J Haginaka

Summary

Affiliation: Mukogawa Women's University
Country: Japan

Publications

  1. ncbi request reprint Separation of enantiomers on a chiral stationary phase based on ovoglycoprotein. II. Comparison of chiral recognition properties with crude ovomucoid
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan
    J Chromatogr A 777:241-7. 1997
  2. ncbi request reprint Uniformly sized molecularly imprinted polymer for (S)-naproxen retention and molecular recognition properties in aqueous mobile phase
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    J Chromatogr A 913:141-6. 2001
  3. ncbi request reprint Anion-exchange high-performance liquid chromatography assays of plasma lipoproteins and modified low-density lipoproteins using a ProtEx-DEAE column
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    J Chromatogr B Biomed Sci Appl 751:161-7. 2001
  4. ncbi request reprint Enantiomer separation of drugs by capillary electrophoresis using proteins as chiral selectors
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    J Chromatogr A 875:235-54. 2000
  5. ncbi request reprint Uniform-sized molecularly imprinted polymer material for (S)-propranolol
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    J Pharm Biomed Anal 22:899-907. 2000
  6. ncbi request reprint Separation of enantiomers on a chiral stationary phase based on ovoglycoprotein. VIII. Chiral recognition ability of partially and completely deglycosylated ovoglycoprotein
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    J Chromatogr B Biomed Sci Appl 745:149-57. 2000
  7. ncbi request reprint Uniform-sized molecularly imprinted polymers for 2-arylpropionic acid derivatives selectively modified with hydrophilic external layer and their applications to direct serum injection analysis
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Hyogo, Japan
    Anal Chem 72:5206-10. 2000
  8. ncbi request reprint Protein-based chiral stationary phases for high-performance liquid chromatography enantioseparations
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    J Chromatogr A 906:253-73. 2001
  9. ncbi request reprint LC packing materials for pharmaceutical and biomedical analysis
    Jun Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    Se Pu 20:508-18. 2002
  10. ncbi request reprint Pharmaceutical and biomedical applications of enantioseparations using liquid chromatographic techniques
    Jun Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    J Pharm Biomed Anal 27:357-72. 2002

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Separation of enantiomers on a chiral stationary phase based on ovoglycoprotein. II. Comparison of chiral recognition properties with crude ovomucoid
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan
    J Chromatogr A 777:241-7. 1997
    ..In addition, OMCHI did not contribute to the enantioselectivity of the solute at all and made little contribution to the retention characteristics...
  2. ncbi request reprint Uniformly sized molecularly imprinted polymer for (S)-naproxen retention and molecular recognition properties in aqueous mobile phase
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    J Chromatogr A 913:141-6. 2001
    ..With regard to the effects of column temperature and flow-rate, the column performance was improved by elevating a column temperature and decreasing a flow-rate...
  3. ncbi request reprint Anion-exchange high-performance liquid chromatography assays of plasma lipoproteins and modified low-density lipoproteins using a ProtEx-DEAE column
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    J Chromatogr B Biomed Sci Appl 751:161-7. 2001
    ..There was an excellent correlation between the two methods. The obtained results reveal that the anion-exchange HPLC method using the ProtEx-DEAE column could be useful for the assays of plasma lipoproteins and modified LDLs...
  4. ncbi request reprint Enantiomer separation of drugs by capillary electrophoresis using proteins as chiral selectors
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    J Chromatogr A 875:235-54. 2000
    ..Furthermore, the advantages and limitations of the two modes and the factors affecting the chiral separations of various drugs by protein-based CE are discussed...
  5. ncbi request reprint Uniform-sized molecularly imprinted polymer material for (S)-propranolol
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    J Pharm Biomed Anal 22:899-907. 2000
    ....
  6. ncbi request reprint Separation of enantiomers on a chiral stationary phase based on ovoglycoprotein. VIII. Chiral recognition ability of partially and completely deglycosylated ovoglycoprotein
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    J Chromatogr B Biomed Sci Appl 745:149-57. 2000
    ..Further, cd-OGCHI still showed chiral recognition abilities for various solutes tested. These results reveal that the chiral recognition site(s) for OGCHI exists on the protein domain of OGCHI...
  7. ncbi request reprint Uniform-sized molecularly imprinted polymers for 2-arylpropionic acid derivatives selectively modified with hydrophilic external layer and their applications to direct serum injection analysis
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Hyogo, Japan
    Anal Chem 72:5206-10. 2000
    ..The optimized column-switching system was applied successfully to the assay of ibuprofen in rat plasma after oral administration...
  8. ncbi request reprint Protein-based chiral stationary phases for high-performance liquid chromatography enantioseparations
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    J Chromatogr A 906:253-73. 2001
    ..This review deals with the properties of HPLC chiral stationary phases based on proteins, and the enantioselective properties and chiral recognition mechanisms of these stationary phases...
  9. ncbi request reprint LC packing materials for pharmaceutical and biomedical analysis
    Jun Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    Se Pu 20:508-18. 2002
    ..This review article deals with the preparation of these materials and the pharmaceutical and biomedical applications of them in recognition of The Society of Chromatographic Sciences Award...
  10. ncbi request reprint Pharmaceutical and biomedical applications of enantioseparations using liquid chromatographic techniques
    Jun Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    J Pharm Biomed Anal 27:357-72. 2002
    ..The pharmaceutical and biomedical applications of enantioseparations using the direct and indirect methods have been considered in this review...
  11. ncbi request reprint Highly stereoselective, uniformly sized molecularly imprinted polymers for cinchona alkaloids in hydro-organic mobile phases
    Jun Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    Anal Sci 19:39-42. 2003
    ..Furthermore, thermodynamic studies reveal that the entropy-driven effect is significant at mobile-phase pH 5.4, while the enthalpy-driven interactions seem to be dominant at mobile-phase pH 9.6...
  12. ncbi request reprint HPLC-based bioseparations using molecularly imprinted polymers
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya 663 8179, Japan
    Bioseparation 10:337-51. 2001
    ..Furthermore, new polymerization methods suitable for preparations of HPLC columns and packing materials using molecular imprinting techniques, and their applications to HPLC-based separations are also dealt with...
  13. ncbi request reprint Separation of enantiomers on HPLC chiral stationary phases based on human plasma alpha1-acid glycoprotein: effect of sugar moiety on chiral recognition ability
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Hyogo, Japan
    Enantiomer 5:37-45. 2000
    ..A sugar chain(s) of AGP cleaved by N-glycosidase might be involved in the enantioselective binding of warfarin enantiomers...
  14. ncbi request reprint Separation of enantiomers on a chiral stationary phase based on ovoglycoprotein. VII. Comparison of chiral recognition ability of ovoglycoprotein from chicken and Japanese quail egg whites
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    J Chromatogr A 858:155-65. 1999
    ..The results obtained reveal that chiral recognition of various solutes could be efficiently attained by using both columns complementarily...
  15. ncbi request reprint Uniformly sized molecularly imprinted polymers: their applications to chiral separation and bioanalysis
    Jun Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya 663 8179, Japan
    Se Pu 22:306-8. 2004
  16. ncbi request reprint Chiral resolution of derivatized amino acids using uniformly sized molecularly imprinted polymers in hydro-organic mobile phases
    Jun Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya, 663 8179 Hyogo, Japan
    Anal Bioanal Chem 378:1907-12. 2004
    ..Furthermore, the baseline separation of Boc-Trp enantiomers was attained within 10 min on the Boc-L-Trp-imprinted 4-VPY- co-EDMA polymers under the optimized HPLC conditions...
  17. ncbi request reprint Separation of enantiomers on a chiral stationary phase based on ovoglycoprotein. III. Effect of aggregation of ovoglycoprotein on chiral resolution
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    J Chromatogr A 830:81-9. 1999
    ..Further, the OGCHI monomer from the reversibly dissociated OGCHI aggregate has chiral recognition ability comparable to that of the native OGCHI...
  18. ncbi request reprint Separation of enantiomers on a chiral stationary phase based on ovoglycoprotein. V. Influence of immobilization method on chiral resolution
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Hyogo, Japan
    J Chromatogr A 840:171-81. 1999
    ..It is suggested that the electrostatic interaction between an amino or carboxyl group of OGCHI and a charged solute should play an important role in chiral recognition of the solute...
  19. ncbi request reprint Uniform-sized molecularly imprinted polymer for (S)-naproxen selectively modified with hydrophilic external layer
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Hyogo, Japan
    J Chromatogr A 849:331-9. 1999
    ..Preliminary results reveal that the surface modified molecularly imprinted polymer could be applicable to direct serum injection assays of (S)-naproxen...
  20. ncbi request reprint Uniform-sized molecularly imprinted polymer for (S)-ibuprofen retention properties in aqueous mobile phases
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    J Chromatogr A 857:117-25. 1999
    ..Further, partial resolution of the enantiomers of ibuprofen metabolites, 2-hydroxy- and 2-carboxyibuprofen, was attained with the (S)-ibuprofen imprinted 4-VPY-EDMA materials...
  21. ncbi request reprint Retentivity and enantioselectivity of uniformly sized molecularly imprinted polymers for d-chlorpheniramine and -brompheniramine in hydro-organic mobile phases
    Jun Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 804:19-24. 2004
    ..Though the respective MIPs gave the highest enantioselectivity for the template molecule, cross-reactivity for CP and BP was observed with them...
  22. ncbi request reprint Uniformly sized molecularly imprinted polymer for d-chlorpheniramine. Evaluation of retention and molecular recognition properties in an aqueous mobile phase
    Jun Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    J Chromatogr A 948:77-84. 2002
    ..Further, the MIP showed the highest recognition for chlorpheniramine and slight recognition for its structurally related compounds, and enantioseparation of pheniramine was attained...
  23. ncbi request reprint Enantioselectivity of bovine serum albumin-bonded columns produced with isolated protein fragments. II. Characterization of protein fragments and chiral binding sites
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    J Chromatogr A 769:215-23. 1997
    ..These results might be due to changes in the globular structure of the BSA fragment and/or changes in the local environment around the binding sites...
  24. ncbi request reprint Separation of basic drug enantiomers by capillary electrophoresis using ovoglycoprotein as a chiral selector: comparison of chiral resolution ability of ovoglycoprotein and completely deglycosylated ovoglycoprotein
    H Matsunaga
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    Electrophoresis 22:3251-6. 2001
    ..OGCHI showed higher resolution for basic drug enantiomers tested than cd-OGCHI. The results suggest that the chiral recognition site(s) for OGCHI exists on the protein domain of OGCHI...
  25. ncbi request reprint Oxidants in cigarette smoke extract modify low-density lipoprotein in the plasma and facilitate atherogenesis in the aorta of Watanabe heritable hyperlipidemic rabbits
    Y Yamaguchi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya 663 8179, Japan
    Atherosclerosis 156:109-17. 2001
    ....
  26. ncbi request reprint Separation of enantiomers on a chiral stationary phase based on ovoglycoprotein. I. Influences of the pore size of base silica materials and bound protein amounts on chiral resolution
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Hyogo, Japan
    J Chromatogr A 773:85-91. 1997
    ..By diminishing the superfluous achiral interaction with base silica materials and/or spacers, much more efficient OGCHI materials should be obtainable...
  27. ncbi request reprint High-performance liquid chromatographic assay of hydroperoxide levels in oxidatively modified lipoproteins
    Y Yamaguchi
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Hyogo, Japan
    J Chromatogr B Biomed Sci Appl 731:223-9. 1999
    ..The proposed method could analyze the HPO levels in N- and Ox-LDLs of WHHL rabbits without extraction of the lipids...
  28. ncbi request reprint Evidence of modified lipoprotein in the plasma of Watanabe heritable hyperlipidemic rabbits by anion-exchange high-performance liquid chromatographic assay
    Y Yamaguchi
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Atherosclerosis 139:323-31. 1998
    ..These results suggest that LDL in WHHL rabbit plasma may undergo mild oxidative modification...
  29. ncbi request reprint Separation of basic drug enantiomers by capillary zone electrophoresis using glucuronyl glucosyl beta-cyclodextrin as a chiral selector
    H Matsunaga
    Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Hyogo, Japan
    Electrophoresis 22:3382-8. 2001
    ..This could be due to that hydrogen bonding or ionic interactions of uncharged and charged glucuronyl glucosyl groups of GUG beta-CD with an analyte could stabilize the inclusion complex...
  30. ncbi request reprint High-performance liquid chromatographic determination of desmosine and isodesmosine in tissues and its application to studies of alteration of elastin induced by atherosclerosis
    Y Yamaguchi
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    J Chromatogr 422:53-9. 1987
    ..e. elstin contents) in the tissues of rats treated with beta-aminopropionitrile and an atherogenic diet. A negative correlation between the contents of these amino acids and of cholesterol was noted in the atherosclerotic aorta...
  31. ncbi request reprint Enantioselectivity of bovine serum albumin-bonded columns produced with isolated protein fragments
    J Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan
    J Chromatogr A 694:71-80. 1995
    ..These results are due to a higher density of chiral recognition site(s) on the BSA-FG75 column. Also, the BSA-FG75 column was as stable as the intact BSA column for a continuous flow of eluent...
  32. ncbi request reprint Preparation and evaluation of a novel chiral stationary phase based on covalently bonded chitosan for ligand-exchange chromatography
    Yueqi Liu
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    J Sep Sci 29:1440-6. 2006
    ..The methanol content and copper(II) ion concentration in the eluent affected retentivity and enantioselectivity. Furthermore, a plausible chiral recognition mechanism for resolution of alpha-amino acids was proposed...
  33. ncbi request reprint Facilitated nitration and oxidation of LDL in cigarette smokers
    Y Yamaguchi
    Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya 663 8179, Japan
    Eur J Clin Invest 35:186-93. 2005
    ..We investigated whether peroxynitrite, a reaction product of cigarette smoke, is involved in facilitated oxidation of LDL in smokers...
  34. ncbi request reprint Uniformly-sized, molecularly imprinted polymers for (-)-epigallocatechin gallate, -epicatechin gallate and -gallocatechin gallate by multi-step swelling and polymerization method
    Jun Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    J Chromatogr A 1156:45-50. 2007
    ..Furthermore, the MIP for (-)-GCg could be successfully used for isolating (-)-EGCg and -ECg from green tea extract...
  35. doi request reprint Monodispersed, molecularly imprinted polymers for cinchonidine by precipitation polymerization
    Yueqi Liu
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya 663 8179, Japan
    Talanta 80:1713-8. 2010
    ..The template molecule, CD, was more retained than its stereoisomer, cinchonine, on the three MIPs, and the stereoseparation factor of 38 was obtained with MIP3...
  36. ncbi request reprint Screening of bitterness-suppressing agents for quinine: the use of molecularly imprinted polymers
    Tazuko Ogawa
    School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien 9 Bancho, Nishinomiya City 663 8179, Japan
    J Pharm Sci 94:353-62. 2005
    ..Finally, the results of human gustatory sensation tests correlated well with the MIP data. The proposed method using MIPs seems to have a potential for screening bitterness-suppressing agents for quinine...
  37. doi request reprint Addition of N-carbobenzyloxy-L-tryptophan as a co-template molecule to molecularly imprinted polymer monoliths for (+)-nilvadipine
    Jun Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya, Hyogo, Japan
    J Chromatogr A 1185:258-62. 2008
    ..These results suggest that co-addition of Cbz-L-Trp could be effective for preparing MIP monoliths for (+)-nilvadipine, whose preparation is difficult...
  38. ncbi request reprint Elevated circulating levels of markers of oxidative-nitrative stress and inflammation in a genetic rat model of metabolic syndrome
    Yu Yamaguchi
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya 663 8179, Japan
    Nitric Oxide 15:380-6. 2006
    ..These findings suggest that oxidative stress, as well as nitrative stress and inflammation, increases in the metabolic syndrome, which may contribute to the development of atherosclerosis...
  39. ncbi request reprint Uniformly sized molecularly imprinted polymers for d-chlorpheniramine: influence of a porogen on their morphology and enantioselectivity
    Jun Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    J Pharm Biomed Anal 46:877-81. 2008
    ..This result suggests the presence of enantioselective binding sites in the swollen state for all the MIPs...
  40. doi request reprint Molecularly imprinted polymers as affinity-based separation media for sample preparation
    Jun Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    J Sep Sci 32:1548-65. 2009
    ..Finally, pharmaceutical, food, bioanalytical, and environmental application of molecularly imprinted SPE will be discussed...
  41. ncbi request reprint Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome
    Yu Yamaguchi
    Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya 663 8179, Japan
    Life Sci 79:2474-9. 2006
    ..This implies that CRA can be beneficial for preventing atherosclerosis-related diseases that are an increasing health care problem worldwide...
  42. ncbi request reprint Uniformly-sized, molecularly imprinted polymers for nicotine by precipitation polymerization
    Haruyo Sambe
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya 663 8179, Japan
    J Chromatogr A 1134:88-94. 2006
    ..Enantioseparation of nicotine was attained using the (S)-nicotine-imprinted MAA-co-DVB polymers. Furthermore, they could selectively trap nicotine in cigarette smoke extracts...
  43. doi request reprint Recent progresses in protein-based chiral stationary phases for enantioseparations in liquid chromatography
    Jun Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 875:12-9. 2008
    ..This review article deals with recent progresses in CSPs based on protein or glycoproteins in LC after 2001, focusing on their enantioselective properties and chiral recognition mechanisms...
  44. ncbi request reprint Peroxynitrite-mediated oxidative modification of low-density lipoprotein by aqueous extracts of cigarette smoke and the preventive effect of fluvastatin
    Yu Yamaguchi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya 663 8179, Japan
    Atherosclerosis 172:259-65. 2004
    ..Fluvastatin may be potentially beneficial to hypercholesterolemic patients with oxidative stress such as smoking...
  45. ncbi request reprint Monodispersed, molecularly imprinted polymers as affinity-based chromatography media
    Jun Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 866:3-13. 2008
    ..Furthermore, applications of MIP microspheres as affinity-based chromatography media, HPLC stationary phases and solid-phase extraction media, will be discussed for pharmaceutical, biomedical and environmental analysis...
  46. ncbi request reprint Fluvastatin reduces modification of low-density lipoprotein in hyperlipidemic rabbit loaded with oxidative stress
    Yu Yamaguchi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, 663 8179, Nishinomiya, Japan
    Eur J Pharmacol 436:97-105. 2002
    ..These results indicate that fluvastatin can exert an antioxidant effect in vivo, with a strong effect on oxidative stress such as smoking, a major risk factor of atherosclerosis...
  47. ncbi request reprint Assay methods of modified lipoproteins in plasma
    Yu Yamaguchi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya 663 8179, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 781:313-30. 2002
    ..This review article summarizes the detection and assay methods of modified lipoproteins in plasma...
  48. ncbi request reprint Separation of basic drug enantiomers by capillary electrophoresis using chicken alpha1-acid glycoprotein: insight into chiral recognition mechanism
    Hisami Matsunaga
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    Electrophoresis 24:2442-7. 2003
    ..These results reveal that the protein domain of the chicken alpha(1)-AGP is responsible for the chiral recognition ability, and that the chiral recognition site(s) for basic drugs exists on the protein domain...
  49. ncbi request reprint Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke
    Yu Yamaguchi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, 663 8179, Nishinomiya, Japan
    FEBS Lett 512:218-22. 2002
    ..A similar increase of 3-nitrotyrosine occurred after incubation of LDL with a peroxynitrite generating agent, 3-morpholinosydnonimine, thus suggesting that prominent pro-oxidants in CSE are peroxynitrite-generating species...
  50. ncbi request reprint Chiral separations by capillary electrophoresis using proteins as chiral selectors
    Jun Haginaka
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Methods Mol Biol 243:291-305. 2004
  51. ncbi request reprint HPLC chiral stationary phases produced with isolated human serum albumin fragments
    Hisami Matsunaga
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    Anal Sci 18:27-30. 2002
    ..Further, the HSA-FG75 column was as stable as the intact HSA column for repetitive injection of samples...
  52. ncbi request reprint Protein domain of chicken alpha(1)-acid glycoprotein is responsible for chiral recognition
    Yutaka Sadakane
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Japan
    Biochem Biophys Res Commun 295:587-90. 2002
    ..Since proteins expressed in E. coli are not modified by any sugar moieties, this result shows that the protein domain of the chicken alpha(1)-AGP is responsible for the chiral recognition...
  53. ncbi request reprint Identification of disulfide bonds and site-specific glycosylation in chicken alpha1-acid glycoprotein by matrix-assisted laser desorption ionization time-of-flight mass spectrometry
    Hisami Matsunaga
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    Anal Biochem 331:358-63. 2004
    ..The results also showed that Asn 16, 70, 77, and 87 were fully glycosylated and that Asn 62 was partially glycosylated...
  54. ncbi request reprint HPLC retention behavior of poly-aromatic-hydrocarbons on aminopropyl silica gels modified with Cu(II)- and Ni(II)-phthalocyanine derivatives in non-polar eluent
    Hiromichi Akizawa
    Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Naka, Okayama 700 8530, Japan
    Chem Pharm Bull (Tokyo) 52:41-6. 2004
    ..All the columns possessed planar recognition ability and were estimated to be potentially useful in the separation and the analysis of PAHs...
  55. ncbi request reprint Investigation of chiral recognition mechanism on chicken alpha(1)-acid glycoprotein using separation system
    Hisami Matsunaga
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Nishinomiya, Hyogo 663 8179, Japan
    J Chromatogr A 1106:124-30. 2006
    ....
  56. ncbi request reprint Molecularly imprinted polymers for triazine herbicides prepared by multi-step swelling and polymerization method. Their application to the determination of methylthiotriazine herbicides in river water
    Haruyo Sambe
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    J Chromatogr A 1152:130-7. 2007
    ..The recoveries of simetryn, ametryn and prometryn at 50 pg/mL were 101%, 95.6% and 95.1%, respectively. This method was successfully applied for the simultaneous determination of simetryn, ametryn and prometryn in river water...
  57. ncbi request reprint Uniformly sized molecularly imprinted polymers for bisphenol A and beta-estradiol: retention and molecular recognition properties in hydro-organic mobile phases
    Haruyo Sanbe
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    J Pharm Biomed Anal 30:1835-44. 2003
    ....
  58. ncbi request reprint Restricted access media-molecularly imprinted polymer for propranolol and its application to direct injection analysis of beta-blockers in biological fluids
    Haruyo Sanbe
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    Analyst 128:593-7. 2003
    ..5 ng ml(-1) with a 50 microl injection. This method could be applicable for the assay of ALP enantiomers at the therapeutic plasma levels, and have wide applicability for the assay of beta-blockers in biological fluids...
  59. doi request reprint Molecularly imprinted polymers for simultaneous determination of antiepileptics in river water samples by liquid chromatography-tandem mass spectrometry
    Kaori Hoshina
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    J Chromatogr A 1216:4957-62. 2009
    ..The concentrations of phenobarbital and phenytoin in river water samples were about 15 and 4 ng/L, respectively, while that of amobarbital was below the limit of quantitation...
  60. ncbi request reprint Preparation of uniformly sized molecularly imprinted polymers for phenolic compounds and their application to the assay of bisphenol A in river water
    Haruyo Sanbe
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    Anal Sci 19:715-9. 2003
    ..999 in the concentration ranges of 25-1000 ppt. The limit of quantitation was 25 ppt with a 5-ml injection. The column-switching HPLC system was successfully applied for the assay of BPA in river water...
  61. ncbi request reprint Simultaneous determination of bisphenol A and its halogenated derivatives in river water by combination of isotope imprinting and liquid chromatography-mass spectrometry
    Haruyo Sambe
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    J Chromatogr A 1134:16-23. 2006
    ..08, 3.67 and 1.58%, respectively. Furthermore, this method was successfully applied for the simultaneous determination of BPA and its halogenated derivatives in river water...
  62. ncbi request reprint Selective surface modification technique for improvement of chromatographic separation selectivity for sugar derivatives
    Ken Hosoya
    Department of Polymer Science, Kyoto Institute of Technology, Japan
    Anal Sci 18:55-8. 2002
    ....
  63. ncbi request reprint HPLC retention behaviors of pi-electron rich compounds on Ni2+- and Cu2+-phthalocyanine derivatives bound to silica gels in polar eluents
    Ikuko Tsukamoto
    Faculty of Medicine, Kagawa University, Ikenobe, Miki cho, Kagawa 761 0793, Japan
    Anal Sci 22:1035-8. 2006
    ..Further, an investigation of the retention behavior of anthracene derivatives having different substituents revealed that the Ni- and Cu-PCS(D) columns could recognize the differences of substituents only in a polar eluent...
  64. ncbi request reprint Improved detectability with a polymer-based trapping device in rapid HPLC analysis for ultra-low levels of bisphenol A (BPA) in environmental samples
    Yoshiyuki Watabe
    Department of Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    Anal Sci 20:133-7. 2004
    ..By employing these precautionary measures and procedures to reduce BPA contamination from the analytical procedure, we could accurately determine l(-10) ppt of BPA in environmental water samples using a column switching HPLC system...
  65. ncbi request reprint Uniformly sized molecularly imprinted polymer for atropine and its application to the determination of atropine and scopolamine in pharmaceutical preparations containing Scopolia extract
    Masanori Nakamura
    Taisho Pharmaceutical Co Ltd, 403 Yoshino Cho 1 Chome, Kita ku, Saitama shi, Saitama 331 9530, Japan
    J Pharm Biomed Anal 37:231-7. 2005
    ..S.D. (%)) of both ingredients was less than 2.0%. The optimized column-switching system was applied successfully to the determination of atropine and scopolamine in a commercial gastrointestinal drug...
  66. ncbi request reprint Retentivity and enantioselectivity of uniformly-sized molecularly imprinted polymers for (S)-nilvadipine in aqueous and non-aqueous mobile phases
    Haruyo Sambe
    Laboratory of Intellectual Fundamentals for Environmental Studies, National Institute for Environmental Studies, 16 2, Onogawa, Tukuba, Ibaraki 305 8506, Japan
    Anal Sci 21:391-5. 2005
    ..Furthermore, the MIP for (S)-nilvadipine gave the highest molecular recognition ability when a porogenic solvent during polymerization was used as the mobile phase modifier...
  67. ncbi request reprint HPLC retention behaviors of poly-aromatic-hydrocarbones on Cu(II)-octabromotetrakis(4-carboxyphenyl)porphine derivatives-immobilized aminopropyl silica gels in polar and non-polar eluents
    Masaki Mifune
    Department of Pharmaceutical Sciences, Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Okayama University, Tsushima Naka, Japan
    Chem Pharm Bull (Tokyo) 54:94-8. 2006
    ....
  68. ncbi request reprint Multiple ligand-binding properties of the lipocalin member chicken alpha1-acid glycoprotein studied by circular dichroism and electronic absorption spectroscopy: the essential role of the conserved tryptophan residue
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, Budapest, P O Box 17, H 1525, Hungary
    Biochim Biophys Acta 1760:1248-73. 2006
    ..Overall, cAGP serves as a simple, ultimate model to extend our knowledge on ligand-binding properties of lipocalins and to study the role of tryptophan residues in molecular recognition processes...
  69. ncbi request reprint Determination of bisphenol A in environmental water at ultra-low level by high-performance liquid chromatography with an effective on-line pretreatment device
    Yoshiyuki Watabe
    Department of Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    J Chromatogr A 1032:45-9. 2004
    ..36 ng/l. This method applied to environmental water and purified water samples containing 2-70 ng/l of BPA successfully. Furthermore, UV detection was performed in some actual analyses...
  70. ncbi request reprint A possible purification method of DNAs' fragments from humic matters in soil extracts using novel stimulus responsive polymer adsorbent
    Ken Hosoya
    Department of Polymer Science, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    J Pharm Biomed Anal 30:1919-22. 2003
    ..Cleaning up of the polymer adsorbent could be performed by washing the adsorbed humic matters with alkaline mobile phase (pH 9) to recover those and realize repeatable use of the adsorbent...
  71. ncbi request reprint Direct injection analysis of bisphenol A in serum by combination of isotope imprinting with liquid chromatography-mass spectrometry
    Haruyo Sambe
    Laboratory of Intellectual Fundamentals for Environmental Studies, National Institute for Environmental Studies, Tukuba, Ibaraki 305 8506, Japan
    Analyst 130:38-40. 2005
    ..A restricted access media-molecularly imprinted polymer was prepared using bisphenol A (BPA)-d16 as a template molecule, and was successfully applied to direct injection analysis of BPA in serum combined with column-switching LC-MS...
  72. ncbi request reprint Displacement and nonlinear chromatographic techniques in the investigation of interaction of noncompetitive inhibitors with an immobilized alpha3beta4 nicotinic acetylcholine receptor liquid chromatographic stationary phase
    Krzysztof Jozwiak
    Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224 6825, USA
    Anal Chem 74:4618-24. 2002
    ..This was consistent with results from a previous in vitro study. The data from this study indicate that the immobilized alpha3beta4-nAChR column and nonlinear chromatography can be used in the study of NCIs at the alpha3beta4-nAChR...
  73. ncbi request reprint Coloration of phenothiazines with metal-containing drugs
    Kouichi Hosomi
    Department of Pharmacy, Nishi Kobe Medical Center, Japan
    Yakugaku Zasshi 124:587-98. 2004
    ..This present observation can be then used in advance to avoid coloration of phenothiazines during preparative procedures with metal-containing drugs such as antacids...
  74. ncbi request reprint Enantiomeric purity determination of acetyl-L-carnitine by NMR with chiral lanthanide shift reagents
    Miyuki Kagawa
    Analytical Development Laboratories, Tanabe Seiyaku, Co Ltd, 16 89, Kashima 3 chome, Yodogawa ku, Osaka 532 8505, Japan
    J Pharm Biomed Anal 38:918-23. 2005
    ..5% of the minor enantiomer (D-form) in acetyl-L-carnitine chloride was found to be possible by 1H NMR with tris[3-(heptafluoropropylhydroxymethylene)-D-camphorato] and praseodymium derivative, (Pr[hfc]3), as chiral shift reagents...