Shinji Goto

Summary

Affiliation: Nagasaki University
Country: Japan

Publications

  1. doi request reprint Glutathione S-transferase pi localizes in mitochondria and protects against oxidative stress
    Shinji Goto
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Free Radic Biol Med 46:1392-403. 2009
  2. doi request reprint DHEA attenuates PDGF-induced phenotypic proliferation of vascular smooth muscle A7r5 cells through redox regulation
    Yoshishige Urata
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Medical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Biochem Biophys Res Commun 396:489-94. 2010
  3. ncbi request reprint Calreticulin, a molecular chaperone in the endoplasmic reticulum, modulates radiosensitivity of human glioblastoma U251MG cells
    Tomohiro Okunaga
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, 852 8523 Nagasaki, Japan
    Cancer Res 66:8662-71. 2006
  4. ncbi request reprint Nuclear glutathione S-transferase pi prevents apoptosis by reducing the oxidative stress-induced formation of exocyclic DNA products
    Kensaku Kamada
    Department of Neurosurgery, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 851 8523, Japan
    Free Radic Biol Med 37:1875-84. 2004
  5. doi request reprint Mitochondrial dysfunction, a probable cause of persistent oxidative stress after exposure to ionizing radiation
    Takako Yoshida
    Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Free Radic Res 46:147-53. 2012
  6. ncbi request reprint 17Beta-estradiol protects against oxidative stress-induced cell death through the glutathione/glutaredoxin-dependent redox regulation of Akt in myocardiac H9c2 cells
    Yoshishige Urata
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    J Biol Chem 281:13092-102. 2006
  7. ncbi request reprint Role of calreticulin in the sensitivity of myocardiac H9c2 cells to oxidative stress caused by hydrogen peroxide
    Yoshito Ihara
    Dept of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki Univ Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Am J Physiol Cell Physiol 290:C208-21. 2006
  8. ncbi request reprint Diethylstilbestrol attenuates antioxidant activities in testis from male mice
    Takahito Kondo
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki 852 8523, Japan
    Free Radic Res 36:957-66. 2002
  9. pmc Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice
    Miho Kawakatsu
    Department of Stem Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    PLoS ONE 8:e60023. 2013
  10. ncbi request reprint Significance of nuclear glutathione S-transferase pi in resistance to anti-cancer drugs
    Shinji Goto
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki 852 8523, Japan
    Jpn J Cancer Res 93:1047-56. 2002

Collaborators

Detail Information

Publications29

  1. doi request reprint Glutathione S-transferase pi localizes in mitochondria and protects against oxidative stress
    Shinji Goto
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Free Radic Biol Med 46:1392-403. 2009
    ....
  2. doi request reprint DHEA attenuates PDGF-induced phenotypic proliferation of vascular smooth muscle A7r5 cells through redox regulation
    Yoshishige Urata
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Medical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Biochem Biophys Res Commun 396:489-94. 2010
    ..In conclusion, the redox regulation of PDGFR-beta is involved in the suppressive effect of DHEA on VSMC proliferation through the up-regulation of GSH/GRX system...
  3. ncbi request reprint Calreticulin, a molecular chaperone in the endoplasmic reticulum, modulates radiosensitivity of human glioblastoma U251MG cells
    Tomohiro Okunaga
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, 852 8523 Nagasaki, Japan
    Cancer Res 66:8662-71. 2006
    ..These results show the novel mechanism by which CRT is involved in the regulation of radiosensitivity and radiation-induced apoptosis in malignant glioma cells...
  4. ncbi request reprint Nuclear glutathione S-transferase pi prevents apoptosis by reducing the oxidative stress-induced formation of exocyclic DNA products
    Kensaku Kamada
    Department of Neurosurgery, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 851 8523, Japan
    Free Radic Biol Med 37:1875-84. 2004
    ..These results suggested that nuclear GSTpi prevents H(2)O(2)-induced DNA damage by scavenging the formation of lipid-peroxide-modified DNA...
  5. doi request reprint Mitochondrial dysfunction, a probable cause of persistent oxidative stress after exposure to ionizing radiation
    Takako Yoshida
    Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Free Radic Res 46:147-53. 2012
    ..Although further experiments are required, results in this study support the hypothesis that mitochondrial dysfunction causes persistent oxidative stress that may contribute to promote radiation-induced genomic instability...
  6. ncbi request reprint 17Beta-estradiol protects against oxidative stress-induced cell death through the glutathione/glutaredoxin-dependent redox regulation of Akt in myocardiac H9c2 cells
    Yoshishige Urata
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    J Biol Chem 281:13092-102. 2006
    ..This mechanism may also play an antiapoptotic role in cancer cells during carcinogenesis or chemotherapy...
  7. ncbi request reprint Role of calreticulin in the sensitivity of myocardiac H9c2 cells to oxidative stress caused by hydrogen peroxide
    Yoshito Ihara
    Dept of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki Univ Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Am J Physiol Cell Physiol 290:C208-21. 2006
    ..Thus we conclude that the level of CRT regulates the sensitivity to apoptosis under oxidative stress due to H2O2 through a change in Ca2+ homeostasis and the regulation of the Ca2+-calpain-caspase-12 pathway in myocardiac cells...
  8. ncbi request reprint Diethylstilbestrol attenuates antioxidant activities in testis from male mice
    Takahito Kondo
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki 852 8523, Japan
    Free Radic Res 36:957-66. 2002
    ..The data suggest that antioxidant activities are impaired by DES, and the levels of GSH are related to DES-induced apoptosis in the testis...
  9. pmc Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice
    Miho Kawakatsu
    Department of Stem Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    PLoS ONE 8:e60023. 2013
    ..Our data suggest that nicaraven effectively diminished the effects of radiation-induced injury in hematopoietic stem/progenitor cells, which is likely associated with the anti-oxidative and anti-inflammatory properties of this compound...
  10. ncbi request reprint Significance of nuclear glutathione S-transferase pi in resistance to anti-cancer drugs
    Shinji Goto
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki 852 8523, Japan
    Jpn J Cancer Res 93:1047-56. 2002
    ..Treatment with ABL had no apparent effect on the cytotoxicity of VP-16 and 5-FU. These results suggest that inhibitors of the nuclear transfer of GSTpi have practical value in producing an increase of sensitivity to DOX, CDDP and CPT-11...
  11. pmc Effects of antioxidants on the quality and genomic stability of induced pluripotent stem cells
    Lan Luo
    1 Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan 2 Department of Surgery and Clinical Sciences, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Sci Rep 4:3779. 2014
    ..Long-term culture will be necessary to confirm whether low dose antioxidants improve the quality and genomic stability of iPS cells. ..
  12. doi request reprint Culture under low physiological oxygen conditions improves the stemness and quality of induced pluripotent stem cells
    Chao Wan Guo
    Department of Stem Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Cell Physiol 228:2159-66. 2013
    ..Long-term culture will be necessary to confirm whether low physiological oxygen levels also improve genomic stability...
  13. ncbi request reprint Hammerhead ribozyme against gamma-glutamylcysteine synthetase attenuates resistance to ionizing radiation and cisplatin in human T98G glioblastoma cells
    Masaharu Tani
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki 852 8523
    Jpn J Cancer Res 93:716-22. 2002
    ..Thus, hammerhead ribozyme against gamma-GCS is suggested to have potential as a cancer gene therapy to reduce the resistance of malignant cells to ionizing radiation and anti-cancer drugs...
  14. pmc Radiation Exposure Decreases the Quantity and Quality of Cardiac Stem Cells in Mice
    Lan Luo
    Department of Stem Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki, 852 8523, Japan
    PLoS ONE 11:e0152179. 2016
    ..Our data suggest that radiation exposure significantly decreases the quantity and quality of CSCs, which may serve as sensitive bio-parameters for predicting future cardiovascular disease risks. ..
  15. pmc Cardiosphere-Derived Cells Facilitate Heart Repair by Modulating M1/M2 Macrophage Polarization and Neutrophil Recruitment
    Al Shaimaa Hasan
    Department of Stem Cell Biology, Atomic Bomb Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    PLoS ONE 11:e0165255. 2016
    ..Our data suggest that CDCs facilitate heart repair by modulating M1/M2 macrophage polarization and neutrophil recruitment, which may provide a new insight into the mechanisms of stem cell-based myocardial repair...
  16. pmc Enhanced autophagy in colorectal cancer stem cells does not contribute to radio-resistance
    Chen Yan
    Department of Stem Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Oncotarget 7:45112-45121. 2016
    ..Although an enhanced basic level of autophagy was found in the CD44+/CD133+ cancer stem cells, our data suggest that the canonical autophagy in cancer cells plays few roles, if any, in radio-sensitivity...
  17. pmc Potency of umbilical cord blood- and Wharton's jelly-derived mesenchymal stem cells for scarless wound healing
    Hanako Doi
    Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Sci Rep 6:18844. 2016
    ..Based on our data, UCB-MSCs are more likely to be a favorable potential stem cell source for scarless wound healing, although a better experimental model is required for confirmation...
  18. ncbi request reprint Ionizing Radiation Impairs Endogenous Regeneration of Infarcted Heart: An In Vivo 18F-FDG PET/CT and 99mTc-Tetrofosmin SPECT/CT Study in Mice
    Lan Luo
    a Department of Stem Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Radiat Res . 2016
    ..The results of this study suggest that whole-body irradiation with 3 Gy gamma rays impairs the endogenous regeneration of infarcted heart, which may indirectly predict future cardiovascular disease risk...
  19. doi request reprint Doxorubicin-induced mitophagy contributes to drug resistance in cancer stem cells from HCT8 human colorectal cancer cells
    Chen Yan
    Department of Stem Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Cancer Lett . 2016
    ..Our data suggested that mitophagy, but not non-selective autophagy, likely contributes to drug resistance in CSCs isolated from HCT8 cells. Further studies in other cancer cell lines will be needed to confirm our findings...
  20. pmc Estrogen deficiency heterogeneously affects tissue specific stem cells in mice
    Yuriko Kitajima
    1 Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan 2 Department of Obstetrics and Gynecology, Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Sci Rep 5:12861. 2015
    ..Estrogen deficiency heterogeneously affected tissue-specific stem cells, suggesting a likely and direct relationship with postmenopausal disorders. ..
  21. pmc Increased expression of PHD3 represses the HIF-1 signaling pathway and contributes to poor neovascularization in pancreatic ductal adenocarcinoma
    Takayuki Tanaka
    Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, 1 12 4 Sakamoto, Nagasaki, 852 8523, Japan
    J Gastroenterol 50:975-83. 2015
    ..By comparing PDAC to hepatocellular carcinoma (HCC), which is well vascularized, we investigated the mechanisms and tumor biological significance of the poor neovascularization in PDAC...
  22. pmc Placental extract protects bone marrow-derived stem/progenitor cells against radiation injury through anti-inflammatory activity
    Miho Kawakatsu
    Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    J Radiat Res 54:268-76. 2013
    ..Placental extract significantly attenuated the acute radiation injury to bone marrow-derived stem/progenitor cells, and this protection is likely to be related to the anti-inflammatory activity of the placental extract...
  23. doi request reprint Nuclear translocation of glutathione S-transferase π is mediated by a non-classical localization signal
    Miho Kawakatsu
    Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Biochem Biophys Res Commun 411:745-50. 2011
    ....
  24. ncbi request reprint Reactive oxygen species accelerate production of vascular endothelial growth factor by advanced glycation end products in RAW264.7 mouse macrophages
    Yoshishige Urata
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan
    Free Radic Biol Med 32:688-701. 2002
    ..These results suggest an important role for AGEs in stimulation of the development of angiogenesis observed in diabetic complications, and that ROS accelerates the AGE-stimulated VEGF expression...
  25. pmc Dose-dependency and reversibility of radiation-induced injury in cardiac explant-derived cells of mice
    Lan Luo
    Department of Stem Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Sci Rep 7:40959. 2017
    ..These data may help us to find the most sensitive and reliable bio-parameter(s) for evaluating radiation-induced injury in CDCs...
  26. doi request reprint Muscle stem cell fate is controlled by the cell-polarity protein Scrib
    Yusuke Ono
    Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan Electronic address
    Cell Rep 10:1135-48. 2015
    ..Thus, Scrib is a regulator of tissue stem cells, controlling population expansion and self-renewal with Scrib expression dynamics directing satellite cell fate. ..
  27. doi request reprint Modest inhibition of the growth hormone axis does not affect mitochondrial reactive oxygen species generation or redox state, unlike calorie restriction
    Takahiro Hayashida
    Department of Investigative Pathology, Unit of Basic Medical Science Department of Biochemistry and Molecular Biology in Diseases, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    Geriatr Gerontol Int 11:496-503. 2011
    ..The present study evaluated the effects of GH inhibition and CR on mitochondrial oxidative stress and redox state in the liver...
  28. ncbi request reprint Deletion of N-terminal residues 23-88 from prion protein (PrP) abrogates the potential to rescue PrP-deficient mice from PrP-like protein/doppel-induced Neurodegeneration
    Ryuichiro Atarashi
    Department of Molecular Microbiology and Immunology, Institute of Atomic Bomb Disease, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    J Biol Chem 278:28944-9. 2003
    ..Our findings provide evidence that the N-terminal residues 23-88 of PrP containing the unique octapeptide-repeat region is crucial for preventing Purkinje cell death in Prnp0/0 mice expressing PrPLP/Dpl in the neuron...
  29. ncbi request reprint Overexpression of calreticulin modulates protein kinase B/Akt signaling to promote apoptosis during cardiac differentiation of cardiomyoblast H9c2 cells
    Kan Kageyama
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki 852 8523, Japan
    J Biol Chem 277:19255-64. 2002
    ..These findings indicate a novel mechanism by which cytoplasmic Akt signaling is modulated to cause apoptosis by a resident protein of the endoplasmic reticulum, calreticulin...