Hiromu Takematsu

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. pmc Correlation index-based responsible-enzyme gene screening (CIRES), a novel DNA microarray-based method for enzyme gene involved in glycan biosynthesis
    Harumi Yamamoto
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Sakyo, Kyoto, Japan
    PLoS ONE 2:e1232. 2007
  2. pmc Quantitative transcriptomic profiling of branching in a glycosphingolipid biosynthetic pathway
    Hiromu Takematsu
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Sakyo, Kyoto 606 8501, Japan
    J Biol Chem 286:27214-24. 2011
  3. ncbi request reprint [Sialic acid modification]
    Hiromu Takematsu
    Tanpakushitsu Kakusan Koso 48:947-51. 2003
  4. ncbi request reprint The requirement for the hydrophobic motif phosphorylation of Ypk1 in yeast differs depending on the downstream events, including endocytosis, cell growth, and resistance to a sphingolipid biosynthesis inhibitor, ISP-1
    Daisuke Tanoue
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Kyoto 606 8501, Japan
    Arch Biochem Biophys 437:29-41. 2005
  5. pmc Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation
    Yuko Naito
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Yoshida Shimoadachi, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 27:3008-22. 2007
  6. pmc Identification of Ypk1 as a novel selective substrate for nitrogen starvation-triggered proteolysis requiring autophagy system and endosomal sorting complex required for transport (ESCRT) machinery components
    Mitsugu Shimobayashi
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Kyoto 606 8501, Japan
    J Biol Chem 285:36984-94. 2010
  7. ncbi request reprint Disturbance of sphingolipid biosynthesis abrogates the signaling of Mss4, phosphatidylinositol-4-phosphate 5-kinase, in yeast
    Takafumi Kobayashi
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Yoshida Shimoadachi, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 280:18087-94. 2005
  8. doi request reprint Sphingosylphosphorylcholine and lysosulfatide have inverse regulatory functions in monocytic cell differentiation into macrophages
    Hiroshi Yamamoto
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Sakyo, Kyoto 606 8501, Japan CREST, JST, Kawaguchi, Saitama, Japan
    Arch Biochem Biophys 506:83-91. 2011
  9. pmc Fpk1/2 kinases regulate cellular sphingoid long-chain base abundance and alter cellular resistance to LCB elevation or depletion
    Yukari Yamane-Sando
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, 46 29 Yoshida Shimoadachi, Sakyo, Kyoto, 606 8502, Japan
    Microbiologyopen 3:196-212. 2014
  10. pmc SLI1 (YGR212W) is a major gene conferring resistance to the sphingolipid biosynthesis inhibitor ISP-1, and encodes an ISP-1 N-acetyltransferase in yeast
    Michiko Momoi
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Kyoto 606 8501, Japan
    Biochem J 381:321-8. 2004

Collaborators

Detail Information

Publications23

  1. pmc Correlation index-based responsible-enzyme gene screening (CIRES), a novel DNA microarray-based method for enzyme gene involved in glycan biosynthesis
    Harumi Yamamoto
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Sakyo, Kyoto, Japan
    PLoS ONE 2:e1232. 2007
    ..However, a systematic approach for assessing the correlation between glycan expression and glycan-related gene expression has not been reported previously...
  2. pmc Quantitative transcriptomic profiling of branching in a glycosphingolipid biosynthetic pathway
    Hiromu Takematsu
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Sakyo, Kyoto 606 8501, Japan
    J Biol Chem 286:27214-24. 2011
    ..Collectively, these data suggest that transcriptomic assessment of macromolecule biosynthetic pathways can disclose a global regulatory mechanism(s) even when unexpected...
  3. ncbi request reprint [Sialic acid modification]
    Hiromu Takematsu
    Tanpakushitsu Kakusan Koso 48:947-51. 2003
  4. ncbi request reprint The requirement for the hydrophobic motif phosphorylation of Ypk1 in yeast differs depending on the downstream events, including endocytosis, cell growth, and resistance to a sphingolipid biosynthesis inhibitor, ISP-1
    Daisuke Tanoue
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Kyoto 606 8501, Japan
    Arch Biochem Biophys 437:29-41. 2005
    ..These data suggest that the ISP-1-resistance pathway is under the regulation of the hydrophobic motif phosphorylation and is separated from the other pathways downstream of Ypk1...
  5. pmc Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation
    Yuko Naito
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Yoshida Shimoadachi, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 27:3008-22. 2007
    ..Thus, Neu5Gc is required for optimal negative regulation, and the reaction is specifically suppressed in activated B cells, i.e., germinal center B cells...
  6. pmc Identification of Ypk1 as a novel selective substrate for nitrogen starvation-triggered proteolysis requiring autophagy system and endosomal sorting complex required for transport (ESCRT) machinery components
    Mitsugu Shimobayashi
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Kyoto 606 8501, Japan
    J Biol Chem 285:36984-94. 2010
    ..Overall, we propose a novel regulation of Ypk1 that is specific to nitrogen limitation...
  7. ncbi request reprint Disturbance of sphingolipid biosynthesis abrogates the signaling of Mss4, phosphatidylinositol-4-phosphate 5-kinase, in yeast
    Takafumi Kobayashi
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Yoshida Shimoadachi, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 280:18087-94. 2005
    ..These data suggested that proper sphingolipids are required for the signaling pathway involving Mss4...
  8. doi request reprint Sphingosylphosphorylcholine and lysosulfatide have inverse regulatory functions in monocytic cell differentiation into macrophages
    Hiroshi Yamamoto
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Sakyo, Kyoto 606 8501, Japan CREST, JST, Kawaguchi, Saitama, Japan
    Arch Biochem Biophys 506:83-91. 2011
    ..These results suggest that SPC enhances, whereas LSF suppresses, monocyte differentiation into macrophages through regulating the Raf/MEK/ERK and PI3K/Akt signaling pathways via distinct mechanisms...
  9. pmc Fpk1/2 kinases regulate cellular sphingoid long-chain base abundance and alter cellular resistance to LCB elevation or depletion
    Yukari Yamane-Sando
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, 46 29 Yoshida Shimoadachi, Sakyo, Kyoto, 606 8502, Japan
    Microbiologyopen 3:196-212. 2014
    ..RSK3, which belongs to the p90-S6K subfamily, was identified as a functional counterpart of Fpk1/2 in mammalian cells as the RSK3 gene functionally complemented the ISP-1-resistant phenotype of fpk1/2∆ cells...
  10. pmc SLI1 (YGR212W) is a major gene conferring resistance to the sphingolipid biosynthesis inhibitor ISP-1, and encodes an ISP-1 N-acetyltransferase in yeast
    Michiko Momoi
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Kyoto 606 8501, Japan
    Biochem J 381:321-8. 2004
    ..These data suggest that Sli1p inactivates ISP-1 due to its N-acetyltransferase activity towards ISP-1...
  11. doi request reprint Wheat germ agglutinin stains dispersed post-golgi vesicles after treatment with the cytokinesis inhibitor psychosine
    Takayuki Kanazawa
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
    J Cell Physiol 215:517-25. 2008
    ..These data suggest that the transport of WGA-positive vesicles to the cleavage furrow is associated with the progression of cytokinesis...
  12. doi request reprint Major glycan structure underlying expression of the Lewis X epitope in the developing brain is O-mannose-linked glycans on phosphacan/RPTPβ
    Shohei Yaji
    Department of Biological Chemistry, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Glycobiology 25:376-85. 2015
    ....
  13. pmc Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways
    Yidi Sun
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Biol Cell 23:2388-98. 2012
    ..We propose that this mechanism serves as the basis for how Orm phosphoregulation controls sphingolipid biosynthesis in response to stress in a kinetically coupled manner...
  14. doi request reprint Establishment of the culture model system that reflects the process of terminal differentiation of connective tissue-type mast cells
    Hirotsugu Takano
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    FEBS Lett 582:1444-50. 2008
    ..The gene expression profile obtained by the microarray analyses was found to reflect many aspects of the differentiation. Our system is thus helpful to gain deeper insights into terminal differentiation of CTMCs...
  15. pmc Analysis of multiple compound-protein interactions reveals novel bioactive molecules
    Hiroaki Yabuuchi
    Department of Systems Biosciences for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Mol Syst Biol 7:472. 2011
    ..The results of this study indicate that data derived from chemical genomics can be highly useful for exploring chemical space, and this systems biology perspective could accelerate drug discovery processes...
  16. pmc Psychosine-triggered endomitosis is modulated by membrane sphingolipids through regulation of phosphoinositide 4,5-bisphosphate production at the cleavage furrow
    Hiroshi Watanabe
    Laboratory of Biological Chemistry, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Mol Biol Cell 27:2037-50. 2016
    ..Depending on the sphingolipid balance between GSLs and SM, Namalwa cells could be effectively converted to viable multiploid cells with psychosine. ..
  17. pmc Ectopic clustering of Cajal-Retzius and subplate cells is an initial pathological feature in Pomgnt2-knockout mice, a model of dystroglycanopathy
    Naoki Nakagawa
    Department of Biological Chemistry, Human Health Sciences, Graduate School of Medicine, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Sci Rep 5:11163. 2015
    ..Our findings demonstrate the initial pathological events in dystroglycanopathy mice and contribute to our understanding of how dystroglycan dysfunction affects brain development and progresses to cobblestone lissencephaly. ..
  18. pmc A Sulfated Glycosaminoglycan Linkage Region is a Novel Type of Human Natural Killer-1 (HNK-1) Epitope Expressed on Aggrecan in Perineuronal Nets
    Keiko Yabuno
    Department of Biological Chemistry, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, 606 8507, Japan
    PLoS ONE 10:e0144560. 2015
    ..These results could lead to discovery of new roles of the HNK-1 epitope in neural plasticity. ..
  19. pmc Role of Site-Specific N-Glycans Expressed on GluA2 in the Regulation of Cell Surface Expression of AMPA-Type Glutamate Receptors
    Yusuke Takeuchi
    Department of Biological Chemistry, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    PLoS ONE 10:e0135644. 2015
    ..Thus, our data suggested that site-specific N-glycans on GluA2 regulate the intracellular trafficking and cell surface expression of AMPAR...
  20. doi request reprint HNK-1 sulfotransferase-dependent sulfation regulating laminin-binding glycans occurs in the post-phosphoryl moiety on α-dystroglycan
    Naoki Nakagawa
    Department of Biological Chemistry, Human Health Sciences, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Glycobiology 23:1066-74. 2013
    ..These results illustrate one possible glycosylation pathway where α-DG function is regulated by opposing actions of HNK-1ST and LARGE. ..
  21. ncbi request reprint Physical and functional association of glucuronyltransferases and sulfotransferase involved in HNK-1 biosynthesis
    Yasuhiko Kizuka
    Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    J Biol Chem 281:13644-51. 2006
    ..These results suggest that the function of this enzyme complex is relevant to the efficient sequential biosynthesis of the HNK-1 carbohydrate...
  22. ncbi request reprint Sphingolipids involved in the induction of multinuclear cell formation
    Yasunori Kozutsumi
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
    Biochim Biophys Acta 1582:138-43. 2002
    ..At present, a definitive model of the function of sphingolipids as to the induction of multinuclear cell formation is not available due to the rudimentary information but possible mechanisms are discussed...
  23. pmc N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution
    Maria Hedlund
    Glycobiology Research and Training Center, Department of Medicine, University of California San Diego, La Jolla, CA 92093 0687, USA
    Mol Cell Biol 27:4340-6. 2007
    ..Adult animals also showed delayed skin wound healing. Loss of Neu5Gc in hominid ancestors approximately 2 to 3 million years ago likely had immediate and long-term consequences for human biology...