Koichi Furukawa

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. doi request reprint Regulatory function of glycosphingolipids in the inflammation and degeneration
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Japan Electronic address
    Arch Biochem Biophys 571:58-65. 2015
  2. doi request reprint Glycosphingolipids in the regulation of the nervous system
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, 466 0065, Japan
    Adv Neurobiol 9:307-20. 2014
  3. pmc Ganglioside deficiency causes inflammation and neurodegeneration via the activation of complement system in the spinal cord
    Yuhsuke Ohmi
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    J Neuroinflammation 11:61. 2014
  4. doi request reprint Disialyl gangliosides enhance tumor phenotypes with differential modalities
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Glycoconj J 29:579-84. 2012
  5. doi request reprint Fine tuning of cell signals by glycosylation
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Biochem 151:573-8. 2012
  6. doi request reprint Regulatory mechanisms of nervous systems with glycosphingolipids
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Neurochem Res 36:1578-86. 2011
  7. ncbi request reprint [Functional analysis of the nervous system in knockout mice of ganglioside synthase genes]
    Koichi Furukawa
    Tanpakushitsu Kakusan Koso 49:2411-6. 2004
  8. ncbi request reprint Glycosphingolipids in engineered mice: insights into function
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Semin Cell Dev Biol 15:389-96. 2004
  9. ncbi request reprint [Function of gangliosides]
    Koichi Furukawa
    Tanpakushitsu Kakusan Koso 48:952-7. 2003
  10. ncbi request reprint [XGalT-1 involved in the synthesis of glyosaminoglycans of proteoglycans and Ehlers-Danlos syndrome (progeroid type)]
    Koichi Furukawa
    Tanpakushitsu Kakusan Koso 48:1152-7. 2003

Detail Information

Publications106 found, 100 shown here

  1. doi request reprint Regulatory function of glycosphingolipids in the inflammation and degeneration
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Japan Electronic address
    Arch Biochem Biophys 571:58-65. 2015
    ..Thus, possibilities that manipulation of synthesis and expression of glycosphingolipids may be applicable for the disease control are now proposed. ..
  2. doi request reprint Glycosphingolipids in the regulation of the nervous system
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, 466 0065, Japan
    Adv Neurobiol 9:307-20. 2014
    ..Identification of natural ligands for individual GSLs is crucial in order to clarify the functions of each structure. ..
  3. pmc Ganglioside deficiency causes inflammation and neurodegeneration via the activation of complement system in the spinal cord
    Yuhsuke Ohmi
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    J Neuroinflammation 11:61. 2014
    ..Therefore, we examined neurodegeneration in double knockout (DKO) mice of ganglioside GM2/GD2 synthase (B4GANLT1) and GD3 synthase (ST8SIA1) genes to clarify roles of gangliosides in the spinal cord...
  4. doi request reprint Disialyl gangliosides enhance tumor phenotypes with differential modalities
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Glycoconj J 29:579-84. 2012
    ..e. increased and decreased adhesion activity. Thus, whole features of glycolipid-enriched microdomain/rafts formed in the individual cancer types seem to determine the main signaling pathway and biological outcome...
  5. doi request reprint Fine tuning of cell signals by glycosylation
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Biochem 151:573-8. 2012
    ..Modes of glycosylation and mechanisms by which glycosylation is involved in the regulation of cell signals are now hot subjects in glycobiology...
  6. doi request reprint Regulatory mechanisms of nervous systems with glycosphingolipids
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Neurochem Res 36:1578-86. 2011
    ....
  7. ncbi request reprint [Functional analysis of the nervous system in knockout mice of ganglioside synthase genes]
    Koichi Furukawa
    Tanpakushitsu Kakusan Koso 49:2411-6. 2004
  8. ncbi request reprint Glycosphingolipids in engineered mice: insights into function
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Semin Cell Dev Biol 15:389-96. 2004
    ..In this review, recent progress in the study of glycosyltransferases involved in the synthesis and modification of GSLs has been summarized with special emphasis on their function...
  9. ncbi request reprint [Function of gangliosides]
    Koichi Furukawa
    Tanpakushitsu Kakusan Koso 48:952-7. 2003
  10. ncbi request reprint [XGalT-1 involved in the synthesis of glyosaminoglycans of proteoglycans and Ehlers-Danlos syndrome (progeroid type)]
    Koichi Furukawa
    Tanpakushitsu Kakusan Koso 48:1152-7. 2003
  11. ncbi request reprint Isolation and functional analysis of the melanoma specific promoter region of human GD3 synthase gene
    Keiko Furukawa
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa, Nagoya 466 0065, Japan
    Biochim Biophys Acta 1627:71-8. 2003
    ..They also commonly contained a GT/CG repeat sequence at upstream of -1200 approximately -1300 nt, suggesting that they form Z-type DNA, and are involved in the gene regulation...
  12. ncbi request reprint Biosignals modulated by tumor-associated carbohydrate antigens: novel targets for cancer therapy
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University, Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, 466 0065, Japan
    Ann N Y Acad Sci 1086:185-98. 2006
    ..These approaches have promoted further understanding of mechanisms by which gangliosides modulate malignant properties of human cancer, and the results obtained here propose novel targets for cancer therapy...
  13. ncbi request reprint Galactosyltransferase I is a gene responsible for progeroid variant of Ehlers-Danlos syndrome: molecular cloning and identification of mutations
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, Japan
    Biochim Biophys Acta 1573:377-81. 2002
    ..The mutations showed, respectively, 10-50% and 0% of the enzyme activity compared with wild type, suggesting that galactosytransferase I (XGal-T1) is at least one of the genes responsible for Ehlers-Danlos syndrome (progeroid variant)...
  14. ncbi request reprint Beta1,4-N-acetylgalactosaminyltransferase--GM2/GD2 synthase: a key enzyme to control the synthesis of brain-enriched complex gangliosides
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, Japan
    Biochim Biophys Acta 1573:356-62. 2002
    ..Molecular mechanisms for these functions of complex gangliosides in vivo remain to be clarified...
  15. doi request reprint Glycoconjugate glycosyltransferases
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Glycoconj J 26:987-98. 2009
    ..Lastly, complex formation of glycosyltransferase proteins with related molecules including subunits, chaperones, and enzyme regulators, that have been recently reported was also summarized...
  16. doi request reprint Molecules in the signaling pathway activated by gangliosides can be targets of therapeutics for malignant melanomas
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University School of Medicine, Showa Ku, Nagoya, Japan
    Proteomics 8:3312-6. 2008
    ....
  17. ncbi request reprint Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins
    Tetsuya Okuda
    Department of Biochemistry II, Nagoya University School of Medicine, Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    J Biol Chem 281:10230-5. 2006
    ..The lethal kinetics were similar regardless of lipopolysaccharide elimination in VT preparation, suggesting that basal Gb3/CD77 levels are sufficient for lethal effects of VTs...
  18. ncbi request reprint Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells
    Kazunori Hamamura
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Biochim Biophys Acta 1780:513-9. 2008
    ..Molecules linking GD3 and FAK such as integrins in the enhanced signaling pathway remain to be investigated...
  19. doi request reprint Dysfunction of muscarinic acetylcholine receptors as a substantial basis for progressive neurological deterioration in GM3-only mice
    Orie Tajima
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Behav Brain Res 206:101-8. 2010
    ..Thus, dysfunction of mAChRs might be a substantial basis for the progressive neurological deterioration in DKO mice...
  20. pmc Ganglioside GD3 enhances adhesion signals and augments malignant properties of melanoma cells by recruiting integrins to glycolipid-enriched microdomains
    Yuki Ohkawa
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    J Biol Chem 285:27213-23. 2010
    ..All these results suggested that integrins assembled and formed a cluster in GEM/rafts, leading to the enhanced signaling and malignant properties under GD3 expression...
  21. pmc Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells
    Kazunori Hamamura
    Departments of Biochemistry II and Oral and Maxillofacial Surgery, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Proc Natl Acad Sci U S A 102:11041-6. 2005
    ..These results suggested that these two molecules function as effectors of GD3-mediated signaling, leading to such malignant properties as rapid cell growth and invasion...
  22. ncbi request reprint Complex formation of Plk1 and INCENP required for metaphase-anaphase transition
    Hidemasa Goto
    Division of Biochemistry, Aichi Cancer Center Research Institute, Nagoya, Aichi 464 8681, Japan
    Nat Cell Biol 8:180-7. 2006
    ..We propose that INCENP phosphorylation by Cdk1 is necessary for the recruitment of Plk1 to the kinetochore, and that the complex formation of Plk1 and Aurora-B on INCENP may play crucial roles in the regulation of chromosomal dynamics...
  23. ncbi request reprint Murine glycosyltransferases responsible for the expression of globo-series glycolipids: cDNA structures, mRNA expression, and distribution of their products
    Yuko Fujii
    Department of Clinical Immunology, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Glycobiology 15:1257-67. 2005
    ..The expression patterns of two genes and their products almost corresponded with some exception. The results would provide essential information for the functional studies of globo-series glycolipids...
  24. ncbi request reprint Differential enhancing effects of alpha2,8-sialyltransferase on the cell proliferation and mobility
    Yutaka Kamimura
    Department of Biochemistry II, Nagoya University School of Medicine, Nagoya 466 0065, Japan
    Int J Oncol 26:337-44. 2005
    ..These results suggest that the enhancing effects of alpha2,8S-T on the proliferation and mobility are differential depending on the cell types, and ganglioside-associating molecules in the individual cell types need to be investigated...
  25. pmc Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin α5β1 and matrix metalloproteinase 9
    Yasuyuki Matsumoto
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    J Biol Chem 288:24264-76. 2013
    ....
  26. pmc Gangliosides play pivotal roles in the regulation of complement systems and in the maintenance of integrity in nerve tissues
    Yuhsuke Ohmi
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya 466 0065, Japan
    Proc Natl Acad Sci U S A 106:22405-10. 2009
    ....
  27. doi request reprint Gangliosides are essential in the protection of inflammation and neurodegeneration via maintenance of lipid rafts: elucidation by a series of ganglioside-deficient mutant mice
    Yuhsuke Ohmi
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Neurochem 116:926-35. 2011
    ..These results indicate that destruction of GEM/rafts is caused by ganglioside deficiency with gradual intensity depending on the degree of defects of their compositions...
  28. ncbi request reprint Mechanisms for the apoptosis of small cell lung cancer cells induced by anti-GD2 monoclonal antibodies: roles of anoikis
    Wei Aixinjueluo
    Department of Biochemistry II and Oral and Maxillofacial Surgery, Nagoya University School of Medicine 65 Tsurumai, Showa Ku, Japan
    J Biol Chem 280:29828-36. 2005
    ....
  29. ncbi request reprint Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C
    Xiangyu Li
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 8550
    J Biol Chem 279:47201-11. 2004
    ..We therefore suggest that Aurora-C is a novel chromosomal passenger protein that cooperates with Aurora-B to regulate mitotic chromosome dynamics in mammalian cells...
  30. doi request reprint Enhancement of malignant properties of human osteosarcoma cells with disialyl gangliosides GD2/GD3
    Hidenobu Shibuya
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Japan
    Cancer Sci 103:1656-64. 2012
    ..These results suggested that GD2/GD3 are responsible for the enhancement of the malignant features of osteosarcomas, and might be candidate targets in molecular-targeted therapy...
  31. ncbi request reprint GD3 synthase gene knockout mice exhibit thermal hyperalgesia and mechanical allodynia but decreased response to formalin-induced prolonged noxious stimulation
    Yoshihiro Handa
    Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Pain 117:271-9. 2005
    ..Moreover, they play an important role in the development of hyperalgesia induced by inflammation...
  32. ncbi request reprint Overexpressed GM1 suppresses nerve growth factor (NGF) signals by modulating the intracellular localization of NGF receptors and membrane fluidity in PC12 cells
    Masashi Nishio
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    J Biol Chem 279:33368-78. 2004
    ....
  33. ncbi request reprint Metastatic potential of mouse Lewis lung cancer cells is regulated via ganglioside GM1 by modulating the matrix metalloprotease-9 localization in lipid rafts
    Qing Zhang
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    J Biol Chem 281:18145-55. 2006
    ....
  34. doi request reprint GM1 / GD1b / GA1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft-localization of gangliosides in a melanoma cell line
    Yu Dong
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 101:2039-47. 2010
    ..This might be a mechanism for the decreased tumor properties in the transfectants of GM1/GD1b/GA1 synthase cDNA...
  35. ncbi request reprint Over-expression of GM1 enhances cell proliferation with epidermal growth factor without affecting the receptor localization in the microdomain in PC12 cells
    Masashi Nishio
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Int J Oncol 26:191-9. 2005
    ..These results suggested that the effects of GM1 expression on the nature of microdomains and growth signals depend on the cell types and receptors analyzed...
  36. pmc Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers
    Motohiro Senda
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Biochem J 402:459-70. 2007
    ..All these findings indicated that DSGG was suppressed during the malignant transformation of the proximal tubules as a maturation arrest of glycosylation...
  37. pmc Disruption of GM2/GD2 synthase gene resulted in overt expression of 9-O-acetyl GD3 irrespective of Tis21
    Keiko Furukawa
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neurochem 105:1057-66. 2008
    ..Increased 9-O-acetyl GD3, in addition to GM3 and GD3, may play an important role in the compensation for deleted complex gangliosides in the mutant mice...
  38. ncbi request reprint Suppression of lung metastasis of mouse Lewis lung cancer P29 with transfection of the ganglioside GM2/GD2 synthase gene
    Ho Hsiang Chen
    Department of Biochemistry II, Nagoya University School of Medicine, Nagoya, Japan
    Int J Cancer 103:169-76. 2003
    ..Phosphorylation of the FAK located at downstream of integrin molecules was markedly reduced in GM(2)(+) transfectants, suggesting that GM(2) suppressed cell adhesion signals via fibronectin-integrin interaction...
  39. ncbi request reprint Overexpression of caveolin-1 in a human melanoma cell line results in dispersion of ganglioside GD3 from lipid rafts and alteration of leading edges, leading to attenuation of malignant properties
    Hideyuki Nakashima
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Cancer Sci 98:512-20. 2007
    ..These results reveal one of the mechanisms by which caveolin-1 curtails the malignant properties of tumor cells...
  40. ncbi request reprint Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides
    Akiko Tsuchida
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, 466 0065, Japan
    J Biol Chem 278:22787-94. 2003
    ..None of them expressed ST6GalNAc V. These results suggested the novel substrate specificity of ST6GalNAc VI, which is responsible for the synthesis of disialyl Lea but not for alpha-series gangliosides in human colon tissues...
  41. doi request reprint Impaired hypoglossal nerve regeneration in mutant mice lacking complex gangliosides: down-regulation of neurotrophic factors and receptors as possible mechanisms
    Daiji Kittaka
    Department of Biochemistry II, Graduate School of Medicine, Nagoya University School of Medicine, Nagoya 466 0065, Japan
    Glycobiology 18:509-16. 2008
    ....
  42. doi request reprint Essential roles of integrin-mediated signaling for the enhancement of malignant properties of melanomas based on the expression of GD3
    Yuki Ohkawa
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Aichi, Japan
    Biochem Biophys Res Commun 373:14-9. 2008
    ..These results suggested that integrin-mediated signaling is essential in the effects of GD3 on the malignant properties of melanomas. Co-localization of GD3 and integrin at the focal adhesion supported these results...
  43. doi request reprint Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x
    Hiroshi Hotta
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, 466 0065, Japan
    Glycoconj J 30:585-97. 2013
    ..All these results together with alternative staining between Lewis y and Ki-67 in cancer tissues and FUT1 transfectants suggested that loss of Lewis y is a crucial event for the late stage of SCCs. ..
  44. pmc TLR4-MD-2 complex is negatively regulated by an endogenous ligand, globotetraosylceramide
    Yuji Kondo
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya 466 0065, Japan
    Proc Natl Acad Sci U S A 110:4714-9. 2013
    ..These results suggest that Gb4 is an endogenous ligand for TLR4-MD-2 and is capable of attenuating LPS toxicity, indicating the possibility for its therapeutic application in endotoxin shock...
  45. doi request reprint Essential roles of gangliosides in the formation and maintenance of membrane microdomains in brain tissues
    Yuhsuke Ohmi
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Neurochem Res 37:1185-91. 2012
    ..Implication of inflammation caused by deficiency of gangliosides in various neurodegenerative diseases was discussed...
  46. ncbi request reprint Genetic mechanisms for the synthesis of fucosyl GM1 in small cell lung cancer cell lines
    Noriyo Tokuda
    Department of Biochemistry II, Nagoya University School of Medicine, Nagoya, Japan
    Glycobiology 16:916-25. 2006
    ..These results should promote the functional analysis of fucosyl GM1 leading to the development of novel therapies for SCLC...
  47. ncbi request reprint Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis
    Yoshihiro Yasui
    Division of Biochemistry, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    J Biol Chem 279:12997-3003. 2004
    ..These results indicate that the phosphorylation of Thr-232 is an essential regulatory mechanism for Aurora-B activation...
  48. ncbi request reprint GM1 expression in H-ras-transformed NIH3T3 results in the suppression of cell proliferation inducing the partial transfer of activated H-ras from non-raft to raft fraction
    Kazunori Hamamura
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Int J Oncol 26:897-904. 2005
    ..e., 32% in C21, and 8% in C34. Since the Ras effector Raf-1 was localized in non-GEM/raft, the growth suppression might be caused, at least partly, by the movement of activated H-ras to GEM/raft fraction...
  49. ncbi request reprint The blood group P1 synthase gene is identical to the Gb3/CD77 synthase gene. A clue to the solution of the P1/P2/p puzzle
    Koichi Iwamura
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    J Biol Chem 278:44429-38. 2003
    ..Differences in the transcriptional regulation in erythrocytes might be a major factor determining P1/P2...
  50. pmc Ganglioside GD3 induces convergence and synergism of adhesion and hepatocyte growth factor/Met signals in melanomas
    Keiko Furukawa
    Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, Kasugai, Japan Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 105:52-63. 2014
    ..These results suggested that GD3 plays a crucial role in the convergence of multiple signals, leading to the synergistic effects of those signals on malignant properties of melanomas. ..
  51. doi request reprint Proteomic analysis of ganglioside-associated membrane molecules: substantial basis for molecular clustering
    Noboru Hashimoto
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Proteomics 12:3154-63. 2012
    ..Representative examples of GD3-associated molecules such as neogenin and MCAM were shown...
  52. doi request reprint Membrane sialidase NEU3 is highly expressed in human melanoma cells promoting cell growth with minimal changes in the composition of gangliosides
    Maiko Miyata
    Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, Aichi, Japan
    Cancer Sci 102:2139-49. 2011
    ..Phosphorylation levels of ERK1/2 with serum stimulation decreased in the NEU3-silenced cells. All these results suggest that NEU3 is highly expressed to enhance malignant phenotypes including apoptosis inhibition in malignant melanomas...
  53. ncbi request reprint Molecular cloning and expression of human ST6GalNAc III: restricted tissue distribution and substrate specificity
    Akiko Tsuchida
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    J Biochem 138:237-43. 2005
    ..e. GM1b and sialyl lactotetraosylceramide, was observed. hST6GalNAc III also showed sialyltransferase activity toward O-glycans (but not N-glycans) in fetuin...
  54. doi request reprint Reduced motor and sensory functions and emotional response in GM3-only mice: emergence from early stage of life and exacerbation with aging
    Orie Tajima
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Behav Brain Res 198:74-82. 2009
    ....
  55. doi request reprint Wisp2/CCN5 up-regulated in the central nervous system of GM3-only mice facilitates neurite formation in Neuro2a cells via integrin-Akt signaling
    Yuki Ohkawa
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Biochem Biophys Res Commun 411:483-9. 2011
    ..Up-regulation of Wisp2/CCN5 in GM3-only mice should be, therefore, a reaction to protect nervous tissues from neurodegeneration caused by ganglioside deficiency...
  56. ncbi request reprint Expression and roles of a xenopus head-forming gene homologue in human cancer cell lines
    Yingsong Zhu
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Nagoya J Med Sci 70:73-82. 2008
    ..Over-expression of hu-Shisa-2 resulted in increased cell growth and invasion, suggesting that hu-Shisa-2 is involved in the evolution and/or progression of human cancers...
  57. pmc Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3
    Kazunori Hamamura
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, USA
    J Biol Chem 286:18526-37. 2011
    ..Knockdown of GD3 synthase resulted in the alleviation of tumor phenotypes and reduced activation levels of Yes. Taken together, these results suggest a role of GD3 in the regulation of Src family kinases...
  58. doi request reprint Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis
    Kenichi Nogimori
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Oncol 49:1369-76. 2016
    ..In conclusion, our results suggest that ppGalNAc-T13 might be a useful prognostic factor of lung cancers. ..
  59. pmc Neogenin, Defined as a GD3-associated Molecule by Enzyme-mediated Activation of Radical Sources, Confers Malignant Properties via Intracytoplasmic Domain in Melanoma Cells
    Kei Kaneko
    From the Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya 466 0065
    J Biol Chem 291:16630-43. 2016
    ..ChIP-sequencing was performed to identify candidates of target genes of Ne-ICD. Some of them actually showed increased expression after expression of Ne-ICD, probably exerting malignant phenotypes of melanomas under GD3 expression. ..
  60. pmc Binding of a sialic acid-recognizing lectin Siglec-9 modulates adhesion dynamics of cancer cells via calpain-mediated protein degradation
    Ilhamjan Sabit
    From the Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya 466 0065, Japan
    J Biol Chem 288:35417-27. 2013
    ..Thus, this might be a mechanism by which cancer cells utilize Siglec-9-derived signals to escape from immunosurveillance. ..
  61. ncbi request reprint Loss of disialyl Lewis(a), the ligand for lymphocyte inhibitory receptor sialic acid-binding immunoglobulin-like lectin-7 (Siglec-7) associated with increased sialyl Lewis(a) expression on human colon cancers
    Keiko Miyazaki
    Department of Molecular Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Res 64:4498-505. 2004
    ..Treatment of cancer cells with butyrate or 5-azacytidine induced strongly disialyl Lewis(a) expression, suggesting that histone deacetylation and/or DNA methylation may be involved in the silencing of the gene in cancers...
  62. doi request reprint O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1
    Yuta Sakaidani
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Biochem Biophys Res Commun 419:14-9. 2012
    ..These results suggest that Eogt1 encodes EGF domain O-GlcNAc transferase and that O-GlcNAcylation reaction in the secretory pathway is a fundamental biochemical process conserved through evolution...
  63. pmc Imipramine inhibition of TRPM-like plasmalemmal Mg2+ transport in vascular smooth muscle cells
    Yukihisa Hamaguchi
    Department of Cell Physiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Cell Mol Med 15:593-601. 2011
    ..This inhibitory effect appears to contribute, at least partially, to the link between antidepressants and the risk of vascular diseases...
  64. ncbi request reprint Aurora-B associated protein phosphatases as negative regulators of kinase activation
    Keiichi Sugiyama
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 0065, Japan
    Oncogene 21:3103-11. 2002
    ..We found that this enzyme is an arginine-directed kinase that can phosphorylate histone H3 at serines 10 and 28 in vitro, suggesting that human Aurora-B is a mitotic histone H3 kinase...
  65. doi request reprint UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor α and interleukin 6
    Maiko Miyata
    Department of Life and Medical Sciences, Chubu University Faculty of Life and Health Sciences, Matsumoto, Kasugai 487 8501, Japan Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Biochem Biophys Res Commun 445:504-10. 2014
    ....
  66. ncbi request reprint Down-regulation of caveolin-1 in mouse Lewis lung cancer P29 is a causal factor for the malignant properties in a high-metastatic subline
    Qing Zhang
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya 466 0065, Japan
    Oncol Rep 16:289-94. 2006
    ..Thus, down-regulation of caveolin-1 in a high-metastatic subline of Lewis lung cancer as defined by DNA array is really a causal factor for the increased malignant properties...
  67. doi request reprint pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen
    Yasuyuki Matsumoto
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Biochem Biophys Res Commun 419:7-13. 2012
    ..These data suggested that high expression of pp-GalNAc-T13 gene generated trimeric Tn antigen on Syndecan-1, leading to the enhanced metastasis...
  68. doi request reprint Efficient generation of useful monoclonal antibodies reactive with globotriaosylceramide using knockout mice lacking Gb3/CD77 synthase
    Yuji Kondo
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Tsurumai, Showa Ku, Nagoya, Japan
    Glycoconj J 28:371-84. 2011
    ..All these results suggested that A4GalT-knockout mice are very useful to generate mAbs against globo-series glycolipids, and that suppressive signaling pathway driven by endogenous Gb3-ligand molecules might be present in B cells...
  69. ncbi request reprint Morphological study of disordered myelination and the degeneration of nerve fibers in the spinal cord of mice lacking complex gangliosides
    Qian Ma
    Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Arch Histol Cytol 66:37-44. 2003
    ....
  70. doi request reprint O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions
    Yuta Sakaidani
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Nat Commun 2:583. 2011
    ..Thus, O-GlcNAcylation of secreted and membrane glycoproteins is a novel mediator of cell-cell or cell-matrix interactions at the cell surface...
  71. doi request reprint Involvement of NGF in the rat model of persistent muscle pain associated with taut band
    Koei Hayashi
    Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Pain 12:1059-68. 2011
    ..NGF expressed in regenerating muscle cells may have an important role in persistent mechanical muscle hyperalgesia which might be relevant to pathogenesis of MPS...
  72. ncbi request reprint Identification of a Drosophila gene encoding xylosylprotein beta4-galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis
    Yoko Nakamura
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    J Biol Chem 277:46280-8. 2002
    ..Our results demonstrate that Drosophila beta4GalT7 has the in vitro and in vivo properties predicted for an ortholog of human beta4GalT7 and is essential for normal animal development through its role in proteoglycan biosynthesis...
  73. ncbi request reprint An anti-GD2 monoclonal antibody enhances apoptotic effects of anti-cancer drugs against small cell lung cancer cells via JNK (c-Jun terminal kinase) activation
    Shoko Yoshida
    Department of Biochemistry II, Nagoya University School of Medicine, Showa Ku, Nagoya 466 0065, Japan
    Jpn J Cancer Res 93:816-24. 2002
    ..These results suggest that anti-GD2 mAbs would be very efficient in combination with anti-cancer drugs, both to achieve SCLC-specific cytotoxicity and to enhance its magnitude...
  74. doi request reprint Positive feedback loop between PI3K-Akt-mTORC1 signaling and the lipogenic pathway boosts Akt signaling: induction of the lipogenic pathway by a melanoma antigen
    Yoshio Yamauchi
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Res 71:4989-97. 2011
    ..We thus propose a positive feedback circuit in which PI3K-Akt-mTORC1-SREBP signaling boosts Akt signaling in human melanoma cells expressing GD3...
  75. ncbi request reprint Incorporation, remodeling and re-expression of exogenous gangliosides in human cancer cell lines in vitro and in vivo
    Masashi Nishio
    Department of Biochemistry II, Nagoya University School of Medicine, Nagoya 466 0065, Japan
    Nagoya J Med Sci 67:35-44. 2004
    ..These results indicated the presence of a pathway for utilization of exogenous gangliosides for remodeling and re-expression in vivo...
  76. pmc Strong antibody reaction against glycosphingolipids injected in liposome-embedded forms in beta3GN-T5 knockout mice
    Xiaoyan Fan
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Nagoya J Med Sci 73:137-46. 2011
    ..These results suggested that beta3Gn-T5 mutant mice are useful for the generation of anti-glycolipid antigens with lacto-/neolacto-core structures expressed in cancer cells...
  77. doi request reprint Glycosphingolipids are not pivotal receptors for Subtilase cytotoxin in vivo: sensitivity analysis with glycosylation-defective mutant mice
    Yuji Kondo
    Department of Biochemistry II, Nagoya University, Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Aichi, Japan
    Biochem Biophys Res Commun 378:179-81. 2009
    ..Consequently, all mutant mice died at around 70h after intraperitoneal injection of 10 microg (or 7.5 microg) of SubAB as well as wild type mice. These results indicated none of glycolipids are not pivotal receptor for SubAB in the body...
  78. pmc Gangliosides GM1 and GM3 in the living cell membrane form clusters susceptible to cholesterol depletion and chilling
    Akikazu Fujita
    Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Mol Biol Cell 18:2112-22. 2007
    ..The present method enabled to capture the molecular distribution of lipids in the cell membrane, and demonstrated that GM1 and GM3 form clusters that are susceptible to cholesterol depletion and chilling...
  79. ncbi request reprint Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms
    Gavin Nicoll
    The School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, GB
    Eur J Immunol 33:1642-8. 2003
    ..These findings have important implications for NK cell cytotoxicity against tumor cells like melanoma that express high levels of GD3 ganglioside...
  80. doi request reprint O-GlcNAc modification of the extracellular domain of Notch receptors
    Yuta Sakaidani
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Methods Enzymol 480:355-73. 2010
    ..We also describe a method to detect O-GlcNAc transferase activity from crude membrane fraction proteins prepared from cultured S2 cells...
  81. ncbi request reprint Refractory skin injury in complex knock-out mice expressing only the GM3 ganglioside
    Masahiro Inoue
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    J Biol Chem 277:29881-8. 2002
    ..Thus, only GM3-expressing mice displayed the important role of gangliosides in maintaining skin integrity via regulation of the peripheral nerves...
  82. ncbi request reprint Roles of glycolipids in the development and maintenance of nervous tissues
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University School of Medicine, Nagoya, Aichi, Japan
    Methods Enzymol 417:37-52. 2006
    ....
  83. doi request reprint TRP channels and ASICs mediate mechanical hyperalgesia in models of inflammatory muscle pain and delayed onset muscle soreness
    Yuko Fujii
    Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Pain 140:292-304. 2008
    ..TRP channels and ASICs are closely related to the development of muscle mechanical hyperalgesia, and TRPV1 is involved in ECC-induced DOMS...
  84. ncbi request reprint Degradation of human Aurora-A protein kinase is mediated by hCdh1
    Sei ichi Taguchi
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai machi, Showa Ku, Nagoya, Japan
    FEBS Lett 519:59-65. 2002
    ....
  85. ncbi request reprint [Drug discovery sciences in Japan with focus on molecular-targeted drugs]
    Koichi Furukawa
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, College of Life and Health Sciences
    Nihon Rinsho 68:1797-802. 2010
    ..Application of results of glycobiology for these trials also seems promising. "On-target" side effects and prediction of drug-sensitivity are now urgent issues to be discreetly solved...
  86. ncbi request reprint Overexpression of GD1a ganglioside sensitizes motor nerve terminals to anti-GD1a antibody-mediated injury in a model of acute motor axonal neuropathy
    John A Goodfellow
    Division of Clinical Neurosciences, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, United Kingdom
    J Neurosci 25:1620-8. 2005
    ..These data indicate that anti-GD1a Abs arise via molecular mimicry and are likely to be clinically relevant in injuring peripheral nerve axonal membranes containing sufficiently high levels of GD1a...
  87. ncbi request reprint b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve
    Masahiko Okada
    Department of Pediatrics, School of Medicine, Nagasaki University, Sakamoto, Nagasaki 852 8501, Japan
    J Biol Chem 277:1633-6. 2002
    ....
  88. pmc Analysis of the role of Aurora B on the chromosomal targeting of condensin I
    Ai Takemoto
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba Science City, Ibaraki, Japan
    Nucleic Acids Res 35:2403-12. 2007
    ..From these results, it is suggested that Aurora B-dependent and Cdc2-independent pathways of the chromosomal targeting of condensin I are present...
  89. ncbi request reprint Induction of cellular immunity by anti-idiotypic antibodies mimicking GD2 ganglioside
    Saroj Basak
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, USA
    Cancer Immunol Immunother 52:145-54. 2003
    ..Our studies demonstrate the induction of ganglioside-specific T cell-dependent immunity by Ab2 in mice. These T cells showed specific reactivity to ganglioside expressed by tumor cells...
  90. ncbi request reprint Characterisation of the immunoglobulin variable region gene usage encoding the murine anti-ganglioside antibody repertoire
    Judith Boffey
    University Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland G51 4TF, United Kingdom
    J Neuroimmunol 165:92-103. 2005
    ..These data indicate that the discrete specificities of ganglioside-binding antibodies are dictated by particular patterns of V gene usage residing within the innate B cell repertoire...
  91. ncbi request reprint Complex gangliosides at the neuromuscular junction are membrane receptors for autoantibodies and botulinum neurotoxin but redundant for normal synaptic function
    Roland W M Bullens
    Department of Neurology, Leiden University Medical Centre, 2300 RC, Leiden, The Netherlands
    J Neurosci 22:6876-84. 2002
    ..These data prove the critical importance of complex gangliosides in mediating pathophysiological events at the neuromuscular synapse...
  92. ncbi request reprint Plasma membrane rafts complete cholesterol synthesis by participating in retrograde movement of precursor sterols
    Yoshio Yamauchi
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 282:34994-5004. 2007
    ..Our results reveal a previously undisclosed function of the PM lipid rafts: they bring cholesterol biosynthesis to completion by participating in the retrograde movement of precursor sterols back to the ER...
  93. ncbi request reprint Cholera toxin activates dendritic cells through dependence on GM1-ganglioside which is mediated by NF-kappaB translocation
    Yuki I Kawamura
    Department of Gastroenterology, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Eur J Immunol 33:3205-12. 2003
    ..These results highlight gangliosides expressed by DC for recognition of the non-self protein bacterial enterotoxin, which employ a unique signaling pathway to induce both innate and adaptive immunity...
  94. ncbi request reprint Role of estrogen receptor-related antigen in initiating the growth of human glioma cells
    M Humayun Khalid
    Department of Neurological Surgery, George Washington University Medical Center, Washington, DC, USA
    J Neurosurg 100:923-30. 2004
    ..The authors evaluated the role of ER-D5 in the growth of gliomas in vitro...
  95. ncbi request reprint Expansion of natural killer cells in mice transgenic for IgM antibody to ganglioside GD2: demonstration of prolonged survival after challenge with syngeneic tumor cells
    Ikuo Kawashima
    Department of Tumor Immunology, Tokyo Metropolitan Organization for Medical Research, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113 8613, Japan
    Int J Oncol 23:381-8. 2003
    ..Taking these results together, our studies demonstrate that the TG mice have significant anti-tumor characteristics, probably due to CDC and NK cell expansion and activation with anti-ganglioside GD2 antibody...
  96. pmc Tolerance to self gangliosides is the major factor restricting the antibody response to lipopolysaccharide core oligosaccharides in Campylobacter jejuni strains associated with Guillain-Barré syndrome
    Tyrone Bowes
    University Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland G51 4TF
    Infect Immun 70:5008-18. 2002
    ..The anti-ganglioside response generated in response to LPS is also dependent on the epitope density of the ganglioside mimicked and can be further manipulated by providing secondary signals via lipid A and CD40 ligation...
  97. ncbi request reprint Roles of complex gangliosides at the neuromuscular junction
    R W M Bullens
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Ann N Y Acad Sci 998:401-3. 2003
  98. ncbi request reprint Gangliosides contribute to stability of paranodal junctions and ion channel clusters in myelinated nerve fibers
    Keiichiro Susuki
    Department of Neurology, Dokkyo Medical University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Glia 55:746-57. 2007
    ..These results indicate that gangliosides are lipid raft components that contribute to stability and maintenance of neuron-glia interactions at paranodes...
  99. ncbi request reprint Stable transfection of GM1 synthase gene into GM1-deficient NG108-15 cells, CR-72 cells, rescues the responsiveness of Trk-neurotrophin receptor to its ligand, NGF
    Tatsuro Mutoh
    2nd Department of Internal Medicine, Faculty of Medicine, Fukui Medical University, Japan
    Neurochem Res 27:801-6. 2002
    ..These studies strongly suggested that GM1 is necessary for the normal expression of the Trk protein function and for normal targeting of the Trk protein to the plasma membrane...
  100. ncbi request reprint Overexpression of ganglioside GM1 results in the dispersion of platelet-derived growth factor receptor from glycolipid-enriched microdomains and in the suppression of cell growth signals
    Teruhiko Mitsuda
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Nagoya, 466 0065 Japan
    J Biol Chem 277:11239-46. 2002
    ..These findings suggested that GM1 regulates signals via PDGF/PDGFR by controlling the distribution of PDGFR in- and outside of GEM, and also interacting with PDGFR in the GEM fraction as a functional constituent of the microdomain...
  101. ncbi request reprint Expression of the Gb3/CD77 synthase gene in megakaryoblastic leukemia cells: implication in the sensitivity to verotoxins
    Keiko Furukawa
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Nagoya 466 0065, Japan
    J Biol Chem 277:11247-54. 2002
    ..This may be one of the causes of thrombocytopenia in patients with hemolytic uremic syndrome...