Y Hasegawa

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint Avoidance of bone marrow suppression using A-5021 as a nucleoside analog for retrovirus-mediated herpes simplex virus type I thymidine kinase gene therapy
    Y Hasegawa
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Cancer Gene Ther 7:557-62. 2000
  2. ncbi request reprint Lymphomatous features of aggressive NK cell leukaemia/lymphoma with massive necrosis, haemophagocytosis and EB virus infection
    N Mori
    First Department of Pathology, Nagoya University School of Medicine, Tsuruma cho 65, Showa Ku, Nagoya 466 8550, Japan
    Histopathology 37:363-71. 2000
  3. ncbi request reprint Estimation of the area under the concentration-versus-time curve of carboplatin following irinotecan using a limited sampling model
    G Asai
    First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya Ekisaikai Hospital, Japan
    Eur J Clin Pharmacol 54:725-7. 1998
  4. ncbi request reprint Effect of erythromycin on matrix metalloproteinase-9 and cell migration
    N Hashimoto
    First Department of Internal Medicine, Department of Clinical Preventive Medicine, Nagoya University School of Medicine, Japan
    J Lab Clin Med 137:176-83. 2001
  5. ncbi request reprint Induction of antitumor immunity by transduction of CD40 ligand gene and interferon-gamma gene into lung cancer
    M Noguchi
    First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya 466-8550, Japan
    Cancer Gene Ther 8:421-9. 2001
  6. ncbi request reprint Telomerase activation and p53 mutations in urethane-induced A/J mouse lung tumor development
    J Ohno
    First Department of Internal Medicine, Department of Clinical Preventive Medicine, Nagoya University School of Medicine, Japan
    Carcinogenesis 22:751-6. 2001
  7. pmc IgG-mediated anaphylaxis via Fc gamma receptor in CD40-deficient mice
    H Wakayama
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Clin Exp Immunol 114:154-60. 1998
  8. ncbi request reprint Natural history of unreduced congenital dislocation of the hip in adults
    Y Hasegawa
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Japan
    Arch Orthop Trauma Surg 120:17-22. 2000
  9. pmc Mechanism of nitric oxide-dependent killing of Mycobacterium bovis BCG in human alveolar macrophages
    Y Nozaki
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Infect Immun 65:3644-7. 1997
  10. ncbi request reprint Genetic alteration of the beta-catenin gene (CTNNB1) in human lung cancer and malignant mesothelioma and identification of a new 3p21.3 homozygous deletion
    K Shigemitsu
    Department of Thoracic Surgery, Nagoya University School of Medicine, Nagoya 466-8550, Japan
    Oncogene 20:4249-57. 2001

Detail Information

Publications17

  1. ncbi request reprint Avoidance of bone marrow suppression using A-5021 as a nucleoside analog for retrovirus-mediated herpes simplex virus type I thymidine kinase gene therapy
    Y Hasegawa
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Cancer Gene Ther 7:557-62. 2000
    ..These results indicate that A-5021 has potent cytotoxic activity as a nucleoside analog for gene therapy using HSV-TK gene, and can be used much more safely than GCV...
  2. ncbi request reprint Lymphomatous features of aggressive NK cell leukaemia/lymphoma with massive necrosis, haemophagocytosis and EB virus infection
    N Mori
    First Department of Pathology, Nagoya University School of Medicine, Tsuruma cho 65, Showa Ku, Nagoya 466 8550, Japan
    Histopathology 37:363-71. 2000
    ..However, its non-leukaemic features remain unclear. We therefore investigated the morphological and immunophenotypic features of this lymphoma...
  3. ncbi request reprint Estimation of the area under the concentration-versus-time curve of carboplatin following irinotecan using a limited sampling model
    G Asai
    First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya Ekisaikai Hospital, Japan
    Eur J Clin Pharmacol 54:725-7. 1998
    ..The aim of this study was to develop limited sampling models for estimating the area under the concentration-versus-time curve (AUC) of carboplatin...
  4. ncbi request reprint Effect of erythromycin on matrix metalloproteinase-9 and cell migration
    N Hashimoto
    First Department of Internal Medicine, Department of Clinical Preventive Medicine, Nagoya University School of Medicine, Japan
    J Lab Clin Med 137:176-83. 2001
    ..These findings suggest that the suppressive effect of EM on MMP-9 activity is one of the anti-inflammatory mechanisms that inhibit the migration of inflammatory cells into the inflammatory site...
  5. ncbi request reprint Induction of antitumor immunity by transduction of CD40 ligand gene and interferon-gamma gene into lung cancer
    M Noguchi
    First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya 466-8550, Japan
    Cancer Gene Ther 8:421-9. 2001
    ..These results indicate that the in vivo priming with CD40L- and IFN-gamma gene-transduced lung cancer cells is a promising strategy for inducing antitumor immunity in the treatment of lung cancer...
  6. ncbi request reprint Telomerase activation and p53 mutations in urethane-induced A/J mouse lung tumor development
    J Ohno
    First Department of Internal Medicine, Department of Clinical Preventive Medicine, Nagoya University School of Medicine, Japan
    Carcinogenesis 22:751-6. 2001
    ....
  7. pmc IgG-mediated anaphylaxis via Fc gamma receptor in CD40-deficient mice
    H Wakayama
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Clin Exp Immunol 114:154-60. 1998
    ..In addition to IgE-mediated anaphylaxis, IgG-mediated anaphylaxis should be considered and the blocking of Fc gammaR would provide one of the therapeutic targets for the control of IgG-mediated hypersensitivity diseases...
  8. ncbi request reprint Natural history of unreduced congenital dislocation of the hip in adults
    Y Hasegawa
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Japan
    Arch Orthop Trauma Surg 120:17-22. 2000
    ..Lumbar degenerative scoliosis of more than 5 deg was observed in 16 patients...
  9. pmc Mechanism of nitric oxide-dependent killing of Mycobacterium bovis BCG in human alveolar macrophages
    Y Nozaki
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Infect Immun 65:3644-7. 1997
    ..These results clearly show that BCG-induced NO and its reactive product with the oxygen radical peroxynitrite could play an important role in the killing of BCG in human AM...
  10. ncbi request reprint Genetic alteration of the beta-catenin gene (CTNNB1) in human lung cancer and malignant mesothelioma and identification of a new 3p21.3 homozygous deletion
    K Shigemitsu
    Department of Thoracic Surgery, Nagoya University School of Medicine, Nagoya 466-8550, Japan
    Oncogene 20:4249-57. 2001
    ..3, where various types of human cancers show frequent allelic loss...
  11. pmc Diagnostic value of the strand displacement amplification method compared to those of Roche Amplicor PCR and culture for detecting mycobacteria in sputum samples
    S Ichiyama
    Department of Clinical Laboratory Medicine, Nagoya University Hospital, Nagoya University School of Medicine, Japan
    J Clin Microbiol 35:3082-5. 1997
    ..3 and 100%, respectively. The high degrees of sensitivity and specificity of the BDProbeTec-SDA system suggest that it should be very useful in clinical laboratories for the rapid detection of mycobacteria in sputum samples...
  12. ncbi request reprint Induction and characterization of minor histocompatibility antigens. Specific primary cytotoxic T lymphocyte responses in vitro
    K Ando
    Department of Immunology, Nagoya University School of Medicine, Aichi, Japan
    J Immunol 140:723-9. 1988
    ..Further study demonstrated that Ia+ adherent cells were the most active cell type as stimulator. Finally, we confirmed that the primary anti-MIHA CTL responses to adherent stimulator cells was MHC-restricted...
  13. ncbi request reprint Head penetration into Hylamer acetabular liner sterilized by gamma irradiation in air and in a nitrogen atmosphere
    K Yamauchi
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Nagoya City, Japan
    J Arthroplasty 16:463-70. 2001
    ..Rapid oxidation by irradiation in air might not be the main cause of high rate of wear in Hylamer liners...
  14. ncbi request reprint Clinical analysis of multiple primary malignancies of the hypopharynx and esophagus
    T Kohmura
    Department of Otorhinolaryngology, Nagoya University School of Medicine, 65 Tsurumai Showaku Nagoya, 466-8560, Japan
    Am J Otolaryngol 22:107-10. 2001
    ..CONCLUSIONS: The prognosis and mild systemic damage after endoscopic esophageal mucosal resection compare favorably with surgery, radiation, or systemic chemotherapy...
  15. ncbi request reprint Concentration and localization of YKL-40 in hip joint diseases
    M Kawasaki
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Japan
    J Rheumatol 28:341-5. 2001
    ..In the synovium, YKL-40 was localized in fibroblasts and macrophages. CONCLUSION: YKL-40 reflects the degree of inflammation rather than cartilage metabolism. YKL-40 may be a useful inflammatory marker of hip joint diseases...
  16. ncbi request reprint Lennert's lymphoma: a variant of cytotoxic T-cell lymphoma?
    Y Yamashita
    First Department of Pathology, Nagoya University School of Medicine, Japan
    Am J Surg Pathol 24:1627-33. 2000
    ..Lennert's lymphoma was formerly known as a CD4+ helper T-cell neoplasm. Our results suggest that, at least in some cases, the neoplastic cells are of cytotoxic T-cell origin...
  17. ncbi request reprint Phase I/II and pharmacologic study of irinotecan and carboplatin for patients with lung cancer
    M Sato
    First Department of Internal Medicine, Nagoya University Graduate School of Medicine, Japan
    Cancer Chemother Pharmacol 48:481-7. 2001
    ..This combination regimen has only modest activity, and further studies are necessary to evaluate a different dose schedule...