Hikaru Hashitani

Summary

Affiliation: Nagoya City University
Country: Japan

Publications

  1. pmc Cellular mechanisms of nitric oxide-induced relaxation of corporeal smooth muscle in the guinea-pig
    Hikaru Hashitani
    Department of Physiology, Nagoya City University Medical School, Nagoya 467 8601, Japan
    J Physiol 538:573-81. 2002
  2. doi request reprint Pacemaker role of pericytes in generating synchronized spontaneous Ca2+ transients in the myenteric microvasculature of the guinea-pig gastric antrum
    Hikaru Hashitani
    Department of Cell Physiology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan Electronic address
    Cell Calcium 58:442-56. 2015
  3. pmc Functional and morphological properties of pericytes in suburothelial venules of the mouse bladder
    Hikaru Hashitani
    Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Br J Pharmacol 167:1723-36. 2012
  4. pmc Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder
    Hikaru Hashitani
    University Department of Pharmacology, Mansfield Road, Oxford OX1 3QT
    Br J Pharmacol 141:183-93. 2004
  5. pmc Identification of interstitial cells of Cajal in corporal tissues of the guinea-pig penis
    Hikaru Hashitani
    Department of Physiology, Nagoya City University Medical School, Nagoya 467 8601, Japan
    Br J Pharmacol 141:199-204. 2004
  6. doi request reprint Functional properties of suburothelial microvessels in the rat bladder
    Hikaru Hashitani
    Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Urol 185:2382-91. 2011
  7. pmc Role of interstitial cells and gap junctions in the transmission of spontaneous Ca2+ signals in detrusor smooth muscles of the guinea-pig urinary bladder
    Hikaru Hashitani
    Department of Physiology, Nagoya City University Medical School, Nagoya 467 8601, Japan
    J Physiol 559:567-81. 2004
  8. pmc Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra
    Hikaru Hashitani
    Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Br J Pharmacol 161:680-94. 2010
  9. pmc Distinct effects of CGRP on typical and atypical smooth muscle cells involved in generating spontaneous contractions in the mouse renal pelvis
    Hikaru Hashitani
    Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Br J Pharmacol 158:2030-45. 2009
  10. pmc Properties of spontaneous Ca2+ transients recorded from interstitial cells of Cajal-like cells of the rabbit urethra in situ
    Hikaru Hashitani
    Department of Regulatory Cell Physiology, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Physiol 583:505-19. 2007

Collaborators

Detail Information

Publications44

  1. pmc Cellular mechanisms of nitric oxide-induced relaxation of corporeal smooth muscle in the guinea-pig
    Hikaru Hashitani
    Department of Physiology, Nagoya City University Medical School, Nagoya 467 8601, Japan
    J Physiol 538:573-81. 2002
    ..These results suggest that decreasing the sensitivity of contractile proteins to Ca(2+) is probably the key mechanism of NO-induced relaxation in CSM of the guinea-pig...
  2. doi request reprint Pacemaker role of pericytes in generating synchronized spontaneous Ca2+ transients in the myenteric microvasculature of the guinea-pig gastric antrum
    Hikaru Hashitani
    Department of Cell Physiology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan Electronic address
    Cell Calcium 58:442-56. 2015
    ..Pericyte Ca(2+) transients arise from Ca(2+) release from the sarco-endoplasmic reticulum and the opening of T-type Ca(2+) VDCCs is required for their synchrony and propagation to arteriolar SMCs...
  3. pmc Functional and morphological properties of pericytes in suburothelial venules of the mouse bladder
    Hikaru Hashitani
    Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Br J Pharmacol 167:1723-36. 2012
    ..We aimed to further explore the morphological and functional characteristics of pericytes in the mouse bladder...
  4. pmc Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder
    Hikaru Hashitani
    University Department of Pharmacology, Mansfield Road, Oxford OX1 3QT
    Br J Pharmacol 141:183-93. 2004
    ....
  5. pmc Identification of interstitial cells of Cajal in corporal tissues of the guinea-pig penis
    Hikaru Hashitani
    Department of Physiology, Nagoya City University Medical School, Nagoya 467 8601, Japan
    Br J Pharmacol 141:199-204. 2004
    ..These results suggest that ICC in the corporal tissue may have a role as pacemakers to drive the bulk of smooth muscles, and that intracellular Ca(2+) stores and gap junctions are critical for the generation of spontaneous excitation...
  6. doi request reprint Functional properties of suburothelial microvessels in the rat bladder
    Hikaru Hashitani
    Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Urol 185:2382-91. 2011
    ..We investigated the properties of suburothelial microvessels, which have a vital role in maintaining microcirculation to cells involved in bladder afferent signaling...
  7. pmc Role of interstitial cells and gap junctions in the transmission of spontaneous Ca2+ signals in detrusor smooth muscles of the guinea-pig urinary bladder
    Hikaru Hashitani
    Department of Physiology, Nagoya City University Medical School, Nagoya 467 8601, Japan
    J Physiol 559:567-81. 2004
    ..IC in the bladder may modulate the transmission of Ca2+ transients originating from smooth muscle cells rather than being the pacemaker of spontaneous activity...
  8. pmc Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra
    Hikaru Hashitani
    Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Br J Pharmacol 161:680-94. 2010
    ....
  9. pmc Distinct effects of CGRP on typical and atypical smooth muscle cells involved in generating spontaneous contractions in the mouse renal pelvis
    Hikaru Hashitani
    Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Br J Pharmacol 158:2030-45. 2009
    ..We investigated the cellular mechanisms underlying spontaneous contractions in the mouse renal pelvis, regulated by calcitonin gene-related peptide (CGRP)...
  10. pmc Properties of spontaneous Ca2+ transients recorded from interstitial cells of Cajal-like cells of the rabbit urethra in situ
    Hikaru Hashitani
    Department of Regulatory Cell Physiology, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Physiol 583:505-19. 2007
    ..ICC-LCs may not act as a coordinated pacemaker electrical network as do ICC in the gastrointestinal (GI) tract. Rather they may randomly increase excitability of USMCs to maintain the tone of urethral smooth muscles...
  11. pmc Interaction between spontaneous and neurally mediated regulation of smooth muscle tone in the rabbit corpus cavernosum
    Hikaru Hashitani
    Department of Regulatory Cell Physiology and Nephrourology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Physiol 569:723-35. 2005
    ..Thus, interaction between spontaneous and neurally mediated regulation of CCSM tone may be fundamental to maintaining the muscle contractility. In addition, both PGs and NO appear to alter CCSM tone with only small changes in [Ca2+]i...
  12. pmc Interaction between interstitial cells and smooth muscles in the lower urinary tract and penis
    Hikaru Hashitani
    Department of Regulatory Cell Physiology and Nephrourology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Physiol 576:707-14. 2006
    ..However, overall contractility of urethral smooth muscles does not necessarily rely on pacemaking of ICs, and thus some population of smooth muscles may also have their own excitability...
  13. pmc Heterogeneous CPA sensitivity of spontaneous excitation in smooth muscle of the rabbit urethra
    Hikaru Hashitani
    Department of Regulatory Cell Physiology, Nagoya City University, Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Br J Pharmacol 148:340-9. 2006
    ..Irrespective of the origin of pacemaking, neurally-released NAd and NO are capable of modulating spontaneous excitation...
  14. pmc Effects of imatinib mesylate on spontaneous electrical and mechanical activity in smooth muscle of the guinea-pig stomach
    H Hashitani
    Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Br J Pharmacol 154:451-9. 2008
    ..Effects of imatinib mesylate, a Kit receptor tyrosine kinase inhibitor, on spontaneous activity of interstitial cells of Cajal (ICC) and smooth muscles in the stomach were investigated...
  15. ncbi request reprint Role of nitric oxide/cyclic GMP pathway in regulating spontaneous excitations in detrusor smooth muscle of the guinea-pig bladder
    Yoshimasa Yanai
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Neurourol Urodyn 27:446-53. 2008
    ..We have investigated the effects of NO donors and phosphodiesterase-5 (PDE5) inhibition on spontaneous excitations in DSM...
  16. ncbi request reprint Altered distribution of interstitial cells in the guinea pig bladder following bladder outlet obstruction
    Yasue Kubota
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Neurourol Urodyn 27:330-40. 2008
    ..We investigated the effects of bladder outlet obstruction (BOO) on the distribution of interstitial cells (ICs) in the guinea-pig bladder...
  17. ncbi request reprint Role of mitochondria in the generation of spontaneous activity in detrusor smooth muscles of the Guinea pig bladder
    Yasue Kubota
    Department of Physiology, Nagoya City University Medical School, Nagoya, Japan
    J Urol 170:628-33. 2003
    ..The rhythmic electrical activity of gastrointestinal smooth muscles is associated with mitochondrial Ca2+ handling. We examined the role of mitochondria in the generation of spontaneous activity in detrusor smooth muscles...
  18. ncbi request reprint Modulation of slow waves by transmural nerve stimulation of smooth muscle tissue isolated from the corpus of the guinea-pig stomach
    Chiharu Tanaka
    Department of Physiology, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    J Smooth Muscle Res 45:109-24. 2009
    ..These results indicate that in the corpus circular smooth muscle, neural modulation of slow waves appeared to be exerted mainly on the amplitude, but not on the frequency...
  19. doi request reprint Role of K+ channels in regulating spontaneous activity in detrusor smooth muscle in situ in the mouse bladder
    Masa Hayase
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Urol 181:2355-65. 2009
    ..We investigated the functional role of K(+) channels for regulating spontaneous activity in mouse bladder detrusor smooth muscle...
  20. ncbi request reprint Inhibitory actions of cilostazol on electrical responses of smooth muscle isolated from the guinea-pig stomach antrum
    Eri Nakamura
    Department of Physiology, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    J Smooth Muscle Res 40:111-24. 2004
    ....
  21. doi request reprint Intercellular communication within the rat anterior pituitary gland. XV. Properties of spontaneous and LHRH-induced Ca2+ transients in the transitional zone of the rat anterior pituitary in situ
    Kazuki Hattori
    Departments of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Endocrinology 154:400-9. 2013
    ..Moreover, LHRH-induced excitation and associated refractoriness appear to be incomplete in neonatal rats and may be acquired during development...
  22. ncbi request reprint Factors which determine the duration of follower potentials in longitudinal smooth muscle isolated from the guinea-pig stomach antrum
    Yuhsuke Shigemasa
    Department of Cell Physiology, Nagoya City University Medical School, Mizuho ku, Nagoya, Japan
    J Smooth Muscle Res 47:89-110. 2011
    ..Proteinkinase C did not seem to participate to the function of mitochondria and internal Ca(2+) stores...
  23. doi request reprint Mechanisms underlying spontaneous constrictions of postcapillary venules in the rat stomach
    Retsu Mitsui
    Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, 1, Kawasumi, Mizuho cho, Mizuho ku, Nagoya, 467 8601, Japan
    Pflugers Arch 468:279-91. 2016
    ..Basal PDE5 activity may continuously counteract vaso-relaxing effects of endothelial NO to maintain spontaneous vasomotion...
  24. ncbi request reprint Regional differences in the frequency of slow waves in smooth muscle of the guinea-pig stomach
    Kazumasa Domae
    Department of Physiology, Nagoya City University Medical School, Japan
    J Smooth Muscle Res 44:231-48. 2008
    ..We suggest that the regional difference in slow wave discharge is produced mainly by ICC-IM, and the role of ICC-MY may be little, if any...
  25. ncbi request reprint Metabolic component of the temperature-sensitivity of slow waves recorded from gastric muscle of the guinea-pig
    Eri Nakamura
    Department of Physiology, Nagoya City University Medical School, Nagoya 467 8601, Japan
    J Smooth Muscle Res 42:33-48. 2006
    ....
  26. ncbi request reprint The role of Ni(2+)-sensitive T-type Ca(2+) channels in the regulation of spontaneous excitation in detrusor smooth muscles of the guinea-pig bladder
    Yoshimasa Yanai
    Department of Nephro urology, Nagoya City University Medical School, Nagoya, Japan
    BJU Int 97:182-9. 2006
    ..To explore the role of Ni(2+)-sensitive T-type Ca(2+) channels in the generation of spontaneous excitation of detrusor smooth muscles...
  27. doi request reprint Electrical properties of purinergic transmission in smooth muscle of the guinea-pig prostate
    Michelle Lam
    Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho ku, Nagoya 467 8601, Japan Electronic address
    Auton Neurosci 194:8-16. 2016
    ..Age-related up-regulation of enzymatic ATP breakdown may be a compensatory mechanism for the enhanced purinergic transmission which would cause hypercontractility arising from increased ATP release in older animals...
  28. ncbi request reprint Intercellular communications within the rat anterior pituitary XII: immunohistochemical and physiological evidences for the gap junctional coupling of the folliculo-stellate cells in the rat anterior pituitary
    Yumi Sato
    Functional Morphology, Nagoya City University Medical Science, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya City, Aichi 467 8601, Japan
    Tissue Cell 37:281-91. 2005
    ....
  29. ncbi request reprint [Cellular mechanism of the generation of spontaneous activity in gastric muscle]
    Eri Nakamura
    Department of Physiology, Nagoya City University Medical School, Japan
    Nihon Yakurigaku Zasshi 123:141-8. 2004
    ..These results suggested that mitochondrial Ca(2+)-handling causes the generation of spontaneous activity in pacemaker cells. Possible involvement of protein kinase C (PKC) in the Ca(2+) signaling system was also suggested...
  30. pmc Ionic basis for the regulation of spontaneous excitation in detrusor smooth muscle cells of the guinea-pig urinary bladder
    Hikaru Hashitani
    University Department of Pharmacology, Mansfield Road, Oxford OX1 3QT, UK
    Br J Pharmacol 140:159-69. 2003
    ..The regulatory mechanisms of action potentials are closely related to the regulation of spontaneous contractions...
  31. pmc Electrical properties of detrusor smooth muscles from the pig and human urinary bladder
    Hikaru Hashitani
    University Department of Pharmacology, Mansfield Road, Oxford OX1 3QT
    Br J Pharmacol 140:146-58. 2003
    ..In addition to large conductance (BK) and small conductance (SK) Ca2+-activated K+ channels, voltage-dependent K+ (VK) channels may play an important role in the regulation of electrical activity of detrusor smooth muscles...
  32. pmc Properties of submucosal venules in the rat distal colon
    Retsu Mitsui
    Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Br J Pharmacol 170:968-77. 2013
    ..Venules within the gut wall may have intrinsic mechanisms for maintaining the circulation even upon the intestinal wall distension. We aimed to explore spontaneous and nerve-mediated contractile activity of colonic venules...
  33. pmc Spontaneous activity in the microvasculature of visceral organs: role of pericytes and voltage-dependent Ca(2+) channels
    Hikaru Hashitani
    Department of Cell Physiology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan
    J Physiol 594:555-65. 2016
    ..Thus pericytes play different roles in different vascular beds in a manner that may well depend on the selective expression of T-type and L-type Ca(2+) channels. ..
  34. doi request reprint Interstitial cell modulation of pyeloureteric peristalsis in the mouse renal pelvis examined using FIBSEM tomography and calcium indicators
    Hikaru Hashitani
    Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467 8601, Japan
    Pflugers Arch . 2017
    ..While ASMCs appear to be the primary pacemaker driving pyeloureteric peristalsis, it was concluded that sub-urothelial HCN3(+), CaV3.1(+) ICs can accelerate ASMC Ca2+ signalling...
  35. doi request reprint Role of PTHrP and Sensory Nerve Peptides in Regulating Contractility of Muscularis Mucosae and Detrusor Smooth Muscle in the Guinea Pig Bladder
    Ken Lee
    Department of Cell Physiology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Electronic address
    J Urol 196:1287-94. 2016
    ..We investigated the neurohumoral modulation of the contractility of bladder muscularis mucosae (mucosa) compared with that of detrusor smooth muscle...
  36. doi request reprint Neurohumoral regulation of spontaneous constrictions in suburothelial venules of the rat urinary bladder
    Yuki Shimizu
    Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Vascul Pharmacol 60:84-94. 2014
    ..In addition, suburothelial venular constrictions appear to be modulated by several bioactive substances that could be released from urothelium or suburothelial sensory nerves. ..
  37. pmc Potassium and ANO1/ TMEM16A chloride channel profiles distinguish atypical and typical smooth muscle cells from interstitial cells in the mouse renal pelvis
    Javed Iqbal
    Department of Physiology Anatomy and Development Biology, Monash University, Clayton, Victoria, Australia
    Br J Pharmacol 165:2389-408. 2012
    ..Although atypical smooth muscle cells (SMCs) in the proximal renal pelvis are thought to generate the pacemaker signals that drive pyeloureteric peristalsis, their location and electrical properties remain obscure...
  38. pmc Functions of ICC-like cells in the urinary tract and male genital organs
    Hikaru Hashitani
    Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Cell Mol Med 14:1199-211. 2010
    ..We also discuss several unsolved issues regarding the identification, properties and functions of ICC-LCs in various urogenital regions in health and disease...
  39. doi request reprint Functional coupling of TRPV4 channels and BK channels in regulating spontaneous contractions of the guinea pig urinary bladder
    Ayu Isogai
    Department of Cell Physiology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, 467 8601, Japan
    Pflugers Arch 468:1573-85. 2016
    ..Despite the membrane hyperpolarization in GSK, Ca(2+) entry mainly through TRPV4 develops the tonic contraction. ..
  40. doi request reprint Functional properties of submucosal venules in the rat stomach
    Retsu Mitsui
    Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, 1, Kawasumi, Mizuho cho, Mizuho ku, Nagoya, 467 8601, Japan
    Pflugers Arch 467:1327-42. 2015
    ..Sympathetic venular constrictions appear to be exclusively mediated by noradrenaline due to the lack of P2X1 receptor in venular SMCs...
  41. doi request reprint Voltage dependence of slow wave frequency in the guinea pig prostate
    Yusuke Shigemasa
    Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Urol 192:1286-92. 2014
    ..We investigated voltage dependent mechanisms in the regulation of slow wave frequency...
  42. doi request reprint Immunohistochemical characteristics of suburothelial microvasculature in the mouse bladder
    Retsu Mitsui
    Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Histochem Cell Biol 140:189-200. 2013
    ..In conclusion, arterioles and venules of the bladder suburothelium are the target of sympathetic, cholinergic and primary afferent nerve fibres. ..
  43. pmc Spontaneous electrical and Ca2+ signals in typical and atypical smooth muscle cells and interstitial cell of Cajal-like cells of mouse renal pelvis
    Richard J Lang
    Department of Physiology, School of Biomedical Sciences, Faculty of Medicine and Health Sciences, Monash University, Clayton, Victoria 3800, Australia
    J Physiol 583:1049-68. 2007
    ..We speculate that ASMCs act as the primary pacemaker in the renal pelvis while ICC-LCs play a supportive role, but can take over pacemaking in the absence of the proximal pacemaker drive...
  44. pmc Atypical slow waves generated in gastric corpus provide dominant pacemaker activity in guinea pig stomach
    Hikaru Hashitani
    Division of Neuroscience, John Curtin School of Medical Research, Canberra, ACT 0200, Australia
    J Physiol 569:459-65. 2005
    ..The experiments show that the corpus provides the dominant pacemaker activity which entrains activity in other regions of the stomach and it is suggested that this activity is generated by corporal intramuscular interstitial cells...