Koichi Izumikawa

Summary

Affiliation: Nagasaki University
Country: Japan

Publications

  1. doi request reprint Recent advances in chronic pulmonary aspergillosis
    Koichi Izumikawa
    Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan Electronic address
    Respir Investig 54:85-91. 2016
  2. pmc Paradoxical response to disseminated non-tuberculosis mycobacteriosis treatment in a patient receiving tumor necrosis factor-α inhibitor: a case report
    Takahiro Takazono
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, Nagasaki, Japan
    BMC Infect Dis 14:114. 2014
  3. doi request reprint Efficacy and safety of garenoxacin tablets on clinically diagnosed atypical pneumonia: postmarketing surveillance in Japan
    Koichi Izumikawa
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan Electronic address
    J Infect Chemother 20:541-8. 2014
  4. doi request reprint Efficacy and safety of garenoxacin tablets on bacterial pneumonia: postmarketing surveillance in Japan
    Koichi Izumikawa
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Electronic address
    J Infect Chemother 20:549-57. 2014
  5. doi request reprint Clinical features, risk factors and treatment of fulminant Mycoplasma pneumoniae pneumonia: a review of the Japanese literature
    Koichi Izumikawa
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Nagasaki University Infection Control and Education Center, Nagasaki University Hospital, Nagasaki, Japan Electronic address
    J Infect Chemother 20:181-5. 2014
  6. doi request reprint Pathogenesis and clinical features of chronic pulmonary aspergillosis - is it possible to distinguish CNPA and CCPA clinically?
    Koichi Izumikawa
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Electronic address
    J Infect Chemother 20:208-12. 2014
  7. pmc A double-blind comparative study of the safety and efficacy of caspofungin versus micafungin in the treatment of candidiasis and aspergillosis
    S Kohno
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Eur J Clin Microbiol Infect Dis 32:387-97. 2013
  8. doi request reprint Bronchoalveolar lavage galactomannan for the diagnosis of chronic pulmonary aspergillosis
    Koichi Izumikawa
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Med Mycol 50:811-7. 2012
  9. doi request reprint Management of chronic pulmonary aspergillosis
    Koichi Izumikawa
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Ann N Y Acad Sci 1272:40-8. 2012
  10. ncbi request reprint A case of splenic abscess during treatment of interstitial pneumonia
    Koichi Izumikawa
    Department of Internal Medicine, Izumikawa Hospital, Nagasaki 859 1504, Japan
    Jpn J Infect Dis 59:320-2. 2006

Detail Information

Publications103 found, 100 shown here

  1. doi request reprint Recent advances in chronic pulmonary aspergillosis
    Koichi Izumikawa
    Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan Electronic address
    Respir Investig 54:85-91. 2016
    ..Additional evidence and translational research regarding diagnosis, management, and drug resistance are urgently needed to improve the outcome of CPA. ..
  2. pmc Paradoxical response to disseminated non-tuberculosis mycobacteriosis treatment in a patient receiving tumor necrosis factor-α inhibitor: a case report
    Takahiro Takazono
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, Nagasaki, Japan
    BMC Infect Dis 14:114. 2014
    ..Here, we report a disseminated non-tuberculosis case caused by TNF-α inhibitor therapy and a probable paradoxical response to antimycobacterial therapy...
  3. doi request reprint Efficacy and safety of garenoxacin tablets on clinically diagnosed atypical pneumonia: postmarketing surveillance in Japan
    Koichi Izumikawa
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan Electronic address
    J Infect Chemother 20:541-8. 2014
    ..0% (1/105), respectively. In conclusion, garenoxacin showed an efficacy rate of greater than 90% for suspected atypical pneumonia and confirmed atypical pneumonia. Garenoxacin is considered to be useful in daily practice...
  4. doi request reprint Efficacy and safety of garenoxacin tablets on bacterial pneumonia: postmarketing surveillance in Japan
    Koichi Izumikawa
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Electronic address
    J Infect Chemother 20:549-57. 2014
    ..6% patients (12/730). In conclusion, garenoxacin showed an efficacy rate of greater than 90% for bacterial pneumonia and is considered to be useful in daily practice...
  5. doi request reprint Clinical features, risk factors and treatment of fulminant Mycoplasma pneumoniae pneumonia: a review of the Japanese literature
    Koichi Izumikawa
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Nagasaki University Infection Control and Education Center, Nagasaki University Hospital, Nagasaki, Japan Electronic address
    J Infect Chemother 20:181-5. 2014
    ....
  6. doi request reprint Pathogenesis and clinical features of chronic pulmonary aspergillosis - is it possible to distinguish CNPA and CCPA clinically?
    Koichi Izumikawa
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Electronic address
    J Infect Chemother 20:208-12. 2014
    ..We examined all types of CPA cases with histopathological evidence to clarify the differences in pathogenesis and clinical features...
  7. pmc A double-blind comparative study of the safety and efficacy of caspofungin versus micafungin in the treatment of candidiasis and aspergillosis
    S Kohno
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Eur J Clin Microbiol Infect Dis 32:387-97. 2013
    ..Consistent with other data on these two agents, the efficacy of caspofungin and micafungin was similar...
  8. doi request reprint Bronchoalveolar lavage galactomannan for the diagnosis of chronic pulmonary aspergillosis
    Koichi Izumikawa
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Med Mycol 50:811-7. 2012
    ..7, they were 66.7% and 63.5%, respectively. GM testing using BALF showed reasonable sensitivity and specificity as compared to that using serum. Thus, assessing GM levels in BALF may enhance the accuracy of diagnosing CPA...
  9. doi request reprint Management of chronic pulmonary aspergillosis
    Koichi Izumikawa
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Ann N Y Acad Sci 1272:40-8. 2012
    ..New antifungal drugs with novel mechanisms of action are also needed...
  10. ncbi request reprint A case of splenic abscess during treatment of interstitial pneumonia
    Koichi Izumikawa
    Department of Internal Medicine, Izumikawa Hospital, Nagasaki 859 1504, Japan
    Jpn J Infect Dis 59:320-2. 2006
    ..Although CT-guided percutaneous drainage followed by postoperative antibiotic therapy are normally required for the treatment of splenic abscess, the patient was successfully treated by the administration of vancomycin without drainage...
  11. doi request reprint A case of pulmonary cryptococcosis followed by pleuritis in an apparently immunocompetent patient during fluconazole treatment
    Koichi Izumikawa
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Med Mycol 46:595-9. 2008
    ..neoformans. Voriconazole with flucytosine and drainage of the pleural effusion were effective in treating the patient...
  12. pmc Evaluation of a rapid immunochromatographic ODK0501 assay for detecting Streptococcus pneumoniae antigen in sputum samples from patients with lower respiratory tract infection
    Koichi Izumikawa
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Clin Vaccine Immunol 16:672-8. 2009
    ..pneumoniae antigen among patients with underlying chronic obstructive pulmonary disease. In conclusion, ODK0501 is noninvasive, rapid, and an accurate tool for diagnosing respiratory infection caused by S. pneumoniae...
  13. ncbi request reprint Unique mutations of the cystic fibrosis transmembrane conductance regulator gene of three cases of cystic fibrosis in Nagasaki, Japan
    Koichi Izumikawa
    The Second Department of Internal Medicine, Nagasaki University School of Medicine
    Intern Med 48:1327-31. 2009
    ..Although the numbers of individuals with CF are very limited, the profiles of CFTR mutations in those patients are likely diverse in Japan...
  14. ncbi request reprint Diffuse alveolar hemorrhage following itraconazole injection
    Koichi Izumikawa
    The Second Department of Internal Medicine, Nagasaki University School of Medicine
    Intern Med 49:497-500. 2010
    ..The patient did not respond to pulse methylprednisolone therapy, but responded dramatically to direct hemoperfusion using a polymyxin B-immobilized fiber column (PMX) therapy...
  15. doi request reprint Chronic aspergillus infections of the respiratory tract: diagnosis, management and antifungal resistance
    Koichi Izumikawa
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Curr Opin Infect Dis 23:584-9. 2010
    ..that requires specific knowledge in terms of disease entity, diagnosis, management and azole resistance. This review focuses on the recent understanding of CPA entity and the emergence of azole resistance in CPA...
  16. ncbi request reprint A case of concurrent sarcoidosis, aortitis syndrome and Crohn's disease
    Koichi Izumikawa
    Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Japan
    Intern Med 50:2915-7. 2011
    ..This is the first report of concurrent sarcoidosis, Crohn's disease and aortitis syndrome in an individual...
  17. doi request reprint Role of the Slt2 mitogen-activated protein kinase pathway in cell wall integrity and virulence in Candida glabrata
    Taiga Miyazaki
    Department of Molecular Microbiology and Immunology, Nagasaki University School of Medicine, Nagasaki, Japan
    FEMS Yeast Res 10:343-52. 2010
    ..These fundamental data will help in further understanding the mechanisms of cell wall stress response in C. glabrata and developing more effective treatments using echinocandin antifungals in clinical settings...
  18. pmc Efficacy of clarithromycin against experimentally induced pneumonia caused by clarithromycin-resistant Haemophilus influenzae in mice
    Shigeki Nakamura
    Second Department of Internal Medicine, Nagasaki University Hospital, and Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan
    Antimicrob Agents Chemother 54:757-62. 2010
    ..influenzae, and this phenomenon may be related to the good penetration of clarithromycin into bronchoepithelial cells. We also believe that conventional drug susceptibility tests may not reflect the in vivo effects of clarithromycin...
  19. doi request reprint In vivo efficacy of biapenem with ME1071, a novel metallo-β-lactamase (MBL) inhibitor, in a murine model mimicking ventilator-associated pneumonia caused by MBL-producing Pseudomonas aeruginosa
    Koichi Yamada
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Int J Antimicrob Agents 42:238-43. 2013
    ..8% with ME1071. These results suggest that ME1071 is potent and effective for treatment of VAP caused by MBL-producing P. aeruginosa...
  20. doi request reprint In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia
    Yoshitomo Morinaga
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Exp Lung Res 36:484-90. 2010
    ..The combination therapy can contribute to treatment of L. pneumophila pneumonia with protecting lungs...
  21. doi request reprint Azithromycin, clarithromycin and telithromycin inhibit MUC5AC induction by Chlamydophila pneumoniae in airway epithelial cells
    Yoshitomo Morinaga
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Pulm Pharmacol Ther 22:580-6. 2009
    ..In this study, we examined whether C. pneumoniae induces MUC5AC mucin in airway epithelial cells. We also examined the effects of macrolide and ketolide antibiotics on the C. pneumoniae-induced mucus production...
  22. pmc Prevotella intermedia induces severe bacteremic pneumococcal pneumonia in mice with upregulated platelet-activating factor receptor expression
    Kentaro Nagaoka
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Infect Immun 82:587-93. 2014
    ..Thus, P. intermedia has the potential to induce severe bacteremic pneumococcal pneumonia with enhanced pneumococcal adhesion to lower airway cells. ..
  23. pmc Azithromycin attenuates lung inflammation in a mouse model of ventilator-associated pneumonia by multidrug-resistant Acinetobacter baumannii
    Koichi Yamada
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Antimicrob Agents Chemother 57:3883-8. 2013
    ..05) in the AZM-treated groups. AZM may have a role for the treatment of VAP with MDRAB because of its anti-inflammatory effects. ..
  24. doi request reprint In vivo efficacy and pharmacokinetics of biapenem in a murine model of ventilator-associated pneumonia with Pseudomonas aeruginosa
    Koichi Yamada
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    J Infect Chemother 18:472-8. 2012
    ..aeruginosa. Therefore, BIPM might be a potent and effective treatment for VAP caused by this bacterium...
  25. ncbi request reprint A case of Legionella pneumophila pneumonia followed by invasive aspergillosis
    Tomomi Saijo
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852 8501, Japan
    Jpn J Infect Dis 61:379-81. 2008
    ....
  26. doi request reprint In vivo efficacy and pharmacokinetics of tomopenem (CS-023), a novel carbapenem, against Pseudomonas aeruginosa in a murine chronic respiratory tract infection model
    Yoshitomo Morinaga
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Antimicrob Chemother 62:1326-31. 2008
    ..We compared the in vivo activity of tomopenem and that of meropenem in a chronic lower respiratory infection mouse model of P. aeruginosa...
  27. pmc Efficacy of SPK-843, a novel polyene antifungal, in comparison with amphotericin B, liposomal amphotericin B, and micafungin against murine pulmonary aspergillosis
    Hiroshi Kakeya
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Antimicrob Agents Chemother 52:1868-70. 2008
    ..0 mg/kg) and liposomal amphotericin B (AmBisome) (8.0 mg/kg)...
  28. doi request reprint Efficacy of ME1036 against meticillin-resistant Staphylococcus aureus and vancomycin-insensitive S. aureus in a model of haematogenous pulmonary infection
    Katsunori Yanagihara
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Int J Antimicrob Agents 32:401-4. 2008
    ..07+/-0.45 for control (P<0.001)). ME1036 produced >3 log(10) reduction versus control against both MRSA strains (>5 log for the VCM-susceptible strain and 3.4 log for the VISA), whereas VCM produced <1.3 log for both strains...
  29. pmc Melting curve analysis for rapid detection of topoisomerase gene mutations in Haemophilus influenzae
    Shigeki Nakamura
    Second Department of Internal Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan
    J Clin Microbiol 47:781-4. 2009
    ..This assay is a useful tool for the detection of fluoroquinolone resistance and for the early detection of preexisting QRDR mutations...
  30. doi request reprint In vivo efficacy of sitafloxacin in a new murine model of non-typeable Haemophilus influenzae pneumonia by sterile intratracheal tube
    Shigeki Nakamura
    Second Department of Internal Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan
    Int J Antimicrob Agents 34:210-4. 2009
    ..influenzae pneumonia. This new murine NTHi pneumonia model appears useful not only for in vivo evaluation of antibiotics but also for analysis of the pathogenesis of H. influenzae pneumonia...
  31. pmc Correlation between triazole treatment history and susceptibility in clinically isolated Aspergillus fumigatus
    Masato Tashiro
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Antimicrob Agents Chemother 56:4870-5. 2012
    ..We should consider the possible appearance of azole-resistant A. fumigatus if itraconazole is used for extended periods...
  32. doi request reprint The glycosylphosphatidylinositol-linked aspartyl protease Yps1 is transcriptionally regulated by the calcineurin-Crz1 and Slt2 MAPK pathways in Candida glabrata
    Taiga Miyazaki
    Department of Molecular Microbiology and Immunology, Nagasaki University School of Medicine, Japan
    FEMS Yeast Res 11:449-56. 2011
    ..glabrata have been characterized using a Δcrz1 mutant, monitoring the expression of YPS1 represents an effective method for measuring the activity of the calcineurin-Crz1 signaling pathway in this fungus...
  33. doi request reprint Functional characterization of the regulators of calcineurin in Candida glabrata
    Taiga Miyazaki
    Department of Molecular Microbiology and Immunology, Nagasaki University School of Medicine, Japan
    FEMS Yeast Res 11:621-30. 2011
    ..Phenotypic analyses of C. glabrata strains lacking either RCNs, calcineurin, or both revealed that calcineurin requires Rcn1, but not Rcn2, for antifungal tolerance in C. glabrata...
  34. pmc Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus
    Rie Kihara
    Department of Pharmacotherapeutics, Nagasaki University Graduate School of Pharmaceutical Sciences, Nagasaki, Japan
    Antimicrob Agents Chemother 52:2163-8. 2008
    ..Our results demonstrate the potency of SMP-601 against MRSA and VISA in murine hematogenous pulmonary infection...
  35. ncbi request reprint A clinical comparative study of piperacillin and sulbactam/ampicillin in patients with community-acquired bacterial pneumonia
    Masafumi Seki
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki
    Intern Med 48:49-55. 2009
    ..To evaluate the clinical usefulness of piperacillin (4 g/day) therapy for community-acquired pneumonia compared to sulbactam/ampicillin (6 g/day)...
  36. doi request reprint Multiplex real-time polymerase chain reaction for rapid detection of beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae
    Shigeki Nakamura
    Second Department of Internal Medicine, Nagasaki University Graduate School of Medical Science, 852 8501 Nagasaki, Japan
    Diagn Microbiol Infect Dis 64:64-9. 2009
    ..influenzae and identify beta-lactam susceptibility in only 3 h and with only one tube. This method will be helpful for the rapid detection of H. influenzae infections and the selection of appropriate antibiotics...
  37. doi request reprint Skn7p is involved in oxidative stress response and virulence of Candida glabrata
    Tomomi Saijo
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Mycopathologia 169:81-90. 2010
    ..These results suggest that Skn7p may play a role in transcriptional regulation of its target genes required for OSR and virulence in C. glabrata...
  38. pmc Toll-like receptor 4 agonistic antibody promotes innate immunity against severe pneumonia induced by coinfection with influenza virus and Streptococcus pneumoniae
    Akitaka Tanaka
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, Nagasaki, Japan
    Clin Vaccine Immunol 20:977-85. 2013
    ..pneumoniae. This immunomodulatory effect of UT12 improves the prognosis of secondary pneumococcal pneumonia and makes UT12 an attractive candidate for treating severe infectious diseases. ..
  39. ncbi request reprint [Efficacy of sivelestat for acute lung injury due to severe bacterial pneumonia with systemic inflammatory response syndrome]
    Shigeki Nakamura
    Second Department of Internal Medicine, Nagasaki University Hospital
    Nihon Kokyuki Gakkai Zasshi 46:793-7. 2008
    ..The purpose of this study is to investigate the effect of sivelestat to ALI due to severe bacterial pneumonia...
  40. pmc Efficacy of AiiM, an N-acylhomoserine lactonase, against Pseudomonas aeruginosa in a mouse model of acute pneumonia
    Yohei Migiyama
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Antimicrob Agents Chemother 57:3653-8. 2013
    ..Thus, AiiM can strongly attenuate P. aeruginosa virulence in a mammalian model and is a potential candidate for use as a therapeutic agent against P. aeruginosa infection. ..
  41. pmc In vivo efficacy of daptomycin against methicillin-resistant Staphylococcus aureus in a mouse model of hematogenous pulmonary infection
    Yosuke Harada
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Antimicrob Agents Chemother 57:2841-4. 2013
    ..001) and decreased the number of abscesses and bacteria in the lungs (P < 0.01). Daptomycin may be an effective therapeutic option for MRSA hematogenous pulmonary infection...
  42. doi request reprint In vivo efficacy of KRP-109, a novel elastase inhibitor, in a murine model of severe pneumococcal pneumonia
    Koichi Yamada
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan
    Pulm Pharmacol Ther 24:660-5. 2011
    ..The present results indicate that KRP-109 reduces lung inflammation in a murine model, and that KRP-109 may be useful for the treatment of patients with severe pneumonia...
  43. pmc In vitro activity of garenoxacin against Streptococcus pneumoniae mutants with characterized resistance mechanisms
    Kazuko Yamamoto
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki City 852 8501, Japan
    Antimicrob Agents Chemother 53:3572-5. 2009
    ..Genetic analysis of the S. pneumoniae mutants created by garenoxacin revealed that the gyrA gene was a primary target of garenoxacin...
  44. ncbi request reprint Synergistic antifungal effect of lactoferrin with azole antifungals against Candida albicans and a proposal for a new treatment method for invasive candidiasis
    Tsutomu Kobayashi
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8501, Japan
    Jpn J Infect Dis 64:292-6. 2011
    ..The results of this study might contribute to the improvement of our understand of the mechanisms underlying the resistance of Candida strains...
  45. pmc A mortality prediction rule for non-elderly patients with community-acquired pneumonia
    Masato Tashiro
    Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    BMC Pulm Med 16:39. 2016
    ..Therefore, we tried to create a mortality prediction rule that is simple and suitable for non-elderly patients with community-acquired pneumonia...
  46. ncbi request reprint Increase of apoptosis in a murine model for severe pneumococcal pneumonia during influenza A virus infection
    Kosuke Kosai
    Second Department of Internal Medicine, Nagasaki University, Nagasaki 852 8501, Japan
    Jpn J Infect Dis 64:451-7. 2011
    ..pneumoniae infection. These data suggest that early onset of apoptosis and its related factors play important roles in fulminant pneumonia resulting from bacterial pneumonia complicated by co-infection with influenza virus...
  47. ncbi request reprint Disease severity in patients with simultaneous influenza and bacterial pneumonia
    Masafumi Seki
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences
    Intern Med 46:953-8. 2007
    ..To determine the differences in the clinical features of bacterial pneumonia patients between patients co-infected with influenza virus or not co-infected...
  48. doi request reprint The heme-binding protein Dap1 links iron homeostasis to azole resistance via the P450 protein Erg11 in Candida glabrata
    Naoki Hosogaya
    Department of Molecular Microbiology and Immunology, Nagasaki University School of Medicine, Nagasaki, Japan
    FEMS Yeast Res 13:411-21. 2013
    ..Our study demonstrates that Dap1 mediates a functional link between iron homeostasis and azole resistance in C. glabrata...
  49. doi request reprint Efficacy of linezolid against Panton-Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) in a mouse model of haematogenous pulmonary infection
    Katsunori Yanagihara
    Department of Laboratory Medicine, Nagasaki University Graduate School of Medical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Int J Antimicrob Agents 34:477-81. 2009
    ..aureus haematogenous infection and improved the survival rate of infected mice compared with VAN. LZD is clinically effective against PVL-positive S. aureus...
  50. pmc Macrolides inhibit Fusobacterium nucleatum-induced MUC5AC production in human airway epithelial cells
    Kentaro Nagaoka
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Antimicrob Agents Chemother 57:1844-9. 2013
    ..Macrolides seem to reduce this mucin production and might represent an additional means of therapeutic intervention for F. nucleatum respiratory tract infections other than CLDM and MTZ...
  51. pmc Efficacy of combination antifungal therapy with intraperitoneally administered micafungin and aerosolized liposomal amphotericin B against murine invasive pulmonary aspergillosis
    Takahiro Takazono
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Antimicrob Agents Chemother 53:3508-10. 2009
    ....
  52. pmc Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata
    Taiga Miyazaki
    Department of Molecular Microbiology and Immunology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Antimicrob Agents Chemother 54:1639-43. 2010
    ..These results suggest that calcineurin regulates both Crz1-dependent and -independent pathways depending on the type of stress...
  53. pmc Antifungal susceptibilities of Aspergillus fumigatus clinical isolates obtained in Nagasaki, Japan
    Masato Tashiro
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Antimicrob Agents Chemother 56:584-7. 2012
    ..Amphotericin B MICs of ≥2 μg/ml and micafungin minimum effective concentrations (MECs) of ≥16 μg/ml were recorded for two and one isolates, respectively...
  54. ncbi request reprint A case of refractory chronic respiratory tract infection due to Pseudomonas aeruginosa successfully controlled by combination of clarithromycin and azithromycin
    Yoshihiro Yamamoto
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Intern Med 51:1383-6. 2012
    ..Here we present a patient refractory to either single low-dose clarithromycin or azithromycin but responded remarkably to the combination usage of both macrolides...
  55. ncbi request reprint Expression and DNA microarray analysis of a platelet activating factor-related molecule in severe pneumonia in mice due to influenza virus and bacterial co-infection
    Masafumi Seki
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8501, Japan
    Jpn J Infect Dis 62:6-10. 2009
    ..These findings suggest that PAF and related molecules play important roles in fulminant pneumonia due to influenza virus infection, especially when severe bacterial pneumonia is complicated by co-infection with influenza virus...
  56. doi request reprint Prospective randomized comparison study of piperacillin/tazobactam and meropenem for healthcare-associated pneumonia in Japan
    Yoshihiro Yamamoto
    Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, Japan
    J Infect Chemother 19:291-8. 2013
    ..To investigate the differences in efficacy profiles of those two regimens, a further confirmatory study with a larger cohort as determined by a power analysis is recommended...
  57. ncbi request reprint A case series of chronic necrotizing pulmonary aspergillosis and a new proposal
    Takayoshi Tashiro
    Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Jpn J Infect Dis 66:312-6. 2013
    ..Although CNPA has characteristic pathological features, it is clinically difficult to distinguish CNPA from CCPA. We propose to use the term chronic progressive pulmonary aspergillosis for both CNPA and CCPA. ..
  58. doi request reprint Establishment of a new murine model of liver abscess induced by Fusobacterium necrophorum injected into the caudal vein
    Kentaro Nagaoka
    1Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Med Microbiol 62:1755-9. 2013
    ..necrophorum liver abscess via haematogenous infection that may be useful for investigating in vivo antimicrobial activity against anaerobic abscesses and understanding the pathogenesis of F. necrophorum infection. ..
  59. ncbi request reprint Effects of specific neutrophil elastase inhibitor, sivelestat sodium hydrate, in murine model of severe pneumococcal pneumonia
    Katsunori Yanagihara
    Second Department of Internal Medicine, University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Exp Lung Res 33:71-80. 2007
    ..A possible explanation for the improved survival is that sivelestat prevents tissue damage by inhibiting NE activity in the lung. Therefore, NE inhibitors may be useful for treating with patients with severe pneumonia...
  60. doi request reprint Subinhibitory concentrations of telithromycin, clarithromycin and azithromycin reduce methicillin-resistant Staphylococcus aureus coagulase in vitro and in vivo
    Katsunori Yanagihara
    Department of Laboratory Medicine, Nagasaki University Graduate School of Medical Sciences, Nagasaki, Japan
    J Antimicrob Chemother 61:647-50. 2008
    ..We also examined the effects of these antibiotics on bacterial survival in a murine model of pulmonary infection, in which the number of bacteria in the lung correlates with the coagulase titre...
  61. ncbi request reprint The roles of the quorum-sensing system in the release of extracellular DNA, lipopolysaccharide, and membrane vesicles from Pseudomonas aeruginosa
    Shigeki Nakamura
    Second Department of Internal Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki 852 8501, Japan
    Jpn J Infect Dis 61:375-8. 2008
    ..It is possible that these extracellular components are supplied from MVs. Investigation of the mechanism of biofilm formation is of particular interest, as it may be useful for designing treatments for severe P. aeruginosa infection...
  62. doi request reprint Characteristics and disease severity of healthcare-associated pneumonia among patients in a hospital in Kitakyushu, Japan
    Masafumi Seki
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Infect Chemother 17:363-9. 2011
    ..This study provides additional evidence that HCAP should be distinguished from CAP and suggests the pathogenesis and therapeutic strategy for HCAP may be similar to those for hospital-acquired pneumonia...
  63. ncbi request reprint Clinical efficacy of micafungin for chronic pulmonary aspergillosis
    Koichi Izumikawa
    Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Tokyo, Japan
    Med Mycol 45:273-8. 2007
    ..No notable adverse effects were documented during MCFG administration. These data suggest that MCFG may be an effective and safe antifungal drug for the treatment of chronic invasive forms of pulmonary aspergillosis...
  64. doi request reprint The definition of healthcare-associated pneumonia (HCAP) is insufficient for the medical environment in Japan: a comparison of HCAP and nursing and healthcare-associated pneumonia (NHCAP)
    Norihito Kaku
    Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan
    J Infect Chemother 19:70-6. 2013
    ..Therefore, there is a need to change the definition of HCAP according to the medical environment in Japan...
  65. ncbi request reprint Evaluation of the Cica Fungi Test Candida, a novel serum Candida mannan antigen kit, and its comparison with Cand-Tec in candidemia patients
    Takahiro Takazono
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, Nagasaki 852 8501, Japan
    Jpn J Infect Dis 64:116-20. 2011
    ..0005). The Cica Fungi Test was thus found to be more reliable and specific than Cand-Tec, and the combined evaluation with the β-D-glucan assay was more efficient for diagnosis of candidemia...
  66. doi request reprint The efficacy and safety of high-dose arbekacin sulfate therapy (once-daily treatment) in patients with MRSA infection
    Yoshihiro Yamamoto
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Infect Chemother 18:241-6. 2012
    ..Although the number of patients was limited, once-daily high-dose arbekacin sulfate therapy may be highly effective, without posing any major safety problems. Further larger-scale studies are needed...
  67. pmc Legionella pneumophila induces cathepsin B-dependent necrotic cell death with releasing high mobility group box1 in macrophages
    Yoshitomo Morinaga
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, 851 2128, Japan
    Respir Res 11:158. 2010
    ..Since necrosis is known to induce inflammation, we investigated whether LPN induces necrosis in macrophages. We also analyzed the involvement of lysosomal cathepsin B in LPN-induced cell death...
  68. ncbi request reprint Potency of DX-619, a novel des-F(6)-quinolone, in haematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus
    Katsunori Yanagihara
    Second Department of Internal Medicine, Nagasaki University Graduate School of Pharmaceutical Sciences, Nagasaki University Graduate School of Medical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Int J Antimicrob Agents 28:212-6. 2006
    ..Our results emphasise the potency of DX-619 against MRSA and VISA murine haematogenous pulmonary infection...
  69. ncbi request reprint The first telithromycin-resistant Streptococcus pneumoniae isolate in Japan associated with erm(B) and mutations in 23S rRNA and riboprotein L4
    Yoichi Hirakata
    Second Department of Internal Medicine, Nagasaki University School of Medicine and Dentistry, Nagasaki 852 8501, Japan
    Jpn J Infect Dis 60:48-50. 2007
    ..Although the long-term clarithromycin administration may have contributed to the induction of resistance in this patient, this could not be confirmed, since S. pneumoniae was not isolated until the present episode...
  70. pmc Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis
    Hiroshi Kakeya
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Antimicrob Agents Chemother 52:1871-2. 2008
    ..0 mg/kg SPK-843 led to better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B and 80 mg/kg fluconazole (P < 0.001), without histopathological renal changes...
  71. doi request reprint Pulmonary cryptococcosis in late pregnancy and review of published literature
    Shigeki Nakamura
    Second Department of Internal Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan
    Mycopathologia 167:125-31. 2009
    ..Pulmonary cryptococcosis should be considered during differential diagnosis as a possible cause of abnormal chest shadow in pregnant patients...
  72. ncbi request reprint Clinical comparative study of sulbactam/ampicillin and imipenem/cilastatin in elderly patients with community-acquired pneumonia
    Katsunori Yanagihara
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Intern Med 45:995-9. 2006
    ..To evaluate the clinical usefulness of sulbactam/ampicillin therapy for community-acquired pneumonia in the elderly...
  73. ncbi request reprint Clinical characteristics of tertiary hospital patients from whom Acinetobacter calcoaceticus-Acinetobacter baumannii complex strains were isolated
    Koichi Yamada
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Intern Med 51:51-7. 2012
    ..baumannii have been increasing. The aim of this study was to assess the clinical characteristics of A. calcoaceticus-A. baumannii complex (Acb complex) strains and to determine the risk factors of this infection...
  74. ncbi request reprint Active surveillance of methicillin-resistant Staphylococcus aureus with the BD GeneOhm MRSA™ assay in a respiratory ward in Nagasaki, Japan
    Koichi Izumikawa
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, Japan
    Jpn J Infect Dis 65:33-6. 2012
    ..The BD GeneOhm MRSA™ assay was proven to be a useful and rapid detection tool for MRSA...
  75. ncbi request reprint Severe Japanese spotted fever successfully treated with fluoroquinolone
    Masafumi Seki
    Nagasaki University Graduate School of Biomedical Sciences, Department of Molecular Microbiology and Immunology, The Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Intern Med 45:1323-6. 2006
    ..R. japonica-specific DNA was detected by PCR from the tick: Haemaphysalis hystricis larvae collected from a mountainous location in Fukuoka, Japan where the patient had been bitten...
  76. ncbi request reprint Clinical characteristics of pneumonia caused by beta-lactamase negative ampicillin resistant Haemophilus influenzae (BLNAR)
    Shigeki Nakamura
    Second Department of Internal Medicine, Nagasaki University Graduate School of Pharmaceutical Sciences, Nagasaki, Japan
    Scand J Infect Dis 39:521-4. 2007
    ..However, BLNAR pneumonia was more prominent in the younger than the older patients. This study should provide useful information for understanding the clinical characteristics of BLNAR pneumonia...
  77. ncbi request reprint Elevated levels of high mobility group box chromosomal protein-1 (HMGB-1) in sera from patients with severe bacterial pneumonia coinfected with influenza virus
    Kosuke Kosai
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical, Sakamoto, Japan
    Scand J Infect Dis 40:338-42. 2008
    ..05), despite similar levels of RANTES and sICAM-1 in the 2 groups. These data suggest that HMGB-1 is involved in the pathogenesis of severe bacterial pneumonia coinfected with influenza virus...
  78. ncbi request reprint Single-cell observation of phagocytosis by human blood dendritic cells
    Hiroshi Ishimoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852 8501, Japan
    Jpn J Infect Dis 61:294-7. 2008
    ..This novel system may be useful for the evaluation of rapid response with human immune cells against bacterial infection...
  79. ncbi request reprint [Study on the blood concentration and clinical efficacy of ceftazidime, a cephem antibiotic at dose of one gram q.i.d, for adult hospital-acquired pneumonia patients]
    Koichi Izumikawa
    The Second Department of Internal Medicine, Nagasaki University School of Medicine
    Jpn J Antibiot 62:9-16. 2009
    ..i.d. was considered to be a good way with increase of drug efficacy by maintaining highly blood concentration over prolonged period, and expected to be a good effect for hospital-acquired pneumonia...
  80. doi request reprint Diagnostic significance of Aspergillus species isolated from respiratory samples in an adult pneumology ward
    Takayoshi Tashiro
    Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University Hospital, Nagasaki, Japan
    Med Mycol 49:581-7. 2011
    ..Repeated isolation of the identical Aspergillus species and detection of anti-Aspergillus antibodies and/or Aspergillus antigens in sera are needed to determine the isolate represents the etiologic agent of disease...
  81. ncbi request reprint [Chronic fungal infection, up-to-date]
    Hiroshi Kakeya
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences
    Kansenshogaku Zasshi 85:333-9. 2011
    ..General antifungals are not highly active to biofilm-formed Aspergillus as same as Candida, and only amphotericin B and its liposomal formulation are expected to be effective in vitro...
  82. doi request reprint Intravenous micafungin versus voriconazole for chronic pulmonary aspergillosis: a multicenter trial in Japan
    Shigeru Kohno
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Infect 61:410-8. 2010
    ..4% vs. 61.1%, P = 0.0004). MCFG was as effective as VRCZ and significantly safer than as an initial treatment of CPA. (UMIN Clinical Trials Registry number, UMIN000001786.)...
  83. doi request reprint Live Legionella pneumophila induces MUC5AC production by airway epithelial cells independently of intracellular invasion
    Yoshitomo Morinaga
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1, Sakamoto, Nagasaki, Japan
    Can J Microbiol 58:151-7. 2012
    ..pneumophila induces MUC5AC production via the ERK-JNK and NF-κB pathways without internalization of bacteria and that the airway epithelium produces mucin as part of the immune response against L. pneumophila...
  84. doi request reprint Comparison of usefulness of plasma procalcitonin and C-reactive protein measurements for estimation of severity in adults with community-acquired pneumonia
    Yoichi Hirakata
    Second Department of Internal Medicine, Nagasaki University School of Medicine and Dentistry, Nagasaki, Japan
    Diagn Microbiol Infect Dis 61:170-4. 2008
    ..3% (28/58) of patients positive for PCT had moderate or severe CAP. Our findings suggest that PCT level might be more useful for estimating CAP severity than CRP level at the 1st visit...
  85. doi request reprint Reversible visual disturbance due to cryptococcal uveitis in a non-HIV individual
    Shigeki Nakamura
    Second Department of Internal Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Med Mycol 46:367-70. 2008
    ..This is a rare case of disseminated cryptococcosis involving uveitis, which was successfully treated by FLCZ. Disseminated cryptococcosis should be considered in cases with mild symptoms and V-A shunt installation for hydrocephalus...
  86. ncbi request reprint Spontaneous pyogenic spondylitis caused by Klebsiella pneumoniae
    Kosuke Kosai
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki
    Intern Med 47:1121-4. 2008
    ..Meropenem trihydrate administration improved her symptoms. Klebsiella pneumoniae isolated from the patient's blood indicated that the organism caused the spontaneous pyogenic spondylitis...
  87. ncbi request reprint A patient with fulminant influenza-related bacterial pneumonia due to Streptococcus pneumoniae followed by Mycobacterium tuberculosis infection
    Masafumi Seki
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki
    Intern Med 47:2043-7. 2008
    ..It is necessary to observe patients with influenza carefully, especially when steroids are used, even if antibiotics are also administered...
  88. ncbi request reprint Importance of controlling drug-resistant Pseudomonas aeruginosa infection: experience from lung transplantation in a cystic fibrosis case
    Yoshihiro Yamamoto
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki
    Intern Med 49:2353-8. 2010
    ..Strict monitoring of infections by the Gram staining and culture of respiratory specimens is considered to be effective in preventing lower respiratory infection in lung transplantation...
  89. doi request reprint Clinical efficacy and safety of micafungin in Japanese patients with chronic pulmonary aspergillosis: a prospective observational study
    Shigeru Kohno
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Med Mycol 49:688-93. 2011
    ..Consequently, MCFG has favorable efficacy and safety profiles in Japanese CPA patients with various backgrounds...
  90. pmc Azithromycin exhibits bactericidal effects on Pseudomonas aeruginosa through interaction with the outer membrane
    Yoshifumi Imamura
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852 8501, Japan
    Antimicrob Agents Chemother 49:1377-80. 2005
    ..aeruginosa PAO1 by displacement of divalent cations from their binding sites on LPS. This action explains, at least in part, the effectiveness of sub-MICs of macrolide antibiotics in pseudomonal chronic airway infection...
  91. doi request reprint Immediate single lobar retransplantation for primary graft dysfunction after living-donor lobar lung transplantation: Report of a case
    Tsutomu Tagawa
    Division of Surgical Oncology, Department of Translational Medical Science, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Surg Today 41:1447-9. 2011
    ..Whether this life-saving retransplant procedure for unexpected primary graft dysfunction after LDLLT can be justified requires further experience and a longer follow-up...
  92. pmc Fluconazole treatment is effective against a Candida albicans erg3/erg3 mutant in vivo despite in vitro resistance
    Taiga Miyazaki
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Antimicrob Agents Chemother 50:580-6. 2006
    ..The finding questions the clinical significance of this resistance mechanism...
  93. ncbi request reprint Lung fibrosis 10 years after cessation of bleomycin therapy
    Masato Tashiro
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Tohoku J Exp Med 216:77-80. 2008
    ..The use of BLM in infants requires strict supervision and observation and careful long-term follow up...
  94. ncbi request reprint [Candidiasis]
    Yoshifumi Imamura
    Second Department of Internal Medicine, Nagasaki University School of Medicine
    Nihon Rinsho 66:2341-4. 2008
    ..MCFG, FLCZ and AMPH-B are recommended as first line drugs for invasive candidiasis, and L-AMB, VRCZ, ITCZ are considered as alternative drugs in Japanese guideline...
  95. ncbi request reprint Clinical features of bacteremia caused by methicillin-resistant Staphylococcus aureus in a tertiary hospital
    Koichi Yamada
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Tohoku J Exp Med 224:61-7. 2011
    ..021). We suggest that poor prognosis achieved with VCM is in part due to its low blood concentration and poor tissue penetration. VCM should not be selected when presumed source of MRSA bacteremia is pneumonia...
  96. ncbi request reprint Leukocytoclastic vasculitis after pneumococcal pneumonia in an elderly adult
    Shigeki Nakamura
    Department of Respiratory Medicine, National Hospital Organization Ureshino Medical Center, Nagasaki
    Intern Med 46:487-90. 2007
    ..Therefore, it is critical to recognize HSV as one of the important complications after bacterial infection, especially Streptococcus pneumoniae...
  97. ncbi request reprint Clinical and bacteriological characteristics of IMP-type metallo-beta-lactamase-producing Pseudomonas aeruginosa
    Yoichi Hirakata
    Department of Laboratory Medicine, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan
    Clin Infect Dis 37:26-32. 2003
    ..These results suggest that precautionary measures against the spread of bla(IMP)-positive isolates are needed, because, for most of such pathogens, no antibiotic is potent enough to be used as a single agent in treatment of infection...
  98. ncbi request reprint Severe Legionnaires' disease successfully treated using a combination of fluoroquinolone, erythromycin, corticosteroid, and sivelestat
    Hiroshi Kakeya
    Division of Respiratory Diseases, Japanese Red Cross Nagasaki Genbaku Isahaya Hospital, Isahaya
    Intern Med 47:773-7. 2008
    ..The outcome suggests that treatment with corticosteroid and sivelestat, in addition to a combination of appropriate anti-Legionella antibiotics, should be considered for patients with severe Legionella pneumonia with ARDS...
  99. ncbi request reprint An autopsy case of Erysipelothrix rhusiopathiae endocarditis
    Yoshihiro Yamamoto
    Department of Internal Medicine, Sasebo City General Hospital, Sasebo
    Intern Med 47:1437-40. 2008
    ..Although about 60 cases of E. rhusiopathiae endocarditis have been reported, Japanese cases are extremely rare...
  100. ncbi request reprint [A successful treatment of Vibrio vulnificus infection]
    Eisuke Sasaki
    Izumikawa Hospital, Department of Laboratory Medicine, Nagasaki University School of Medicine
    Kansenshogaku Zasshi 76:391-5. 2002
    ....
  101. ncbi request reprint A case of Mycobacterium nonchromogenicum pulmonary infection showing multiple nodular shadows in an immunocompetent patient
    Toyomitsu Sawai
    Department of Internal Medicine, Isahaya Health Insurance General Hospital, Isahaya 854 8501, Japan
    Diagn Microbiol Infect Dis 54:311-4. 2006
    ..The common finding of M. nonchromogenicum pulmonary infection on chest X-ray is a solitary cavity. The present report describes an unusual case of M. nonchromogenicum primary pulmonary infection showing multiple nodular shadows...