Norio Yamamoto

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. pmc Therapeutic potential of a gamma-secretase inhibitor for hearing restoration in a guinea pig model with noise-induced hearing loss
    Yosuke Tona
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kawaharacho 54, Shogoin, Sakyoku, Kyoto 606 8507, Japan
    BMC Neurosci 15:66. 2014
  2. pmc A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment
    Takayuki Nakagawa
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    BMC Med 12:219. 2014
  3. pmc Identification of tympanic border cells as slow-cycling cells in the cochlea
    Mirei Taniguchi
    Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Japan
    PLoS ONE 7:e48544. 2012
  4. doi request reprint Rbpj regulates development of prosensory cells in the mammalian inner ear
    Norio Yamamoto
    Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, NIDCD, NIH, Bethesda, MD 20892, USA
    Dev Biol 353:367-79. 2011
  5. ncbi request reprint Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling
    Kenji Tanigaki
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto, 606 8501, Japan
    Immunity 20:611-22. 2004
  6. ncbi request reprint Role of the F-box protein Skp2 in cell proliferation in the developing auditory system in mice
    Youyi Dong
    Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kawaharacho 54, Shogoin, Sakyo ku, 606 8507 Kyoto, Japan
    Neuroreport 14:759-61. 2003
  7. ncbi request reprint Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision
    Hua Han
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Int Immunol 14:637-45. 2002
  8. ncbi request reprint Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas
    Norio Yamamoto
    Department of Medical Chemistry and Molecular Biology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Mol Med (Berl) 84:37-45. 2006
  9. ncbi request reprint Multiple roles of Notch signaling in cochlear development
    Shinji Takebayashi
    Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoinkawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Dev Biol 307:165-78. 2007
  10. doi request reprint Transplantation of mouse induced pluripotent stem cells into the cochlea
    Koji Nishimura
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Neuroreport 20:1250-4. 2009

Collaborators

Detail Information

Publications32

  1. pmc Therapeutic potential of a gamma-secretase inhibitor for hearing restoration in a guinea pig model with noise-induced hearing loss
    Yosuke Tona
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kawaharacho 54, Shogoin, Sakyoku, Kyoto 606 8507, Japan
    BMC Neurosci 15:66. 2014
    ..The present study aimed to illustrate the feasibility of pharmacologically inhibiting Notch signaling by using a gamma-secretase inhibitor for treating sensorineural hearing loss...
  2. pmc A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment
    Takayuki Nakagawa
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    BMC Med 12:219. 2014
    ..This study aimed to examine the efficacy and safety of topical insulin-like growth factor-1 (IGF-1) therapy in comparison to intratympanic corticosteroid therapy...
  3. pmc Identification of tympanic border cells as slow-cycling cells in the cochlea
    Mirei Taniguchi
    Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Japan
    PLoS ONE 7:e48544. 2012
    ..Immunohistochemically, these cells stained positive for the immature cell marker Nestin. But it will be difficult to achieve regeneration of the cochlear function because these slow-cycling cells disappear in the mature murine cochlea...
  4. doi request reprint Rbpj regulates development of prosensory cells in the mammalian inner ear
    Norio Yamamoto
    Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, NIDCD, NIH, Bethesda, MD 20892, USA
    Dev Biol 353:367-79. 2011
    ..These results suggest important roles for Rbpj and notch signaling in multiple aspects of inner ear development including prosensory cell maturation, cellular differentiation and survival...
  5. ncbi request reprint Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling
    Kenji Tanigaki
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto, 606 8501, Japan
    Immunity 20:611-22. 2004
    ..Our data demonstrated that Notch/RBP-J signaling regulates gammadelta T cell generation and migration, alphabeta T cell maturation, terminal differentiation of CD4(+) T cells into Th1/Th2 cells, and activation of T cells...
  6. ncbi request reprint Role of the F-box protein Skp2 in cell proliferation in the developing auditory system in mice
    Youyi Dong
    Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kawaharacho 54, Shogoin, Sakyo ku, 606 8507 Kyoto, Japan
    Neuroreport 14:759-61. 2003
    ..These findings suggest that Skp2 plays a crucial role in development of mammalian auditory systems...
  7. ncbi request reprint Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision
    Hua Han
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Int Immunol 14:637-45. 2002
    ..Myeloid and B lineage differentiation appears normal in the bone marrow of RBP-J-inactivated mice. These results suggest that RBP-J, probably by mediating Notch signaling, controls T versus B cell fate decision in lymphoid progenitors...
  8. ncbi request reprint Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas
    Norio Yamamoto
    Department of Medical Chemistry and Molecular Biology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Mol Med (Berl) 84:37-45. 2006
    ....
  9. ncbi request reprint Multiple roles of Notch signaling in cochlear development
    Shinji Takebayashi
    Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoinkawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Dev Biol 307:165-78. 2007
    ..Second, Notch signaling is required for the induction of Prox1-positive supporting cells. Third, Notch signaling is required for the maintenance of supporting cells...
  10. doi request reprint Transplantation of mouse induced pluripotent stem cells into the cochlea
    Koji Nishimura
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Neuroreport 20:1250-4. 2009
    ..Some transplants expressed vesicular glutamate transporter 1, which is a marker for glutamatergic neurons. These findings indicate that iPS cells can be used as a source of transplants for the regeneration of spiral ganglion neurons...
  11. doi request reprint Localization of septin proteins in the mouse cochlea
    Atsuhiro Yoshida
    Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto City, Kyoto 606 8507, Japan
    Hear Res 289:40-51. 2012
    ..Immunohistochemical analysis of Sept4 null mice showed that compensatory expression of SEPT5 in the phalangeal process of Deiters' cells may have caused functional compensation of hearing ability in Sept4 null mice...
  12. doi request reprint Audiometric outcomes of topical IGF1 treatment for sudden deafness refractory to systemic steroids
    Takayuki Nakagawa
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Otol Neurotol 33:941-6. 2012
    ....
  13. doi request reprint Prostaglandin E receptor subtype EP4 agonist serves better to protect cochlea than prostaglandin E1
    Ryusuke Hori
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Auris Nasus Larynx 40:539-42. 2013
    ..The present study aimed to examine whether an E-prostanoid receptor 4 (EP4) agonist has superior protective effects to those of prostaglandin E1 (PGE1) in a guinea pig model of noise trauma...
  14. pmc Role of prostaglandin E receptor subtypes EP2 and EP4 in autocrine and paracrine functions of vascular endothelial growth factor in the inner ear
    Ryusuke Hori
    Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kawaharacho 54, Shogoin, Sakyo ku, 606 8507 Kyoto, Japan
    BMC Neurosci 11:35. 2010
    ..We also examined the localization of EP2, VEGF, Flt-1, and Flk-1 in the cochlea by immunohistochemistry...
  15. ncbi request reprint Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells
    Norio Yamamoto
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Konoe cho, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    Curr Biol 13:333-8. 2003
    ..These results suggest that Notch/RBP-J signaling regulates the cell fate determination of hair follicular stem cells at the bulge region...
  16. doi request reprint Role of PGE-type receptor 4 in auditory function and noise-induced hearing loss in mice
    Kiyomi Hamaguchi
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kawaharacho 54, Shogoin, Sakyoku, Kyoto 606 8507, Japan
    Neuropharmacology 62:1841-7. 2012
    ..EP4 might therefore be an effective target for cochlear disease therapeutics...
  17. pmc Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss: a prospective clinical trial
    Takayuki Nakagawa
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    BMC Med 8:76. 2010
    ..We tested the safety and efficacy of topical insulin-like growth factor 1 (IGF1) application using gelatin hydrogels as a treatment for SSHL...
  18. doi request reprint Insulin-like growth factor 1 inhibits hair cell apoptosis and promotes the cell cycle of supporting cells by activating different downstream cascades after pharmacological hair cell injury in neonatal mice
    Yushi Hayashi
    Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606 8507, Japan Electronic address
    Mol Cell Neurosci 56:29-38. 2013
    ..These results indicate that IGF-1 is a growth factor that efficiently regulates different mechanisms through different downstream cascades, thereby protecting cochlear hair cells. ..
  19. doi request reprint Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells
    Yasunori Saitoh
    Department of Molecular Virology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Blood 111:5118-29. 2008
    ..These results indicate that the deregulated expression of NIK plays a critical role in constitutive NF-kappaB activation in ATL and H-RS cells, and suggest also that NIK is an attractive molecular target for cancer therapy...
  20. doi request reprint A minimally invasive approach for cochlear implantation using a microendoscope
    Harukazu Hiraumi
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kawaharacho 54, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Eur Arch Otorhinolaryngol 270:477-81. 2013
    ..The microendoscope allowed cochlear implantation surgery to be performed with a mastoidectomy of minimal size...
  21. doi request reprint Reprogramming of mouse cochlear cells by transcription factors to generate induced pluripotent stem cells
    Xiang Xin Lou
    1 Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 6068507
    Cell Reprogram 15:514-9. 2013
    ....
  22. ncbi request reprint A novel technique for inducing local inner ear damage
    Takayuki Nakagawa
    Department of Otolaryngology Head and Neck Surgery, Kyoto University, Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, 606 8507 Kyoto, Japan
    Hear Res 176:122-7. 2003
    ..This model, hence, enables the use of various genetic tools in studies for mechanisms of hair cell apoptosis...
  23. doi request reprint The effect of pre-operative developmental delays on the speech perception of children with cochlear implants
    Harukazu Hiraumi
    Department of Otolaryngology Head and Neck Surgery, Kyoto University, Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, Japan
    Auris Nasus Larynx 40:32-5. 2013
    ..The objective of this study was to evaluate the relationship between developmental delays and speech perception in pre-lingually deafened cochlear implant recipients...
  24. doi request reprint Insulin-like growth factor 1 induces the transcription of Gap43 and Ntn1 during hair cell protection in the neonatal murine cochlea
    Yushi Hayashi
    Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan Electronic address
    Neurosci Lett 560:7-11. 2014
    ..Moreover the time window of Gap43 and Ntn1 transcription was limited to within 12h after IGF-1 treatment, indicating that downstream gene expression was tightly controlled by IGF-1. ..
  25. doi request reprint Detection of the petrosquamosal sinus in chronic otitis media using high-resolution CT
    Harukazu Hiraumi
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Otolaryngol Head Neck Surg 149:488-91. 2013
    ..To evaluate the prevalence of the persistent petrosquamosal venous sinus in patients with chronic otitis media using a high-resolution CT scan...
  26. pmc Myosin II regulates extension, growth and patterning in the mammalian cochlear duct
    Norio Yamamoto
    Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA
    Development 136:1977-86. 2009
    ..Our results also provide insights into the cellular mechanisms that are required for the formation of highly ordered cellular patterns...
  27. doi request reprint Effect of cisplatin on distortion product otoacoustic emissions in Japanese patients
    Peem Eiamprapai
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto City, Kyoto, Japan
    Laryngoscope 122:1392-6. 2012
    ..The objectives of this study were to determine the incidence rate of cisplatin ototoxicity and to determine the threshold dose causing ototoxicity in the Japanese population...
  28. doi request reprint Risk group stratification based on preoperative factors to predict survival after nephroureterectomy in patients with upper urinary tract urothelial carcinoma
    Shigeru Sakano
    Department of Urology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, Japan
    Ann Surg Oncol 20:4389-96. 2013
    ..We performed risk group stratification to predict survival based on specific preoperative factors...
  29. doi request reprint Cardamonin suppresses nitric oxide production via blocking the IFN-γ/STAT pathway in endotoxin-challenged peritoneal macrophages of ICR mice
    Amane Takahashi
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Life Sci 89:337-42. 2011
    ..In this study, we examined the effects of 6 flavonoids on lipopolysaccharide (LPS)-induced NO generation in macrophage (Mφ), and addressed molecular mechanisms of cardamonin...
  30. ncbi request reprint Efficient induction of HIV-1 replication in latently infected cells through contact with CD4+ T cells: involvement of NF-kappaB activation
    Xiaohua Qi
    Department of Molecular Virology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Virology 361:325-34. 2007
    ....
  31. ncbi request reprint Production and characterization of a monoclonal antibody specific to Nef-associated factor 1 (Naf1)/A20-binding inhibitor of NF-kappaB activation (ABIN-1)
    Myint Oo Chang
    Department of Molecular Virology, Bio Response, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Hybridoma (Larchmt) 24:248-57. 2005
    ..By Western blot analysis of recombinant Naf1-N fusion proteins with overlapping N-terminal sequences, the epitope targeted by anti-Naf1 MAb was determined as the 81-88-amino acid region of human Naf1...
  32. ncbi request reprint Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells
    Kenji Tanigaki
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto, 606 8501, Japan
    Nat Immunol 3:443-50. 2002
    ..In contrast, these mice exhibited increased mortality rates after blood-borne bacterial infection, which indicates that MZB cells play pivotal roles in the clearance of these bacteria...