Yasuhiko Tabata

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Tissue regeneration based on growth factor release
    Yasuhiko Tabata
    Institute for Frontier Medical Sciences, Kyoto University, Japan
    Tissue Eng 9:S5-15. 2003
  2. ncbi request reprint Tissue regeneration based on tissue engineering technology
    Yasuhiko Tabata
    Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Congenit Anom (Kyoto) 44:111-24. 2004
  3. ncbi request reprint Current status of regenerative medical therapy based on drug delivery technology
    Yasuhiko Tabata
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Reprod Biomed Online 16:70-80. 2008
  4. doi request reprint How controlled release technology can aid gene delivery
    Jun ichiro Jo
    a Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku Kyoto 606 8507, Japan 81 75 751 4121 81 75 751 4646
    Expert Opin Drug Deliv 12:1689-701. 2015
  5. pmc A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment
    Takayuki Nakagawa
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    BMC Med 12:219. 2014
  6. doi request reprint Prevention of trinitrobenzene sulfonic acid-induced experimental colitis by oral administration of a poly(lactic-coglycolic acid) microsphere containing prostaglandin E₂ receptor subtype 4 agonist
    Tatsuya Okamoto
    Department of Surgery Hepato pancreatico biliary and Transplantation, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Pharmacol Exp Ther 341:340-9. 2012
  7. pmc Cationized gelatin-HVJ envelope with sodium borocaptate improved the BNCT efficacy for liver tumors in vivo
    Hitoshi Fujii
    Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    Radiat Oncol 6:8. 2011
  8. pmc Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss: a prospective clinical trial
    Takayuki Nakagawa
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    BMC Med 8:76. 2010
  9. pmc Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice
    Ediriweera P S Chandana
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    BMC Dev Biol 10:84. 2010
  10. ncbi request reprint Influence of gelatin complexation on cell proliferation activity and proteolytic resistance of basic fibroblast growth factor
    Y Tabata
    Institute for Frontier Medical Sciences, Kyoto University, Japan
    J Biomater Sci Polym Ed 11:571-82. 2000

Collaborators

Detail Information

Publications127 found, 100 shown here

  1. ncbi request reprint Tissue regeneration based on growth factor release
    Yasuhiko Tabata
    Institute for Frontier Medical Sciences, Kyoto University, Japan
    Tissue Eng 9:S5-15. 2003
    ..In this article, tissue regeneration based on the release of growth factors is reviewed to emphasize the significance of drug delivery systems in tissue engineering...
  2. ncbi request reprint Tissue regeneration based on tissue engineering technology
    Yasuhiko Tabata
    Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Congenit Anom (Kyoto) 44:111-24. 2004
    ..The paper presented here overviews recent research data on tissue regeneration based on tissue engineering, and briefly explains the key technology of tissue engineering...
  3. ncbi request reprint Current status of regenerative medical therapy based on drug delivery technology
    Yasuhiko Tabata
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Reprod Biomed Online 16:70-80. 2008
    ..Several concrete examples of regenerative medical therapy based on the cell scaffolding and drug delivery system of growth factors and genes are introduced here to emphasize the significance of biomaterials in tissue engineering...
  4. doi request reprint How controlled release technology can aid gene delivery
    Jun ichiro Jo
    a Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku Kyoto 606 8507, Japan 81 75 751 4121 81 75 751 4646
    Expert Opin Drug Deliv 12:1689-701. 2015
    ..Biodegradable biomaterials are useful as materials for the controlled release-based gene delivery technology and various biodegradable biomaterials have been developed...
  5. pmc A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment
    Takayuki Nakagawa
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    BMC Med 12:219. 2014
    ..This study aimed to examine the efficacy and safety of topical insulin-like growth factor-1 (IGF-1) therapy in comparison to intratympanic corticosteroid therapy...
  6. doi request reprint Prevention of trinitrobenzene sulfonic acid-induced experimental colitis by oral administration of a poly(lactic-coglycolic acid) microsphere containing prostaglandin E₂ receptor subtype 4 agonist
    Tatsuya Okamoto
    Department of Surgery Hepato pancreatico biliary and Transplantation, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Pharmacol Exp Ther 341:340-9. 2012
    ..These results suggest that EP4-MS protect mice from TNBS-induced colitis by intestinal local ONO-AE2-724 delivery. The EP4-MS may offer a promising new therapeutic strategy to treat inflammatory bowel diseases...
  7. pmc Cationized gelatin-HVJ envelope with sodium borocaptate improved the BNCT efficacy for liver tumors in vivo
    Hitoshi Fujii
    Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    Radiat Oncol 6:8. 2011
    ..In this study, we developed a novel vector for 10B (sodium borocaptate: BSH) delivery using HVJ-E and cationized gelatin for treating multiple liver tumors with BNCT without severe adverse events...
  8. pmc Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss: a prospective clinical trial
    Takayuki Nakagawa
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    BMC Med 8:76. 2010
    ..We tested the safety and efficacy of topical insulin-like growth factor 1 (IGF1) application using gelatin hydrogels as a treatment for SSHL...
  9. pmc Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice
    Ediriweera P S Chandana
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    BMC Dev Biol 10:84. 2010
    ..Mice lacking the membrane-anchored metalloproteinase regulator Reck die in utero around embryonic day 10.5 with halted vascular development; however, the mechanisms by which this phenotype arises remain unclear...
  10. ncbi request reprint Influence of gelatin complexation on cell proliferation activity and proteolytic resistance of basic fibroblast growth factor
    Y Tabata
    Institute for Frontier Medical Sciences, Kyoto University, Japan
    J Biomater Sci Polym Ed 11:571-82. 2000
    ..It is possible that the complexing gelatin covers bFGF molecules, resulting in suppression of their interaction with the cell surface receptor as well as protection from their enzymatic attack...
  11. ncbi request reprint Controlled release of vascular endothelial growth factor by use of collagen hydrogels
    Y Tabata
    Institute for Frontier Medical Sciences, Kyoto University, Japan
    J Biomater Sci Polym Ed 11:915-30. 2000
    ..We concluded that in our hydrogel system, biologically-active VEGF was released as a result of in vivo degradation of the hydrogel...
  12. ncbi request reprint Bone formation at a rabbit skull defect by autologous bone marrow cells combined with gelatin microspheres containing TGF-beta1
    Y Tabata
    Institute for Frontier Medical Sciences, Kyoto University, Japan
    J Biomater Sci Polym Ed 11:891-901. 2000
    ..These findings indicate that a combination of gelatin microspheres containing TGF-beta1 enabled BM cells to enhance the osteoinductive ability, resulting in bone formation even at the cell number at which BM cells alone were ineffective...
  13. ncbi request reprint [Significance of tissue engineering in regenerative medicine]
    Yasuhiko Tabata
    Tanpakushitsu Kakusan Koso 47:770-8. 2002
  14. ncbi request reprint [Present status of regenerative medical therapy and its potential in dentistry]
    Yasuhiko Tabata
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University
    Nihon Hotetsu Shika Gakkai Zasshi 49:563-8. 2005
    ..Tissue engineering of cell scaffolding and DDS technologies that provide cells with a local environment suitable to induce tissue regeneration, is important to realize regenerative medical therapy...
  15. ncbi request reprint Significance of release technology in tissue engineering
    Yasuhiko Tabata
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Drug Discov Today 10:1639-46. 2005
    ..Tissue engineering is the key to this regeneration environment; release technology often enhances the in vivo stability of growth factors and related genes and prolongs the maintenance of biological functions for tissue regeneration...
  16. ncbi request reprint Regenerative inductive therapy based on DDS technology of protein and gene
    Yasuhiko Tabata
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto, 606 8507, Japan
    J Drug Target 14:483-95. 2006
    ..This paper overviews the present status and future direction of tissue engineering for regenerative inductive therapy, briefly explaining the key technology of tissue engineering, especially DDS of growth factor and gene...
  17. ncbi request reprint [Development of functional drug carriers to realize advanced medical therapy]
    Yasuhiko Tabata
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Japan
    Yakugaku Zasshi 127:825-37. 2007
    ..This paper overviews functional drug carriers indispensable for DDS which are part of the fundamental technology and methodology to achieve such advances...
  18. doi request reprint Bone regeneration using titanium nonwoven fabrics combined with fgf-2 release from gelatin hydrogel microspheres in rabbit skull defects
    Norihisa Ichinohe
    Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Tissue Eng Part A 14:1663-71. 2008
    ..It is concluded that the combination of HA-like coating and FGF-2 release promotes Ti induction of bone regeneration...
  19. pmc Biomaterial technology for tissue engineering applications
    Yasuhiko Tabata
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J R Soc Interface 6:S311-24. 2009
    ..Several examples of tissue engineering applications with the cell scaffold and DDS of growth factors and genes are introduced to emphasize the significance of biomaterial technology in new therapeutic and research fields...
  20. ncbi request reprint Impregnation of plasmid DNA into three-dimensional scaffolds and medium perfusion enhance in vitro DNA expression of mesenchymal stem cells
    Hossein Hosseinkhani
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Tissue Eng 11:1459-75. 2005
    ..We conclude that a combination of plasmid DNA-impregnated PGA-reinforced sponge and the perfusion method was promising to promote in vitro gene expression for MSCs...
  21. ncbi request reprint Perfusion culture enhances osteogenic differentiation of rat mesenchymal stem cells in collagen sponge reinforced with poly(glycolic Acid) fiber
    Hossein Hosseinkhani
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Tissue Eng 11:1476-88. 2005
    ..2 mL/min, although they increased with culture time period. It may be concluded that appropriate perfusion conditions enable MSCs to positively improve the extent of proliferation and differentiation...
  22. ncbi request reprint Controlled release of matrix metalloproteinase-1 plasmid DNA prevents left ventricular remodeling in chronic myocardial infarction of rats
    Xue Lin
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circ J 73:2315-21. 2009
    ..The present study investigated whether administration of controlled release matrix metalloproteinase-1 (MMP-1) plasmid DNA prevents left ventricular (LV) remodeling in a rat chronic myocardial infarction (MI) model...
  23. ncbi request reprint Administration of control-released hepatocyte growth factor enhances the efficacy of skeletal myoblast transplantation in rat infarcted hearts by greatly increasing both quantity and quality of the graft
    Keiichi Tambara
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circulation 112:I129-34. 2005
    ....
  24. doi request reprint Less-invasive and highly effective method for preventing methicillin-resistant Staphylococcus aureus graft infection by local sustained release of vancomycin
    Hisashi Sakaguchi
    Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Thorac Cardiovasc Surg 135:25-31. 2008
    ..aureus graft infection. Therefore, we investigated whether a local sustained release of vancomycin prevents methicillin-resistant S. aureus graft infection...
  25. ncbi request reprint Insulin-like growth factor-1 enhances the efficacy of myoblast transplantation with its multiple functions in the chronic myocardial infarction rat model
    Naoki Kanemitsu
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Heart Lung Transplant 25:1253-62. 2006
    ..Insulin-like growth factor-1 (IGF-1) has anti-apoptotic and angiogenic effects, and induces myocyte hypertrophy. Our hypothesis is that topical and slow-release IGF-1 enhances the efficacy of Tx through its multiple functions...
  26. ncbi request reprint Efficient gene transfer by pullulan-spermine occurs through both clathrin- and raft/caveolae-dependent mechanisms
    Isao Kanatani
    Department of Urology, Kyoto University Graduate School of Medicine, 54 Shogoinkawara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Control Release 116:75-82. 2006
    ..We conclude that pullulan-spermine is a promising carrier for gene transfection, and that cellular uptake of pullulan-spermine-plasmid DNA complexes is mediated by clathrin- and raft/caveolae-dependent endocytotic pathways...
  27. doi request reprint Characterization of in vivo effects of platelet-rich plasma and biodegradable gelatin hydrogel microspheres on degenerated intervertebral discs
    Kazuhide Sawamura
    Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Tissue Eng Part A 15:3719-27. 2009
    ..These results provide an improved understanding of the therapeutic effects of PRP-GHM treatment of degenerated IVDs...
  28. ncbi request reprint New therapeutic approach for impaired arteriogenesis in diabetic mouse hindlimb ischemia
    Shyamal Chandra Bir
    Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circ J 72:633-40. 2008
    ....
  29. doi request reprint Controlled release of matrix metalloproteinase 1 with or without skeletal myoblasts transplantation improves cardiac function of rat hearts with chronic myocardial infarction
    Xue Lin
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Tissue Eng Part A 15:2699-706. 2009
    ..In conclusion, controlled release of MMP-1 was effective in cardioprotection in postmyocardial infarction although the combination with cell transplantation showed the similar effect...
  30. ncbi request reprint Expression profile of plasmid DNA obtained using spermine derivatives of pullulan with different molecular weights
    Jun ichiro Jo
    Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Biomater Sci Polym Ed 18:883-99. 2007
    ..These findings indicate that the cationized pullulan derivative is a promising non-viral carrier of plasmid DNA which is internalized in a receptor-mediated fashion...
  31. ncbi request reprint Osteogenic differentiation of mesenchymal stem cells in biodegradable sponges composed of gelatin and beta-tricalcium phosphate
    Yoshitake Takahashi
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biomaterials 26:3587-96. 2005
    ..We concluded that the attachment, proliferation, and osteogenic differentiation of MSC were influenced by sponge composition of gelatin and betaTCP as the cell scaffold...
  32. ncbi request reprint Enhanced anti-fibrotic activity of plasmid DNA expressing small interference RNA for TGF-beta type II receptor for a mouse model of obstructive nephropathy by cationized gelatin prepared from different amine compounds
    Toshihiro Kushibiki
    Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Kawara cho Shogoin, Sakyo ku, Kyoto, Japan
    J Control Release 110:610-7. 2006
    ..It is concluded that retrograde injection of TGF-betaR siRNA expression vector plasmid DNA complexed with the cationized gelatin is available to suppress the progression of renal interstitial fibrosis...
  33. ncbi request reprint Enhanced angiogenesis by gelatin hydrogels incorporating basic fibroblast growth factor in rabbit model of hind limb ischemia
    Kazuhiko Doi
    Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Shogoin, Kyoto 606 8507, Japan
    Heart Vessels 22:104-8. 2007
    ..In conclusion, sustained release of bFGF using gelatin hydrogel augmented angiogenesis and improved tissue blood flow after excision of the femoral artery...
  34. pmc Nontoxic genetic engineering of mesenchymal stem cells using serum-compatible pullulan-spermine/DNA anioplexes
    Devang K Thakor
    Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Tissue Eng Part C Methods 17:131-44. 2011
    ..It is therefore plausible that anioplex-transfected MSCs or other stem/progenitor cells with autologous potential could be applied to disorders such as neurotrauma or neuropathic pain that involve the spinal cord and brain...
  35. ncbi request reprint Sustained-release erythropoietin ameliorates cardiac function in infarcted rat-heart without inducing polycythemia
    Xue Lin
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Japan
    Circ J 71:132-7. 2007
    ..The usefulness of sustained-release erythropoietin for improving left ventricular (LV) function without polycythemia was evaluated in a rat chronic myocardial infarction model...
  36. ncbi request reprint Improved therapeutic efficacy in cardiomyocyte transplantation for myocardial infarction with release system of basic fibroblast growth factor
    Masaya Yamamoto
    Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Artif Organs 27:181-4. 2003
    ..The combination of bFGF-induced angiogenesis and cardiomyocyte transplantation is a promising procedure to improve the LV function in rats with myocardial infarction...
  37. ncbi request reprint Toward surgical angiogenesis using slow-released basic fibroblast growth factor
    Yutaka Sakakibara
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Eur J Cardiothorac Surg 24:105-11; discussion 112. 2003
    ....
  38. ncbi request reprint Pdx-1 enables insulin secretion by regulating synaptotagmin 1 gene expression
    Natsuki Nakajima-Nagata
    Center for Molecular Biology and Genetics, Kyoto University, 53 Kawahara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 318:631-5. 2004
    ..Our data indicate that Pdx-1 might contribute to the regulation of insulin release by promoting Syt1 expression in vivo, and provide useful information for future therapy of diabetes mellitus...
  39. ncbi request reprint Cationized catalase-loaded hydrogel for growth inhibition of peritoneally disseminated tumor cells
    Kenji Hyoudou
    Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    J Control Release 122:151-8. 2007
    ..These findings indicate that the sustained release of ED-catalase from hydrogels into the cavity is highly effective in inhibiting the growth of peritoneally disseminated tumor cells...
  40. doi request reprint Prevention of pulmonary metastasis from subcutaneous tumors by binary system-based sustained delivery of catalase
    Kenji Hyoudou
    Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Control Release 137:110-5. 2009
    ..These findings indicate that sustaining catalase activity in the blood circulation achieved by the use of pegylation and gelatin hydrogel can reduce the incidence of tumor cell metastasis...
  41. doi request reprint Therapeutic treatment with sustained-release platelet-rich plasma restores blood perfusion by augmenting ischemia-induced angiogenesis and arteriogenesis in diabetic mice
    Shyamal Chandra Bir
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Vasc Res 48:195-205. 2011
    ..The objective of this investigation was to establish the effectiveness of sustained-release platelet-rich plasma (PRP) on perfusion and neovascularization in diabetic murine hind limb ischemia...
  42. ncbi request reprint Therapeutic effects of rectal administration of basic fibroblast growth factor on experimental murine colitis
    Minoru Matsuura
    Department of Gastroenterology and Endoscopic Medicine, Kyoto University, Kyoto, Japan
    Gastroenterology 128:975-86. 2005
    ..The aim of this study was to examine the efficacy of bFGF on 2 experimental murine colitis models and to investigate its molecular mechanisms...
  43. doi request reprint Positive effect on bone fusion by the combination of platelet-rich plasma and a gelatin β-tricalcium phosphate sponge: a study using a posterolateral fusion model of lumbar vertebrae in rats
    Shin ichi Okamoto
    Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Tissue Eng Part A 18:157-66. 2012
    ..These results indicate that the PRP sponge could, therefore, be potentially useful as an attractive and less invasive method for bone fusion...
  44. ncbi request reprint The development of new immunoisolatory devices possessing the ability to induce neovascularization
    Tomonori Sakurai
    Department of Organ Reconstruction, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan, 606 8507
    Cell Transplant 12:527-35. 2003
    ..Here we demonstrated that the combination of both FGF-2 impregnated in gelatin microspheres and collagen-coated MRPB could give an effective system of neovascularization suitable for subcutaneous implantation of a bioartificial pancreas...
  45. ncbi request reprint Enhanced osteoinduction by controlled release of bone morphogenetic protein-2 from biodegradable sponge composed of gelatin and beta-tricalcium phosphate
    Yoshitake Takahashi
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biomaterials 26:4856-65. 2005
    ..These results suggest that the maintenance of the intrasponge space necessary for the osteoinduction is one factor contributing to the osteoinduction extent of BMP-2-incorporating sponges...
  46. ncbi request reprint Preparation of poly(ethylene glycol)-introduced cationized gelatin as a non-viral gene carrier
    Toshihiro Kushibiki
    Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Biomater Sci Polym Ed 16:1447-61. 2005
    ..It is concluded that the PEG-cationized gelatin was a promising non-viral gene carrier to enhance gene expression in vivo...
  47. ncbi request reprint Controlled release of plasmid DNA from hydrogels prepared from gelatin cationized by different amine compounds
    Toshihiro Kushibiki
    Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Shogoin, Kyoto 606 8507, Japan
    J Control Release 112:249-56. 2006
    ..It was concluded that plasmid DNA of biological activity was released from every cationized gelatin hydrogel accompanied with the in vivo degradation, resulting in enhanced and prolonged gene expression...
  48. doi request reprint Preparation of collagen/gelatin sponge scaffold for sustained release of bFGF
    Satoru Takemoto
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Tissue Eng Part A 14:1629-38. 2008
    ....
  49. ncbi request reprint Sustained release of prostaglandin E1 potentiates the impaired therapeutic angiogenesis by basic fibroblast growth factor in diabetic murine hindlimb ischemia
    Yuhong Huang
    Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circ J 72:1693-9. 2008
    ..Prostaglandin E1 (PGE1) is a potent vasodilator and improves endothelial function. Thus, PGE1 could potentiate the angiogenic properties of bFGF in patients with diabetes mellitus...
  50. doi request reprint Adhesion and proliferation of human adipo-stromal cells for two- or three-dimensional poly(ethylene terephthalate) substrates with or without RGD immobilization
    Sachiko Inoue
    Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Biomater Sci Polym Ed 20:721-36. 2009
    ..Phosphorylation of focal adhesion kinase (FAK) was also enhanced by the RGD immobilization on the PET non-woven fabrics...
  51. doi request reprint In situ adipogenesis in fat tissue augmented by collagen scaffold with gelatin microspheres containing basic fibroblast growth factor
    Yu Kimura
    Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Japan
    J Tissue Eng Regen Med 4:55-61. 2010
    ..This technique might be applicable for the reconstruction of volume contour deformities by trauma or surgical interventions of adipose tissue in a minimally invasive manner...
  52. doi request reprint Preparation of cationized polysaccharides as gene transfection carrier for bone marrow-derived mesenchymal stem cells
    Jun ichiro Jo
    Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Biomater Sci Polym Ed 21:185-204. 2010
    ..The cationized pullulan is a promising non-viral carrier of plasmid DNA for MSCs...
  53. ncbi request reprint Development of biologic coronary artery bypass grafting in a rabbit model: revival of a classic concept with modern biotechnology
    Koji Ueyama
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Thorac Cardiovasc Surg 127:1608-15. 2004
    ..We have developed a technique for biologic coronary artery bypass grafting, which is a revival of a classic concept with modern biotechnology...
  54. ncbi request reprint Fabrication of an optimal urethral graft using collagen-sponge tubes reinforced with Copoly(L-lactide/epsilon-caprolactone) fabric
    Isao Kanatani
    Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Tissue Eng 13:2933-40. 2007
    ..These findings suggest that creation of a scaffold suitable for urethral tissue regeneration will depend not only on the biomaterial composition, but also on the fabrication technique...
  55. ncbi request reprint Bioartificial pancreas transplantation at prevascularized intermuscular space: effect of angiogenesis induction on islet survival
    A N Balamurugan
    Department of Organ Reconstruction, Field of Clinical Application, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Pancreas 26:279-85. 2003
    ..Bioartificial pancreas (BAP) transplantation offers a potential treatment of diabetes mellitus. The optimal site for BAP transplantation has not yet been established...
  56. ncbi request reprint The efficient prevascularization induced by fibroblast growth factor 2 with a collagen-coated device improves the cell survival of a bioartificial pancreas
    Tomonori Sakurai
    Department of Organ Reconstruction, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Pancreas 28:e70-9. 2004
    ..We recently developed a new immunoisolatory device that has the ability to induce neovascularization for subcutaneous transplantation. We applied the newly developed device to subcutaneous transplantation of a bioartificial pancreas...
  57. ncbi request reprint Type I collagen can function as a reservoir of basic fibroblast growth factor
    Akihiro Kanematsu
    Department of Biomaterial, Institute for Frontier Medical Sciences, Kyoto University, 53 Shogoin kawara cho, Sakyo, Kyoto 606 8507, Japan
    J Control Release 99:281-92. 2004
    ..These results suggest the significance and therapeutic utility of type I collagen as a reservoir of bFGF...
  58. doi request reprint Controlled release of bone morphogenetic protein-2 enhances recruitment of osteogenic progenitor cells for de novo generation of bone tissue
    Yu Kimura
    Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Tissue Eng Part A 16:1263-70. 2010
    ..It is conceivable that the local concentration of BMP-2 modifies the recruitment profile of progenitor cells with an osteogenic potential around the release site of BMP-2, resulting in regulated volume of de novo generated bone tissue...
  59. ncbi request reprint Adipose tissue engineering based on human preadipocytes combined with gelatin microspheres containing basic fibroblast growth factor
    Yu Kimura
    Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biomaterials 24:2513-21. 2003
    ..We conclude that combination of gelatin microspheres containing bFGF and preadipocytes with the collagen sponge is essential to achieve tissue engineering of fat tissue...
  60. doi request reprint Practical induction system for dopamine-producing cells from bone marrow stromal cells using spermine-pullulan-mediated reverse transfection method
    Kentaro Nagane
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Tissue Eng Part A 15:1655-65. 2009
    ..Our study indicates the availability of the reverse transfection method for the induction of dopamine-producing neuronal cells from BMSCs, which is expected to apply to cell-based therapy in Parkinson's disease...
  61. doi request reprint Effect of modification manner on the photodynamic antitumor activity of C60 modified with pullulan
    Jian Liu
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    J Biomater Sci Polym Ed 22:2147-63. 2011
    ..It is concluded that the manner of pullulan modification is a key factor contributing to the photodynamic antitumor activity of modified C(60)...
  62. ncbi request reprint Elimination of local macrophages in intestine prevents chronic colitis in interleukin-10-deficient mice
    Norihiko Watanabe
    Department of Gastroenterology, Graduate School of Medicine, and Institute for Frontier Medical Science, Kyoto University, Kyoto, Japan
    Dig Dis Sci 48:408-14. 2003
    ..Our study implies that elimination of resident macrophages in the intestine may become a therapeutic approach to IBD...
  63. ncbi request reprint Collagenous matrices as release carriers of exogenous growth factors
    Akihiro Kanematsu
    Department of Urology, Graduate School of Medicine, Kyoto University, Shogoin Kawaracho 54, Sakyo, Kyoto 606 8507, Japan
    Biomaterials 25:4513-20. 2004
    ..These findings demonstrate that the collagenous matrices function as release carriers of growth factors. This feature is promising to create a scaffold, which has a nature to control the tissue regeneration actively...
  64. ncbi request reprint Therapeutic angiogenesis by the controlled release of basic fibroblast growth factor for ischemic limb and heart injury: toward safety and minimal invasiveness
    Hiroyuki Nakajima
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaracho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Artif Organs 7:58-61. 2004
    ..The controlled release of bFGF was effective for both limb and heart ischemia and is considered to be suitable for clinical use because its application in animals was feasible and safe with minimal invasiveness...
  65. ncbi request reprint Preparation of hybrid scaffold from fibrin and biodegradable polymer fiber
    Akishige Hokugo
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Shogoin, Kyoto 606 8507, Japan
    Biomaterials 27:61-7. 2006
    ..It is concluded that the fibrin sponge reinforced by fiber incorporation is a promising three-dimensional scaffold of cells for tissue engineering...
  66. ncbi request reprint Acceleration of aneurysm healing by hollow fiber enabling the controlled release of basic fibroblast growth factor
    Osamu Kawakami
    Department of Neurosurgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Neurosurgery 58:355-64; discussion 355-64. 2006
    ..We examined feasibility of the material in embolization healing aneurysm by bFGF-induced tissue organization...
  67. ncbi request reprint In situ regeneration of adipose tissue in rat fat pad by combining a collagen scaffold with gelatin microspheres containing basic fibroblast growth factor
    Yosuke Hiraoka
    Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Tissue Eng 12:1475-87. 2006
    ..We conclude that combination of scaffold collagen with an appropriate controlled release of bFGF was essential to achieve the in situ formation of adipose tissue even without preadipocytes...
  68. ncbi request reprint In vitro transfection of plasmid DNA by cationized gelatin prepared from different amine compounds
    Toshihiro Kushibiki
    Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Biomater Sci Polym Ed 17:645-58. 2006
    ..The present study indicates that there is an optimal N+/P- mixing ratio and a type of amine compound or cationization extent of cationized gelatin to enhance the transfection efficiency of plasmid DNA...
  69. ncbi request reprint Combined treatment with sustained-release basic fibroblast growth factor and heparin enhances neovascularization in hypercholesterolemic mouse hindlimb ischemia
    Yoshio Arai
    Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circ J 71:412-7. 2007
    ..Whether the combined treatment with sustained-release basic fibroblast growth factor (bFGF) and heparin enhances neovascularization in hypercholesterolemic mouse hindlimb ischemia was investigated...
  70. ncbi request reprint Skull bone regeneration in nonhuman primates by controlled release of bone morphogenetic protein-2 from a biodegradable hydrogel
    Yoshitake Takahashi
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Tissue Eng 13:293-300. 2007
    ..We conclude that the controlled release of BMP-2 for a certain time period was essential to inducing the osteoinductive potential of BMP-2...
  71. ncbi request reprint A reverse transfection technology to genetically engineer adult stem cells
    Arimichi Okazaki
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Tissue Eng 13:245-51. 2007
    ..It is possible that medium circulation improves the culture conditions of cells in terms of oxygen and nutrition supply and waste excretion, resulting in enhanced gene expression...
  72. doi request reprint Adipogenesis induced by human adipose tissue-derived stem cells
    Wakako Tsuji
    Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Tissue Eng Part A 15:83-93. 2009
    ..Only trace of human-origin adipose tissue was observed in other groups implanted ASCs. Our results show that human ASCs not only function as progenitor cells for in vivo adipogenesis, but also induce de novo adipogenesis for long period...
  73. ncbi request reprint Transplantation of genetically engineered mesenchymal stem cells improves cardiac function in rats with myocardial infarction: benefit of a novel nonviral vector, cationized dextran
    Jun ichiro Jo
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Tissue Eng 13:313-22. 2007
    ..Thus, this genetic engineering technology using the non-viral spermine-dextran is a promising strategy to improve MSC therapy for ischemic heart disease...
  74. ncbi request reprint Acceleration of aneurysm healing by controlled release of basic fibroblast growth factor with the use of polyethylene terephthalate fiber coils coated with gelatin hydrogel
    Taketo Hatano
    Department of Neurosurgery and Clinical Research Unit, Kyoto National Hospital, Kyoto, Japan
    Neurosurgery 53:393-400; discussion 400-1. 2003
    ....
  75. ncbi request reprint Experimental tissue regeneration by DDS technology of bio-signaling molecules
    Yu Kimura
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Dermatol Sci 47:189-99. 2007
    ..This paper overviews the recent status of tissue regeneration therapy based on the DDS technology of bio-signaling molecules...
  76. ncbi request reprint Prevascularization with gelatin microspheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation
    Yutaka Sakakibara
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Japan
    J Thorac Cardiovasc Surg 124:50-6. 2002
    ..We therefore designed a study to investigate the efficacy of prevascularization in ischemic regions before cell transplantation...
  77. ncbi request reprint Sustained release of cis-hydroxyproline in the treatment of experimental proliferative vitreoretinopathy in rabbits
    Tsutomu Yasukawa
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto, Japan
    Graefes Arch Clin Exp Ophthalmol 240:672-8. 2002
    ..To evaluate the efficacy of sustained-release cis-4-hydroxyproline (CHP), a proline analog that inhibits collagen secretion, on experimental proliferative vitreoretinopathy (PVR) in rabbits...
  78. ncbi request reprint Time course of de novo adipogenesis in matrigel by gelatin microspheres incorporating basic fibroblast growth factor
    Yu Kimura
    The Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Tissue Eng 8:603-13. 2002
    ..We conclude that gelatin microspheres incorporating bFGF enable Matrigel to efficiently induce de novo adipogenesis at the implanted site in respect to the formation rate and volume of adipose tissue...
  79. ncbi request reprint A new gene delivery system based on controlled release technology
    Toshihiro Kushibiki
    Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Curr Drug Deliv 1:153-63. 2004
    ..A new system of gene release based on biodegradable hydrogel is introduced...
  80. ncbi request reprint Factors related to the efficacy of skeletal muscle cell transplantation and future approaches with control-released cell growth factors and minimally invasive surgery
    Keiichi Tambara
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Int J Cardiol 95:S13-5. 2004
  81. ncbi request reprint Nanomaterials of drug delivery systems for tissue regeneration
    Yasuhiko Tabata
    Department of Biomaterials, Institute for Frontieer Medical Sciences, Kyoto University, Kyoto, Japan
    Methods Mol Biol 300:81-100. 2005
    ..In this chapter, several research approaches to tissue regeneration are reviewed to emphasize the significance of biomaterials and DDS technologies in regenerative medicine...
  82. ncbi request reprint Effect of culture substrate and fibroblast growth factor addition on the proliferation and differentiation of human adipo-stromal cells
    Sachiko Inoue
    Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Biomater Sci Polym Ed 16:57-77. 2005
    ..These findings indicate that the proliferation and differentiation of human adipose tissue-derived stromal cells are influenced by the culture substrate and the concentration of FGF-2 used for proliferation...
  83. ncbi request reprint Augmented bone regeneration activity of platelet-rich plasma by biodegradable gelatin hydrogel
    Akishige Hokugo
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Japan
    Tissue Eng 11:1224-33. 2005
    ..It is likely that the gelatin hydrogel permitted the controlled release of bioactive growth factors, resulting in factor-induced promotion of bone regeneration...
  84. ncbi request reprint Tissue engineering by modulated gene delivery
    Masaya Yamamoto
    Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Kyoto, 606 8507, Japan
    Adv Drug Deliv Rev 58:535-54. 2006
    ..This paper overviews the recent development of gene-modified tissue engineering, briefly explaining delivery technologies necessary to modulate the efficiency of gene transfection...
  85. ncbi request reprint Enhanced bone regeneration at a segmental bone defect by controlled release of bone morphogenetic protein-2 from a biodegradable hydrogel
    Masaya Yamamoto
    Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Tissue Eng 12:1305-11. 2006
    ..8 wt% than that with the lower or higher water content. We concluded that the biodegradable gelatin hydrogel is a promising controlled release carrier of BMP-2 for bone regeneration at the segmental bone defect...
  86. ncbi request reprint Intervertebral disc regeneration using platelet-rich plasma and biodegradable gelatin hydrogel microspheres
    Masateru Nagae
    Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Tissue Eng 13:147-58. 2007
    ..Our results suggest that the combined administration of PRP and gelatin hydrogel microspheres into the IVD may be a promising therapeutic modality for IVD degeneration...
  87. doi request reprint Regeneration of anterior cruciate ligament by biodegradable scaffold combined with local controlled release of basic fibroblast growth factor and collagen wrapping
    Yuta Kimura
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Tissue Eng Part C Methods 14:47-57. 2008
    ....
  88. ncbi request reprint [Important contribution and necessity of stem cells scaffolds for regenerative medicine and the therapeutic applications]
    Yasuhiko Tabata
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University
    Nihon Rinsho 66:881-6. 2008
    ....
  89. ncbi request reprint Promoted growth of murine hair follicles through controlled release of basic fibroblast growth factor
    Makoto Ozeki
    Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Tissue Eng 8:359-66. 2002
    ..These results indicate that the controlled release of bFGF positively affects the hair growth cycle of mice...
  90. ncbi request reprint In vivo promoted growth of mice hair follicles by the controlled release of growth factors
    Makoto Ozeki
    Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biomaterials 24:2387-94. 2003
    ..Neither empty gelatin nor collagen hydrogels affected hair follicle growth. These findings indicate that the controlled release enabled the growth factor to positively act on the hair growth cycle of mice...
  91. ncbi request reprint [Significance of tissue engineering in clinical practice of regenerative medicine]
    Yasuhiko Tabata
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University
    Nihon Rinsho 61:411-6. 2003
    ..This paper describes the present status and research data of tissue engineering to emphasize the considerable significance in regenerative medicine...
  92. ncbi request reprint Intramyocardial sustained delivery of basic fibroblast growth factor improves angiogenesis and ventricular function in a rat infarct model
    Atsushi Iwakura
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Japan
    Heart Vessels 18:93-9. 2003
    ..In conclusion, intramyocardial injection of bFGF-impregnated gelatin hydrogels induces functionally significant angiogenesis and improves left ventricular systolic and diastolic function in the infarcted myocardium of rats...
  93. ncbi request reprint Controlled release by biodegradable hydrogels enhances the ectopic bone formation of bone morphogenetic protein
    Masaya Yamamoto
    Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biomaterials 24:4375-83. 2003
    ..We concluded that the controlled release technology of BMP-2 for a certain time period was essential to induce the potential activity for bone formation...
  94. ncbi request reprint Suppression of the progress of disseminated pancreatic cancer cells by NK4 plasmid DNA released from cationized gelatin microspheres
    Toshihiro Kushibiki
    Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Pharm Res 21:1109-18. 2004
    ..Controlled release by a biodegradable hydrogel enabled the NK4 plasmid DNA to exert the tumor suppression effects...
  95. ncbi request reprint Influence of culture method on the proliferation and osteogenic differentiation of human adipo-stromal cells in nonwoven fabrics
    Kaori Yasuda
    Field of Tissue Engineering, Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Tissue Eng 10:1587-96. 2004
    ..It is concluded that fabric fiber diameter and culture method greatly affected the proliferation and differentiation of cells in nonwoven fabrics...
  96. ncbi request reprint Controlled release of platelet growth factors enhances bone regeneration at rabbit calvaria
    Akishige Hokugo
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kawara cho Shogoin, Sakyo ku, Kyoto, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:44-8. 2007
    ..In this study, the feasibility of gelatin hydrogels for controlled release of platelet growth factors and the consequent enhancement of PRP-induced bone regeneration were evaluated in rabbit calvarial defect...
  97. ncbi request reprint Enhanced proliferation and osteogenic differentiation of rat mesenchymal stem cells in collagen sponge reinforced with different poly(ethylene terephthalate) fibers
    Tomoaki Takamoto
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    J Biomater Sci Polym Ed 18:865-81. 2007
    ....
  98. doi request reprint Adipose tissue formation in collagen scaffolds with different biodegradabilities
    Yu Kimura
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    J Biomater Sci Polym Ed 21:463-76. 2010
    ..The area of regenerated adipose tissue was maximal in the collagen sponge with a degradation time of 2 weeks. No influence of the time profile of bFGF release on the area of regenerated adipose tissue was detected...
  99. doi request reprint In vitro proliferation and chondrogenic differentiation of rat bone marrow stem cells cultured with gelatin hydrogel microspheres for TGF-beta1 release
    Toshihiro Ogawa
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Biomater Sci Polym Ed 21:609-21. 2010
    ....
  100. ncbi request reprint Cloning and functional expression of the rat brain KIR6.2 channel
    M Takano
    Department of Physiology and Biophysics, Faculty of Medicine, Kyoto University, Japan
    Jpn J Physiol 46:491-5. 1996
    ..When KIR6.2 was co-expressed with CFTR or MDR1, no K+ channel activity was recorded...
  101. ncbi request reprint Hepatocyte growth factor supply accelerates compensatory hypertrophy caused by portal branch ligation in normal and jaundiced rats
    T Kaido
    Department of Surgery and Surgical Basic Science, Kyoto University School of Medicine, Kyoto, 606 8507, Japan
    J Surg Res 85:115-9. 1999
    ..In this report, we examined whether HGF is also useful in accelerating compensatory hypertrophy caused by portal branch ligation in normal and jaundiced rats...