Masato Tsurudome

Summary

Affiliation: Mie University
Country: Japan

Publications

  1. pmc The Fusion Protein Specificity of the Parainfluenza Virus Hemagglutinin-Neuraminidase Protein Is Not Solely Defined by the Primary Structure of Its Stalk Domain
    Masato Tsurudome
    Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine, Tsu City, Mie, Japan
    J Virol 89:12374-87. 2015
  2. ncbi request reprint Identification of regions on the fusion protein of human parainfluenza virus type 2 which are required for haemagglutinin-neuraminidase proteins to promote cell fusion
    M Tsurudome
    Department of Microbiology, Mie University School of Medicine, Tsu, Japan
    J Gen Virol 79:279-89. 1998
  3. pmc Hemagglutinin-neuraminidase-independent fusion activity of simian virus 5 fusion (F) protein: difference in conformation between fusogenic and nonfusogenic F proteins on the cell surface
    M Tsurudome
    Department of Microbiology, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    J Virol 75:8999-9009. 2001
  4. pmc Effects of hemagglutinin-neuraminidase protein mutations on cell-cell fusion mediated by human parainfluenza type 2 virus
    Masato Tsurudome
    Department of Microbiology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507 Japan
    J Virol 82:8283-95. 2008
  5. ncbi request reprint [Viral fusion mechanisms]
    Masato Tsurudome
    Department of Microbiology, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Uirusu 55:207-19. 2005
  6. ncbi request reprint A mutant fusion (F) protein of simian virus 5 induces hemagglutinin-neuraminidase-independent syncytium formation despite the internalization of the F protein
    Masato Tsurudome
    Department of Microbiology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Virology 347:11-27. 2006
  7. pmc Identification of domains on the fusion (F) protein trimer that influence the hemagglutinin-neuraminidase specificity of the f protein in mediating cell-cell fusion
    Masato Tsurudome
    Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    J Virol 85:3153-61. 2011
  8. ncbi request reprint The conserved carboxyl terminus of human parainfluenza virus type 2 V protein plays an important role in virus growth
    Machiko Nishio
    Department of Microbiology, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie, 514 8507, Japan
    Virology 362:85-98. 2007
  9. ncbi request reprint Failure of multinucleated giant cell formation in k562 cells infected with newcastle disease virus and human parainfluenza type 2 virus
    Izumi Yamakawa
    Department of Microbiology, Mie University Graduate School of Medicine, Japan
    Microbiol Immunol 51:601-8. 2007
  10. pmc Full conversion of the hemagglutinin-neuraminidase specificity of the parainfluenza virus 5 fusion protein by replacement of 21 amino acids in its head region with those of the simian virus 41 fusion protein
    Masato Tsurudome
    Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    J Virol 87:8342-50. 2013

Collaborators

Detail Information

Publications32

  1. pmc The Fusion Protein Specificity of the Parainfluenza Virus Hemagglutinin-Neuraminidase Protein Is Not Solely Defined by the Primary Structure of Its Stalk Domain
    Masato Tsurudome
    Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine, Tsu City, Mie, Japan
    J Virol 89:12374-87. 2015
    ..36 or with the SV41 F protein, similar to the SV41 HN protein. Thus, we conclude that the F protein specificity of the HN protein that is observed in the fusion event is not solely defined by the primary structure of the HN stalk domain...
  2. ncbi request reprint Identification of regions on the fusion protein of human parainfluenza virus type 2 which are required for haemagglutinin-neuraminidase proteins to promote cell fusion
    M Tsurudome
    Department of Microbiology, Mie University School of Medicine, Tsu, Japan
    J Gen Virol 79:279-89. 1998
    ..These regions on the PIV-2 F protein may be involved in a putative functional interaction with HN proteins, which is considered to be a prerequisite for cell fusion...
  3. pmc Hemagglutinin-neuraminidase-independent fusion activity of simian virus 5 fusion (F) protein: difference in conformation between fusogenic and nonfusogenic F proteins on the cell surface
    M Tsurudome
    Department of Microbiology, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    J Virol 75:8999-9009. 2001
    ..The native conformation of L22P may represent an intermediate between native and postfusion conformations of a typical paramyxovirus F protein...
  4. pmc Effects of hemagglutinin-neuraminidase protein mutations on cell-cell fusion mediated by human parainfluenza type 2 virus
    Masato Tsurudome
    Department of Microbiology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507 Japan
    J Virol 82:8283-95. 2008
    ..Notably, the limited cell-cell fusion by H-83/186 virus was greatly promoted by lysophosphatidic acid, a stimulator of the Ras and Rho family GTPases...
  5. ncbi request reprint [Viral fusion mechanisms]
    Masato Tsurudome
    Department of Microbiology, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Uirusu 55:207-19. 2005
    ..The crystal structures of F and the attachment protein HN have recently been clarified, which will facilitate studies of the molecular mechanism of F-mediated membrane fusion...
  6. ncbi request reprint A mutant fusion (F) protein of simian virus 5 induces hemagglutinin-neuraminidase-independent syncytium formation despite the internalization of the F protein
    Masato Tsurudome
    Department of Microbiology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Virology 347:11-27. 2006
    ..Intriguingly, it disappeared from the cell surface due to its internalization, while inducing extensive syncytium formation. These results indicate that L22P may display an internalization signal during the course of fusion induction...
  7. pmc Identification of domains on the fusion (F) protein trimer that influence the hemagglutinin-neuraminidase specificity of the f protein in mediating cell-cell fusion
    Masato Tsurudome
    Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    J Virol 85:3153-61. 2011
    ....
  8. ncbi request reprint The conserved carboxyl terminus of human parainfluenza virus type 2 V protein plays an important role in virus growth
    Machiko Nishio
    Department of Microbiology, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie, 514 8507, Japan
    Virology 362:85-98. 2007
    ..Depletion of AIP1/Alix by small interfering RNA suppressed virus growth. These data suggest that the conserved carboxyl terminus of the V protein plays an important role in virus growth...
  9. ncbi request reprint Failure of multinucleated giant cell formation in k562 cells infected with newcastle disease virus and human parainfluenza type 2 virus
    Izumi Yamakawa
    Department of Microbiology, Mie University Graduate School of Medicine, Japan
    Microbiol Immunol 51:601-8. 2007
    ..An unknown regulatory mechanism of virus-induced cell fusion may function on the cell surface of K562 cells...
  10. pmc Full conversion of the hemagglutinin-neuraminidase specificity of the parainfluenza virus 5 fusion protein by replacement of 21 amino acids in its head region with those of the simian virus 41 fusion protein
    Masato Tsurudome
    Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    J Virol 87:8342-50. 2013
    ....
  11. pmc Identification of paramyxovirus V protein residues essential for STAT protein degradation and promotion of virus replication
    Machiko Nishio
    Department of Microbiology, Mie University School of Medicine, Tsu Shi, Mie Prefecture, Japan
    J Virol 79:8591-601. 2005
    ..Interestingly, many of the residues that are essential for anti-IFN activity, e.g., the Cys of this cluster and Phe207 within this cluster, as well as the Trp of this motif, are also essential for promoting virus growth...
  12. ncbi request reprint Identification of amino acids essential for the human parainfluenza type 2 virus V protein to lower the intracellular levels of the STAT2
    Yuji Kozuka
    Department of Microbiology, Mie University School of Medicine, 2 174, Edobashi, Tsu Shi, Mie Prefecture 514 8507, Japan
    Virology 317:208-19. 2003
    ..On the other hand, HeLa/SV41V, HeLa/S216D, and HeLa1217R cells are resistant to both IFNs. Intriguingly, HeLa/A105E and HeLa/H108P cells were found to be sensitive to IFN-gamma...
  13. ncbi request reprint The properties of recombinant Sendai virus having the P gene of Sendai virus pi strain derived from BHK cells persistently infected with Sendai virus
    Machiko Nishio
    Department of Microbiology, Mie University Graduate School of Medicine, 2 174, Edobashi, 514 8507 Tsu Shi, Mie Prefecture, Japan
    Med Microbiol Immunol 195:151-8. 2006
    ..The specific amino acid substitutions unique to the SeVpi are 18. Information about the complete genome sequences of SeVpi strain is important to totally understand the persistent infection and lower pathogenicity of SeV...
  14. ncbi request reprint Recombinant Sendai viruses with L1618V mutation in their L polymerase protein establish persistent infection, but not temperature sensitivity
    Machiko Nishio
    Department of Microbiology, Mie University School of Medicine, Mie Prefecture 514 8507, Japan
    Virology 329:289-301. 2004
    ..Three amino acid substitutions are also found in the Ppi protein, but rSeV(Ppi) does not show these phenotypes...
  15. pmc Human parainfluenza virus type 2 V protein inhibits genome replication by binding to the L protein: possible role in promoting viral fitness
    Machiko Nishio
    Department of Microbiology, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    J Virol 82:6130-8. 2008
    ..A possible role for this inhibition of genome replication in promoting viral fitness is discussed...
  16. ncbi request reprint Cytological properties of stromal cells derived from giant cell tumor of bone (GCTSC) which can induce osteoclast formation of human blood monocytes without cell to cell contact
    Makoto Nishimura
    Department of Microbiology, Mie University School of Medicine, Tsu Shi, Mie Prefecture 514 8507, Japan
    J Orthop Res 23:979-87. 2005
    ..Some lines of GCTSC expressed alkaline phosphatase, osteocalcin and Cbfa1, suggesting that GCTSC are intimately related to osteoblastic lineage...
  17. ncbi request reprint The functional interaction between CD98 and CD147 in regulation of virus-induced cell fusion and osteoclast formation
    Kouki Mori
    Department of Microbiology, Mie University School of Medicine, 2 174 Edobashi, Tsu Shi, 514 8507 Mie Prefecture, Japan
    Med Microbiol Immunol 193:155-62. 2004
    ..Ab2 and 3 also suppressed CD98-mediated cell fusion of monocytes. This study indicates the functional interaction between CD98 and CD147 in the regulation of cell fusion...
  18. ncbi request reprint Identification of RNA-binding regions on the P and V proteins of human parainfluenza virus type 2
    Machiko Nishio
    Department of Microbiology, Mie University School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    Med Microbiol Immunol 195:29-36. 2006
    ..Intriguingly, the P and V proteins of hPIV2 can selectively bind to the viral RNA under our experimental conditions...
  19. pmc Human parainfluenza virus type 2 L protein regions required for interaction with other viral proteins and mRNA capping
    Machiko Nishio
    Department of Microbiology, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    J Virol 85:725-32. 2011
    ..We propose that this conserved region of L also binds GTP (or GDP) to carry out the second step of the unconventional nonsegmented negative-strand virus capping reaction...
  20. pmc Early stage of establishment of persistent Sendai virus infection: unstable dynamic phase and then selection of viruses which are tightly cell associated, temperature sensitive, and capable of establishing persistent infection
    Morihiro Ito
    Department of Microbiology, School of Medicine, Mie University, 2 174 Edobashi, Tsu Shi, Mie Prefecture 514 8507, Japan
    J Virol 78:11939-51. 2004
    ..This study shows that there is an unstable dynamic phase at an early stage of the establishment of persistent Sendai virus infection (steady state), and then viruses capable of establishing persistent infection are selected...
  21. ncbi request reprint Characterization of Sendai virus persistently infected L929 cells and Sendai virus pi strain: recombinant Sendai viruses having Mpi protein shows lower cytotoxicity and are incapable of establishing persistent infection
    Machiko Nishio
    Department of Microbiology, Mie University School of Medicine, 2 174, Edobashi, Tsu Shi, Mie Prefecture, 514 8507, Japan
    Virology 314:110-24. 2003
    ..Amino acid 116 of the Mpi protein is related to the nuclear translocation and lower cytopathogenesis, whereas aa183 is involved in the interaction between M protein and viral glycoproteins...
  22. ncbi request reprint Up-regulated expression of a novel gene in activated human peripheral blood mononuclear cells that is a truncated paralog of the human system L-amino acid transporter 1
    Morihiro Ito
    Department of Microbiology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Japan
    Int J Biochem Cell Biol 34:1152-63. 2002
    ..This study intends to examine whether these novel transcripts have biological significance through elucidating their genetic aspects and expression profiles in human cells...
  23. pmc Human parainfluenza virus type 4 is incapable of evading the interferon-induced antiviral effect
    Machiko Nishio
    Department of Microbiology, Mie University School of Medicine, 2 174, Edobashi, Tsu Shi, Mie Prefecture, 514 8507 Japan
    J Virol 79:14756-68. 2005
    ..Moreover, we established HeLa cells persistently infected with hPIV4 to make sure of the inability to escape IFN and confirmed that hPIV4 is the only paramyxovirus analyzed to date that can't evade the IFN-induced antiviral responses...
  24. pmc Graf1 Controls the Growth of Human Parainfluenza Virus Type 2 through Inactivation of RhoA Signaling
    Keisuke Ohta
    Department of Microbiology, School of Medicine, Wakayama Medical University, Wakayam, Japan
    J Virol 90:9394-405. 2016
    ..These results collectively suggested that hPIV-2 P and V proteins enhanced hPIV-2 growth by binding to Graf1 and that Graf1 inhibits hPIV-2 growth through RhoA inactivation...
  25. ncbi request reprint Fucoidan inhibits parainfluenza virus type 2 infection to LLCMK2 cells
    Naomi Taoda
    Department of Microbiology, Suzuka University of Medical Science, Suzuka, Mie, Japan
    Biomed Res 29:331-4. 2008
    ....
  26. doi request reprint Three-dimensional stereotactic ROI template for measuring regional cerebral blood flow in 99mTc-ECD SPECT: comparison with the manual tracing method
    Naoki Nagasawa
    Department of Radiology, Mie University School of Medicine, Mie, Japan
    Nucl Med Commun 30:155-9. 2009
    ..This study was undertaken to compare the rCBF values obtained using the 3DSRT method and the conventional manual tracing method...
  27. ncbi request reprint Human osteosarcoma-derived cell lines produce soluble factor(s) that induces differentiation of blood monocytes to osteoclast-like cells
    Noriki Miyamoto
    Department of Microbiology, Mie University School of Medicine, Tsu, Japan
    Int Immunopharmacol 2:25-38. 2002
    ..9 cells in the presence of OCIF for 14 days, HOS cell-mediated osteoclastogenesis was suppressed, indicating that RANK-RANKL system is involved in the HOS cell-mediated osteoclastogenesis...
  28. doi request reprint Completion of the full-length genome sequence of human parainfluenza virus types 4A and 4B: sequence analysis of the large protein genes and gene start, intergenic and end sequences
    Hiroshi Komada
    Department of Microbiology, Suzuka University of Medical Science Suzuka, Mie, Japan
    Arch Virol 156:161-6. 2011
    ....
  29. ncbi request reprint Possible activation of murine T lymphocyte through CD98 is independent of interleukin 2/interleukin 2 receptor system
    Hiroshi Komada
    Department of Microbiology, Mie University School of Medicine, Mie, Japan
    Biomed Res 27:61-7. 2006
    ..Taken together with these findings, it was speculated that the CD98 system is independent of the IL-2/IL-2R system in murine T lymphocyte activation...
  30. doi request reprint Enhanced growth of influenza A virus by coinfection with human parainfluenza virus type 2
    Hideo Goto
    Department of Microbiology, School of Medicine, Wakayama Medical University, Wakayama, Japan
    Med Microbiol Immunol 205:209-18. 2016
    ..These results indicate that cell fusion induced by hPIV2 infection is beneficial to IAV replication and that enhanced viral replication by coinfection with different viruses can modify their pathological consequences. ..
  31. pmc Intranasally administered antigen 85B gene vaccine in non-replicating human Parainfluenza type 2 virus vector ameliorates mouse atopic dermatitis
    Hiroshi Kitagawa
    Department of Dermatology, Mie University, Graduate School of Medicine, Tsu, Mie, Japan
    PLoS ONE 8:e66614. 2013
    ..The respiratory tract epithelium captured rhPIV2 effectively without remarkable cytotoxic effects. These results suggested that rhPIV2/Ag85B might be a potent therapeutic tool to control allergic disorders. ..
  32. ncbi request reprint In vitro inhibition of human influenza A virus infection by fruit-juice concentrate of Japanese plum (Prunus mume SIEB. et ZUCC)
    Sangchai Yingsakmongkon
    Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto, Kasugai, Aichi 487 8501, Japan
    Biol Pharm Bull 31:511-5. 2008
    ....