School of Engineering, Nagoya University, Chikusa ku, Nagoya 464 8603, Japan
    Cancer Sci 94:906-13. 2003
    ..The present paper is the first to describe the multiple noninferior FNN modeling system. This system is a powerful tool for predicting outcome and classifying patients, and is applicable to other heterogeneous diseases...
  14. ncbi request reprint Construction of robust prognostic predictors by using projective adaptive resonance theory as a gene filtering method
    Hiro Takahashi
    Department of Biotechnology, School of Engineering, Nagoya University Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    Bioinformatics 21:179-86. 2005
    ....
  15. ncbi request reprint Construction and delivery of tissue-engineered human retinal pigment epithelial cell sheets, using magnetite nanoparticles and magnetic force
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Japan
    Tissue Eng 11:489-96. 2005
    ..This novel methodology, termed "magnetic force-based tissue engineering" (Mag-TE), is a possible approach for CNV treatment...
  16. ncbi request reprint Medical application of functionalized magnetic nanoparticles
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    J Biosci Bioeng 100:1-11. 2005
    ..Thus, the applications of these functionalized magnetic nanoparticles with their unique features will further improve medical techniques...
  17. ncbi request reprint Heat shock protein 70 expression induces antitumor immunity during intracellular hyperthermia using magnetite nanoparticles
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    Cancer Immunol Immunother 52:80-8. 2003
    ..This phenomenon, which may be termed in situ vaccination, has important implications for the development of novel antitumor therapies...
  18. ncbi request reprint Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University
    Cancer Sci 94:308-13. 2003
    ..This study supports the combined use of IT and IH using MCLs in patients with advanced malignancies...
  19. ncbi request reprint Tissue engineering using magnetite nanoparticles and magnetic force: heterotypic layers of cocultured hepatocytes and endothelial cells
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Nagoya, Japan
    Tissue Eng 10:833-40. 2004
    ..These results suggest that this novel use of magnetite nanoparticles and magnetic force, which we refer to as "magnetic force-based tissue engineering" (Mag-TE), offers a major advancement in tissue engineering...
  20. ncbi request reprint Screening of cytokines to enhance vaccine effects of heat shock protein 70-rich tumor cell lysate
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    J Biosci Bioeng 100:36-42. 2005
    ..These results suggest that IL-12 represents an important modulator of antitumor immune responses induced by HCLV, and may facilitate further efforts to develop novel cancer immunotherapies based on HSP70-mediated vaccination...
  21. ncbi request reprint Peptide array-based interaction assay of solid-bound peptides and anchorage-dependant cells and its effectiveness in cell-adhesive peptide design
    Ryuji Kato
    Department of Biotechnology, School of Engineering, Nagoya University, Nagoya 464 8603, Japan
    J Biosci Bioeng 101:485-95. 2006
    ..By following such indicative rules, numerous amino acid combinations can be effectively screened for further examination of novel peptide design...
  22. ncbi request reprint Cancer immunotherapy based on intracellular hyperthermia using magnetite nanoparticles: a novel concept of "heat-controlled necrosis" with heat shock protein expression
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya, 464 8603, Japan
    Cancer Immunol Immunother 55:320-8. 2006
    ..In the present article, cancer immunology and immunotherapy based on hyperthermia, and HSP expression are reviewed and discussed...
  23. pmc Artificial neural network approach for selection of susceptible single nucleotide polymorphisms and construction of prediction model on childhood allergic asthma
    Yasuyuki Tomita
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    BMC Bioinformatics 5:120. 2004
    ..Here, we propose a susceptible marker-selectable artificial neural network (ANN) for predicting development of allergic disease...
  24. ncbi request reprint High-throughput screening of cell death inducible short peptides from TNF-related apoptosis-inducing ligand sequence
    Mina Okochi
    Department of Biotechnology, School of Engineering, Nagoya University, Nagoya 464 8603, Japan
    FEBS Lett 580:885-9. 2006
    ..Peptide sequence with RNSCWSKD (TRAIL(227-234)) that exist in the zinc-binding site revealed high cell death inducible activity. Apoptotic cell death was observed when cells were treated with soluble synthesized peptide...
  25. ncbi request reprint Fuzzy neural network applied to gene expression profiling for predicting the prognosis of diffuse large B-cell lymphoma
    Tatsuya Ando
    Department of Biotechnology, School of Engineering, Nagoya University, Chikusa ku, Nagoya 464 8603, Japan
    Jpn J Cancer Res 93:1207-12. 2002
    ..FNNs are powerful tools for extracting significant biological markers affecting prognosis, and are applicable to various kinds of expression profiling data for any malignancy...
  26. ncbi request reprint Industrial application of fuzzy control in bioprocesses
    Hiroyuki Honda
    Department of Biotechnology, School of Engineering, Nagoya University, Nagoya 464 8603, Japan
    Adv Biochem Eng Biotechnol 87:151-71. 2004
    ..Successful results on this research will be also explained...
  27. ncbi request reprint Effect of functional magnetic particles on radiofrequency capacitive heating: an in vivo study
    Masashige Shinkai
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    Jpn J Cancer Res 93:103-8. 2002
    ..Complete tumor suppression was observed in 71% (5 / 7) of MCLs-injected rats, and the hyperthermic effect was greatly improved by the MCLs...
  28. ncbi request reprint Screening of stress enhancer based on analysis of gene expression profiles: enhancement of hyperthermia-induced tumor necrosis by an MMP-3 inhibitor
    Naoki Kato
    Department of Biotechnology, School of Engineering, Nagoya University, Chikusa ku, Nagoya 464 8603, Japan
    Cancer Sci 94:644-9. 2003
    ..This valuable conclusion was reached as a direct result of the gene expression profiling that was performed in these studies...
  29. ncbi request reprint Analysis of organic solvent tolerance in Escherichia coli using gene expression profiles from DNA microarrays
    Shuhei Hayashi
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    J Biosci Bioeng 95:379-83. 2003
    ..It should be noted that we succeeded in finding a gene related to OST activity using only DNA microarray data, without any biochemical or biological knowledge...
  30. pmc Hyperthermia using magnetite cationic liposomes for hamster osteosarcoma
    Fumiko Matsuoka
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    Biomagn Res Technol 2:3. 2004
    ..In the treated hamsters, no regrowth of osteosarcomas was observed over a period of 3 months after the complete regression. CONCLUSION: These results suggest that this treatment is effective for osteosarcoma...
  31. ncbi request reprint Novel strategy for protein exploration: high-throughput screening assisted with fuzzy neural network
    Ryuji Kato
    School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    J Mol Biol 351:683-92. 2005
    ..The results have shown that with the aid of bioinformatic analysis, high-throughput screening can expand its potential for exploring vast combinatorial sequence spaces of proteins...
  32. ncbi request reprint Prognostic models in patients with non-small-cell lung cancer using artificial neural networks in comparison with logistic regression
    Taizo Hanai
    Department of Biotechnology, Graduate School of Engineering, Nagoya University, Chikusa ku, Nagoya 469 8603, Japan
    Cancer Sci 94:473-7. 2003
    ....
  33. ncbi request reprint Enhanced activity of 3alpha-hydroxysteroid dehydrogenase by addition of the co-solvent 1-butyl-3-methylimidazolium (L)-lactate in aqueous phase of biphasic systems for reductive production of steroids
    Mina Okochi
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    J Biotechnol 128:376-82. 2007
    ..In a coupled-enzyme system comprising HSDH and formate dehydrogenase (FDH), a two-fold increase in production rate of androsterone was obtained when utilizing [Bmim][lactate] with NADH regeneration...
  34. ncbi request reprint Large-scale micropropagation system of plant cells
    Hiroyuki Honda
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    Adv Biochem Eng Biotechnol 91:105-34. 2004
    ..Viscous additive supplemented culture, which is including the successful results obtained by us for callus regeneration, is also introduced...
  35. pmc Discovery of glpC, an organic solvent tolerance-related gene in Escherichia coli, using gene expression profiles from DNA microarrays
    Kazunori Shimizu
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    Appl Environ Microbiol 71:1093-6. 2005
    ..Among these genes, glpC encoding the anaerobic glycerol-3-phosphate dehydrogenase subunit C remarkably increased the organic solvent tolerance...
  36. pmc Size dependent heat generation of magnetite nanoparticles under AC magnetic field for cancer therapy
    Jun Motoyama
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Nagoya 464 8603, Japan
    Biomagn Res Technol 6:4. 2008
    ..We estimated heating capacity of magnetite nanoparticles by measuring its specific absorption rate (SAR) against irradiation of the alternating magnetic field (AMF)...
  37. ncbi request reprint Enhanced anthocyanin production from grape callus in an air-lift type bioreactor using a viscous additive-supplemented medium
    Hiroyuki Honda
    Department of Biotechnology, School of Engineering, Nagoya University, Chikusa ku, Nagoya 464 8603, Japan
    J Biosci Bioeng 94:135-9. 2002
    ..8% CMC was added to the medium to prepare the N-medium. A change of the flow pattern is considered to be the cause of the decrease in hydrodynamic stress, resulting in enhanced pigment production due to the enlargement of the callus...
  38. ncbi request reprint Analysis of expression profile using fuzzy adaptive resonance theory
    Shuta Tomida
    Department of Biotechnology, School of Engineering Nagoya University, Furo cho, Chikusa ku, Japan
    Bioinformatics 18:1073-83. 2002
    ..In order to realize such a successful clustering, we investigate a clustering method based on adaptive resonance theory (ART) in this report...
  39. ncbi request reprint Angiotensin II inhibitory peptide found in the receptor sequence using peptide array
    Ryuji Kato
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    Biochem Biophys Res Commun 315:22-9. 2004
    ..These results indicate that our screening strategy utilizing peptide array is an effective approach for the peptide drug development...