Y Sasaki

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. pmc Detection of multiple QTL with epistatic effects under a mixed inheritance model in an outbred population
    Akira Narita
    Laboratory of Animal Breeding and Genetics, Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan
    Genet Sel Evol 36:415-33. 2004
  2. ncbi request reprint Comparison of genetic gains per year for carcass traits among breeding programs in the Japanese Brown and the Japanese Black cattle
    Y Sasaki
    Graduate School of Agriculture, Kyoto University, 606 8502, Japan
    J Anim Sci 84:317-23. 2006
  3. ncbi request reprint Exploration of genes showing intramuscular fat deposition-associated expression changes in musculus longissimus muscle
    Y Sasaki
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Anim Genet 37:40-6. 2006
  4. ncbi request reprint Identification of novel non-insulin-dependent diabetes mellitus susceptibility loci in the Otsuka Long-Evans Tokushima fatty rat by MQM-mapping method
    K Sugiura
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Sakyoku, Kyoto 606, Japan
    Mamm Genome 10:1126-31. 1999
  5. doi request reprint Association of single nucleotide polymorphisms in the endothelial differentiation sphingolipid G-protein-coupled receptor 1 gene with marbling in Japanese Black beef cattle
    T Yamada
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Sakyoku, Kyoto 606 8502, Japan
    Anim Genet 40:209-16. 2009
  6. doi request reprint Genomic organization and promoter analysis of the bovine ADAM12 gene
    Y Taniguchi
    Laboratory of Animal Breeding and Genetics Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto
    Anim Biotechnol 19:178-89. 2008
  7. doi request reprint The use of link provider data to improve national genetic evaluation across weakly connected subpopulations
    H Nakaoka
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Kyoto, 606 8502, Japan
    J Anim Sci 87:62-71. 2009
  8. ncbi request reprint Genome-wide linkage disequilibrium in two Japanese beef cattle breeds
    M Odani
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto, Japan
    Anim Genet 37:139-44. 2006
  9. ncbi request reprint Effectiveness of adjusting for heterogeneity of variance in genetic evaluation of Japanese Black cattle
    H Nakaoka
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Kyoto, 606 8502, Japan
    J Anim Sci 85:2429-36. 2007
  10. ncbi request reprint Identification of epistatic interactions involved in non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat
    T Yamada
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Kyoto, Kyoto 606 8502
    Exp Anim 50:115-23. 2001

Collaborators

Detail Information

Publications69

  1. pmc Detection of multiple QTL with epistatic effects under a mixed inheritance model in an outbred population
    Akira Narita
    Laboratory of Animal Breeding and Genetics, Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan
    Genet Sel Evol 36:415-33. 2004
    ..The method will help ascertain the complicated structure of quantitative traits...
  2. ncbi request reprint Comparison of genetic gains per year for carcass traits among breeding programs in the Japanese Brown and the Japanese Black cattle
    Y Sasaki
    Graduate School of Agriculture, Kyoto University, 606 8502, Japan
    J Anim Sci 84:317-23. 2006
    ..These results indicate that the on-farm progeny testing program with BLUP is a very powerful approach for genetic improvement of carcass traits in Japanese Wagyu beef cattle...
  3. ncbi request reprint Exploration of genes showing intramuscular fat deposition-associated expression changes in musculus longissimus muscle
    Y Sasaki
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Anim Genet 37:40-6. 2006
    ..Among the 35 annotated genes, 6 (BTG2, PDHB, SORBS1, TRDN, TTN and MGP) have been related to changes in intramuscular fat deposition, possibly by exerting effects on adipocyte-lineage cells or on the milieux surrounding them...
  4. ncbi request reprint Identification of novel non-insulin-dependent diabetes mellitus susceptibility loci in the Otsuka Long-Evans Tokushima fatty rat by MQM-mapping method
    K Sugiura
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Sakyoku, Kyoto 606, Japan
    Mamm Genome 10:1126-31. 1999
    ..There is epistatic interaction between Nidd2 and 14/of. Additionally, our results indicated that the novel QTLs could show no linkage with body weight, but Nidd12/of has an interaction with body weight...
  5. doi request reprint Association of single nucleotide polymorphisms in the endothelial differentiation sphingolipid G-protein-coupled receptor 1 gene with marbling in Japanese Black beef cattle
    T Yamada
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Sakyoku, Kyoto 606 8502, Japan
    Anim Genet 40:209-16. 2009
    ..These findings suggest that EDG1 SNPs, although they may not be regarded as a causal mutation, may be useful for effective marker-assisted selection to increase the levels of marbling in Japanese Black beef cattle...
  6. doi request reprint Genomic organization and promoter analysis of the bovine ADAM12 gene
    Y Taniguchi
    Laboratory of Animal Breeding and Genetics Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto
    Anim Biotechnol 19:178-89. 2008
    ..5- to 2-fold in 3T3-L1, but not in Cos-1. These results suggested that the two distal regions might contribute to the preadipocyte-specific expression of ADAM12 gene...
  7. doi request reprint The use of link provider data to improve national genetic evaluation across weakly connected subpopulations
    H Nakaoka
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Kyoto, 606 8502, Japan
    J Anim Sci 87:62-71. 2009
    ..The results demonstrate that the link provider data could be used to unify within-prefecture evaluation to form a Japanese national genetic evaluation across weakly connected subpopulations...
  8. ncbi request reprint Genome-wide linkage disequilibrium in two Japanese beef cattle breeds
    M Odani
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto, Japan
    Anim Genet 37:139-44. 2006
    ..These results indicate that LD mapping is a useful tool for fine-mapping quantitative trait loci of economically important traits in Japanese beef cattle...
  9. ncbi request reprint Effectiveness of adjusting for heterogeneity of variance in genetic evaluation of Japanese Black cattle
    H Nakaoka
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Kyoto, 606 8502, Japan
    J Anim Sci 85:2429-36. 2007
    ..05). The results suggest that the genetic evaluation becomes more accurate by adjusting the data using the procedure developed in this study...
  10. ncbi request reprint Identification of epistatic interactions involved in non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat
    T Yamada
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Kyoto, Kyoto 606 8502
    Exp Anim 50:115-23. 2001
    ..These findings demonstrate that inter-allelic interactions are likely to be an important component of NIDDM susceptibility...
  11. ncbi request reprint Analysis of expressed sequence tags from a cDNA library of somatic nuclear transfer-derived cloned bovine whole foetus
    Y Taniguchi
    Laboratory of Animal Genetics and Breeding, Graduate School of Agriculture, Kyoto University, Sakyoku, Kyoto 606-8502, Japan
    Anim Genet 32:1-6. 2001
    ..In future, the list of genes might help facilitate the understanding of physiology of foetal development in somatic nuclear transfer-derived cloned bovine foetus...
  12. ncbi request reprint Rapid communication: nucleotide sequence of bovine C/EBP beta gene
    I Yamaoka
    Department of Animal Science, Faculty of Agriculture, Kyoto University, Japan
    J Anim Sci 75:587. 1997
  13. ncbi request reprint Radiation hybrid mapping of genes showing intramuscular fat deposition-associated expression changes in bovine musculus longissimus muscle
    T Yamada
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Anim Genet 37:184-5. 2006
  14. ncbi request reprint Chromosomal assignments of eight expressed sequence tags for unknown genes showing early embryonic death-associated changes of expression patterns in the fetal placenta of the cow carrying somatic nuclear-derived cloned embryo
    T Yamada
    Laboratory of Animal Genetics and Breeding, Graduate School of Agriculture, Kyoto University, Sakyoku, Kyoto, Japan
    Anim Biotechnol 18:287-90. 2007
    ....
  15. ncbi request reprint Molecular cloning, expression analysis, promoter characterization, and chromosomal localization of the bovine PREF1 gene
    Y Minoshima
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Sakyoku, Kyoto, Japan
    Anim Genet 32:333-9. 2001
    ..The chromosomal location of the PREF1 gene was determined by fluorescence in situ hybridization (FISH). The PREF1 gene locates on bovine chromosome 21q24...
  16. ncbi request reprint Computer image analysis for prediction of carcass composition from cross-sections of Japanese Black steers
    A B Karnuah
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto-shi, 606-8502 Japan
    J Anim Sci 79:2851-6. 2001
    ..63, 0.44, and 0.29, respectively. The results indicate that the information obtained from the carcass cross-sections by the computer image analysis method can be used to predict carcass composition in Japanese Black steers...
  17. ncbi request reprint Generation of a total of 6483 expressed sequence tags from 60 day-old bovine whole fetus and fetal placenta
    M Oishi
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Sakyoku, Kyoto, Japan
    Anim Biotechnol 15:1-8. 2004
    ..The catalog is used to examine expression profile of genes in 60 day-old bovine fetus and placenta...
  18. pmc Lapatinib monotherapy in patients with relapsed, advanced, or metastatic breast cancer: efficacy, safety, and biomarker results from Japanese patients phase II studies
    M Toi
    Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaracho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Br J Cancer 101:1676-82. 2009
    ..Efficacy and safety of lapatinib monotherapy was evaluated in Japanese breast cancer patients after trastuzumab-based therapies...
  19. ncbi request reprint Effects of vitamin E and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats
    T Noguchi
    Graduate School of Human and Environmental Studies, Kyoto University, Japan
    Hypertens Res 24:735-42. 2001
    ....
  20. ncbi request reprint Rapid communication: nucleotide sequence of bovine C/EBP alpha gene
    Y Taniguchi
    Department of Animal Science, Faculty of Agriculture, Kyoto University, Japan
    J Anim Sci 74:2554. 1996
  21. ncbi request reprint An essential gene of Escherichia coli that has sequence similarity to a chloroplast gene of unknown function
    Y Nagano
    Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan
    Mol Gen Genet 228:62-4. 1991
    ..We then selected plasmid-segregated strains and found no cells containing the disrupted dedB gene, indicating that disruption of the dedB gene was lethal in polA strains of E. coli...
  22. ncbi request reprint Direct evidence of autosomal recessive inheritance of Arg24 to termination codon in purine nucleoside phosphorylase gene in a family with a severe combined immunodeficiency patient
    Y Sasaki
    Department of Safety Research on Biologics, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan
    Hum Genet 103:81-5. 1998
    ..A lack of PNP protein was also confirmed by immunoblot analysis of the patient's hemolysate. This could be the first report providing evidence of autosomal recessive inheritance in PNP deficiency by sequence-based analysis...
  23. pmc DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers
    A Satoh
    First Department of Internal Medicine, Sapporo Medical University, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Br J Cancer 86:1817-23. 2002
    ..Thus, aberrant DNA methylation and histone deacetylation of the 5' CpG island, but not the edge of the CpG island, appears to play a key role in silencing death-associated protein kinase expression in gastrointestinal malignancies...
  24. ncbi request reprint Estimation of heritability for Tying-up syndrome in the Thoroughbred racehorse by Gibbs sampling
    H Oki
    Japan Racing Association, Equine Research Institute, Utsunomiya City, Tochigi, Japan
    J Anim Breed Genet 122:289-93. 2005
    ..e. heritability of 0.42 or 0.43 for Tying-up...
  25. ncbi request reprint Chromosomal mapping of HSPCB and MYL1 expressed abundantly in the bovine fetus
    Y Muramatsu
    Department of Food Science, Shizuoka Eiwa College, Ikeda, Shizuoka, Japan
    Anim Biotechnol 14:83-6. 2003
    ..HSPCB and MYL1 were assigned to bovine chromosomes 23 and 2, respectively...
  26. ncbi request reprint Mapping of bovine CEBPD gene to BTA14q15-17
    N Ihara
    Shirakawa Institute of Animal Genetics, Nishigo, Fukushima 961 8061, Japan
    Anim Genet 34:470-1. 2003
  27. pmc Attractin/mahogany/zitter plays a critical role in myelination of the central nervous system
    T Kuramoto
    Carcinogenesis Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Proc Natl Acad Sci U S A 98:559-64. 2001
    ..We conclude from these results that the membrane Atrn has a critical role in normal myelination in the CNS and would provide insights into the physiology of myelination as well as the etiology of myelin diseases...
  28. ncbi request reprint Genotype x environment interaction effects on carcass traits in Japanese Black cattle
    T Ibi
    Department of Animal Research, Agura Farm, Nasushiobara 325 0033, Japan
    J Anim Sci 83:1503-10. 2005
    ..Consequently, carcass traits measured in these two different regions or management systems can be treated as the same traits...
  29. ncbi request reprint Mutational analysis of the beta-catenin gene in gastric carcinomas
    Y Sasaki
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, Sapporo, Japan
    Tumour Biol 22:123-30. 2001
    ....
  30. ncbi request reprint Gene expressions of canine angiopoietin-1 and -2 in normal tissues and spontaneous tumours
    Y Kato
    Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Kameino 1866, Fujisawa, Kanagawa 252 8510, Japan
    Res Vet Sci 81:280-6. 2006
    ..Higher mRNA expression level of canine Ang-2 was demonstrated in mammary simple carcinomas, haemangiosarcoma and hepatocellular carcinoma in comparison with normal tissues...
  31. ncbi request reprint A deletion of the paracellin-1 gene is responsible for renal tubular dysplasia in cattle
    Y Ohba
    Faculty of Agriculture, Division of Veterinary Medicine, Gifu University, Yanagido, Gifu, 501 1193, Japan
    Genomics 68:229-36. 2000
    ..Therefore, we concluded that deletion of the paracellin-1 gene is responsible for renal tubular dysplasia of cattle, and the cattle disease could be a good model for the human disease...
  32. ncbi request reprint Somatic cell hybrid mapping of expressed sequence tags for genes showing early embryonic death-associated changes of expression patterns in the fetal placenta of the cow carrying somatic nuclear-derived cloned embryo
    Y Muramatsu
    Department of Food Sciences, Shizuoka Eiwa Gakuin University Junior College, Surugaku, Shizuoka, Japan
    Anim Biotechnol 18:55-9. 2007
    ....
  33. ncbi request reprint Plasmid profiles of virulent Rhodococcus equi isolates from soil environment on horse-breeding farms in Hungary
    L Makrai
    Department of Microbiology and Infectious Diseases, Faculty of Veterinary Science, Szent Istvan University, Hungária krt 23 25, 1143, Budapest, Hungary
    Acta Vet Hung 54:11-8. 2006
    ..This study demonstrates that the virulent form of R. equi is very widespread in the soil environment of these stud farms in Hungary and the plasmid pattern is different from farm to farm...
  34. ncbi request reprint Chromosomal mapping of calmodulin 1 (CALM1) and alpha-globin 1 genes (HBA1) in the bovine
    Y Muramatsu
    Department of Food Science, Shizuoka Eiwa College, Ikeda, Japan
    Anim Biotechnol 12:137-40. 2001
    ..Results from the present study should contribute to improvement in map resolution of bovine chromosomes and increase comparative information available on bovine chromosomes...
  35. pmc Nitrite reductase gene enrichment improves assimilation of NO(2) in Arabidopsis
    M Takahashi
    Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, 739-8526 Japan
    Plant Physiol 126:731-41. 2001
    ..The flux control coefficients of nitrate reductase and glutamine synthetase were much smaller than this value. Together, these findings indicate that NiR is a controlling enzyme in NO(2) assimilation by plants...
  36. ncbi request reprint Chromosomal assignments of expressed sequence tags for collagen binding protein 2 (CBP2) and alpha-1 antitrypsin (PI) in the bovine
    Y Muramatsu
    Department of Food Science, Shizuoka Eiwa College, Ikeda, Shizuoka, Japan
    Anim Genet 32:327-8. 2001
  37. ncbi request reprint Prevalence of virulent Rhodococcus equi in soil from five R. equi-endemic horse-breeding farms and restriction fragment length polymorphisms of virulence plasmids in isolates from soil and infected foals in Texas
    S Takai
    Department of Animal Hygiene, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
    J Vet Diagn Invest 13:489-94. 2001
    ..equi from clinical and environmental samples on horse-breeding farms in Texas. There is not a strong correlation between the presence of virulent R. equi in farm soils and the R. equi disease status of those farms...
  38. ncbi request reprint Genomic organization, transcription start sites, and chromosomal location of the Drosophila cortactin gene
    T Katsube
    Neurogenetics Research Project, Mitsubishi Kasei Institute of Life Sciences, Machida shi, Tokyo Japan
    Genes Genet Syst 76:65-70. 2001
    ..S1 nuclease mapping revealed one major and several minor transcription start sites. The cytological location of the Drosophila cortactin gene is between chromosome segments 93B3 and 93B7...
  39. ncbi request reprint Involvement of cyclooxygenase-1, prostaglandin E2 and EP1 receptors in acid-induced HCO3- secretion in stomach
    K Takeuchi
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Yamashina, Japan
    J Physiol Pharmacol 57:661-76. 2006
    ..They further show that the presence of EP1 receptors is essential for the increase in the secretion of HCO(3)(-) in response to mucosal acidification in the stomach...
  40. pmc Influence of the CYP2D6*10 allele on the metabolism of mexiletine by human liver microsomes
    C Senda
    Department of Drug Metabolism and Pharmacokinetics, Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co, Hyogo
    Br J Clin Pharmacol 52:100-3. 2001
    ..CONCLUSIONS: The metabolism of mexiletine to form PHM and HMM appears to be impaired to a significant extent in human liver microsomes from hetero- and homozygotes of CYP2D6*10...
  41. ncbi request reprint Clinical features of renal tubular dysplasia, a new hereditary disease in Japanese Black cattle
    Y Ohba
    Division of Veterinary Medicine, Faculty of Agriculture, Gifu University, Yanagido, Japan
    Vet Rec 149:115-8. 2001
    ..The disease was diagnosed as renal tubular dysplasia by histopathological examination...
  42. ncbi request reprint [Tuberculosis of the elderly (above the age of 75) in national hospitals]
    M Mori
    National Tokyo Hospital
    Kekkaku 76:533-43. 2001
    ..Because tuberculosis, once the disease of the young, is becoming rapidly the disease of the elderly, it is imperative for us to make necessary adjustments to meet this inevitable trend...
  43. ncbi request reprint Adenovirus-mediated transfer of the p53 family genes, p73 and p51/p63 induces cell cycle arrest and apoptosis in colorectal cancer cell lines: potential application to gene therapy of colorectal cancer
    Y Sasaki
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, W-17, Chuo-ku, Sapporo, 060-8556 Japan
    Gene Ther 8:1401-8. 2001
    ..These results suggest that adenovirus-mediated p73beta and p51A/p63gamma transfer are potential novel approaches for the treatment of human cancers, particularly for tumors that are resistant to p53 gene therapy...
  44. ncbi request reprint Genotypic characterization of VapA positive Rhodococcus equi in foals with pulmonary affection and their soil environment on a warmblood horse breeding farm in Germany
    M Venner
    Equine Clinic, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Res Vet Sci 83:311-7. 2007
    ..These results suggest that the majority of foals were exposed to and infected with three pulsotypes of VapA positive R. equi containing an 85-kb type I plasmid...
  45. ncbi request reprint Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity
    J Adolfsson
    Department of Stem Cell Biology, Institute of Laboratory Medicine, University Hospital of Lund, S-221 85 Lund, Sweden
    Immunity 15:659-69. 2001
    ..Thus, upregulation of flt3 expression on Lin(-)Sca1(+)c-kit(+) HSC cells is accompanied by loss of self-renewal capacity but sustained lymphoid-restricted reconstitution potential...
  46. pmc Proportion of peripheral blood and decidual CD4(+) CD25(bright) regulatory T cells in pre-eclampsia
    Y Sasaki
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    Clin Exp Immunol 149:139-45. 2007
    ..These findings suggest that a decreased number of T(reg) cells was present in pre-eclampsia, and these changes might break the maternal tolerance to the fetus...
  47. ncbi request reprint Involvement of CPI-17 downregulation in the dysmotility of the colon from dextran sodium sulphate-induced experimental colitis in a mouse model
    K Sato
    Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    Neurogastroenterol Motil 19:504-14. 2007
    ..These results suggest that the suppression of carbachol-induced contraction in mice with colitis is attributable at least partially to the increased activity of myosin phosphatase following the downregulation of CPI-17...
  48. ncbi request reprint [Mycoplasma pneumoniae detection from throat swab by two-step polymerase chain reaction]
    N Okazaki
    Kanagawa Prefectural Public Health Laboratories, Department of Bacteriology and Pathology
    Kansenshogaku Zasshi 72:742-6. 1998
    ..These results indicate that the two-step PCR method is a useful tool for detection of M. pneumoniae in clinical specimens, although it requires a relatively sophisticated in technique...
  49. ncbi request reprint Molecular cloning and expression of rat prostaglandin E receptor EP2 subtype
    T Sando
    Department of Medicine, Kyoto University Faculty of Medicine, Japan
    Biochem Biophys Res Commun 200:1329-33. 1994
    ..Northern blot analysis demonstrated that the EP2 mRNA is widely expressed in various tissues, the significant expression being observed in the thymus, lung, spleen, heart stomach, and pancreas...
  50. ncbi request reprint [Detection of Mycoplasma pneumoniae from throat swab by polymerase chain reaction]
    N Okazaki
    Department of Bacteriology and Pathology, Kanagawa Prefectural Public Health Laboratories
    Kansenshogaku Zasshi 69:723-8. 1995
    ..The positive rate was increased to 36% by using both the PCR and the serology methods. From these results it was concluded that the PCR method is useful for laboratory diagnosis of M. pneumoniae infections...
  51. ncbi request reprint Molecular and genetic analyses of arylamine N-acetyltransferase polymorphism of rabbit liver
    Y Sasaki
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neurosciences, Japan
    J Biol Chem 266:13243-50. 1991
    ..and Deguchi, T. (1990) J. Biol. Chem. 265, 4630-4634; Deguchi, T., Mashimo, M., and Suzuki, T. (1990) J. Biol. Chem. 265, 12757-12760)...
  52. ncbi request reprint Serum growth hormone and insulin-like growth factor-1 concentrations in Japanese black cattle with growth retardation
    H Kitagawa
    Division of Veterinary Medicine, Faculty of Agriculture, Gifu University, Japan
    J Vet Med Sci 63:167-70. 2001
    ..Calves with growth retardation had higher serum GH concentrations and lower serum IGF-I concentrations. These findings suggested defects in the GH-IGF-1 axis, such as in the GH-receptor...
  53. ncbi request reprint cDNA cloning of mutant catalase in acatalasemic beagle dog: single nucleotide substitution leading to thermal-instability and enhanced proteolysis of mutant enzyme
    K Nakamura
    Drug Metabolism and Pharmacokinetics Research Laboratories, Sankyo Co Ltd, 2 58, Hiromachi 1 Chome, Shinagawa ku, Tokyo 140 8710, Japan
    Int J Biochem Cell Biol 32:1183-93. 2000
    ..These results suggested that the proteolytic degradation mediated most likely by proteasome might be involved in disposing of the mutant catalase in acatalasemic erythroid cells...
  54. ncbi request reprint Characterization of virulence plasmid types in Rhodococcus equi isolates from foals, pigs, humans and soil in Hungary
    L Makrai
    Department of Microbiology and Infectious Diseases, Faculty of Veterinary Science, Szent Istvan University, Hungária krt 23 25, 1143, Budapest, Hungary
    Vet Microbiol 88:377-84. 2002
    ..Furthermore, same intermediately virulence plasmid type was found in both human and pig isolates...
  55. ncbi request reprint Expression of chloride channel, ClC-5, and its role in receptor-mediated endocytosis of albumin in OK cells
    Y Sasaki
    Institute of Pharmaceutical Sciences, Faculty of Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan
    Biochem Biophys Res Commun 282:212-8. 2001
    ..These results suggest that chloride channel, most likely ClC-5, plays an important role in the receptor-mediated endocytosis of albumin in OK cells...
  56. ncbi request reprint Chromosomal assignments of expressed sequence tags for ACTG1, AHSG, COL1A1, GNAS1, and RPLP1 expressed abundantly in the bovine foetus
    Y Muramatsu
    Department of Food Science, Shizuoka Eiwa College, Ikeda, Shizuoka 422 8005, Japan
    Anim Genet 33:230-1. 2002
  57. ncbi request reprint Pathological changes of renal tubular dysplasia in Japanese black cattle
    Y Sasaki
    Laboratory of Internal Medicine, Faculty of Agriculture, Gifu University, Japan
    Vet Rec 150:628-32. 2002
    ..It was concluded that renal tubular dysplasia was the primary lesion of the disease, and that interstitial fibrosis and reductions in the numbers of nephrons were secondary lesions...
  58. ncbi request reprint Molecular analysis of medicinally-used Chinese and Japanese Curcuma based on 18S rRNA gene and trnK gene sequences
    H Cao
    Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan
    Biol Pharm Bull 24:1389-94. 2001
    ..zedoaria, as well as in the Japanese population of C. zedoaria and in one group of C. kwangsiensis with a purple-colored band in leaves. New taxonomic information to be used for authenticating Curcuma drugs was obtained...
  59. ncbi request reprint Involvement of Hgs/Hrs in signaling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1
    Y Sasaki
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine and CREST Program of the Japan Science, and Technology Corporation, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Biol Chem 276:29943-52. 2001
    ..These results suggest that Hgs is involved in the TAK1-JNK and Pak1-serum response factor pathways for the c-fos induction that is initiated by cytokines...
  60. ncbi request reprint Renal reabsorption of magnesium and calcium by cattle with renal tubular dysplasia
    Y Ohba
    Division of Veterinary Medicine, Faculty of Agriculture, Gifu University, Japan
    Vet Rec 151:384-7. 2002
    ..In cattle with the condition the rate of reabsorption of magnesium by the kidneys was low, but the rate of reabsorption of calcium was normal...
  61. pmc Both gene expression for orotate phosphoribosyltransferase and its ratio to dihydropyrimidine dehydrogenase influence outcome following fluoropyrimidine-based chemotherapy for metastatic colorectal cancer
    W Ichikawa
    Second Department of Surgery, Saitama Medical School, 38, Moro Hongo, Moroyama cho, Iruma gun, Saitama 350 0495, Japan
    Br J Cancer 89:1486-92. 2003
    ..0014). In conclusion, both the expression of OPRT gene and the OPRT/DPD ratio might be useful as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer...
  62. ncbi request reprint Effects of genotype matching of feline major histocompatibility complex (FLA) class II DRB on skin-allograft transplantation in cats
    Y Kuwahara
    Division of Veterinary Medicine, Faculty of Agriculture, Gifu University, Japan
    J Vet Med Sci 63:1097-101. 2001
    ....
  63. ncbi request reprint Analysis of the immunoglobulin heavy chain gene variable region of CD5-positive and -negative diffuse large B cell lymphoma
    N Nakamura
    Department of Pathology, Fukushima Medical University School of Medicine, Japan
    Leukemia 15:452-7. 2001
    ..CD5 is not an activated antigen in DLBCL, but a specific marker of the B1 subset of the B cells, and de novo CD5+ DLBCL may therefore be derived from this unique subset...
  64. ncbi request reprint Vascular endothelial growth factor mRNA synthesis by peripheral blood mononuclear cells in patients with acute myocardial infarction
    Y Sasaki
    First Department of Internal Medicine, Nara Medical University, 840 Shijo, Kashihara, 634-8522, Japan
    Int J Cardiol 81:51-60. 2001
    ..The present findings suggest that PBMCs may be one of the candidates responsible for elevated circulatory VEGF protein following aMI. In addition, VEGF mRNA may be overexpressed in PBMCs in response to cardiac muscle damage...
  65. ncbi request reprint Involvement of Rho-kinase in inflammatory and neuropathic pain through phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS)
    S Tatsumi
    Department of Anesthesiology, Osaka Medical College, Takatsuki 569 8686, Japan
    Neuroscience 131:491-8. 2005
    ..Taken together, the present study demonstrates that Rho-kinase is involved in inflammatory pain and the maintenance of neuropathic pain through phosphorylation of MARCKS at Ser159...
  66. ncbi request reprint Interferon sensitivity-determining region of nonstructural region 5A of hepatitis C virus genotype 1b correlates with serum alanine aminotransferase levels in chronic infection
    K Yoshioka
    Department of Internal Medicine, Division of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Viral Hepat 12:139-45. 2005
    ..These results suggest that NS5A with more substitutions in ISDR may lose the ability to block host antiviral pathways and to protect hepatocytes from apoptosis...
  67. pmc Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours
    M Murai
    First Department of Internal Medicine, Sapporo Medical University, Sapporo 060 8556, Japan
    Br J Cancer 92:1165-72. 2005
    ..These results suggest that aberrant DNA methylation of the 5' CpG island and histone deacetylation play key roles in silencing BNIP3 expression in haematopoietic tumours...
  68. ncbi request reprint Comparative studies on susceptibilities of two different Japanese isolates of Oncomelania nosophora to three strains of Schistosoma japonicum originating from Japan, China, and the Philippines
    M Kirinoki
    Department of Tropical Medicine and Parasitology, Dokkyo University School of Medicine, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Parasitology 130:531-7. 2005
    ..We found differences in the development of the parasite between the isolates of snails from early after exposure...
  69. ncbi request reprint Analysis of measles virus binding sites of the CD46 gene in patients with subacute sclerosing panencephalitis
    K Kusuhara
    Dept of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Infect Dis 181:1447-9. 2000
    ..One control subject, but no SSPE patients, had the G/A176 polymorphism in a heterozygous pattern. Thus, it is not likely that CD46 gene alteration has a role as a host susceptibility factor in the development of SSPE...