Yoshikazu Miwa

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint 15-deoxy-delta 12,14-prostaglandin J2 and laminar fluid shear stress stabilize c-IAP1 in vascular endothelial cells
    Yoji Taba
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Am J Physiol Heart Circ Physiol 285:H38-46. 2003
  2. doi request reprint Association of PLA2G7 polymorphisms with carotid atherosclerosis in hypertensive Japanese
    Yoshikazu Miwa
    National Cardiovascular Center, Osaka, Japan
    Hypertens Res 32:1112-8. 2009
  3. doi request reprint Association of serum lipocalin-type prostaglandin D synthase levels with subclinical atherosclerosis in untreated asymptomatic subjects
    Yoshikazu Miwa
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hypertens Res 31:1931-9. 2008
  4. ncbi request reprint Identification of gene polymorphism in lipocalin-type prostaglandin D synthase and its association with carotid atherosclerosis in Japanese hypertensive patients
    Yoshikazu Miwa
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Biochem Biophys Res Commun 322:428-33. 2004
  5. ncbi request reprint Involvement of clusterin in 15-deoxy-delta12,14-prostaglandin J2-induced vascular smooth muscle cell differentiation
    Yoshikazu Miwa
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 319:163-8. 2004
  6. ncbi request reprint Insertion/deletion polymorphism in clusterin gene influences serum lipid levels and carotid intima-media thickness in hypertensive Japanese females
    Yoshikazu Miwa
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Biochem Biophys Res Commun 331:1587-93. 2005
  7. ncbi request reprint Pulse pressure is an independent predictor for the progression of aortic wall calcification in patients with controlled hyperlipidemia
    Yoshikazu Miwa
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Hypertension 43:536-40. 2004
  8. ncbi request reprint Physiology and pharmacology of the prostaglandin J2 family
    Yoshikazu Miwa
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Nihon Yakurigaku Zasshi 123:34-40. 2004
  9. ncbi request reprint Association of genetic polymorphisms of ACADSB and COMT with human hypertension
    Kei Kamide
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    J Hypertens 25:103-10. 2007
  10. ncbi request reprint Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population
    Jin Yang
    Divisions of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    J Hypertens 23:1497-505. 2005

Collaborators

Detail Information

Publications49

  1. ncbi request reprint 15-deoxy-delta 12,14-prostaglandin J2 and laminar fluid shear stress stabilize c-IAP1 in vascular endothelial cells
    Yoji Taba
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Am J Physiol Heart Circ Physiol 285:H38-46. 2003
    ..These results suggested that 15d-PGJ2 inhibits endothelial cell apoptosis through, at least in part, c-IAP1 protein stabilization. This mechanism might be involved in the antiapoptotic effect of laminar shear stress...
  2. doi request reprint Association of PLA2G7 polymorphisms with carotid atherosclerosis in hypertensive Japanese
    Yoshikazu Miwa
    National Cardiovascular Center, Osaka, Japan
    Hypertens Res 32:1112-8. 2009
    ..Taken together, our data suggest an ethnic difference and the possible involvement of genetic polymorphisms of PLA2G7 in the prevalence of carotid atherosclerosis in the hypertensive Japanese, especially in men...
  3. doi request reprint Association of serum lipocalin-type prostaglandin D synthase levels with subclinical atherosclerosis in untreated asymptomatic subjects
    Yoshikazu Miwa
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hypertens Res 31:1931-9. 2008
    ..084, p=0.075). In conclusion, our results suggest that an increase in serum L-PGDS concentration is associated with the progression of atherosclerosis...
  4. ncbi request reprint Identification of gene polymorphism in lipocalin-type prostaglandin D synthase and its association with carotid atherosclerosis in Japanese hypertensive patients
    Yoshikazu Miwa
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Biochem Biophys Res Commun 322:428-33. 2004
    ..71 (95% CI: 0.58-0.88)]. Our results suggested that 4111 A>C polymorphism in the L-PGDS gene contributes to the development of carotid atherosclerosis in Japanese hypertensive patients...
  5. ncbi request reprint Involvement of clusterin in 15-deoxy-delta12,14-prostaglandin J2-induced vascular smooth muscle cell differentiation
    Yoshikazu Miwa
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 319:163-8. 2004
    ..Our results suggested that clusterin is involved in 15d-PGJ(2)-induced nodule formation and cell differentiation in VSMCs...
  6. ncbi request reprint Insertion/deletion polymorphism in clusterin gene influences serum lipid levels and carotid intima-media thickness in hypertensive Japanese females
    Yoshikazu Miwa
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Biochem Biophys Res Commun 331:1587-93. 2005
    ..In conclusion, the clusterin gene polymorphism may contribute to the serum lipid levels and the progression of carotid atherosclerosis in hypertensive Japanese females...
  7. ncbi request reprint Pulse pressure is an independent predictor for the progression of aortic wall calcification in patients with controlled hyperlipidemia
    Yoshikazu Miwa
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Hypertension 43:536-40. 2004
    ..389, P<0.001) among the blood pressure components. These results suggested that increase in pulse pressure promotes the progression of vascular calcification...
  8. ncbi request reprint Physiology and pharmacology of the prostaglandin J2 family
    Yoshikazu Miwa
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Nihon Yakurigaku Zasshi 123:34-40. 2004
    ..Based on these results, we have hypothesized that the PGJ(2) family synthesized in vascular wall plays an important physiological role to protect vascular cells from atherogenic stimuli...
  9. ncbi request reprint Association of genetic polymorphisms of ACADSB and COMT with human hypertension
    Kei Kamide
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    J Hypertens 25:103-10. 2007
    ..We examined the association of human homologues of these genes with human hypertension...
  10. ncbi request reprint Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population
    Jin Yang
    Divisions of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    J Hypertens 23:1497-505. 2005
    ..We studied whether genetic variations in RGS2 are implicated in hypertension or other phenotypes in Japanese hypertensive individuals and the general population...
  11. ncbi request reprint Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 281:38489-97. 2006
    ..These results suggest that DIF-3 induces degradation of cyclin D1 through the GSK-3beta- and DYRK1B-mediated threonine phosphorylation in HeLa cells...
  12. doi request reprint Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population
    Kei Kamide
    Division of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
    Hypertens Res 34:740-6. 2011
    ..Taken together, these data suggest that genetic polymorphisms in RGS2 are associated with intima-media thickening of carotid artery in humans...
  13. ncbi request reprint Genetic variations of HSD11B2 in hypertensive patients and in the general population, six rare missense/frameshift mutations
    Kei Kamide
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Hypertens Res 29:243-52. 2006
    ..Taken together, our results indicate that missense mutations in HSD11B2 do not substantially contribute to essential hypertension in Japanese...
  14. doi request reprint Associations of hypertension and its complications with variations in the xanthine dehydrogenase gene
    Jin Yang
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Hypertens Res 31:931-40. 2008
    ..0006). Our results suggest that genetic variations in XDH contribute partly to hypertension and its complications, including atherosclerosis and CKD...
  15. ncbi request reprint Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes
    Kei Kamide
    Division of Hypertension and Nephrology, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Hypertens 17:446-9. 2004
    ..The objective of this study was to test whether more subtle changes of WNK4 could be implicated in hypertension or renal failure...
  16. ncbi request reprint Genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockers
    Kei Kamide
    Division of Hypertension and Nephrology, Research Institute, National Cardiovascular Center, Suita, Japan
    Circ J 73:732-40. 2009
    ..The response of blood pressure (BP) to L-type dihydropyridine calcium-channel blockers (dCCBs) differs among individuals...
  17. ncbi request reprint Activator protein-1 mediates shear stress-induced prostaglandin d synthase gene expression in vascular endothelial cells
    Megumi Miyagi
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Arterioscler Thromb Vasc Biol 25:970-5. 2005
    ..We attempted to determine the molecular mechanism of fluid shear stress-induced lipocalin-type prostaglandin D synthase (l-PGDS) expression in vascular endothelial cells...
  18. doi request reprint Therapeutic effect of {beta}-adrenoceptor blockers using a mouse model of dilated cardiomyopathy with a troponin mutation
    Dong Yun Zhan
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cardiovasc Res 84:64-71. 2009
    ..Using a mouse model of inherited DCM with a troponin mutation, we aim to study the treatment benefits of beta-blockers...
  19. ncbi request reprint Celecoxib induces apoptosis by inhibiting the expression of survivin in HeLa cells
    Kazuhiro Fukada
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 357:1166-71. 2007
    ..Our findings might provide a new insight into the anti-cancer effects of celecoxib...
  20. doi request reprint Celecoxib-induced degradation of T-cell factors-1 and -4 in human colon cancer cells
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Biochem Biophys Res Commun 377:1185-90. 2008
    ..Our results suggest that TCF-1 and TCF-4 degradation may involve the inhibition of the Wnt/beta-catenin signaling pathway induced by celecoxib...
  21. ncbi request reprint Six missense mutations of the epithelial sodium channel beta and gamma subunits in Japanese hypertensives
    Kei Kamide
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Hypertens Res 27:333-8. 2004
    ..Thus, further investigation of these mutations, including functional analyses, will be needed...
  22. ncbi request reprint A novel missense mutation, F826Y, in the mineralocorticoid receptor gene in Japanese hypertensives: its implications for clinical phenotypes
    Kei Kamide
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Hypertens Res 28:703-9. 2005
    ....
  23. ncbi request reprint Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation
    Cheng Kun Du
    Department of Clinical Pharmacology, Kyushu University Graduate School of Medicine, Maidashi, Higashi ku, Fukuoka, Japan
    Circ Res 101:185-94. 2007
    ....
  24. ncbi request reprint An alternative fast and convenient genotyping method for the screening of angiotensin converting enzyme gene polymorphisms
    Chihiro Tanaka
    Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
    Hypertens Res 26:301-6. 2003
    ..We also concluded that testicular ACE may manifest a deletion of six amino acids that may result in deleterious function of this enzyme...
  25. doi request reprint The involvement of aldosterone in cyclic stretch-mediated activation of NADPH oxidase in vascular smooth muscle cells
    Takahiro Ohmine
    Faculty of Medical Sciences, Department of Clinical Pharmacology, Kyushu University, Fukuoka 812 8582, Japan
    Hypertens Res 32:690-9. 2009
    ..We also suggest the potential benefit of eplerenone in the treatment of cardiovascular diseases...
  26. ncbi request reprint Dictyostelium differentiation-inducing factor-1 binds to mitochondrial malate dehydrogenase and inhibits its activity
    Tomoko Matsuda
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pharmacol Sci 112:320-6. 2010
    ..These results suggest that the inhibition of mMDH activity by DIF-1 and 2-MIDIF-1 could be one of the mechanisms to induce anti-proliferative effects, independent of the inhibition of the Wnt/beta-catenin signaling pathway...
  27. ncbi request reprint Differentiation-inducing factor-1 induces cyclin D1 degradation through the phosphorylation of Thr286 in squamous cell carcinoma
    Jun Mori
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Exp Cell Res 310:426-33. 2005
    ..These results suggest that DIF-1 induces degradation of cyclin D1 through the GSK-3beta-mediated phosphorylation of Thr286...
  28. ncbi request reprint Aryl hydrocarbon receptor mediates laminar fluid shear stress-induced CYP1A1 activation and cell cycle arrest in vascular endothelial cells
    Zhiyi Han
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cardiovasc Res 77:809-18. 2008
    ....
  29. ncbi request reprint Induction of cyclooxygenase-2 expression by fluid smear stress in vascular endothelial cells
    Hiroyasu Inoue
    Department of Pharmacology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Adv Exp Med Biol 525:141-4. 2003
  30. pmc Biological actions of green tea catechins on cardiac troponin C
    Naoto Tadano
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 161:1034-43. 2010
    ..In this study, we investigated direct actions of green tea catechins on cardiac muscle function to explore their uses as potential drugs for cardiac muscle disease...
  31. ncbi request reprint Differentiation-inducing factor-1 suppresses gene expression of cyclin D1 in tumor cells
    Tania Yasmin
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 338:903-9. 2005
    ..Eliminating the TCF/LEF consensus site from the cyclin D1 promoter diminished the effect of DIF-1. These results suggest that DIF-1 inhibits Wnt/beta-catenin signaling, resulting in the suppression of cyclin D1 promoter activity...
  32. ncbi request reprint Differentiation-inducing factor-1 alters canonical Wnt signaling and suppresses alkaline phosphatase expression in osteoblast-like cell lines
    Etsuko Matsuzaki
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Bone Miner Res 21:1307-16. 2006
    ..We found that DIF-1 inhibited this pathway, resulting in the suppression of ALP promoter activity through the TCF/LEF binding site...
  33. ncbi request reprint The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics
    Tetsutaro Matayoshi
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Hypertens Res 27:821-33. 2004
    ..Both newly detected TSC C1784T and ADRB3 T727C are gene polymorphisms susceptible to the antihypertensive effect of TZDs in patients with EHT. Thus, the prediction of BP reduction by TZDs may be possible by evaluating these two SNPs...
  34. ncbi request reprint A promoter variant of the ATP-binding cassette transporter A1 gene alters the HDL cholesterol level in the general Japanese population
    Keisuke Shioji
    Department of Epidemiology, Research Institute, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    J Hum Genet 49:141-7. 2004
    ..These results indicate that ABCA1 G(-273)C has a significant effect on the HDL-C level in the general Japanese population, but not on the incidence of MI...
  35. ncbi request reprint Celecoxib inhibits the expression of survivin via the suppression of promoter activity in human colon cancer cells
    Naoko Sakoguchi-Okada
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Pharmacol 73:1318-29. 2007
    ..Our results suggested that NSAIDs could inhibit proliferation and induce apoptosis in colon cancer cells by inhibition of survivin expression and the Wnt/beta-catenin signaling pathway...
  36. doi request reprint Improvement of blood pressure control in a hypertension clinic in Japan: a 15-year follow-up study
    Yuko Ohta
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Clin Exp Hypertens 31:553-9. 2009
    ....
  37. doi request reprint Knockout of the l-pgds gene aggravates obesity and atherosclerosis in mice
    Reiko Tanaka
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 378:851-6. 2009
    ..In conclusion, l-pgds deficiency induces obesity and facilitates atherosclerosis, probably through the regulation of inflammatory responses...
  38. ncbi request reprint Propyl gallate, a strong antioxidant, increases the Ca2+ sensitivity of cardiac myofilament
    Naoto Tadano
    Depertment of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Japan
    J Pharmacol Sci 109:456-8. 2009
    ....
  39. ncbi request reprint Transcriptional and posttranscriptional regulation of cyclooxygenase-2 expression by fluid shear stress in vascular endothelial cells
    Hiroyasu Inoue
    Department of Pharmacology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Arterioscler Thromb Vasc Biol 22:1415-20. 2002
    ..Fluid shear stress induces cyclooxygenase (COX)-2 gene expression in vascular endothelial cells. We investigated the underlying mechanism of this induction...
  40. ncbi request reprint Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3beta and degrades cyclin D1 in mammalian cells
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Graduate School of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 278:9663-70. 2003
    ..These results suggested that DIF-3 activates GSK-3beta to accelerate the proteolysis of cyclin D1 and that this mechanism is involved in the DIF-3-induced G(0)/G(1) arrest in mammalian cells...
  41. ncbi request reprint Glycogen synthase kinase-3beta is tyrosine-phosphorylated by MEK1 in human skin fibroblasts
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 316:411-5. 2004
    ..This is the first report to suggest that MEK1/2 phosphorylates not only ERK1/2 but also GSK-3beta...
  42. ncbi request reprint PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts
    Ayako Nakazono-Kusaba
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Eur J Pharmacol 497:155-60. 2004
    ..These results suggested that PKC412-induced apoptosis, but not staurosporine-induced apoptosis, is mainly mediated by the caspase-dependent mechanism...
  43. ncbi request reprint SCH00013, a novel Ca(2+) sensitizer with positive inotropic and no chronotropic action in heart failure
    Naoto Tadano
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pharmacol Sci 97:53-60. 2005
    ..These results strongly suggested that SCH00013 is a novel Ca(2+) sensitizer that elicits a positive inotropic and no chronotropic effect in heart failure, probably through enhancing the Frank-Starling mechanism...
  44. doi request reprint Association between arterial stiffness and cerebral white matter lesions in community-dwelling elderly subjects
    Takahiro Ohmine
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fuuoka, Japan
    Hypertens Res 31:75-81. 2008
    ..Although further study is needed to clarify the difference between WML subtypes, our study suggests that the measurement of ba-PWV is a simple and useful tool for detecting cerebral arterial dysfunction...
  45. ncbi request reprint Cardiac troponin T mutation R141W found in dilated cardiomyopathy stabilizes the troponin T-tropomyosin interaction and causes a Ca2+ desensitization
    Qun Wei Lu
    Department of Clinical Pharmacology, Kyushu University Graduate School of Medicine, Fukuoka 812 8582, Japan
    J Mol Cell Cardiol 35:1421-7. 2003
    ....
  46. ncbi request reprint Shear stress induces expression of vascular endothelial growth factor receptor Flk-1/KDR through the CT-rich Sp1 binding site
    Takeo Abumiya
    National Cardiovascular Center Research Institute, Osaka, Japan
    Arterioscler Thromb Vasc Biol 22:907-13. 2002
    ..These results suggest that shear stress induces Flk-1/KDR expression through the CT-rich Sp1 binding site...
  47. ncbi request reprint Prostaglandin J2 family and the cardiovascular system
    Toshiyuki Sasaguri
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Curr Vasc Pharmacol 2:103-14. 2004
    ..If this hypothesis is correct, PGJ2 family members or other similar substances may provide novel preventive and therapeutic strategies for the treatment of vascular diseases...
  48. ncbi request reprint Differentiation-inducing factor-1-induced growth arrest of K562 leukemia cells involves the reduction of ERK1/2 activity
    Emi Akaishi
    Department of Basic Sciences for Medicine, Gunma University School of Health Sciences, Maebashi 371 8514, Japan
    Eur J Pharmacol 485:21-9. 2004
    ..The present results suggest that ERK inactivation may be involved in DIF-1-induced growth arrest and that PI-3K activity is not required for DIF-1-induced growth arrest in K562 cells...
  49. ncbi request reprint Association of ceramides in human plasma with risk factors of atherosclerosis
    Ikuyo Ichi
    Department of Food Science and Nutrition, Nara Women s University, Nara 630 8506, Japan
    Lipids 41:859-63. 2006
    ..B-ox showed a significant positive correlation with the plasma ceramide level. Based on these results, we propose that the ceramide level in human plasma is a risk factor at the early stages of atherosclerosis...