Tetsuji Nagao

Summary

Country: Japan

Publications

  1. ncbi request reprint An improved technique for repeated gavage administration to rat neonates
    Chiaki Watanabe
    Hatano Research Institute, Food and Drug Safety Center, Hadano, Kanagawa, Japan
    Congenit Anom (Kyoto) 43:177-9. 2003
  2. ncbi request reprint Developmental toxicity of the topoisomerase inhibitor, etoposide, in rabbits after intravenous administration
    T Nagao
    Department of Reproductive and Developmental Toxicology, Hatano Research Institute, Food and Drug Safety Center, Hadano, Kanagawa, Japan
    Teratog Carcinog Mutagen 19:233-41. 1999
  3. ncbi request reprint Increased incidence of malformations in the offspring of male mice prenatally exposed to synthetic estrogens
    Tetsuji Nagao
    Laboratory of Developmental Biology, Department of Life Science, Kinki University, Kowakae 3 4 1, Higashiosaka, Osaka 577 8502, Japan
    Adv Exp Med Biol 518:211-7. 2003
  4. ncbi request reprint Maternal and developmental toxicity in mice by aminophenylnorharman, formed from norharman and aniline
    T Naga
    Department of Life Science, Faculty of Science and Technology, Kinki University, Osaka, Japan
    Hum Exp Toxicol 21:147-51. 2002
  5. ncbi request reprint Low-dose bisphenol A does not affect reproductive organs in estrogen-sensitive C57BL/6N mice exposed at the sexually mature, juvenile, or embryonic stage
    Tetsuji Nagao
    Department of Reproductive and Developmental Biology, Hatano Research Institute, Food and Drug Safety Center, Kanagawa 257, Japan
    Reprod Toxicol 16:123-30. 2002
  6. ncbi request reprint Reproductive effects in male and female rats from neonatal exposure to p-octylphenol
    T Nagao
    Department of Reproductive and Developmental Biology, Hatano Research Institute, Food and Drug Safety Center, Hadano, Kanagawa, Japan
    Reprod Toxicol 15:683-92. 2001
  7. ncbi request reprint Reproductive effects in male and female rats of neonatal exposure to genistein
    T Nagao
    Department of Reproductive and Developmental Biology, Hatano Research Institute, Food and Drug Safety Center, Hadano, Kanagawa, Japan
    Reprod Toxicol 15:399-411. 2001
  8. ncbi request reprint Reproductive effects of nonylphenol in rats after gavage administration: a two-generation study
    T Nagao
    Department of Reproductive and Developmental Biology, Hatano Research Institute, Food and Drug Safety Center, 729 5 Ochiai, 257 8523, Hadano, Kanagawa, Japan
    Reprod Toxicol 15:293-315. 2001
  9. ncbi request reprint Oral administration of clomiphene to neonatal rats causes reproductive tract abnormalities
    T Nagao
    Department of Reproductive and Developmental Biology, Hatano Research Institute, Food and Drug Safety Center, Kanagawa, Japan
    Teratog Carcinog Mutagen 21:213-21. 2001
  10. ncbi request reprint Effect of butyl benzyl phthalate in Sprague-Dawley rats after gavage administration: a two-generation reproductive study
    T Nagao
    Department of Reproductive and Developmental Toxicology, Hatano Research Institute, Food and Drug Safety Center, 729 5 Ochiai, Hadano, 257 8523, Kanagawa, Japan
    Reprod Toxicol 14:513-32. 2000

Collaborators

Detail Information

Publications22

  1. ncbi request reprint An improved technique for repeated gavage administration to rat neonates
    Chiaki Watanabe
    Hatano Research Institute, Food and Drug Safety Center, Hadano, Kanagawa, Japan
    Congenit Anom (Kyoto) 43:177-9. 2003
    ....
  2. ncbi request reprint Developmental toxicity of the topoisomerase inhibitor, etoposide, in rabbits after intravenous administration
    T Nagao
    Department of Reproductive and Developmental Toxicology, Hatano Research Institute, Food and Drug Safety Center, Hadano, Kanagawa, Japan
    Teratog Carcinog Mutagen 19:233-41. 1999
    ..It was concluded that anatomical defects (skeletal malformation or variation) in rabbits were induced by intravenous etoposide treatment during early organogenesis and that they occurred in the presence of maternal toxicity...
  3. ncbi request reprint Increased incidence of malformations in the offspring of male mice prenatally exposed to synthetic estrogens
    Tetsuji Nagao
    Laboratory of Developmental Biology, Department of Life Science, Kinki University, Kowakae 3 4 1, Higashiosaka, Osaka 577 8502, Japan
    Adv Exp Med Biol 518:211-7. 2003
  4. ncbi request reprint Maternal and developmental toxicity in mice by aminophenylnorharman, formed from norharman and aniline
    T Naga
    Department of Life Science, Faculty of Science and Technology, Kinki University, Osaka, Japan
    Hum Exp Toxicol 21:147-51. 2002
    ..More detailed studies are warranted to assess the possible risks to pregnant women from exposure to APNH...
  5. ncbi request reprint Low-dose bisphenol A does not affect reproductive organs in estrogen-sensitive C57BL/6N mice exposed at the sexually mature, juvenile, or embryonic stage
    Tetsuji Nagao
    Department of Reproductive and Developmental Biology, Hatano Research Institute, Food and Drug Safety Center, Kanagawa 257, Japan
    Reprod Toxicol 16:123-30. 2002
    ..The results of this study indicate that exposure of estrogen-sensitive C57BL/6N mice to low-dose BPA did not reduce sperm density or disrupt development of the male reproductive organs...
  6. ncbi request reprint Reproductive effects in male and female rats from neonatal exposure to p-octylphenol
    T Nagao
    Department of Reproductive and Developmental Biology, Hatano Research Institute, Food and Drug Safety Center, Hadano, Kanagawa, Japan
    Reprod Toxicol 15:683-92. 2001
    ..Therefore, it is concluded that NOAEL (no-observed adverse effect level) for systemic toxicity was < or =12.5 mg/kg/day and that for reproductive toxicity was 100 mg/kg/day under the present experimental condition...
  7. ncbi request reprint Reproductive effects in male and female rats of neonatal exposure to genistein
    T Nagao
    Department of Reproductive and Developmental Biology, Hatano Research Institute, Food and Drug Safety Center, Hadano, Kanagawa, Japan
    Reprod Toxicol 15:399-411. 2001
    ..The results of this study indicate that early neonatal exposure to genistein caused dysfunction of postpubertal reproductive performance as well as abnormal development of gonads in female but not in male rats...
  8. ncbi request reprint Reproductive effects of nonylphenol in rats after gavage administration: a two-generation study
    T Nagao
    Department of Reproductive and Developmental Biology, Hatano Research Institute, Food and Drug Safety Center, 729 5 Ochiai, 257 8523, Hadano, Kanagawa, Japan
    Reprod Toxicol 15:293-315. 2001
    ..These results of NP suggested that the no observed adverse effect level (NOAEL) on reproductive capacity is 50 mg/kg/day or greater in parent animals, and 10 mg/kg/day in the next generation under the present experimental condition...
  9. ncbi request reprint Oral administration of clomiphene to neonatal rats causes reproductive tract abnormalities
    T Nagao
    Department of Reproductive and Developmental Biology, Hatano Research Institute, Food and Drug Safety Center, Kanagawa, Japan
    Teratog Carcinog Mutagen 21:213-21. 2001
    ..These results suggested that early neonatal exposure to clomiphene induced marked reproductive tract abnormalities in males after puberty, as well as in females...
  10. ncbi request reprint Effect of butyl benzyl phthalate in Sprague-Dawley rats after gavage administration: a two-generation reproductive study
    T Nagao
    Department of Reproductive and Developmental Toxicology, Hatano Research Institute, Food and Drug Safety Center, 729 5 Ochiai, Hadano, 257 8523, Kanagawa, Japan
    Reprod Toxicol 14:513-32. 2000
    ..From these data, it would appear that 20 mg/kg BBP is a no observed adverse effect level (NOAEL) for reproductive effects on parent animals and the next generation...
  11. ncbi request reprint Effects of prenatal and postnatal exposure to styrene dimers and trimers on reproductive function in rats
    T Nagao
    Department of Reproductive and Developmental Toxicology, Hatano Research Institute, Food and Drug Safety Center, Kanagawa, Japan
    Reprod Toxicol 14:403-15. 2000
    ..These results indicate that SDT administered at doses as high as 1.0 mg/kg (1000 times the estimated human daily intake) did not produce reproductive toxicity in dams or offspring...
  12. ncbi request reprint Possible mechanism of congenital malformations induced by exposure of mouse preimplantation embryos to mitomycin C
    T Nagao
    Department of Developmental Toxicology, Hatano Research Institute, Food and Drug Safety Center, Kanagawa 257 8523, Japan
    Teratology 61:248-61. 2000
    ....
  13. ncbi request reprint Reproductive function in rats exposed neonatally to bisphenol A and estradiol benzoate
    T Nagao
    Department of Reproductive and Developmental Toxicology, Hatano Research Institute, Kanagawa, Japan
    Reprod Toxicol 13:303-11. 1999
    ....
  14. ncbi request reprint Intrauterine position and postnatal growth in Sprague-Dawley rats and ICR mice
    Tetsuji Nagao
    Department of Life Science, Faculty of Science and Technology, Kinki University, Kowakae 3 4 1, Higashiosaka, Osaka 577 8502, Japan
    Reprod Toxicol 18:109-20. 2004
    ..The results of this study suggested that the intrauterine position of the embryos/fetuses did not affect the postnatal growth of the reproductive organs, sexual maturation, or behavior in rats and mice...
  15. ncbi request reprint Influence of di-(2-ethylhexyl)phthalate on fetal testicular development by oral administration to pregnant rats
    Mariko Shirota
    Hatano Research Institute, Food and Drug Safety Center, Kanagawa
    J Toxicol Sci 30:175-94. 2005
    ..Thus, 125 mg/kg/day is considered the no-observed-effect-level of DEHP on testicular development of rats by exposure in utero during the period of organogenesis...
  16. doi request reprint Newly developed mouse newborn behavioral testing method for evaluating the risk of neurotoxicity of environmental toxicants
    Tetsuji Nagao
    Laboratory of Developmental Biology, Department of Life Science, Kinki University, 3 4 1 Kowakae, Higashiosaka, Osaka, 577 8502, Japan
    J Appl Toxicol 33:1514-9. 2013
    ..In addition, we confirmed the usefulness of our method by determining the activity of mouse newborns with microcephaly induced by prenatal exposure to a neurotoxicant, methylnitrosourea...
  17. doi request reprint Early embryonic losses in mice induced by diethylstilbestrol
    Tetsuji Nagao
    Department of Life Science, Kinki University, Higashi Osaka, Japan
    Congenit Anom (Kyoto) 49:269-73. 2009
    ..The results of the present study suggest that decidual hypoplasia and subsequent placental hemorrhage causes fetal death due to the administration of DES during the early stage of pregnancy...
  18. doi request reprint Developmental effects of oral exposure to diethylstilbestrol on mouse placenta
    Tetsuji Nagao
    Laboratory of Developmental Biology, Department of Life Science, Kinki University, Osaka, 577 8502, Japan
    J Appl Toxicol 33:1213-21. 2013
    ....
  19. ncbi request reprint Locomotor hyperactivity following prenatal exposure to 5-bromo-2'-deoxyuridine: neurochemical and behavioral evidence of dopaminergic and serotonergic alterations
    Makiko Kuwagata
    Safety Testing Laboratory, Food and Drug Safety Center, Hatano Research Institute, 729 5 Ochiai, Hadano, Kanagawa 257 8523, Japan
    Toxicol Lett 152:63-71. 2004
    ..Thus, prenatal exposure to BrdU induced alterations in both the DA and 5-HT systems...
  20. doi request reprint Early to middle gestational exposure to diethylstilbestrol impairs the development of labyrinth zone in mouse placenta
    Nao Kagawa
    Department of Life Science, Faculty of Science and Technology, Kinki, University, Osaka, Japan
    Congenit Anom (Kyoto) 54:116-9. 2014
    ..These findings suggest that impaired LZ development may be related to the embryolethality of DES. ..
  21. ncbi request reprint Neurobehavioral evaluation of mouse newborns exposed prenatally to low-dose bisphenol A
    Tetsuji Nagao
    Laboratory of Developmental Biology, Department of Life Science, Kinki University
    J Toxicol Sci 39:231-5. 2014
    ..5 µg/kg/day. We suggest that our developed testing method may provide a useful addition to neurobehavioral assessment in very young rodents exposed to environmental hormone mimics. ..
  22. ncbi request reprint Cardiovascular malformations induced by prenatal exposure to phenobarbital in rats
    Hirokazu Okuda
    Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Kanagawa, Japan
    Congenit Anom (Kyoto) 46:97-104. 2006
    ..Severe cardiovascular malformations induced by PB caused deaths on early postnatal days. However, slight malformations such as isolated VSD persisted until weaning, and did not affect postnatal viability...