Norio Wake

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. doi request reprint Establishment of a new diagnostic method for hydropic villi by using TSSC3 antibody
    Norio Wake
    Research Center for Environment and Developmental Medical Sciences, Kyushu University, Fukuoka, Japan
    J Obstet Gynaecol Res 39:1230-5. 2013
  2. doi request reprint Malignant transformation of mature cystic teratoma to squamous cell carcinoma involves altered expression of p53- and p16/Rb-dependent cell cycle regulator proteins
    Atsuko Iwasa
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pathol Int 58:757-64. 2008
  3. doi request reprint Endometrial stromal sarcomas and related high-grade sarcomas: immunohistochemical and molecular genetic study of 31 cases
    Shuichi Kurihara
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, Japan
    Am J Surg Pathol 32:1228-38. 2008
  4. doi request reprint Level of reactive oxygen species induced by p21Waf1/CIP1 is critical for the determination of cell fate
    Takafumi Inoue
    Department of Obstetrics and Gynecology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Cancer Sci 100:1275-83. 2009
  5. pmc Endometrial cancer side-population cells show prominent migration and have a potential to differentiate into the mesenchymal cell lineage
    Kiyoko Kato
    Department of Obstetrics and Gynecology, School of Medicine, Kyushu University, Fukuoka, Japan
    Am J Pathol 176:381-92. 2010
  6. doi request reprint Coincident expression of beta-catenin and cyclin D1 in endometrial stromal tumors and related high-grade sarcomas
    Shuichi Kurihara
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Mod Pathol 23:225-34. 2010
  7. ncbi request reprint Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts
    Kazuo Asanoma
    Division of Molecular and Cell Therapeutics, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara Beppu Oita 874 0838, Japan
    J Reprod Med 49:617-26. 2004
  8. doi request reprint Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumors
    Masafumi Yasunaga
    Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Hum Pathol 40:965-74. 2009
  9. ncbi request reprint Cytoplasmic and stromal expression of laminin γ 2 chain correlates with infiltrative invasion in ovarian mucinous neoplasms of gastro-intestinal type
    Emi Okuma
    Department of Anatomic Pathology, Kyushu University Hospital, Fukuoka, Japan
    Oncol Rep 24:1569-76. 2010
  10. doi request reprint Hobnail-like cells in serous borderline tumor do not represent concomitant incipient clear cell neoplasms
    Yoshihiro Ohishi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hum Pathol 40:1168-75. 2009

Detail Information

Publications70

  1. doi request reprint Establishment of a new diagnostic method for hydropic villi by using TSSC3 antibody
    Norio Wake
    Research Center for Environment and Developmental Medical Sciences, Kyushu University, Fukuoka, Japan
    J Obstet Gynaecol Res 39:1230-5. 2013
    ..TSSC3 play an important role in the differentiation from trophoblast stem cells to progenitors and/or labyrinth trophoblast through the TSSC3/PI3K/Akt/Mash2 signaling pathway. ..
  2. doi request reprint Malignant transformation of mature cystic teratoma to squamous cell carcinoma involves altered expression of p53- and p16/Rb-dependent cell cycle regulator proteins
    Atsuko Iwasa
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pathol Int 58:757-64. 2008
    ..The results indicate that alterations in both the p53 and p16-Rb pathways are associated with SCC arising in MCT...
  3. doi request reprint Endometrial stromal sarcomas and related high-grade sarcomas: immunohistochemical and molecular genetic study of 31 cases
    Shuichi Kurihara
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, Japan
    Am J Surg Pathol 32:1228-38. 2008
    ..Our data suggest that UES-U shares some molecular genetic and immunohistochemical characteristics with ESS-LG, but UES-P considerably differs from ESS-LG...
  4. doi request reprint Level of reactive oxygen species induced by p21Waf1/CIP1 is critical for the determination of cell fate
    Takafumi Inoue
    Department of Obstetrics and Gynecology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Cancer Sci 100:1275-83. 2009
    ..The magnitude of intracellular ROS levels in response to p21 elicited either senescence or apoptosis in the cancer cell lines...
  5. pmc Endometrial cancer side-population cells show prominent migration and have a potential to differentiate into the mesenchymal cell lineage
    Kiyoko Kato
    Department of Obstetrics and Gynecology, School of Medicine, Kyushu University, Fukuoka, Japan
    Am J Pathol 176:381-92. 2010
    ..These findings demonstrate that SP cells have cancer stem-like cell features, including the potential to differentiate into the mesenchymal cell lineage...
  6. doi request reprint Coincident expression of beta-catenin and cyclin D1 in endometrial stromal tumors and related high-grade sarcomas
    Shuichi Kurihara
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Mod Pathol 23:225-34. 2010
    ..This finding raises the possibility that cyclin D1 is upregulated by beta-catenin in these high-grade sarcomas previously called high-grade endometrial stromal sarcoma...
  7. ncbi request reprint Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts
    Kazuo Asanoma
    Division of Molecular and Cell Therapeutics, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara Beppu Oita 874 0838, Japan
    J Reprod Med 49:617-26. 2004
    ..To isolate a choriocarcinoma suppressor gene and analyze its structure and function...
  8. doi request reprint Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumors
    Masafumi Yasunaga
    Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Hum Pathol 40:965-74. 2009
    ....
  9. ncbi request reprint Cytoplasmic and stromal expression of laminin γ 2 chain correlates with infiltrative invasion in ovarian mucinous neoplasms of gastro-intestinal type
    Emi Okuma
    Department of Anatomic Pathology, Kyushu University Hospital, Fukuoka, Japan
    Oncol Rep 24:1569-76. 2010
    ..The staining pattern of mural nodules was similar to that of infiltrative invasion. The infiltrative invasion of GI-type ovarian mucinous neoplasms may be promoted by cytoplasmic and/or stromal expression of laminin γ 2 chain...
  10. doi request reprint Hobnail-like cells in serous borderline tumor do not represent concomitant incipient clear cell neoplasms
    Yoshihiro Ohishi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hum Pathol 40:1168-75. 2009
    ..Recognition of our conclusion may protect a patient with "conspicuous hobnail-like cells in serous borderline tumor" from an erroneous overdiagnosis of "concomitant clear cell carcinoma admixed with serous borderline tumor."..
  11. ncbi request reprint HOP/NECC1, a novel regulator of mouse trophoblast differentiation
    Kazuo Asanoma
    Division of Molecular and Cell Therapeutics, Kyushu University, Japan
    J Biol Chem 282:24065-74. 2007
    ....
  12. pmc Prognosis and long-term neurodevelopmental outcome in conservatively treated twin-to-twin transfusion syndrome
    Xiangqun Li
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    BMC Pregnancy Childbirth 11:32. 2011
    ..3-26% of survivors. The purpose of this study was to investigate long-term neurodevelopmental outcome in conservatively treated TTTS...
  13. ncbi request reprint An inhibitory effect on cell proliferation by blockage of the MAPK/estrogen receptor/MDM2 signal pathway in gynecologic cancer
    Shin Suga
    Department of Molecular Genetics, Division of Molecular and Cell Therapeutics, Medical Institute of Bioregulation, Kyushu University, Maidadhi 3 1 1, Higashi ku, Fukuoka, Japan
    Gynecol Oncol 105:341-50. 2007
    ..We previously demonstrated that that the Ras/ER/MDM2 pathway was critical for NIH3T3 cell transformation. In this study, we examined the effect of blocking this pathway on cell growth in gynecologic cancer cells...
  14. doi request reprint Nuclear localization of E-cadherin but not beta-catenin in human ovarian granulosa cell tumours and normal ovarian follicles and ovarian stroma
    Yoshihiro Ohishi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Histopathology 58:423-32. 2011
    ..The aim of this study was to confirm subcellular localization of key molecules of Wnt signalling (beta-catenin and E-cadherin) in human ovarian GCTs...
  15. doi request reprint Induction of senescence by progesterone receptor-B activation in response to cAMP in ovarian cancer cells
    Akira Takahashi
    Department of Molecular Genetics, Division of Molecular and Cell Therapeutics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Gynecol Oncol 113:270-6. 2009
    ..In this study, we examined the effect of cAMP treatment on cell growth in Ras-transformed NIH3T3 cells and ovarian cancer cells...
  16. pmc Isolation and characterization of human trophoblast side-population (SP) cells in primary villous cytotrophoblasts and HTR-8/SVneo cell line
    Tomoka Takao
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    PLoS ONE 6:e21990. 2011
    ..These features shown by the SP cells suggested that IL7R and IL1R2 are available as markers to detect the SP cells and that vCTB progenitor cells and trophoblast stem cells were involved in the SP cell population...
  17. doi request reprint Short-term and long-term outcomes of 214 cases of non-immune hydrops fetalis
    Kotaro Fukushima
    Department of Obstetrics and Gynecology, Kyushu University Hospital, Kyushu University, Fukuoka, Japan
    Early Hum Dev 87:571-5. 2011
    ..Additionally, while survival was improved with intensive perinatal care during the perinatal period, aggressive perinatal intervention was not a prognostic factor for neurological outcome...
  18. doi request reprint The level of RCAS1 expression is inversely correlated with the number of vimentin-positive stromal cells in epithelial ovarian cancer
    Kenzo Sonoda
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Gynecol Cancer 19:838-43. 2009
    ..RCAS1 may contribute to connective tissue remodeling by altering the number of vimentin-positive cells in epithelial ovarian cancer...
  19. ncbi request reprint K-Ras and H-Ras activation promote distinct consequences on endometrial cell survival
    Yumiko Ninomiya
    Department of Molecular Genetics, Division of Molecular and Cell Therapeutics, Medical Institute of Bioregulation, Kyushu University, Oita, Japan
    Cancer Res 64:2759-65. 2004
    ..Coordination of the two pathways contributes to endometrial cell survival...
  20. pmc The maternally expressed gene Tssc3 regulates the expression of MASH2 transcription factor in mouse trophoblast stem cells through the AKT-Sp1 signaling pathway
    Tomoka Takao
    Research Center for Environment and Developmental Medical Sciences, Graduate School of Medical Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 287:42685-94. 2012
    ..This is the first report describing that TSSC3 plays an important role in the differentiation from TS to trophoblast progenitors and/or labyrinth trophoblasts through the TSSC3/PI3K/AKT/MASH2 signaling pathway...
  21. pmc Oxidative stress produced by xanthine oxidase induces apoptosis in human extravillous trophoblast cells
    Masaharu Murata
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Reprod Dev 59:7-13. 2013
    ..H(2)O(2) also induced apoptosis in primary cultured trophoblasts. In conclusion, ROS produced by XO induced apoptosis and affected EVT function including invasion and differentiation...
  22. doi request reprint Ultrasound evaluation of fetal brain dysfunction based on behavioral patterns
    Seiichi Morokuma
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Brain Dev 35:61-7. 2013
    ..We concluded that this method was mainly useful in the clinical setting for establishing the first indication for fetal CNS examination for functional impairment, rendering it suitable for clinical application...
  23. doi request reprint Low-dose mithramycin exerts its anticancer effect via the p53 signaling pathway and synergizes with nutlin-3 in gynecologic cancers
    Tatsuhiro Ohgami
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 101:1387-95. 2010
    ..These observations provide a better understanding of the mechanisms of mithramycin activity, and suggest a potential role for combining mithramycin and nutlin-3 as a chemotherapeutic treatment for gynecologic cancers...
  24. doi request reprint Homeobox gene HOPX is epigenetically silenced in human uterine endometrial cancer and suppresses estrogen-stimulated proliferation of cancer cells by inhibiting serum response factor
    Shinichiro Yamaguchi
    Department of Obstetrics and Gynecology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Int J Cancer 124:2577-88. 2009
    ..Knockdown of HOPX in immortalized human endometrial cells resulted in accelerated proliferation. Our study indicates that transcriptional silencing of HOPX results from hypermethylation of the HOPpromoter, which leads to HEC development...
  25. doi request reprint E-cadherin nuclear staining is useful for the diagnosis of ovarian adult granulosa cell tumor
    Yoshihiro Ohishi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Hum Pathol 43:808-17. 2012
    ..E-cadherin should be included in the immunohistochemical panel for an accurate diagnosis of ovarian adult granulosa cell tumors...
  26. ncbi request reprint The lung-to-thorax transverse area ratio at term and near term correlates with survival in isolated congenital diaphragmatic hernia
    Kiyomi Tsukimori
    Department of Obstetrics and Gynecology, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812, Japan
    J Ultrasound Med 27:707-13. 2008
    ....
  27. doi request reprint Expression and localization of E-cadherin and β-catenin in uterine carcinosarcoma
    Izumi Nishimura
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, 812 8582, Japan
    Virchows Arch 458:85-94. 2011
    ..Furthermore, although the precise mechanism is unclear, nuclear β-catenin expression in sarcomatous components may also be associated with biphasic morphology and heterologous sarcomatous differentiation...
  28. doi request reprint Incidence of postmolar gestational trophoblastic disease in androgenetic moles and the morphological features associated with low risk postmolar gestational trophoblastic disease
    Eisuke Kaneki
    Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Cancer Sci 101:1717-21. 2010
    ..The JSOG classification based on the morphology of hydropic villi is reliable for the diagnosis of CHM, but inaccurate for the diagnosis of PHM or "microscopic" moles...
  29. doi request reprint Prenatal diagnosis of a retroperitoneal lymphangioma: a case and review
    Masahiro Hachisuga
    Department of Gynecology and Obstetrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Fetal Diagn Ther 24:177-81. 2008
    ..It is important to observe the size and extension of such tumors in order to determine the prospect for neonatal prognosis, as well as to make decisions on the delivery timing and style...
  30. doi request reprint Cardiac hypertrophy of one fetus and selective growth restriction of the other fetus in a monochorionic twin pregnancy
    Yukiko Kondo
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Obstet Gynaecol Res 36:401-4. 2010
    ..We believe our case will assist the discussion surrounding the etiology of cardiac hypertrophy in monochorionic twins...
  31. doi request reprint Correlation between the presence of liver herniation and perinatal outcome in prenatally diagnosed fetal omphalocele
    Nobuhiro Hidaka
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Perinat Med 37:66-71. 2009
    ..To investigate the association between the presence of liver herniation and perinatal course and outcome of fetal omphalocele...
  32. pmc Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer
    Tomoko Yoneda
    Department of Obstetrics and Gynecology, School of Medicine, Kyushu University, Fukuoka 812 8582, Japan
    Oncol Rep 30:25-34. 2013
    ..The presence of the SNP309 G allele and TP53 codon 72 Arg/Arg genotype is associated with an increased risk of endometrial cancer in Japanese women...
  33. pmc Evaluation of haplotype inference using definitive haplotype data obtained from complete hydatidiform moles, and its significance for the analyses of positively selected regions
    Koichiro Higasa
    Division of Genome Analysis, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    PLoS Genet 5:e1000468. 2009
    ..We also show that the true haplotype data presented here is useful to assess and improve the accuracy of phasing of Asian genotypes...
  34. doi request reprint Three cases of acute fatty liver of pregnancy: postpartum clinical course depends on interval between onset of symptoms and termination of pregnancy
    Kaai Aso
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Matern Fetal Neonatal Med 23:1047-9. 2010
    ..We hypothesise that the interval between the onset of symptoms and termination of pregnancy is an important factor for acuity of the disorder and patient morbidity or mortality...
  35. doi request reprint Cervical length predicts placental adherence and massive hemorrhage in placenta previa
    Kotaro Fukushima
    Department of Obstetrics and Gynecology, Kyushu University Hospital, Kyushu University, Fukuoka, Japan
    J Obstet Gynaecol Res 38:192-7. 2012
    ..To evaluate the relationship between cervical length (CL) and obstetrical outcome in women with placenta previa...
  36. ncbi request reprint Prognostic implications of the nuclear localization of Y-box-binding protein-1 and CXCR4 expression in ovarian cancer: their correlation with activated Akt, LRP/MVP and P-glycoprotein expression
    Yoshinao Oda
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 98:1020-6. 2007
    ..These results indicate that YB-1 nuclear expression and CXCR4 expression are important prognostic factors in ovarian carcinoma...
  37. doi request reprint CD10 immunostaining distinguishes atypical polypoid adenomyofibroma (atypical polypoid adenomyoma) from endometrial carcinoma invading the myometrium
    Yoshihiro Ohishi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hum Pathol 39:1446-53. 2008
    ..This difference should lead to a more accurate diagnosis of APA (pseudo-myoinvasive lesion). Furthermore, the histogenesis of APA may perhaps be explained by "myofibromatous metaplasia" of the endometrial stromal cells...
  38. ncbi request reprint Activation of STAT3/5 signal pathways in complete mole and repression in choriocarcinoma cell lines
    Hidenori Kato
    Division of Molecular and Cell Therapeutics, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Tsurumihara 4546, Beppu City, Oita 874 0838, Japan
    J Reprod Med 51:41-8. 2006
    ..Because our previous study of microarray suggested that STAT5 and its downstream target, survivin, were up-regulated in complete mole (CM), we clarified the status of STAT-mediated signal transduction in CM and choriocarcinoma (CC)...
  39. pmc Regulation of the Mechanism of TWIST1 Transcription by BHLHE40 and BHLHE41 in Cancer Cells
    Kazuo Asanoma
    Department of Obstetrics and Gynecology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mol Cell Biol 35:4096-109. 2015
    ..We propose that BHLHE40/41 are promising markers to predict the aggressiveness of each HEC case and that molecular targeting strategies involving BHLHE40/41 and SP1 may effectively regulate HEC progression. ..
  40. pmc SNP55, a new functional polymorphism of MDM2-P2 promoter, contributes to allele-specific expression of MDM2 in endometrial cancers
    Kanako Okamoto
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    BMC Med Genet 16:67. 2015
    ..Although many studies have been performed to demonstrate the mechanism of allele-specific expression (ASE) on SNP309, they have only utilized in vitro techniques. It is unknown whether ASE of MDM2 is ascribed solely to SNP309, in vivo...
  41. doi request reprint Successful management of cervico-isthmic pregnancy delivered at term
    Atsuhiko Sakai
    Department of Obstetrics and Gynecology, Kyushu University Hospital, Fukuoka, Japan
    J Obstet Gynaecol Res 39:371-4. 2013
    ..Although a cervico-isthmic pregnancy constitutes a high-risk pregnancy, fertility-sparing management without a hysterectomy or blood transfusion was possible by not removing the placenta manually during the operation...
  42. ncbi request reprint Adenovirus-mediated calponin h1 gene therapy directed against peritoneal dissemination of ovarian cancer: bifunctional therapeutic effects on peritoneal cell layer and cancer cells
    Tomonori Ogura
    Department of Gynecology and Obstetrics, Graduate School of Medical Sciences, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 12:5216-23. 2006
    ..The purpose of this study is to evaluate the efficacy of i.p. CNh1 gene therapy against peritoneal dissemination of ovarian cancer...
  43. ncbi request reprint Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1
    Hidenori Kato
    Department of Molecular Genetics, Division of Molecular and Cell Therapeutics, Medical Institute of Bioregulation, Kyushu University, Tsurumihara 4546, Beppu City, Oita 874 0838, Japan
    Int J Cancer 118:1144-53. 2006
    ..These results also suggested the availability of negative regulation of HIF-1 signals for uterine cancer treatment, especially for uterine sarcomas that have worse prognosis and show a high frequency of EGLN1 gene abnormality...
  44. ncbi request reprint Expression of progesterone receptor B is associated with G0/G1 arrest of the cell cycle and growth inhibition in NIH3T3 cells
    Shinji Horiuchi
    Department of Molecular Genetics, Division of Molecular and Cell Therapeutics, Medical Institute of Bioregulation, Kyushu University, Tsurumihara 4546, Beppu, Oita, 874 0838, Japan
    Exp Cell Res 305:233-43. 2005
    ..Finally, we showed that PR-B modulation involved in the regulation of NIH3T3 cell proliferation was independent of nuclear estrogen receptor (ER) activity but dependent on non-genomic ER activity...
  45. ncbi request reprint Specific apoptosis induction in human papillomavirus-positive cervical carcinoma cells by photodynamic antisense regulation
    Asako Yamayoshi
    Department of Molecular Genetics, Division of Molecular and Cell Therapeutics, Kyushu University, Maidashi, Fukuoka 812 8582, Japan
    Oligonucleotides 17:66-79. 2007
    ..These results suggest that the photodynamic antisense strategy has the great therapeutic potential in HPV-positive cervical cancers...
  46. ncbi request reprint The biological role of the unique molecule RCAS1: a bioactive marker that induces connective tissue remodeling and lymphocyte apoptosis
    Kenzo Sonoda
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Front Biosci 13:1106-16. 2008
    ..Further exploration of the biological function of RCAS1 should help in the development of new therapeutic strategies against human malignancies...
  47. doi request reprint 8-Hydroxy-2-deoxyguanosine staining in placenta is associated with maternal serum uric acid levels and gestational age at diagnosis in pre-eclampsia
    Kotaro Fukushima
    Department of Obstetrics and Gynecology, Kyushu University Hospital, Kyushu University, Fukuoka, Japan
    Am J Hypertens 24:829-34. 2011
    ..Abnormal activation and/or dysfunction of the maternal vascular endothelium have been implicated as a cause of the placental ischemia and oxidative damage associated with pregnancy-induced hypertension (PIH)...
  48. doi request reprint Inhibition of nitric oxide synthetase at mid-gestation in rats is associated with increases in arterial pressure, serum tumor necrosis factor-alpha, and placental apoptosis
    Kiyomi Tsukimori
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Hypertens 21:477-81. 2008
    ....
  49. doi request reprint Ovarian undifferentiated carcinoma resembling giant cell carcinoma of the lung
    Masafumi Yasunaga
    Department of Anatomic Pathology, Kyushu University Hospital, Fukuoka, Japan
    Pathol Int 58:244-8. 2008
    ..The recognition of this type of ovarian tumor is important for clinical management, because adjuvant chemotherapy is the standard treatment for clinical management of epithelial ovarian cancer...
  50. doi request reprint Spontaneous resolution of cystic hygroma and hydrops in a fetus with Noonan's syndrome
    Asuka Kiyota
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Fetal Diagn Ther 24:499-502. 2008
    ..Serial evaluation of affected fetuses with ultrasound imaging may help clarify pathogenesis of cystic hygroma with associated hydrops, as well as mechanisms underlying spontaneous resolution...
  51. doi request reprint Prenatal diagnosis of trisomy 16 mosaicism manifested as pulmonary artery stenosis
    Nobuhiro Hidaka
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka, Japan
    J Clin Ultrasound 37:107-11. 2009
    ..The pregnancy was legally terminated. A review of previous reports suggests that abnormalities of outlet tracts are rarely encountered in fetuses with trisomy 16 mosaicism revealed via amniocentesis...
  52. doi request reprint Can we diagnose invasive cervical cancer during pregnancy as precise as in nonpregnant women?: maternal and perinatal outcome in pregnancies complicated with cervical cancers
    Kotaro Fukushima
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Int J Gynecol Cancer 19:1439-45. 2009
    ..The option of therapeutic delay should be carefully discussed. Patient counseling should address the issue that risk may not be precisely estimated because of the possibility that disease severity may be underestimated during pregnancy...
  53. pmc A definitive haplotype map as determined by genotyping duplicated haploid genomes finds a predominant haplotype preference at copy-number variation events
    Yoji Kukita
    Division of Genome Analysis, Research Center for Genetic Information, Kyushu University, Fukuoka 812 8582, Japan
    Am J Hum Genet 86:918-28. 2010
    ....
  54. doi request reprint Receptor-binding cancer antigen expressed on SiSo cells induces apoptosis via ectodomain shedding
    Kenzo Sonoda
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Exp Cell Res 316:1795-803. 2010
    ..K562 apoptosis could be induced only by co-culturing with SiSo or soluble RCAS1. RCAS1 is thus secreted by ectodomain shedding, which may represent a pivotal step in RCAS1-induced apoptosis initiation...
  55. doi request reprint Three-dimensional power Doppler sonography in the diagnosis of a cystic sacrococcygeal teratoma mimicking a meningomyelocele: A case report
    Maiko Sugitani
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Clin Ultrasound 37:410-3. 2009
    ..We report a case in which three-dimensional power Doppler imaging was helpful for making a correct prenatal diagnosis of a type 1 cystic sacrococcygeal teratoma, which mimicked a meningomyelocele...
  56. doi request reprint Clinical utility of augmentation index as a new parameter of peripheral circulation in human fetuses
    Yasuyuki Fujita
    Department of Obstetrics and Gynecology, Kyushu University, Fukuoka, Japan
    Early Hum Dev 89:601-5. 2013
    ..Therefore in this study we aimed to evaluate the utility of fetal AI calculated from aortic pulse waveforms for detecting the altered peripheral circulation in human fetuses...
  57. ncbi request reprint Biologic significance of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) as a pivotal regulator of tumor growth through angiogenesis in human uterine cancer
    Kenzo Sonoda
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer 110:1979-90. 2007
    ..To clarify whether RCAS1 exacerbates tumor progression, the authors investigated the association between RCAS1 expression and tumor growth potential...
  58. ncbi request reprint Differential diagnosis between complete and partial mole by TSSC3 antibody completely correlates to DNA diagnosis
    Hidenori Kato
    Division of Molecular and Cell Therapeutics, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Oita, Japan
    Diagn Mol Pathol 14:164-9. 2005
    ..Immunohistochemical (IHC) analysis also produced the same results. The complete silencing of TSSC3 in cases of CHM will provide a novel, convenient strategy for the diagnosis of molar lesions in the placenta...
  59. doi request reprint Prenatal three-dimensional images of proximal focal femoral deficiency produced by helical computed tomography
    Yuka Otera
    Departments of Gynecology and Obstetrics, Kyushu University, Fukuoka 812 8582, Japan
    Fetal Diagn Ther 25:349-53. 2009
    ..Proximal focal femoral deficiency (PFFD) is a rare skeletal disorder characterized by failure in development of the subtrochanteric region of the femoral shaft, with varying degrees of shortening of the proximal femur...
  60. doi request reprint Serum uric acid levels correlate with plasma hydrogen peroxide and protein carbonyl levels in preeclampsia
    Kiyomi Tsukimori
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Hypertens 21:1343-6. 2008
    ..Increased serum uric acid has been postulated to directly promote oxidative stress. The aim of this study was to investigate whether serum uric acid level correlated with superoxide generation and oxidative stress in preeclampsia...
  61. doi request reprint Characteristics and perinatal course of prenatally diagnosed fetal abdominal wall defects managed in a tertiary center in Japan
    Nobuhiro Hidaka
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Obstet Gynaecol Res 35:40-7. 2009
    ..To identify the clinical characteristics of fetal abdominal wall defects managed at a single institution and to provide information regarding the most likely clinical course of the affected fetuses...
  62. doi request reprint Ischemic ileal perforation in the donor of monochorionic twins complicated by twin-twin transfusion syndrome
    Kiyomi Tsukimori
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Chuo Ku, Fukuoka, Japan
    Fetal Diagn Ther 26:173-6. 2009
    ..Histopathology showed a focal area of erosion, possibly from ischemia. We also discuss the clinical features of ischemic intestinal complications of TTTS and review the literature...
  63. doi request reprint Improvement in the outcome of patients with antenatally diagnosed congenital diaphragmatic hernia using gentle ventilation and circulatory stabilization
    Kouji Masumoto
    Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Pediatr Surg Int 25:487-92. 2009
    ..In contrast, from 2004 to the present, a combination of gentle ventilation (GV) and a delayed operation was selected, which was performed when the patient's circulatory stabilization (CS) was achieved...
  64. doi request reprint A retrospective chart review of the perinatal period in 22 pregnancies of 16 women with Moyamoya disease
    Kotaro Fukushima
    Comprehensive Maternity and Perinatal Care Unit, Department of Obstetrics and Gynecology, Kyushu University Hospital, Kyushu University, Fukuoka, Japan
    J Clin Neurosci 19:1358-62. 2012
    ..Neurological events, however, may still occur postpartum even in well-managed patients. MMD may mimic the signs and symptoms of other neurological or psychiatric disorders, thereby complicating diagnosis and management...
  65. doi request reprint "Piling up" clear cells in müllerian-type mucinous and mixed cell-type borderline tumor do not represent concomitant clear cell neoplasms
    Yoshihiro Ohishi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Hum Pathol 43:1618-26. 2012
    ....
  66. doi request reprint Antenatally diagnosed congenital orbital teratoma in which rupture was associated with intrauterine fetal death
    Ai Anami
    Department of Obstetrics and Gynecology, Kyushu University Hospital, Kyushu University, Fukuoka, Japan
    J Obstet Gynaecol Res 38:578-81. 2012
    ..At 32 weeks', the patient presented with fetal demise and rupture of the mass was noted. Fetal COTs, like sacrococcygeal teratomas, carry the risk of rupture. MRI in utero is useful for evaluating the extent of disease...
  67. ncbi request reprint Increased inflammatory markers are associated with early periventricular leukomalacia
    Kiyomi Tsukimori
    Department of Obstetrics and Gynaecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Dev Med Child Neurol 49:587-90. 2007
    ..The excess O(2) (-) produced by activated neutrophils with increased pro-inflammatory cytokine production could play a role in the molecular cascade leading to white matter damage in PVL...
  68. ncbi request reprint Prenatal sonographic diagnosis of a hiatal hernia in a fetus with asplenia syndrome
    Nari Yamamoto
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka 812 8582, Japan
    J Ultrasound Med 26:1257-61. 2007
  69. pmc Abnormal fetal movements, micrognathia and pulmonary hypoplasia: a case report. Abnormal fetal movements
    Seiichi Morokuma
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Japan
    BMC Pregnancy Childbirth 10:46. 2010
    ..In this paper we report the case of a preterm infant with micrognathia and pulmonary hypoplasia who presented abnormal fetal movements...
  70. doi request reprint Neutrophil-derived reactive oxygen species can modulate neutrophil adhesion to endothelial cells in preeclampsia
    Kiyomi Tsukimori
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Hypertens 21:587-91. 2008
    ..Neutrophil activation has been implicated in the pathophysiology of preeclampsia. The aim of this study was to investigate whether neutrophil-derived reactive oxygen species (ROS) modulate adhesion to endothelial cells in preeclampsia...