Genomes and Genes
Affiliation: Kyoto University
- Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3H Takebayashi
Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Yoshida, Konoe cho, Sakyo ku, 606 8501, Kyoto, Japan
Mech Dev 99:143-8. 2000..These results indicate that Olig2 expression is not limited to the oligodendrocyte lineage but includes immature neuronal progenitors and multipotential neuron/glia progenitors as well as embryonic olfactory neurons...
- Non-overlapping expression of Olig3 and Olig2 in the embryonic neural tubeHirohide Takebayashi
Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Yoshida, Konoe cho, Sakyo ku, Kyoto 606 8501, Japan
Mech Dev 113:169-74. 2002..5. Olig3 is specifically and transiently expressed in different types of progenitors of embryonic central nervous system and then disappears in the course of development...
- The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineagesHirohide Takebayashi
Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Yoshida, Konoe cho, Sakyo ku, Japan
Curr Biol 12:1157-63. 2002..Our data provide the first evidence that a single gene mutation leads to the loss of two cell types, motoneuron and oligodendrocyte...
- Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in miceS Yoshida
Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Dev Biol 240:517-30. 2001..In addition, Sgn1 expression exhibits a reverse relationship with the development of male phenotypes, suggesting its role in gender dimorphism in the salivary glands...
- Involvement of the Olig2 transcription factor in cholinergic neuron development of the basal forebrainMiki Furusho
Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies Sokendai, Okazaki, Aichi 444 8787, Japan
Dev Biol 293:348-57. 2006..The present study provides the first direct evidence for involvement of the Olig2 gene in cholinergic differentiation in the basal forebrain...
- Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cellsNoritaka Masahira
Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8787, Japan
Dev Biol 293:358-69. 2006..These findings demonstrate that motoneurons and oligodendrocytes are not the only cell types originating from this domain...
- Expression of the basic helix-loop-factor Olig2 in the developing retina: Olig2 as a new marker for retinal progenitors and late-born cellsKoji Shibasaki
Center for Aging and Developmental Biology, University of Rochester, School of Medicine, Rochester, NY 14642, USA
Gene Expr Patterns 7:57-65. 2007..Thus, Olig2 is an marker both for retinal progenitor cells during embryonic stages, and also for differentiated retinal subpopulations within the GCL and INL during postnatal stages...
- NG2 and Olig2 expression provides evidence for phenotypic deregulation of cultured central nervous system and peripheral nervous system neural precursor cellsCecile Dromard
INSERM U583, Physiopathologie et Thérapie des Déficits Sensoriels et Moteurs Institut des Neurosciences de Montpellier, Hopital St Eloi, BP 74103 80, avenue Augustin Fliche 34091 Montpellier Cedex 05, France
Stem Cells 25:340-53. 2007..These data provide new evidence for profound phenotypic modifications in CNS and PNS neural precursor cells induced by culture conditions...
- Regulation of glial development by cystatin CAkiko Hasegawa
Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies Sokendai, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Aichi, Japan
J Neurochem 100:12-22. 2007..The antibody increased the number of oligodendrocytes and their precursors. Therefore, CysC modifies glial development in addition to its activity against neural stem/precursor cells...
- Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic Olig2-expressing precursorsGoichi Miyoshi
Neuroscience Program and Department of Cell Biology, Smilow Research Center, New York University School of Medicine, New York, New York 10016, USA
J Neurosci 27:7786-98. 2007..We observe that the physiological subtypes of cortical interneurons are, to a large degree, unique to their time point of generation...
- Regional- and temporal-dependent changes in the differentiation of Olig2 progenitors in the forebrain, and the impact on astrocyte development in the dorsal palliumKatsuhiko Ono
Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, 5 1 Higashiyama, Myodaiji, Okazaki, Aichi 444 8787, Japan
Dev Biol 320:456-68. 2008..These observations indicate that embryonic Olig2+ progenitor cells change their differentiative properties during development, and also that Olig2 plays a role in astrocyte development in a region-specific manner...
- Basic fibroblast growth factor endows dorsal telencephalic neural progenitors with the ability to differentiate into oligodendrocytes but not gamma-aminobutyric acidergic neuronsMasahiko Abematsu
Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
J Neurosci Res 83:731-43. 2006....
- Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortexLeda Dimou
Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, 80336 Munich, Germany
J Neurosci 28:10434-42. 2008..Thus, our results demonstrate the continuous generation of mature, myelinating oligodendrocytes in the WM, whereas cells in the GM generated mostly postmitotic NG2(+) glia...
- Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig2 and Nkx2.2 in the control of oligodendrocyte differentiationHui Fu
Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
Development 129:681-93. 2002..In support of this suggestion, inhibition of expression of these two transcription factors in culture by antisense oligonucleotides has an additive inhibitory effect on OLP differentiation and proteolipid protein (PLP) gene expression...
- Evidence for a second wave of oligodendrogenesis in the postnatal cerebral cortex of the mouseAnna Ivanova
Laboratory of Neural Information, National Institute for Physiological Sciences, Okazaki National Research Institutes, Aichi, Japan
J Neurosci Res 73:581-92. 2003..In the second wave, there might be two different types of precursor cells: PLP/DM20(+) cells populating only inner layers and PDGFRalpha(+) cells, which might eventually myelinate the outer regions as well...
- The potential to induce glial differentiation is conserved between Drosophila and mammalian glial cells missing genesYasuno Iwasaki
Division of Molecular Neurobiology, National Institute for Physiological Sciences, Okazaki, Aichi 444 8585, Japan
Development 130:6027-35. 2003..The mammalian homolog of Drosophila gcm, mouse Gcm1, exhibits the potential to induce gliogenesis, but may function in the generation of a minor subpopulation of glial cells...
- Anti-human Olig2 antibody as a useful immunohistochemical marker of normal oligodendrocytes and gliomasHideaki Yokoo
Department of Pathology, Gunma University Graduate School of Medicine, Maebashi, Japan
Am J Pathol 164:1717-25. 2004..Neither central neurocytoma nor schwannoma cases were stained. Our antibody was demonstrated to be useful in recognizing normal oligodendrocytes on paraffin sections, and applicable in diagnosis of some brain tumors...
- Converse control of oligodendrocyte and astrocyte lineage development by Sonic hedgehog in the chick spinal cordEric Agius
Centre de Biologie du Developpement, UMR5547 CNRS UPS, Universite Paul Sabatier, Toulouse, France
Dev Biol 270:308-21. 2004..We propose that specification of distinct glial lineages is the result of a choice that depends on Shh signalling...
- Short-term lineage analysis of dorsally derived Olig3 cells in the developing spinal cordLei Ding
Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, 5 1 Higashiyama, Myodaiji, Okazaki, 444 8787, Japan
Dev Dyn 234:622-32. 2005..Dorsal midline cells were also LacZ-positive during development. These findings suggest that dorsal Olig3 cells contribute to dorsal midline cells and commissural interneurons at intermediate and ventral levels...
- Gliogenic radial glial cells show heterogeneity in the developing mouse spinal cordYasuhiro Ogawa
Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, 5 1 Higashiyama, Myodaiji, Okazaki, Japan
Dev Neurosci 27:364-77. 2005..This raises the idea that astrocytes generated from different domains along the dorsoventral axis in the mouse spinal cord have distinct characteristics...
- Improved preservation of X-gal reaction product for electron microscopy using hydroxypropyl methacrylateNoritaka Masahira
Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki, Aichi 444 8787, Japan
Neurosci Lett 374:17-20. 2005..The protocol presented here appears to be useful for lineage determination by TEM of all types of X-gal-stained tissues...
- Murine model of Alexander disease: analysis of GFAP aggregate formation and its pathological significanceKenji F Tanaka
Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki 444 8787, Japan
Glia 55:617-31. 2007..These results indicate that the presence of GFAP aggregates containing mutant GFAP is not sufficient to induce a major phenotype of Alexander disease, even though it causes some abnormalities in the mouse...
- In vivo transcriptional profile analysis reveals RNA splicing and chromatin remodeling as prominent processes for adult neurogenesisDaniel A Lim
Department of Neurological Surgery and Developmental and Stem Cell Biology Program, University of California, San Francisco, CA 94143, USA
Mol Cell Neurosci 31:131-48. 2006....