Y Okubo

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Osteoinduction by bone morphogenetic protein-2 via adenoviral vector under transient immunosuppression
    Y Okubo
    Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    Biochem Biophys Res Commun 267:382-7. 2000
  2. ncbi request reprint Osteoinduction by recombinant human bone morphogenetic protein-2 at intramuscular, intermuscular, subcutaneous and intrafatty sites
    Y Okubo
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Japan
    Int J Oral Maxillofac Surg 29:62-6. 2000
  3. ncbi request reprint In vitro and in vivo studies of a bone morphogenetic protein-2 expressing adenoviral vector
    Y Okubo
    Graduate School of Medicine, Kyoto University, Japan
    J Bone Joint Surg Am 83:S99-104. 2001
  4. ncbi request reprint The time course study of osteoinduction by bone morphogenetic protein-2 via adenoviral vector
    Y Okubo
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Japan
    Life Sci 70:325-36. 2001
  5. ncbi request reprint Effect of hyperbaric oxygenation on bone induced by recombinant human bone morphogenetic protein-2
    Y Okubo
    Graduate Student, Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto
    Br J Oral Maxillofac Surg 39:91-5. 2001
  6. ncbi request reprint Simple and effective osteoinductive gene therapy by local injection of a bone morphogenetic protein-2-expressing recombinant adenoviral vector and FK506 mixture in rats
    S Kaihara
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo ku, Kyoto, Japan
    Gene Ther 11:439-47. 2004
  7. ncbi request reprint Bone induction by Escherichia coli -derived recombinant human bone morphogenetic protein-2 compared with Chinese hamster ovary cell-derived recombinant human bone morphogenetic protein-2
    K Bessho
    Assistant Professor, Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Br J Oral Maxillofac Surg 38:645-649. 2000
  8. ncbi request reprint Effect of elcatonin on osteoinduction by recombinant human bone morphogenetic protein-2
    Y Okubo
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    Biochem Biophys Res Commun 269:317-21. 2000
  9. ncbi request reprint Preclinical study of recombinant human bone morphogenetic protein-2: application of hyperbaric oxygenation during bone formation under unfavourable condition
    Y Okubo
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Shogoin, Japan
    Int J Oral Maxillofac Surg 32:313-7. 2003
  10. doi request reprint Comparison of human mesenchymal stem cells derived from bone marrow, synovial fluid, adult dental pulp, and exfoliated deciduous tooth pulp
    Y Isobe
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Int J Oral Maxillofac Surg 45:124-31. 2016

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Osteoinduction by bone morphogenetic protein-2 via adenoviral vector under transient immunosuppression
    Y Okubo
    Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    Biochem Biophys Res Commun 267:382-7. 2000
    ..The activity of osteoinduction in Group I was higher than that in Group II. These results suggest that gene therapy with AxCAOBMP-2 under transient immunosuppression may be useful for bone reconstruction...
  2. ncbi request reprint Osteoinduction by recombinant human bone morphogenetic protein-2 at intramuscular, intermuscular, subcutaneous and intrafatty sites
    Y Okubo
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Japan
    Int J Oral Maxillofac Surg 29:62-6. 2000
    ..Five microg of rhBMP-2, a relatively low dose, induced adequate new bone formation in all sites. The variations of osteoinductive activity of rhBMP-2 in various sites may be due to differences in the blood supply...
  3. ncbi request reprint In vitro and in vivo studies of a bone morphogenetic protein-2 expressing adenoviral vector
    Y Okubo
    Graduate School of Medicine, Kyoto University, Japan
    J Bone Joint Surg Am 83:S99-104. 2001
    ....
  4. ncbi request reprint The time course study of osteoinduction by bone morphogenetic protein-2 via adenoviral vector
    Y Okubo
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Japan
    Life Sci 70:325-36. 2001
    ..These results suggest that gene therapy with AxCAOBMP-2 under transient immunosuppression may be useful for bone reconstruction...
  5. ncbi request reprint Effect of hyperbaric oxygenation on bone induced by recombinant human bone morphogenetic protein-2
    Y Okubo
    Graduate Student, Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto
    Br J Oral Maxillofac Surg 39:91-5. 2001
    ..These results suggest that HBO accelerated the activity and rate of osteoinduction by rhBM P-2...
  6. ncbi request reprint Simple and effective osteoinductive gene therapy by local injection of a bone morphogenetic protein-2-expressing recombinant adenoviral vector and FK506 mixture in rats
    S Kaihara
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo ku, Kyoto, Japan
    Gene Ther 11:439-47. 2004
    ..These results indicate that coinjection of FK506 significantly promotes osteoinduction. In addition, local injection of FK506 may also make it possible to prevent a decrease of gene expression with other adenoviral vector...
  7. ncbi request reprint Bone induction by Escherichia coli -derived recombinant human bone morphogenetic protein-2 compared with Chinese hamster ovary cell-derived recombinant human bone morphogenetic protein-2
    K Bessho
    Assistant Professor, Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Br J Oral Maxillofac Surg 38:645-649. 2000
    ..Quantitative analysis indicated that the activity of ErhBMP-2 was similar to that of CrhBMP-2, so ErhBMP-2 may be useful for inducing bone formation...
  8. ncbi request reprint Effect of elcatonin on osteoinduction by recombinant human bone morphogenetic protein-2
    Y Okubo
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    Biochem Biophys Res Commun 269:317-21. 2000
    ..These results suggested that elcatonin is effective in enhancing osteoinduction by rhBMP-2 within the dose range of this study, and that elcatonin has an anabolic effect on osteoblasts in addition to an antiresorptive effect...
  9. ncbi request reprint Preclinical study of recombinant human bone morphogenetic protein-2: application of hyperbaric oxygenation during bone formation under unfavourable condition
    Y Okubo
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Shogoin, Japan
    Int J Oral Maxillofac Surg 32:313-7. 2003
    ..Hyperbaric oxygenation therapy may increase the clinical application of rhBMP-2 to unfavourable condition...
  10. doi request reprint Comparison of human mesenchymal stem cells derived from bone marrow, synovial fluid, adult dental pulp, and exfoliated deciduous tooth pulp
    Y Isobe
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Int J Oral Maxillofac Surg 45:124-31. 2016
    ..Variability was found in the differentiation potential corresponding to the tendency of the original tissue to differentiate. It is suggested that the cell type should be selected depending on the regenerative treatment regimen. ..
  11. doi request reprint The effects of C-type natriuretic peptide on craniofacial skeletogenesis
    K Nakao
    Department of Oral and Maxillofacial Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Dent Res 92:58-64. 2013
    ..These results indicate that CNP primarily stimulates endochondral ossification in the craniofacial region and is crucial for midfacial skeletogenesis...
  12. ncbi request reprint Regeneration of articular cartilage defects in the temporomandibular joint of rabbits by fibroblast growth factor-2: a pilot study
    H Takafuji
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, 54 Syogoin, Kawahara cho, Sakyo ku, Kyoto shi 606 8507, Japan
    Int J Oral Maxillofac Surg 36:934-7. 2007
    ..The present results suggest that an optimum concentration of FGF-2 could restore defects of TMJ articular cartilage clinically...
  13. ncbi request reprint Visualization of IP(3) dynamics reveals a novel AMPA receptor-triggered IP(3) production pathway mediated by voltage-dependent Ca(2+) influx in Purkinje cells
    Y Okubo
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Neuron 32:113-22. 2001
    ..These results revealed a novel IP(3) signaling pathway in Purkinje cells that can be elicited by synaptic inputs from climbing fibers...
  14. ncbi request reprint Effectiveness of kampo medicine (sai-boku-to) in treatment of patients with glossodynia
    K Bessho
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 86:682-6. 1998
    ..The purpose of this study was to evaluate the usefulness of a Kampo medicine (Sai-boku-to) for treatment of patients with glossodynia...
  15. ncbi request reprint Regeneration of defects in the articular cartilage in rabbit temporomandibular joints by bone morphogenetic protein-2
    T Suzuki
    Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, Ishikawa, Japan
    Br J Oral Maxillofac Surg 40:201-6. 2002
    ..However, this study supports the contention that BMP-2 may be useful in the regeneration of cartilage in TMJ disease...