Miki Nakao

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint Molecular cloning and protein analysis of divergent forms of the complement component C3 from a bony fish, the common carp (Cyprinus carpio): presence of variants lacking the catalytic histidine
    M Nakao
    Laboratory of Marine Biological Chemistry, Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University, Fukuoka, Japan
    Eur J Immunol 30:858-66. 2000
  2. pmc Extensive expansion and diversification of the chemokine gene family in zebrafish: identification of a novel chemokine subfamily CX
    Hisayuki Nomiyama
    Department of Molecular Enzymology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860 8556, Japan
    BMC Genomics 9:222. 2008
  3. ncbi request reprint A complement C3 fragment equivalent to mammalian C3d from the common carp (Cyprinus carpio): generation in serum after activation of the alternative pathway and detection of its receptor on the lymphocyte surface
    Miki Nakao
    Laboratory of Marine Biochemistry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Hakozaki, Fukuoka 812 8581, Japan
    Fish Shellfish Immunol 16:139-49. 2004
  4. ncbi request reprint Expansion of genes encoding complement components in bony fish: biological implications of the complement diversity
    Miki Nakao
    Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Hakozaki, 812 8581, Fukuoka, Japan
    Dev Comp Immunol 27:749-62. 2003
  5. ncbi request reprint Molecular cloning of the complement regulatory factor I isotypes from the common carp (Cyprinus carpio)
    Miki Nakao
    Laboratory of Marine Biochemistry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Hakozaki, 812 8581 Fukuoka, Japan
    Immunogenetics 54:801-6. 2003
  6. ncbi request reprint Lectin pathway of bony fish complement: identification of two homologs of the mannose-binding lectin associated with MASP2 in the common carp (Cyprinus carpio)
    Miki Nakao
    Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Kyushu University, Hakozaki, Fukuoka, Japan
    J Immunol 177:5471-9. 2006
  7. ncbi request reprint Molecular cloning of the complement (C1r/C1s/MASP2-like serine proteases from the common carp (Cyprinus carpio)
    M Nakao
    Laboratory of Marine Biological Chemistry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Hakozaki, Fukuoka, Japan
    Immunogenetics 52:255-63. 2001
  8. ncbi request reprint Diversity of complement factor B/C2 in the common carp (Cyprinus carpio): three isotypes of B/C2-A expressed in different tissues
    Miki Nakao
    Laboratory of Marine Biological Chemistry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Hakozaki, Fukuoka, 812 8581, Japan
    Dev Comp Immunol 26:533-41. 2002
  9. ncbi request reprint The complement component C5 of the common carp (Cyprinus carpio): cDNA cloning of two distinct isotypes that differ in a functional site
    Yoko Kato
    Laboratory of Marine Biochemistry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Hakozaki, 812 8581 Fukuoka, Japan
    Immunogenetics 54:807-15. 2003
  10. ncbi request reprint Purification and characterization of tributyltin-binding protein type 2 from plasma of Japanese flounder, Paralichthys olivaceus
    Yumi Oba
    Laboratory of Marine Environmental Science, Division of Marine Biological Chemistry, Department of Bioscience and Biotechnology, Kyushu University, Higashi ku, Fukuoka, 812 8581, Japan
    J Biochem 142:229-38. 2007

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Molecular cloning and protein analysis of divergent forms of the complement component C3 from a bony fish, the common carp (Cyprinus carpio): presence of variants lacking the catalytic histidine
    M Nakao
    Laboratory of Marine Biological Chemistry, Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University, Fukuoka, Japan
    Eur J Immunol 30:858-66. 2000
    ....
  2. pmc Extensive expansion and diversification of the chemokine gene family in zebrafish: identification of a novel chemokine subfamily CX
    Hisayuki Nomiyama
    Department of Molecular Enzymology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860 8556, Japan
    BMC Genomics 9:222. 2008
    ..Prior to this study, however, only incomplete lists of the zebrafish chemokine genes were reported...
  3. ncbi request reprint A complement C3 fragment equivalent to mammalian C3d from the common carp (Cyprinus carpio): generation in serum after activation of the alternative pathway and detection of its receptor on the lymphocyte surface
    Miki Nakao
    Laboratory of Marine Biochemistry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Hakozaki, Fukuoka 812 8581, Japan
    Fish Shellfish Immunol 16:139-49. 2004
    ..These properties agree well with those reported for mammalian CR2...
  4. ncbi request reprint Expansion of genes encoding complement components in bony fish: biological implications of the complement diversity
    Miki Nakao
    Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Hakozaki, 812 8581, Fukuoka, Japan
    Dev Comp Immunol 27:749-62. 2003
    ..Overall, the present data suggest that the expanded genes of the carp complement system produce more diversified functional components than are known for mammals. The biological significance of this diversity is discussed...
  5. ncbi request reprint Molecular cloning of the complement regulatory factor I isotypes from the common carp (Cyprinus carpio)
    Miki Nakao
    Laboratory of Marine Biochemistry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Hakozaki, 812 8581 Fukuoka, Japan
    Immunogenetics 54:801-6. 2003
    ..In addition, homology search of the fugu genome database using the carp FI-A and FI-B sequences identified a putative fugu factor I gene, which has an exon/intron organization different from that of the human orthologue...
  6. ncbi request reprint Lectin pathway of bony fish complement: identification of two homologs of the mannose-binding lectin associated with MASP2 in the common carp (Cyprinus carpio)
    Miki Nakao
    Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Kyushu University, Hakozaki, Fukuoka, Japan
    J Immunol 177:5471-9. 2006
    ..These results imply that bony fish have developed a diverged set of MBL homologs that function in the lectin complement pathway...
  7. ncbi request reprint Molecular cloning of the complement (C1r/C1s/MASP2-like serine proteases from the common carp (Cyprinus carpio)
    M Nakao
    Laboratory of Marine Biological Chemistry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Hakozaki, Fukuoka, Japan
    Immunogenetics 52:255-63. 2001
    ..Although phylogenetic tree analysis does not definitively assign carp C1r/s-A and C1r/s-B, they might represent ancestral molecules which later diverged into C1r, C1s, and MASP2 of higher vertebrates...
  8. ncbi request reprint Diversity of complement factor B/C2 in the common carp (Cyprinus carpio): three isotypes of B/C2-A expressed in different tissues
    Miki Nakao
    Laboratory of Marine Biological Chemistry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Hakozaki, Fukuoka, 812 8581, Japan
    Dev Comp Immunol 26:533-41. 2002
    ..Phylogenetic analysis suggests that B/C2-A3 diverged before separation of carp and zebrafish. B/C2-A3 represent a novel B/C2-lineage functioning as an acute phase reactant in cyprinid fish...
  9. ncbi request reprint The complement component C5 of the common carp (Cyprinus carpio): cDNA cloning of two distinct isotypes that differ in a functional site
    Yoko Kato
    Laboratory of Marine Biochemistry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Hakozaki, 812 8581 Fukuoka, Japan
    Immunogenetics 54:807-15. 2003
    ..Possible functional divergence among the C5 isotypes in carp is discussed...
  10. ncbi request reprint Purification and characterization of tributyltin-binding protein type 2 from plasma of Japanese flounder, Paralichthys olivaceus
    Yumi Oba
    Laboratory of Marine Environmental Science, Division of Marine Biological Chemistry, Department of Bioscience and Biotechnology, Kyushu University, Higashi ku, Fukuoka, 812 8581, Japan
    J Biochem 142:229-38. 2007
    ..Analysis of the motif sequence of the amino acid sequence and the structure of the gene encoding TBT-bp 2 suggested that this protein belongs to the lipocalin superfamily...
  11. doi request reprint Purification and characterization of tributyltin-binding protein of tiger puffer, Takifugu rubripes
    Yumi Oba
    Laboratory of Marine Environmental Science, Faculty of Agriculture, Kyushu University, Hakozaki 6 10 1, Higashi ku, Fukuoka, 812 8581, Japan
    Comp Biochem Physiol C Toxicol Pharmacol 153:17-23. 2011
    ..Phylogenetic analysis suggests that functionalization of TBT-bps has occurred during evolution, and that the functions of this group of proteins might be important for fish survival...
  12. ncbi request reprint Two divergent isotypes of the fourth complement component from a bony fish, the common carp (Cyprinus carpio)
    Junichi Mutsuro
    Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Kyushu University, Hakozaki, Fukuoka, Japan
    J Immunol 175:4508-17. 2005
    ..The results suggest that C4-1 and C4-2 represent two major lineages of C4 that are present in carp serum, have distinct binding specificities, and are functional in the classical/lectin pathways of complement activation...
  13. ncbi request reprint Diversified components of the bony fish complement system: more genes for robuster innate defense?
    Miki Nakao
    Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Kyushu University, Hakozaki, Fukuoka 812 8581, Japan
    Adv Exp Med Biol 586:121-38. 2006
  14. doi request reprint Molecular characterization and expression analysis of three membrane-bound complement regulatory protein isoforms in the ginbuna crucian carp Carassius auratus langsdorfii
    Indriyani Nur
    Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 6 10 1 Hakozaki, Fukuoka 812 8581, Japan
    Fish Shellfish Immunol 35:1333-7. 2013
    ....
  15. doi request reprint Molecular evidence for the existence of two distinct IL-8 lineages of teleost CXC-chemokines
    Nevien K Abdelkhalek
    Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Hakozaki, Fukuoka 812 8581, Japan
    Fish Shellfish Immunol 27:763-7. 2009
    ..The results, taken together, are strongly indicative of the presence of two major IL-8-like lineages of CXC-chemokines in teleost...
  16. ncbi request reprint Purification and functional assessment of C3a, C4a and C5a of the common carp (Cyprinus carpio) complement
    Yoko Kato
    Laboratory of Marine Biochemistry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Hakozaki, Fukuoka 812 8581, Japan
    Dev Comp Immunol 28:901-10. 2004
    ..5-1 nM, whereas C3a or C4a showed no significant activity. The results suggest that C3a, C4a and C5a of bony fish have functionally diverged to the state similar to their mammalian homologs...
  17. doi request reprint The binding spectra of carp C3 isotypes against natural targets independent of the binding specificity of their thioester
    Satoko Ichiki
    Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Japan
    Dev Comp Immunol 38:10-6. 2012
    ..Overall, the present data imply that non-His type C3 plays a significant role against bacterial infections in the fish defense system...
  18. doi request reprint Enhancement of menadione stress tolerance in yeast by accumulation of hypotaurine and taurine: co-expression of cDNA clones, from Cyprinus carpio, for cysteine dioxygenase and cysteine sulfinate decarboxylase in Saccharomyces cerevisiae
    Ken ichi Honjoh
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, 812 8581, Japan
    Amino Acids 38:1173-83. 2010
    ..The yeast cells expressing corresponding genes showed tolerance to oxidative stress induced by menadione, but not to freezing-thawing stress...
  19. doi request reprint Functional analysis of membrane-bound complement regulatory protein on T-cell immune response in ginbuna crucian carp
    Indriyani Nur
    Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812 8581, Japan Aquaculture Department, Fisheries and Marine Science Faculty, Halu Oleo University, Kendari 93232, Indonesia
    Mol Immunol 70:1-7. 2016
    ..These findings indicate that Tecrem may act as a T-cell moderator and imply that the complement system in teleost, as well as mammals, plays an important role for linking adaptive and innate immunity. ..
  20. doi request reprint Identification of anti-viral cytotoxic effector cells in the ginbuna crucian carp, Carassius auratus langsdorfii
    Tomonori Somamoto
    Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812 8581, Japan
    Dev Comp Immunol 39:370-7. 2013
    ..These results indicate that CMC induced by viral-infection is executed by not only CTLs but monocytes and CD8/IgM-negative lymphocytes...
  21. doi request reprint The complement system in teleost fish: progress of post-homolog-hunting researches
    Miki Nakao
    Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812 8581, Japan
    Dev Comp Immunol 35:1296-308. 2011
    ..Importance of the protein level characterization of the complement components is also emphasized, especially for understanding of the isotypic diversity of the components, a unique feature of teleost complement system...
  22. doi request reprint Molecular characterization of MHC class I and beta-2 microglobulin in a clonal strain of ginbuna crucian carp, Carassius auratus langsdorfii
    Shinji Urabe
    Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Hakozaki, Fukuoka, Japan
    Fish Shellfish Immunol 31:469-74. 2011
    ..The MHC class I and β(2)m sequences from one clonal strain will facilitate our understanding of the interaction of MHC class I with β(2)m in teleosts...
  23. ncbi request reprint Expression profiles of TCRbeta and CD8alpha mRNA correlate with virus-specific cell-mediated cytotoxic activity in ginbuna crucian carp
    Tomonori Somamoto
    Inland Station, National Research Institute of Aquaculture, FRA, Mie, Japan
    Virology 348:370-7. 2006
    ..The present study suggests that fish possess virus-specific cytotoxic cells with phenotype and gene expression pattern similar to those of CTLs in mammals...
  24. doi request reprint A CD46-like molecule functional in teleost fish represents an ancestral form of membrane-bound regulators of complement activation
    Masakazu Tsujikura
    Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Kyushu University, Hakozaki, Fukuoka 812 8581, Japan
    J Immunol 194:262-72. 2015
    ..Thus, the present findings provide the evidence of complement regulation by a membrane-bound group 2 RCA in bony fish, implying the host-cell protection is an evolutionarily conserved mechanism in regulation of the complement system. ..
  25. doi request reprint Local and systemic adaptive immune responses toward viral infection via gills in ginbuna crucian carp
    Tomonori Somamoto
    Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812 8581, Japan Electronic address
    Dev Comp Immunol 52:81-7. 2015
    ..Thus, the gills could be prospective antigen-sensitization sites for mucosal vaccination...
  26. doi request reprint Carp thrombocyte phagocytosis requires activation factors secreted from other leukocytes
    Takahiro Nagasawa
    Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812 8581, Japan
    Dev Comp Immunol 52:107-11. 2015
    ....
  27. doi request reprint Helper function of CD4⁺ lymphocytes in antiviral immunity in ginbuna crucian carp, Carassius auratus langsdorfii
    Tomonori Somamoto
    Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812 8581, Japan Electronic address
    Dev Comp Immunol 44:111-5. 2014
    ..These findings suggest that inducing a secondary antibody response requires CD4(+) cell help, and secondary cell-mediated immunity can be induced both by CD4(+) cells and leukocytes other than CD4(+) cells. ..
  28. doi request reprint In vitro generation of viral-antigen dependent cytotoxic T-cells from ginbuna crucian carp, Carassius auratus langsdorfii
    Tomonori Somamoto
    Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Hakozaki, Fukuoka 812 8581, Japan
    Virology 389:26-33. 2009
    ..These results provide evidence that the teleost effector cells generated in vitro correspond to virus-specific CTL and they recognize virus-infected target cells in a similar manner of mammalian counterparts...
  29. doi request reprint Ulcer disease prophylaxis in koi carp by bath immersion with chicken egg yolk containing anti-Aeromonas salmonicida IgY
    Hongjian Gan
    Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812 8581, Japan
    Res Vet Sci 99:82-6. 2015
    ..Thus, passive immunization induced by immersing fish into aquarium water containing specific IgY is a prospective prophylaxis against diseases caused by pathogens that invade the skin and gills. ..
  30. doi request reprint Guideline for hereditary angioedema (HAE) 2010 by the Japanese Association for Complement Research - secondary publication
    Takahiko Horiuchi
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Allergol Int 61:559-62. 2012
    ..This is a 2010 year version and will be updated according to any pertinent medical advancements...
  31. ncbi request reprint Purification and identification of a tributyltin-binding protein from serum of Japanese flounder, Paralichthys olivaceus
    Yohei Shimasaki
    Laboratory of Marine Biochemistry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan
    Environ Toxicol Chem 21:1229-35. 2002
    ..A high expression level of TBT-bp gene was found in the liver, but the gene was slightly detectable in the kidney and brain...
  32. ncbi request reprint Molecular cloning, structural analysis and expression of complement component Bf/C2 genes in the nurse shark, Ginglymostoma cirratum
    Dong Ho Shin
    Department of Biological Sciences, Florida International University, University Park, Miami, FL 33199, USA
    Dev Comp Immunol 31:1168-82. 2007
    ..Phylogenetic analysis indicates that GcBf/C2-1 and -2 and TrscBf of Triakis scyllia (another shark species) originated from a common ancestor and share a remote ancestor with Bf and C2 of mammals and bony fish...
  33. ncbi request reprint Molecular cloning and characterisation of a carp (Cyprinus carpio) cytokine-like cDNA that shares sequence similarity with IL-6 subfamily cytokines CNTF, OSM and LIF
    Kazuhiro Fujiki
    Department of Biology, University of Waterloo, 200 University Avenue West, N2L 3G1, Waterloo, Ont, Canada
    Dev Comp Immunol 27:127-36. 2003
    ..SA-PC showed significantly higher M17 mRNA levels than normal head kidney cells, which are considered to be a source of the SA-PC, indicating that M17 is inducible by inflammatory stimulation...
  34. ncbi request reprint Characterisation of a fourth immunoglobulin light chain isotype in the common carp
    Jun Ishikawa
    Department of Applied Biological Science, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Fish Shellfish Immunol 16:369-79. 2004
    ..Southern blot analyses suggested that the locus of carp L2 has a cluster-like organisation. Phylogenetic analyses showed that both carp VL2 and CL2 amino acid sequences highly clustered with other teleost L2 sequences...
  35. ncbi request reprint Sensing bacterial flagellin by membrane and soluble orthologs of Toll-like receptor 5 in rainbow trout (Onchorhynchus mikiss)
    Tadayuki Tsujita
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537 8511, Japan
    J Biol Chem 279:48588-97. 2004
    ....
  36. ncbi request reprint The immune responses of common carp, Cyprinus carpio L., injected with carp interleukin-1beta gene
    Tomoya Kono
    United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima 890 0065, Japan
    J Interferon Cytokine Res 22:413-9. 2002
    ..Thus, the cloned homolog of IL-1beta from carp has all the functional similarities to the mammalian IL-1beta gene...
  37. ncbi request reprint Discovery of a novel immunoglobulin heavy chain gene chimera from common carp (Cyprinus carpio L.)
    Ram Savan
    Faculty of Agriculture, University of Miyazaki, Gakuen kibanadai Nishi 1 1, Miyazaki, 889 2192, Japan
    Immunogenetics 57:458-63. 2005
    ..Expression studies of the IGH genes suggest that there is an increase in chimeric immunoglobulin gene transcription when stimulated with lipopolysaccharide...
  38. ncbi request reprint Characterization of immunoglobulin light chain isotypes in the common carp
    Mitsuru Tomana
    Department of Applied Biological Science, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Immunogenetics 54:120-9. 2002
    ..6-kb transcripts, possibly corresponding to fully spliced (LVJC) and truncated (JC/J-C) forms, respectively...