M Akahoshi

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. doi request reprint Acquired hemophilia in a patient with systemic lupus erythematosus: a case report and literature review
    Mitsuteru Akahoshi
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, and Department of Internal Medicine, Chihaya Hospital, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Mod Rheumatol 18:511-5. 2008
  2. ncbi request reprint Roles of genetic variations in signalling/immunoregulatory molecules in susceptibility to systemic lupus erythematosus
    Mitsuteru Akahoshi
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, RIKEN Yokohama Institute, RIKEN, Yokohama, Japan
    Semin Immunol 18:224-9. 2006
  3. ncbi request reprint Promoter polymorphisms in the IRF3 gene confer protection against systemic lupus erythematosus
    M Akahoshi
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, RIKEN Yokohama Institute, The Institute of Physical and Chemical Research RIKEN, Yokohama, Japan
    Lupus 17:568-74. 2008
  4. doi request reprint Mutation screening of the CARD15 gene in sarcoidosis
    M Akahoshi
    The Institute of Physical and Chemical Research, Yokohama, Japan
    Tissue Antigens 71:564-7. 2008
  5. ncbi request reprint Absence of association between the MCP-1 gene polymorphism and histological phenotype of lupus nephritis
    H Nakashima
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Lupus 13:165-7. 2004
  6. pmc Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor alpha (WSX-1)
    N Sugiyama
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Rheum Dis 67:1461-7. 2008
  7. ncbi request reprint Association between ADAM33 polymorphisms and adult asthma in the Japanese population
    T Hirota
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Yokohama, Japan
    Clin Exp Allergy 36:884-91. 2006
  8. ncbi request reprint Two polymorphisms within interleukin-3 (hIL3) gene detected by mismatch PCR/RFLP
    H Nakashima
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Genes Immun 1:156-8. 1999
  9. ncbi request reprint Anti-monocyte chemoattractant protein-1 gene therapy attenuates nephritis in MRL/lpr mice
    S Shimizu
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Rheumatology (Oxford) 43:1121-8. 2004
  10. ncbi request reprint Predominance of Th1 immune response in diffuse proliferative lupus nephritis
    K Masutani
    Kyushu University, Fukuoka, Japan
    Arthritis Rheum 44:2097-106. 2001

Collaborators

Detail Information

Publications27

  1. doi request reprint Acquired hemophilia in a patient with systemic lupus erythematosus: a case report and literature review
    Mitsuteru Akahoshi
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, and Department of Internal Medicine, Chihaya Hospital, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Mod Rheumatol 18:511-5. 2008
    ..She was successfully treated with oral predonisolone and cyclosporine in combination with steroid and cyclophosphamide pulse therapy...
  2. ncbi request reprint Roles of genetic variations in signalling/immunoregulatory molecules in susceptibility to systemic lupus erythematosus
    Mitsuteru Akahoshi
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, RIKEN Yokohama Institute, RIKEN, Yokohama, Japan
    Semin Immunol 18:224-9. 2006
    ..In this article we describe an overview of the latest findings in the genetics of SLE, especially focusing on the genetic variations in the signalling or immunoregulatory molecules including CD28 and IRF family members...
  3. ncbi request reprint Promoter polymorphisms in the IRF3 gene confer protection against systemic lupus erythematosus
    M Akahoshi
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, RIKEN Yokohama Institute, The Institute of Physical and Chemical Research RIKEN, Yokohama, Japan
    Lupus 17:568-74. 2008
    ..In conclusion, we showed that the promoter SNPs of the IRF3 gene were significantly associated with resistance against SLE...
  4. doi request reprint Mutation screening of the CARD15 gene in sarcoidosis
    M Akahoshi
    The Institute of Physical and Chemical Research, Yokohama, Japan
    Tissue Antigens 71:564-7. 2008
    ..Sarcoidosis patients with these mutations have no specific clinical features with regard to course of the disease or disease severity. Our results indicate that in general, CARD15 mutations may not contribute to the risk of sarcoidosis...
  5. ncbi request reprint Absence of association between the MCP-1 gene polymorphism and histological phenotype of lupus nephritis
    H Nakashima
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Lupus 13:165-7. 2004
    ..In this study we assessed the significance of the MCP-1 gene in determination of the histological phenotype in lupus nephritis. There was no association between the risk of DPGN and the MCP-1 gene genotype...
  6. pmc Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor alpha (WSX-1)
    N Sugiyama
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Rheum Dis 67:1461-7. 2008
    ....
  7. ncbi request reprint Association between ADAM33 polymorphisms and adult asthma in the Japanese population
    T Hirota
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Yokohama, Japan
    Clin Exp Allergy 36:884-91. 2006
    ..It is important to know whether the association exists in ethnically diverse populations...
  8. ncbi request reprint Two polymorphisms within interleukin-3 (hIL3) gene detected by mismatch PCR/RFLP
    H Nakashima
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Genes Immun 1:156-8. 1999
    ..We clarified that these substitutions were frequent polymorphisms in the Japanese population by using the mismatch-PCR (polymerase chain reaction)/RFLP (restriction fragment length polymorphism) method...
  9. ncbi request reprint Anti-monocyte chemoattractant protein-1 gene therapy attenuates nephritis in MRL/lpr mice
    S Shimizu
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Rheumatology (Oxford) 43:1121-8. 2004
    ..The aim of this study was to examine whether anti-MCP-1 gene therapy inhibits the progression of nephritis in MRL/lpr mice...
  10. ncbi request reprint Predominance of Th1 immune response in diffuse proliferative lupus nephritis
    K Masutani
    Kyushu University, Fukuoka, Japan
    Arthritis Rheum 44:2097-106. 2001
    ..In patients with lupus nephritis, the peripheral blood Th1:Th2 ratio could be useful as a parameter that reflects the renal histologic activity or the strength of the local Thl response...
  11. ncbi request reprint The combination of polymorphisms within interferon-gamma receptor 1 and receptor 2 associated with the risk of systemic lupus erythematosus
    H Nakashima
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    FEBS Lett 453:187-90. 1999
    ..The greatest risk of the development of SLE was detected in the individuals who had the combination of IFNGR1 Met14/Val14 genotype and IFNGR2 Gln64/Gln64 genotype...
  12. ncbi request reprint Genetically determined interferon-gamma production influences the histological phenotype of lupus nephritis
    K Miyake
    Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Rheumatology (Oxford) 41:518-24. 2002
    ..To clarify whether the interferon-gamma (IFN-gamma) gene (IFNG) is associated with the histological phenotype of lupus nephritis...
  13. ncbi request reprint Strong polarization toward Th1 immune response in ANCA-associated glomerulonephritis
    K Masutani
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Clin Nephrol 59:395-405. 2003
    ....
  14. ncbi request reprint Association between IFNA genotype and the risk of systemic lupus erythematosus
    Hitoshi Nakashima
    Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Maidashi 3 1 1, 812 8582 Higashi ku, Fukuoka, Japan
    Clin Rheumatol 24:38-40. 2005
    ..The results showed that no IFN-alpha genotype was significantly associated with the risk of SLE...
  15. ncbi request reprint Association between IL-4 genotype and IL-4 production in the Japanese population
    H Nakashima
    Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Genes Immun 3:107-9. 2002
    ..These results make it likely that IL-4 genotype could influence the type of immune response...
  16. ncbi request reprint Association of the IL12RB1 promoter polymorphisms with increased risk of atopic dermatitis and other allergic phenotypes
    Naomi Takahashi
    Laboratory of Genetics of Allergic Diseases, SNP Research Center, RIKEN, Kanagawa, Japan
    Hum Mol Genet 14:3149-59. 2005
    ..Our results suggested that in individuals with the -111T/T genotype, reduced IL-12Rbeta1 expression may lead to increased Th2 cytokine production in the skin and contribute to the development of AD and other subsequent allergic diseases...
  17. ncbi request reprint Association between IFNA genotype and the risk of sarcoidosis
    Mitsuteru Akahoshi
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, Institute of Physical and Chemical Research, RIKEN Yokohama Institute, Yokohama, Japan
    Hum Genet 114:503-9. 2004
    ..This study suggests that possession of the IFNA allele with higher levels of IFN-alpha significantly increases the risk of sarcoidosis...
  18. ncbi request reprint Functional haplotypes of IL-12B are associated with childhood atopic asthma
    Tomomitsu Hirota
    Laboratory for Genetics of Allergic Diseases, Single Nucleotide Polymorphism Research Center, Institute of Physical and Chemical Research RIKEN, Kanagawa, Japan
    J Allergy Clin Immunol 116:789-95. 2005
    ..Although associations between polymorphisms of IL-12B on chromosome 5q31-33 and asthma have been reported, the genetic influences of the polymorphisms and haplotype of IL-12B are unclear...
  19. ncbi request reprint Association between genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma
    Tomomitsu Hirota
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Kanagawa 230 0045, Japan
    J Hum Genet 49:370-5. 2004
    ..These results indicated that specific variants of the DAP3 gene might be associated with the mechanisms responsible for adult BA and contribute to airway inflammation and remodeling...
  20. ncbi request reprint Influence of interleukin-12 receptor beta1 polymorphisms on tuberculosis
    Mitsuteru Akahoshi
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hum Genet 112:237-43. 2003
    ..This genetic variation may predispose individuals to tuberculosis infection by diminishing receptor responsiveness to IL-12 and to IL-23, leading to partial dysfunction of interferon-gamma-mediated immunity...
  21. ncbi request reprint Th1/Th2 balance of SLE patients with lupus nephritis
    Hitoshi Nakashima
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka
    Rinsho Byori 54:706-13. 2006
    ..Therefore the value of Th1/Th2 ratio of the peripheral CD4+ T cells in SLE patients could be a useful index to predict histopathology of lupus nephritis...
  22. ncbi request reprint Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma
    Mitsuteru Akahoshi
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, RIKEN Yokohama Institute, Institute of Physical and Chemical Research RIKEN, Tsurumi ku, Kanagawa, Japan
    Hum Genet 117:16-26. 2005
    ....
  23. ncbi request reprint Protection against autoimmune nephritis in MyD88-deficient MRL/lpr mice
    Atsushi Sadanaga
    Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Arthritis Rheum 56:1618-28. 2007
    ..To determine whether innate receptor signals play an important role in the development of autoimmune nephritis in MRL/lpr mice, an experimental model of lupus nephritis...
  24. ncbi request reprint Coding SNP in tenascin-C Fn-III-D domain associates with adult asthma
    Akira Matsuda
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, RIKEN, Yokohama, Japan
    Hum Mol Genet 14:2779-86. 2005
    ..In addition, TNC expression in lung fibroblasts increases with Th2 immune cytokine stimulation. Thus, Leu1677Ile may be valuable marker for evaluating the risk for developing asthma and plays a role in its pathogenesis...
  25. ncbi request reprint Lack of association between the IL13 variant Arg110Gln and susceptibility to cedar pollinosis in a Japanese population
    Lei Cheng
    Department of Otorhinolaryngology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Int Arch Allergy Immunol 139:25-30. 2006
    ..Recent studies revealed that a common variant in the coding region of the IL13 gene, Arg110Gln, has been implicated in the development of asthma and atopy...
  26. ncbi request reprint Association of the RIP2 gene with childhood atopic asthma
    Kazuko Nakashima
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, RIKEN, Kanagawa, Japan
    Allergol Int 55:77-83. 2006
    ..The aim of our study was to examine whether polymorphisms or haplotypes in RIP2 were associated with childhood atopic asthma in a Japanese population...
  27. ncbi request reprint Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis
    Makiko Shimizu
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, RIKEN, Yokohama, Japan
    Hum Mol Genet 14:2919-27. 2005
    ..Our findings will contribute to the evaluation of one of the genetic risk factors for AD...