Naoki Fujita

Summary

Affiliation: Mie University
Country: Japan

Publications

  1. pmc Hepatic oxidative DNA damage is associated with increased risk for hepatocellular carcinoma in chronic hepatitis C
    H Tanaka
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Sciences, Mie University Graduate School of Medicine, Mie, Japan
    Br J Cancer 98:580-6. 2008
  2. doi request reprint Comparison of hepatic oxidative DNA damage in patients with chronic hepatitis B and C
    N Fujita
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Sciences, Mie University Graduate School of Medicine, Mie, Japan
    J Viral Hepat 15:498-507. 2008
  3. doi request reprint Iron overload is associated with hepatic oxidative damage to DNA in nonalcoholic steatohepatitis
    Naoki Fujita
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Sciences, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Cancer Epidemiol Biomarkers Prev 18:424-32. 2009
  4. ncbi request reprint Effects of bezafibrate in patients with chronic hepatitis C virus infection: combination with interferon and ribavirin
    N Fujita
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mie University School of Medicine, Mie, Japan
    J Viral Hepat 13:441-8. 2006
  5. ncbi request reprint Hepatic oxidative DNA damage correlates with iron overload in chronic hepatitis C patients
    Naoki Fujita
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Science, Mie University Graduate School of Medicine, Mie, Japan
    Free Radic Biol Med 42:353-62. 2007
  6. ncbi request reprint Hepatitis C virus free-virion and immune-complex dynamics during interferon therapy with and without ribavirin in genotype-1b chronic hepatitis C patients
    N Fujita
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mie University School of Medicine, Mie, Japan
    J Viral Hepat 13:190-8. 2006
  7. pmc Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C
    Naoki Fujita
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Science, Mie University Graduate School of Medicine, Mie, Japan
    Mol Med 13:97-104. 2007
  8. ncbi request reprint Hepatic iron accumulation is associated with disease progression and resistance to interferon/ribavirin combination therapy in chronic hepatitis C
    Naoki Fujita
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Science, Mie University Graduate School of Medicine, Mie, Japan
    J Gastroenterol Hepatol 22:1886-93. 2007
  9. doi request reprint Patients with chronic hepatitis C achieving a sustained virological response to peginterferon and ribavirin therapy recover from impaired hepcidin secretion
    Naoki Fujita
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Sciences, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    J Hepatol 49:702-10. 2008
  10. pmc Identification of treatment efficacy-related host factors in chronic hepatitis C by ProteinChip serum analysis
    Naoki Fujita
    Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Mie, Japan
    Mol Med 17:70-8. 2011

Detail Information

Publications55

  1. pmc Hepatic oxidative DNA damage is associated with increased risk for hepatocellular carcinoma in chronic hepatitis C
    H Tanaka
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Sciences, Mie University Graduate School of Medicine, Mie, Japan
    Br J Cancer 98:580-6. 2008
    ..The strong correlation between hepatic DNA damage and iron overload suggests that the iron content may be a strong mediator of oxidative stress and iron reduction may reduce HCC incidence in patients with chronic hepatitis C...
  2. doi request reprint Comparison of hepatic oxidative DNA damage in patients with chronic hepatitis B and C
    N Fujita
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Sciences, Mie University Graduate School of Medicine, Mie, Japan
    J Viral Hepat 15:498-507. 2008
    ....
  3. doi request reprint Iron overload is associated with hepatic oxidative damage to DNA in nonalcoholic steatohepatitis
    Naoki Fujita
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Sciences, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Cancer Epidemiol Biomarkers Prev 18:424-32. 2009
    ..In conclusion, iron overload may play an important role in the pathogenesis of NASH by generating oxidative DNA damage and iron reduction therapy may reduce hepatocellular carcinoma incidence in patients with NASH...
  4. ncbi request reprint Effects of bezafibrate in patients with chronic hepatitis C virus infection: combination with interferon and ribavirin
    N Fujita
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mie University School of Medicine, Mie, Japan
    J Viral Hepat 13:441-8. 2006
    ..This pilot study provides further evidence of an association between HCV and LDL in serum and suggests the potential usefulness of bezafibrate as an anti-HCV reagent for the treatment of CHC patients...
  5. ncbi request reprint Hepatic oxidative DNA damage correlates with iron overload in chronic hepatitis C patients
    Naoki Fujita
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Science, Mie University Graduate School of Medicine, Mie, Japan
    Free Radic Biol Med 42:353-62. 2007
    ....
  6. ncbi request reprint Hepatitis C virus free-virion and immune-complex dynamics during interferon therapy with and without ribavirin in genotype-1b chronic hepatitis C patients
    N Fujita
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mie University School of Medicine, Mie, Japan
    J Viral Hepat 13:190-8. 2006
    ..In conclusion, analysis of early IC-HCV dynamics is useful for predicting the response to therapy and for understanding the mechanism of action of antiviral drugs in chronic hepatitis C patients...
  7. pmc Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C
    Naoki Fujita
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Science, Mie University Graduate School of Medicine, Mie, Japan
    Mol Med 13:97-104. 2007
    ....
  8. ncbi request reprint Hepatic iron accumulation is associated with disease progression and resistance to interferon/ribavirin combination therapy in chronic hepatitis C
    Naoki Fujita
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Science, Mie University Graduate School of Medicine, Mie, Japan
    J Gastroenterol Hepatol 22:1886-93. 2007
    ....
  9. doi request reprint Patients with chronic hepatitis C achieving a sustained virological response to peginterferon and ribavirin therapy recover from impaired hepcidin secretion
    Naoki Fujita
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Sciences, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    J Hepatol 49:702-10. 2008
    ..The aim of this study is to determine the clinical relevance of hepatic producing iron regulatory hormone-hepcidin, on iron overload in patients with chronic hepatitis C (CHC)...
  10. pmc Identification of treatment efficacy-related host factors in chronic hepatitis C by ProteinChip serum analysis
    Naoki Fujita
    Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Mie, Japan
    Mol Med 17:70-8. 2011
    ..Our data also may help us understand the mechanism for treatment resistance and development of more effective antiviral therapy targeted toward the modulation of lipogenesis or iron homeostasis in CHC patients...
  11. ncbi request reprint Iron overload in nonalcoholic steatohepatitis
    Naoki Fujita
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Sciences, Mie University Graduate School of Medicine, Mie, Japan
    Adv Clin Chem 55:105-32. 2011
    ..Larger controlled trials of longer duration are warranted to assess the long-term clinical benefit of phlebotomy and/or iron-restricted diet in NAFLD/NASH...
  12. ncbi request reprint Accumulation of 8-nitroguanine in the liver of patients with chronic hepatitis C
    Shinichiro Horiike
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    J Hepatol 43:403-10. 2005
    ....
  13. pmc Branched-chain amino acid supplementation reduces oxidative stress and prolongs survival in rats with advanced liver cirrhosis
    Motoh Iwasa
    Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan
    PLoS ONE 8:e70309. 2013
    ..BCAA prolongs survival in cirrhotic rats and this was likely the consequences of reduced iron accumulation, oxidative stress and fibrosis and improved glucose metabolism in the liver. ..
  14. doi request reprint Regional reduction in gray and white matter volume in brains of cirrhotic patients: voxel-based analysis of MRI
    Motoh Iwasa
    Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Edobashi 2 174, Tsu, Mie, 514 8507, Japan
    Metab Brain Dis 27:551-7. 2012
    ..Abnormal function in the above regions may account for the ammonia-mediated changes and neuropsychological deficits in hepatic encephalopathy...
  15. ncbi request reprint Nonimmune complexed HCV RNA titer in serum as a predictor of interferon response in patients with chronic hepatitis C
    Naoki Fujita
    Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan
    Am J Gastroenterol 98:645-52. 2003
    ....
  16. ncbi request reprint Twice-a-day versus once-a-day interferon-beta therapy in chronic hepatitis C
    Masahiko Kaito
    Third Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu City, Mie, Japan 514 8507
    Hepatogastroenterology 50:775-8. 2003
    ..We compared the efficacy and safety of twice-a-day versus once-a-day of natural interferon-beta for the initial treatment of patients with chronic hepatitis C...
  17. ncbi request reprint Different hepatitis C virus dynamics of free-virions and immune-complexes after initiation of interferon-alpha in patients with chronic hepatitis C
    Naoki Fujita
    Third Department of Internal Medicine, Mie University School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    J Hepatol 39:1013-9. 2003
    ..To elucidate the mechanisms of action of interferon (IFN) against hepatitis C virus (HCV), we studied the serum HCV dynamics of free-virions (FV) and immune-complexes (IC) in patients treated with IFN...
  18. ncbi request reprint Effect of lactoferrin in patients with chronic hepatitis C: combination therapy with interferon and ribavirin
    Masahiko Kaito
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Sciences, Institute of Medical Science, Mie University Graduate School of Medicine, Tsu, Japan
    J Gastroenterol Hepatol 22:1894-7. 2007
    ..The aim of this study was to evaluate the effect of combined triple therapy of lactoferrin, interferon and ribavirin in patients with CHC...
  19. doi request reprint Visceral fat volume predicts new-onset type 2 diabetes in patients with chronic hepatitis C
    Motoh Iwasa
    Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan
    Diabetes Res Clin Pract 94:468-70. 2011
    ..Increased visceral fat area (VFA) was associated with high values of HbA1c. The variables associated with a high risk of new-onset diabetes had a VFA>101 cm(2) in CHC, but not in NAFLD...
  20. ncbi request reprint Ultrastructural demonstration of hepatitis B virus production in a mouse model produced by hydrodynamic transfection
    Masayoshi Konishi
    Center for Physical and Mental Health, Mie University, Mie, Japan
    Int J Mol Med 20:31-6. 2007
    ..This mouse model may be useful for screening in vivo the efficacy of antiviral drugs...
  21. doi request reprint Value of the apparent diffusion coefficient for quantification of low-grade hepatic encephalopathy
    Ryosuke Sugimoto
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Sciences, Institute of Medical Science, Mie University Graduate School of Medicine, Tsu, Japan
    Am J Gastroenterol 103:1413-20. 2008
    ..Minimal hepatic encephalopathy (HE) is associated with poorer quality of life and increased work disability. Recently, low-grade cerebral edema has been implicated in chronic liver disease...
  22. ncbi request reprint Morphological identification of hepatitis C virus E1 and E2 envelope glycoproteins on the virion surface using immunogold electron microscopy
    Masahiko Kaito
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Science, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Int J Mol Med 18:673-8. 2006
    ..These particles also specifically reacted with both anti-E1 and E2 antibodies. This is the first report showing the presence of both HCV E1 and E2 glycoproteins on HCV virion surface in human plasma samples...
  23. ncbi request reprint Circulating level of large splice variants of tenascin-C is a marker of piecemeal necrosis activity in patients with chronic hepatitis C
    Hideaki Tanaka
    Department of Gastroenterology and Hepatology, Institute of Clinical Medicine and Biomedical Sciences, Mie University Graduate School of Medicine, Japan
    Liver Int 26:311-8. 2006
    ....
  24. ncbi request reprint Upregulation of transferrin receptor 2 and ferroportin 1 mRNA in the liver of patients with chronic hepatitis C
    Masaki Takeo
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mie University School of Medicine, Mie, Japan
    J Gastroenterol Hepatol 20:562-9. 2005
    ..The mechanism of iron accumulation in the liver is not known. In the present study, hepatic messenger RNA (mRNA) expression of transferrin receptor (TfR)1, TfR2, and ferroportin (FP)1 was measured in patients with chronic hepatitis (CH)...
  25. doi request reprint Molecular epidemiology and genetic history of European-type genotype 3 hepatitis E virus indigenized in the central region of Japan
    Tatsunori Nakano
    Department of Internal Medicine, Fujita Health University Nakakuri Sanatorium, Mie 514 1295, Japan
    Infect Genet Evol 12:1524-34. 2012
    ..Because hepatitis E cases caused by 3e strains are relatively rare in Japan, molecular evolutionary analyses of HEV infection in Mie prefecture is important for preventing a future hepatitis endemic or epidemic by 3e strains in Japan...
  26. ncbi request reprint Unidentified virus-like particles are detected in plasmas with elevated ALT levels: are they significant of etiological agent(s) of non-B, non-C hepatitis?
    Masahiko Kaito
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Science, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    Med Mol Morphol 40:23-8. 2007
    ..Spherical VLPs are detected in HBV- and HCV-negative plasmas significantly correlated with the elevation of ALT, suggesting that they are implicated in non-B, non-C hepatitis...
  27. ncbi request reprint Efficacy of long-term dietary restriction of total calories, fat, iron, and protein in patients with chronic hepatitis C virus
    Motoh Iwasa
    Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
    Nutrition 20:368-71. 2004
    ..We evaluated the balance of energy intake and changes in physical and hematologic indices of nutrition after a long-term dietary therapy...
  28. ncbi request reprint The ultrastructural morphology of native hepatitis B virus
    Masahiko Kaito
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Science, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Med Mol Morphol 39:136-45. 2006
    ..In conclusion, this study showed for the first time that the native replicative form of HBV is cobra- and horn-shaped...
  29. ncbi request reprint Morphology of hepatitis C and hepatitis B virus particles as detected by immunogold electron microscopy
    Masahiko Kaito
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Science, Mie University Graduate School of Medicine, Tsu, Mie, 514 8507, Japan
    Med Mol Morphol 39:63-71. 2006
    ..The study showed that the detection limit of virus using this method is 10(7) virions/ml...
  30. ncbi request reprint Early diagnosis of hepatocellular carcinoma using a sensitive assay for serum des-gamma-carboxy prothrombin: a prospective study
    Jiro Ikoma
    Third Department of Internal Medicine, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Hepatogastroenterology 49:235-8. 2002
    ....
  31. doi request reprint Nutrition therapy using a multidisciplinary team improves survival rates in patients with liver cirrhosis
    Motoh Iwasa
    Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan Electronic address
    Nutrition 29:1418-21. 2013
    ..The present study retrospectively analyzed whether nutrition therapy for liver cirrhosis (LC), performed by a multidisciplinary team that includes registered dieticians, improves survival rates...
  32. ncbi request reprint Impaired regulation of serum hepcidin during phlebotomy in patients with chronic hepatitis C
    Ryosuke Sugimoto
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Sciences, Mie University Graduate School of Medicine, Mie
    Hepatol Res 39:619-24. 2009
    ..This relative impairment of hepcidin expression may be relevant to disease progression, and thus correction of its regulation may be beneficial for these iron-overloaded C-HCV patients...
  33. ncbi request reprint Value of the extracellular water ratio for assessment of cirrhotic patients with and without ascites
    Nagisa Hara
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Sciences, Institute of Medical Science, Mie University Graduate School of Medicine, and
    Hepatol Res 39:1072-9. 2009
    ..Conclusion: Liver cirrhosis was characterized by a redistribution of body water. The ECW ratio is a reliable tool for quantification of redistribution of body water and can predict the development of ascites...
  34. doi request reprint Elevation of branched-chain amino acid levels in diabetes and NAFL and changes with antidiabetic drug treatment
    Motoh Iwasa
    Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, Japan Electronic address
    Obes Res Clin Pract 9:293-7. 2015
    ..The decrease in BCAAs with improved glucose metabolism suggests that abnormal glucose metabolism is also a factor in elevated BCAA levels. ..
  35. doi request reprint Reactive nitrogen species mediate DNA damage in Helicobacter pylori-infected gastric mucosa
    Masaki Katsurahara
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biochemical Sciences, Mie University Graduate School of Medicine, Mie, Japan
    Helicobacter 14:552-8. 2009
    ..In this study, RNS-mediated DNA damage in gastric mucosa was observed directly using a newly developed antibody to 8-NG to clarify how H. pylori infection causes nitrative DNA damage to gastric epithelial cells...
  36. doi request reprint Restriction of calorie and iron intake results in reduction of visceral fat and serum alanine aminotransferase and ferritin levels in patients with chronic liver disease
    Motoh Iwasa
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Sciences, Institute of Medical Science, Mie University Graduate School of Medicine Division of Dietary Service, Mie University School Hospital, Tsu, Japan
    Hepatol Res 40:1188-94. 2010
    ..Visceral fat may be a central target for future interventions, not only in NAFLD but also in hepatitis C...
  37. ncbi request reprint Expression of large tenascin-C splice variants by hepatic stellate cells/myofibroblasts in chronic hepatitis C
    Amro El-Karef
    Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Mie, Japan
    J Hepatol 46:664-73. 2007
    ..Earlier studies have suggested involvement of tenascin-C (TN-C) in liver fibrosis. Here, we examined expression of TN-C variants and types of alternatively spliced fibronectin-type III (FNIII) repeats in chronic hepatitis...
  38. pmc Improvement of regional cerebral blood flow after oral intake of branched-chain amino acids in patients with cirrhosis
    Mika Yamamoto
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    World J Gastroenterol 11:6792-9. 2005
    ..To evaluate the effect of oral intake of branched-chain amino acids (BCAA) on brain perfusion in patients with liver cirrhosis...
  39. doi request reprint Effect of suppressor of cytokine signaling on hepcidin production in hepatitis C virus replicon cells
    Hirohide Miyachi
    Department of Gastroenterology and Hepatology, Mie University Graduate school of Medicine Center for Physical and Mental Health, Mie University Graduate School of Medicine Department of Immunology, Mie University Graduate School of Medicine, Mie, Japan Klinik für Unfall, Hand und Wiederherstellungschirurgie, J W Goethe Universität Frankfurt, Frankfurt am Main, Germany
    Hepatol Res 41:364-74. 2011
    ..The modulation of SOCS1 and SOCS3 in HCV-infected hepatocytes may explain, at least in part, the relative shortage of hepcidin production in CH-C...
  40. ncbi request reprint Evaluating response to nutritional therapy using the branched-chain amino acid/tyrosine ratio in patients with chronic liver disease
    N Kawamura-Yasui
    Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
    J Clin Lab Anal 13:31-4. 1999
    ..The results of this study showed that BTR is a good index of the hepatic parenchymal damage and that it may be a useful marker for monitoring response to nutritional therapy in patients with chronic liver disease...
  41. ncbi request reprint Biliary excretion of TT virus (TTV)
    N Nakagawa
    Third Department of Internal Medicine, Mie University School of Medicine, Mie Ken, Japan
    J Med Virol 61:462-7. 2000
    ..TTV DNA was detected only in serum from some patients, suggesting that replication of TTV may occur in other organs as well as in the liver...
  42. doi request reprint Patients achieving clearance of HCV with interferon therapy recover from decreased retinol-binding protein 4 levels
    M Iwasa
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Sciences, Institute of Medical Science, Mie University Graduate School of Medicine, Tsu, Japan
    J Viral Hepat 16:716-23. 2009
    ..This is further supported by the observation that RBP4 levels increased significantly after treatment only in sustained virological response (SVR) patients and reached levels comparable to those of healthy subjects...
  43. ncbi request reprint Paraformaldehyde protects of hepatitis C virus particles during ultracentrifugation
    N Fujita
    Third Department of Internal Medicine, Mie University School of Medicine, Mie, Japan
    J Med Virol 63:108-16. 2001
    ..11-1.14 g/mL. This study describes a useful method for the purification of HCV virions, and provides new insights for elucidating the physicochemical properties of HCV particles...
  44. ncbi request reprint 5-Aza-2'-deoxycytidine induces histone hyperacetylation of mouse centromeric heterochromatin by a mechanism independent of DNA demethylation
    S Takebayashi
    Faculty of Bioresources, Mie University, 1515 Kamihama, Tsu, Mie, 514 8507, Japan
    Biochem Biophys Res Commun 288:921-6. 2001
    ..Our results suggest that 5-azadC-induced histone hyperacetylation is independent of DNA demethylation and that DNA methylation is not essential for the maintenance of the histone hypoacetylated state in centromeric heterochromatin...
  45. doi request reprint New findings regarding the epidemic history and population dynamics of Japan-indigenous genotype 3 hepatitis E virus inferred by molecular evolution
    Tatsunori Nakano
    Department of Internal Medicine, Fujita Health University Nanakuri Sanatorium, Mie, Japan
    Liver Int 32:675-88. 2012
    ....
  46. ncbi request reprint [Alcohol consumption and metabolic syndrome]
    Naoki Fujita
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Nihon Arukoru Yakubutsu Igakkai Zasshi 45:157-66. 2010
    ....
  47. doi request reprint Alcohol consumption and metabolic syndrome
    Naoki Fujita
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Sciences, Mie University Graduate School of Medicine, Mie, Japan
    Hepatol Res 41:287-95. 2011
    ..This article reviews the relation of alcohol consumption and components of metabolic syndrome, and discusses the epidemiological evidence for alcohol's putative vascular protective effects and plausible underlying biological mechanisms...
  48. ncbi request reprint Disturbances in hepatocellular function during cardiopulmonary bypass using propofol anaesthesia
    N Okano
    Department of Anesthesiology, Saitama Cardiovascular and Pulmonary Center, 1696 Itai Kounanchyo Osato-gun, Saitama 360-0105, Japan
    Eur J Anaesthesiol 18:798-804. 2001
    ..793, P=0.0036, hepatic venous hyaluronate during bypass vs. that at 6 h after bypass; r=0.795, P=0.0035). CONCLUSIONS: Hepatocellular integrity might be disturbed during cardiopulmonary bypass when propofol anaesthesia is used...
  49. ncbi request reprint Long-term outcome of systemic cyclosporine treatment following penetrating keratoplasty
    K Inoue
    Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
    Jpn J Ophthalmol 45:378-82. 2001
    ..CONCLUSION: Systemic cyclosporine treatment for several months did not reduce the incidence of rejection nor improve the rate of graft clarity in the long term in high-risk patients after PKP...
  50. ncbi request reprint Combination therapy with indinavir, ritonavir, and delavirdine and nucleoside reverse transcriptase inhibitors in patients with HIV/AIDS who have failed multiple antiretroviral combinations
    M Grodesky
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    HIV Clin Trials 2:193-9. 2001
    ..The use of IDV/RTV/DLV and two NRTIs as salvage therapy has merit in patients who have no viable treatment options. A prospective trial utilizing this drug combination is warranted...
  51. ncbi request reprint Subcutaneous infection with Mycobacterium fortuitum after allogeneic bone marrow transplantation
    A Okano
    Second Department of Medicine, Kyoto Prefectural University of Medicine, 465 Kawaramachi-Hirokoji, Kami-gyoku, Kyoto, 602-8566, Japan
    Bone Marrow Transplant 28:709-11. 2001
    ..Mycobacterial infections should be considered in SCT patients with undiagnosed refractory chronic cutaneous infection, and surgical debridement is useful for the diagnosis and treatment of such infections...
  52. doi request reprint Inferior clinical outcome of the CD4+ cell count-guided antiretroviral treatment interruption strategy in the SMART study: role of CD4+ Cell counts and HIV RNA levels during follow-up
    Jens D Lundgren
    Copenhagen HIV Programme CHIP, Faculty of Health Sciences, University of Copenhagen, Panum Institute, 2200 Copenhagen N, Denmark
    J Infect Dis 197:1145-55. 2008
    ..Rates and predictors of opportunistic disease or death (OD/death) and the relative risk (RR) in DC versus VS groups according to the latest CD4+ cell count and HIV RNA level are reported...
  53. ncbi request reprint Comparison of conventional and diffusion-weighted MRI and proton MR spectroscopy in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like events
    K Abe
    Department of Neurology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, 565 0871 Osaka, Japan
    Neuroradiology 46:113-7. 2004
    ..Our findings suggest a possible predictive ability of (1)H-MRS, in showing early MELAS lesions and supports the hypothesis that mitochondrial metabolic dysfunction may precedes abnormalities on DWI...
  54. ncbi request reprint Risk for opportunistic disease and death after reinitiating continuous antiretroviral therapy in patients with HIV previously receiving episodic therapy: a randomized trial
    W M El-Sadr
    Ann Intern Med 149:289-99. 2008
    ..Episodic use of antiretroviral therapy guided by CD4+ cell counts is inferior to continuous antiretroviral therapy...
  55. pmc Circulating cell-free DNA as a predictive marker for distant metastasis of hepatitis C virus-related hepatocellular carcinoma
    Y Tokuhisa
    1Department of Surgery II, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Br J Cancer 97:1399-403. 2007
    ..Our results suggest that the serum cfDNA level reflects the metastatic potential of HCV-related HCC and that it can be a useful predictive biomarker for distant metastasis after curative surgery...